Yu de tek lithium? Dɔn yu fɔ no bɔt dis denja! (Litiɔm Tɔksisiti) .

Yu ɔ pɔrsin wae yu sabi kin yuse lithium, na mɛrɛsin wae dɔktɔ kin gi yu fɔ sɔm kayn mɛntɛl hεlth sik, mɔr di bipolar disorder? Pan ɔl we dis mɛrɛsin kin rili ɛp we yu yuz am fayn, if yu tek am tumɔs, dat kin mek yu gɛt wan bad bad tin we dɛn kɔl lithium toxicity. Lɛ wi tɔk bɔt dis tide. Fɔ tɔk am simpul wan, lithium toxicity na we yu bɔdi gɛt tumɔs lithium. Dis kin mek yu bɛlɛ at pwɛl (lɛk fɔ vɔmit, dayarɛa) ɛn gɛt sɔm sayn dɛm na yu nervɔs sistɛm (lɛk fɔ kɔnfyus, fɔ shek). If dɛn nɔ trit am fayn, dis kin mek pɔsin in layf de pan denja. Litiɔm na sɔl we de na di wɔl. I de ridyus di mania. Na dat mek bɔku tɛm dɔktɔ dɛn kin gi dɛn dis mɛrɛsin fɔ di sik we dɛn kɔl bipolar disorder. Bɔt di margin bitwin wan sef ɛn denja doz fɔ dis mɛrɛsin rili smɔl. Dis min se ivin if yu du am tumɔs smɔl, i nɔ go ebul fɔ bia fɔ di bɔdi.

Aw di litiɔm toxiciti kin apin?

Bɔku we dɛn de we dis kin apin. Lɛ wi si wetin dɛn bi.

Akyu Tɔksisiti

Dis kin apin if yu tek bɔku litiɔm pils wantɛm wantɛm, ɔ if yu bɔdi nɔ gɛt bɛtɛ wata wantɛm wantɛm. Tink bɔt am, sɔntɛnde yu kin mek mistek we yu de tek yu mɛrɛsin. Dat kin apin.

Fɔ tek mɔ pas aw yu nid ɛvride (Acute-on-chronic Toxicity) .

Dis kin apin if yu nɔmal fɔ tek lithium ɛvride, bɔt wan de yu tek ɛkstra doz, ɔ if yu bɔdi nɔ gɛt wata wan de. Fɔ ɛgzampul, if yu nɔ drink bɛtɛ wata fɔ tu ɔ tri dez, ɔ if yu vɔmit bɔku ɛn yu nɔ gɛt wata na yu bɔdi.

Pɔyzin we nɔ de dɔn

Dis kin apin bikɔs we yu tek lithium ɛvride, di lithium we de na yu bɔdi kin go ɔp smɔl smɔl ɛn bɔku as tɛm de go. Dis kin apin izi wan. Bɔku tin dɛn lɛk we yu nɔ gɛt wata na yu bɔdi, yu kidni wɛlbɔdi, ɛn ɔda mɛrɛsin dɛn we yu de tek kin afɛkt aw yu bɔdi de yuz litiɔm.

Wetin na di lɛvɛl dɛn we di litiɔm gɛt?

Dɔktɔ dɛn kin chɛk yu litiɔm lɛvɛl wit blɔd tɛst. Yu dɔktɔ go disayd us lɛvul fayn fɔ yu. in jεnarכl, di lithium tכksisiti lεvεl dεm dεn divayd lεk dis:

• Mild tכksisiti : 1.5 to 2.5 mmol/L.
• Modarεt tכksisiti: 2.5 to 3.5 mmol/L.
• Sivεr tכksisiti: I hכy pas 3.5 mmol/L.

Yu nɔ nid fɔ tink tumɔs bɔt dis yunit we dɛn kɔl milimol (`mmol/L`), na sɔntin we impɔtant to dɔktɔ. Wae impɔtant fɔ yu na fɔ no bɔt de sik.

Wetin na di sayn dɛm fɔ lithium toxicity?

Dɛn sayn ya kin difrɛn difrɛn wan fɔ di kayn pɔyzin ɛn aw i bad.

Di simptom dɛm fɔ akyu ɛn akyu-ɔn-krɔnik pɔyzin

tεm lεk dis, di fכs tin we kin kam na yu maynd na bεlε prכblεm (Gastrointestinal - GI prכblεm). Dat min se:

• Nɔs ɛn vɔmit .
• Dayarɛa (we pɔsin kin vɔmit).
• Bɛlɛ we de at .
• Fɔ fil lɛk se yu bɛlɛ ful-ɔp.

Dɛn sayn ya kin bigin fɔ sho insay wan awa afta yu tek bɔku lithium.

Impɔtant: If yu gɛt dɛn sik ya, i rili impɔtant fɔ go to dɔktɔ wantɛm wantɛm.

If di pɔyzin na smɔl to siriɔs, di sayn dɛm we gɛt fɔ du wit di nervɔs sistɛm kin fala di bɛlɛ we de pwɛl. Dɛn tin ya na:

• Chenj na di mental stet: I kin kɔmɔt frɔm smɔl kɔnfyushɔn to siriɔs delirium.
• Shek we pɔsin nɔ ebul fɔ kɔntrol (Tremors).
• lכs f כ bεlε εn kכdכnayshכn we yu de waka כ tinap (`Ataxia`).
• Di mɔsul dɛn we de twitch (`Myoclonus`).
• Slurring fɔ tɔk (`Dysarthria`).
• Hyperreflexia (we yu de riak pasmak).
• di muvmεnt we di yay dεm nכ de kכntro (Nystagmus).
• If i siriɔs, fiva kin bɔku (Hyperthermia).
• If i siriɔs, yu kin gɛt sik dɛn we de mek yu sik .
• Insay siriɔs kes dɛm, yu kin lɔs yu kɔnshɛns (`Kɔma`).

If yu de tek lithium ɛn yu gɛt ɛni wan pan dɛn sik ya, yu fɔ go to dɔktɔ wantɛm wantɛm.

Simptom dɛm fɔ Kronik Litiɔm Tɔksisiti

We pɔsin it litiɔm fɔ lɔng tɛm, bɔku tɛm i kin pwɛl di kidni dɛn. Dis kin mek yu gɛt difrɛn kayn sik dɛn na yu kidni, ɛn ɛni wan pan dɛn gɛt in yon sayn dɛn. Na sɔm pan di tin dɛn we kin apin:

Nɛfrɔjɛnik Dayabitis Insipidus

Dis na we yu kidni dɛn nɔ ebul fɔ balans di wata we de na yu bɔdi fayn fayn wan. Dɛn nɔ kin ebul fɔ ansa di antidiuretic hormone (ADH) fayn fayn wan. Di sayn dɛm na:

• We yu nɔ gɛt wata na yu bɔdi: yu mɔt de dray, yu taya, ɛn yu de tɔn diziz.
• Fɔ fil se yu tɔsti pasmak (` Polydipsia` ).
• Pas bɔku urine (`Polyuria`).

Nefrayt we de lɔs sɔdiɔm

insay dis, di damej pan di kidni dεm de mek di εlektrolayt imbalans na di bכdi. Di sayn dɛm na:

• Di bɔdi de tɔn ɛn wik.
• Di chenj dɛn we de apin na di maynd.
• Taya.
• Fɔ tɔsti pasmak.
• Fɔ pis pasmak (`Polyuria`).

Nɛfrɔtik Sindrom

insay dis kכndishכn, yu kidni dεm de kכl tu mכch protin na yu urine (`Proteinuria`). Sayn dɛn:

• Di kɔlɔstrel we de go ɔp (Hyperlipidemia).
• Swel na di leg ɛn ankles (`Edema`).
• Di it nɔ de te.
• Bɛlɛ de at.
• Di urine de fom.

di εndokrin sistεm prכblεm kin apin bak bikoz fכ di lithium pכyzin fכ lכng tεm. Ɛgzampul dɛn:

• di tayroyd fכnshכn de dכn (`Hypothyroidism`).
• di aktvכti we di tayroyd gland de inkrεs (`Hyperthyroidism`).
• di aktvכti we di paratayroyd gland dεm de inkrεs (`Hyperparathyroidism`).

If yu gɛt ɛni wan pan dɛn sik ya we yu de tek litiɔm, tɔk to dɔktɔ kwik kwik wan.

Di rilayshɔn bitwin litiɔm ɛn sɛrotonin sindrom

Lithium kin mek yu gɛt wan sik we dɛn kɔl sɛrotonin syndrome. Dis risk kin pasmak if yu de tek ɔda mɛrɛsin wae de afɛkt di sɛrotonin lɛvɛl. Dis kin mek pɔsin in layf de pan denja bak. Di sayn dɛm fɔ sɛrotonin sindrom (we kin kɔmɔt frɔm smɔl to siriɔs):

• We pɔsin nɔ de rɛst.
• Nɔs ɛn vɔmit.
• Rɔnbɛlɛ.
• Di pupil dɛn na di yay kin big.
• Tremor.
• Fɔ wɔri, fɔ nɔ gɛt rɛst.
• Grind ɛn pres mitbɔl.
• Swet ɛn shek shek.
• Kɔnfyushɔn, we pɔsin nɔ de no natin (Delirium).
• Di at we de blo.
• Di ay blɔd prɛshɔn.

If yu gɛt dɛn sik ya, go to dɔktɔ wantɛm wantɛm!

Wetin na di tin dɛn we kin mek di litiɔm gɛt pɔyzin?

Tri men rizin dɛn de fɔ dis:

• If yu it lithium pasmak: If yu tek bɔku lithium pils, ilɛksɛf na bay wilful ɔ aksidɛnt, i kin mek yu gɛt akyu ɔ akyu-ɔn-krɔnik pɔyzin. Dis kin apin bak if dɔktɔ inkrisayz yu doz tumɔs, bɔt dis nɔ kin apin so ɔltɛm.
• Di wata we de kɔmɔt na yu bɔdi ɔ we yu de chenj yu wata: Dis na di tin we kin mek yu nɔ gɛt wata pas ɔl. We di bɔdi lɔs sɔdiɔm (sɔl) ɛn wata, di kidni dɛn kin tek di litiɔm bak. Dis kin mek di litiɔm we de na di blɔd bɔku. Di tin dɛn we kin mek i apin na:
• We yu de vɔmit.
• We dayarɛa de apin.
• We yu gɛt fiva.
• Kidni we nɔ de wok fayn.
• We yu de tek mɛrɛsin dɛn we de mek yu pis, lɛk diuretics.
• We yu de du ɛksɛsayz pasmak.
• Fɔ swet pasmak (Hyperhidrosis).
• Jɔs lɛk we yu nɔ de drink wata.
• We yu de it tin we nɔ gɛt bɔku sɔl.
• At kכndishכn dεm (`Kכnjεstiv at fεil`).
• We uman gɛt bɛlɛ ɔ we i de bɔn pikin.
• Tayroyd gland de chenj (`Hyperthyroidism`).
• Isyu dɛm we gɛt fɔ du wit di we aw pɔsin de pul di litiɔm: Sɔntɛnde di bɔdi nɔ kin ebul fɔ pul di litiɔm fayn fayn wan. Dis kin bi bak bikɔs ɔf di rizin dɛn we wi dɔn tɔk bɔt.

Udat de pan ay risk fɔ gɛt lithium toxicity?

Dɛn pipul ya de pan ay risk fɔ gɛt chronic lithium toxicity:

• Pipul dɛn we dɔn pas 50 ia.
• Pipul dɛn we gɛt tayroyd sik.
• Pipul dɛn we nɔ kin wok fayn na dɛn kidni.
• Pipul dɛn we gɛt dayabitis insipidus.

Ivin if yu yuz lithium fɔ lɔng tɛm, yu kin gɛt mɔ risk fɔ gɛt nephrogenic diabetes insipidus, we na lithium kin mek yu gɛt am. Dis kin mek yu gɛt lithium toxicity. If yu gɛt ɛni wan pan dɛn sik ya we yu de tek litiɔm, tɔk to yu dɔktɔ.

Aw dɔktɔ dɛn kin no se di litiɔm gɛt pɔyzin?

Fɔ no gud gud wan aw dis kin tranga, dis infɔmeshɔn rili impɔtant fɔ dɔktɔ dɛn:

• Aw bɔku litiɔm yu tek?
• Ustɛm yu tek am?
• Bɔt yu bin tek ɛni ɔda mɛrɛsin ɔ ɔda tin dɛn di sem tɛm?
• Yu tink se na bay wilful dɛn bin du dis ɔ na mistek?

Fɔ mek dɛn no se litiɔm gɛt pɔyzin, dɔktɔ dɛn kin du bɔku tɛst dɛn. Sɔm pan dɛn na:

• Blɔd tɛst fɔ chɛk di lɛvɛl we di litiɔm de na yu blɔd.
• Blɔd tɛst we de chɛk di lɛvɛl dɛn we di ilɛktrɔlayt dɛn (lɛk sɔdiɔm ɛn kalsiɔm) de na yu blɔd.
• Blɔd tɛst we de chɛk di tayroyd-stimulating hormone (TSH) lɛvɛl.
• Urinalysis we dɛn kin du.
• di kidni fכnshכn tεst dεm (lεk di bכdi yuria εn kriaytinin lεvεl).
• di bren imej tεst dεm (dεn kin du dis bכku bכku wan).

Dɔktɔ dɛn go de wach yu wɛlbɔdi bak fɔ tin dɛn lɛk:

• Yu at wit wan `EKG` (ilɛktrokardiogram).
• Aw bɔku yu de pis (urine output).
• yu כksijεn lεvεl - bכku tεm dεn kin mכsu am wit `puls כksimita` (`puls ox`).

Aw dɛn kin trit di litiɔm toxiciti?

Di tritmɛnt fɔ akyu ɛn akyu-ɔn-krɔnik litiɔm pɔyzin kin difrɛn difrɛn wan bay aw i bad ɛn aw yu kin rich kwik kwik wan na di imejensi rum. De men gol na fɔ pul di lithium na yu bɔdi ɛn kɔntrol yu sik dɛn. Di tritmɛnt kin inklud:

• Gastric lavage we dɛn kin yuz fɔ mek di bɔdi.
• irigashɔn fɔ di wan ol bɔdi: Dis min se yu fɔ gi spɛshal wata bay yu mɔt ɔ tru wan tiub we dɛn put tru di nos insay di bɛlɛ. dis de pul כl di lithium we de kכmכt na di gεstrointestinal trakt.
• Activated charcoal: Dɛn kin gi yu dis if yu dɔn tek ɔda mɛrɛsin ɔ tin dɛn.
• Ɛmodayalis: Dis na di men we fɔ pul di litiɔm na di kidni.
• Gi salin (`IV fluid`).
• Difrɛn mɛrɛsin dɛn kin trit di sayn dɛn we pɔsin kin gɛt.

Bɔku tɛm, dɛn go trit yu na imejensi rum. If di pɔyzin rili bad, yu kin nid fɔ trit yu na say usay dɛn de kia fɔ pipul dɛn we sik bad bad wan (ICU).

Tritmɛnt fɔ Kronik Litiɔm Tɔksisiti

Bɔku tɛm, we pɔsin gɛt litiɔm pɔyzin fɔ lɔng tɛm, dat kin mek di kidni pwɛl. Di tritmɛnt dipen pan di kayn kidni prɔblɛm. I kin nid fɔ mek dɛn du ɛmodayalis.

Wetin na de chans fɔ mek yu wɛl pan dis kayn tin? (Prɔgnosis) .

Fɔ wɛl frɔm di lithium toxicity dipen pan di kayn pɔyzin, aw i bad, ɛn aw yu go go to dɔktɔ kwik kwik wan. Pipul dεm wae nכ de divεlכp nyurolכjik simptom frכm akyu lithium tכksisiti kin nכ kin gεt lכng tεm kכmplikεshכn. Bɔt if yu gɛt siriɔs nyurolɔjik sayn dɛm, dɛn kin de fɔ ɔltɛm. Na dat mek i rili impɔtant fɔ gɛt tritmɛnt kwik kwik wan. If i siriɔs, di pɔyzin we di litiɔm gɛt kin mek pɔsin kɔma, in bren pwɛl, ɔ ivin day. Krכnik lithium tכksisiti kin at fכ no biכs di simptom dεm kin divεlכp as tεm de go. Dis delay kin mek yu gɛt prɔblɛm wit yu kidni ɛn nervɔs sistɛm fɔ lɔng tɛm.

Aw fɔ mek di litiɔm nɔ gɛt pɔyzin?

If yu fala dɛn step ya, i kin ɛp fɔ mek yu nɔ gɛt akyu litiɔm toxiciti:

• Tek yu mɛrɛsin dɛn jɔs lɛk aw dɛn tɛl yu fɔ tek am: Tek di kayn lithium (ɛn ɔda mɛrɛsin dɛn) nɔmɔ we yu dɔktɔ tɛl yu fɔ tek. Kip wan lɛbl pan yu mɛrɛsin bɔtul dɛn, ɔ rayt di tɛm dɛn we yu tek am. Dis kin ɛp yu fɔ avɔyd fɔ tek dabl doz bay aksidɛnt.
• Kip yu lithium mɛrɛsin sef: Kip am usay pikin ɛn ɔda pipul dɛn nɔ go ebul fɔ rich.
• Stay hydrated: yu fɔ gɛt wata:Drink bɔku wata. If yu nɔ gɛt wata na yu bɔdi, dat kin mek yu gɛt litiɔm pɔyzin. Tɛl yu dɔktɔ if yu gɛt vɔmit, dayarɛa, ɔ fiva.
• Ɔltɛm tɛl yu dɔktɔ wan list fɔ ɔl di mɛrɛsin dɛn we yu de tek: Bifo yu bigin fɔ tek nyu mɛrɛsin, tɛl yu dɔktɔ se yu de tek lithium (ɛn ɛni ɔda mɛrɛsin). Sɔm mɛrɛsin kin afɛkt di we aw yu bɔdi de handle lithium.
• Tɛl yu dɔktɔ if yu gɛt ɛni nyu ɔ wantɛm wantɛm chenj na yu wɛlbɔdi: fɔ ɛgzampul, bɛlɛ ɛn ɔmon (endocrine) chenj.

If yu de tink bɔt fɔ kil yusɛf, ɔ if yu de tink fɔ tek tumɔs litiɔm bay wilful, duya go na di ɔspitul imejensi dipatmɛnt we de nia yu, ɔ tɔk to pɔsin we yu trɔst. Insay Sri Lanka, yu kin gɛt ɛp bak frɔm ɔganayzeshɔn dɛn lɛk Sumithrayo (fon nɔmba 0112692909 ɔ 0112682535).

If yu de tek lithium fɔ lɔng tɛm, yu dɔktɔ go tɛl yu fɔ du blɔd ɛn urine tɛst ɔltɛm fɔ wach yu wɛlbɔdi. Dɛn tɛst ya kin ɛp fɔ no di kronik litiɔm toxiciti kwik kwik wan. Dis na di tɛst ɛn gaydlayn dɛn:

• Dɛn kin chɛk di litiɔm lɛvɛl na di blɔd insay tri to fayv dez afta dɛn dɔn bigin fɔ gɛt litiɔm ɔ chenj di doz.
• Fɔ di wan dɛn we de tek mɛrɛsin fɔ lɔng tɛm , dɛn kin chɛk di litiɔm lɛvɛl na di blɔd ɛvri tri to siks mɔnt.
• Dɛn kin chɛk di ilɛktrɔlayt, yuria, ɛn kriaytinin lɛvɛl ɛvri tri to siks mɔnt.
• di kalsiכm εn tayroyd stimulating hormone (TSH) lεvεl dεm dεn de chεk εvri siks to twεlv mכnt.

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

Litiɔm na mɛrɛsin we rili pawaful ɛn we de wok fayn, bɔt i nid fɔ tek tɛm mɔ we yu de yuz am. Lithium toxicity na wan prɔblɛm we kin mek yu layf de pan denja we kin apin we yu tek di mɛrɛsin tumɔs ɔ we yu lɔs bɔku wata we yu de tek di mɛrɛsin. Tɔk to yu dɔktɔ bɔt aw fɔ mek yu nɔ gɛt lithium toxicity ɛn di sayn dɛm we yu fɔ wach fɔ. Dɔktɔ dɛn de fɔ ɛp yu ɛn mek yu gɛt wɛlbɔdi. So, nɔ fred fɔ aks if yu gɛt ɛni kwɛstyɔn ɔ tin we de mɔna yu. Mɛmba se di tin we impɔtant pas ɔl na fɔ tek yu mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu fɔ tek, di rayt tɛm. Dɔn bak, nɔ fɔgɛt fɔ drink bɔku wata.