Lɛ wi lan bɔt Malignant Hyperthermia, we na wan bad bad tin we kin apin to pɔsin we dɛn de anestez pɔsin we dɛn de du ɔpreshɔn.

If yu ɔ sɔmbɔdi na yu famili ɛva gɛt fɔ du ɔpreshɔn, dɛn go gi yu anestezi bifo dat, nɔto so? Fɔ tɔk am simpul wan, i de mek wi slip kpatakpata. Bɔt fɔ sɔm pipul dɛn, sɔm pan di mɛrɛsin dɛn we dɛn kin yuz fɔ dis anestezi kin mek dɛn gɛt bad bad tin we dɛn nɔ go ebul fɔ imajin, ɛn dɛn kin ivin mek dɛn day. Tide wi de tɔk bɔt malignant hyperthermia , we na wan sik we denja bɔt we pɔsin kin trit if dɛn no am kwik.

Wetin na Malignant Hyperthermia?

Fɔ tɔk am simpul wan, Malignant Hyperthermia na wan sik we pɔsin kin gɛt we i kam pan jɛnɛtiks. Dis min se na tin we pɔsin kin gɛt frɔm dɛn gret gret granpa dɛn. We pɔsin we gɛt dis sik gɛt sɔm kayn anestezi we dɛn de du ɔpreshɔn, in bɔdi kin riak bad bad wan. Dis na imejensi we kin mek pɔsin in layf de pan denja. Bɔt di tin we impɔtant pas ɔl na ya na dat dis nɔ kin apin wit ɛvri mɛrɛsin we dɛn kin yuz fɔ anestesia we dɛn de du ɔpreshɔn. Na smɔl nɔmba nɔmɔ pan drɔgs kin mek dis riakshɔn. Pantap dat, if dɛn no am, dɛn kin trit am kwik kwik wan. Bɔrku tɛm, pɔrsin nɔr kin no se dɛn gɛt wan jin muteshon wae gɛt fɔ du wit dis na in bɔdi. Bikɔs dɛn nɔ de sho ɛni sayn na nɔmal layf. Di prɔblɛm kin jɔs apin we da patikyula mɛrɛsin de we de mek pɔsin nɔ fil fayn, kam insay di bɔdi.

Udat dɛn de pan denja mɔ?

Dis risk kin de mɔr if pɔrsin na di famili gɛt dis sik.

• Famili histri: If yu fambul we de nia yu - mama, papa, brɔda, sista, ɔ pikin - dɔn gɛt malignant hyperthermia, yu kin gɛt mɔ risk. So, if yu ɛva du ɔpreshɔn, i impɔtant fɔ tɛl di dɔktɔ we de anestez bɔt dis famili istri .
• Sɔm mɔsul sik dɛn: Ilɛksɛf nɔbɔdi na yu famili nɔ gɛt dis prɔblɛm, pipul dɛn we gɛt sɔm mɔsul sik dɛn we nɔ kin apin so ɔltɛm kin gɛt mɔ prɔblɛm. Fɔ ɛgzampul:
• Sɛntral kɔr sik
• Di sik we dɛn kɔl multiminicore
• Di sik we dɛn kɔl King-Denborough syndrome
• STAC3 dizayd

Dɛn tin ya nɔ kin apin so ɔltɛm, bɔt if yu ɔ sɔmbɔdi na yu famili gɛt wan, i impɔtant fɔ mek yu dɔktɔ no.

Aw dis sik kin kɔmɔn?

Dis na rili kɔmɔn sik. Statistikin sho se dis sik kin apin pan lɛk wan pan ɛvri 100,000 ɔpreshɔn dɛn we big pipul dɛn kin du. Pan yɔŋ pikin dɛn, dis nɔmba kin pas smɔl, dat na, wan pan ɛvri 30,000 ɔpreshɔn dɛn. I fayn bak fɔ no se af pan di sik pipul dɛn we dɛn no nɔ rich 19. Bɔt sayɛnsman dɛn tink se pipul dɛn we gɛt dis kayn sik kin bɔku na di sosayti. Dis na bikɔs, ivin if dɛn gɛt di jin, if dɛn nɔ gɛt anestetik drɔgs we de mek dɛn riakshɔn de ɔlsay na dɛn layf, dis kɔndishɔn nɔ go ɛva kam.

Wetin na di sayn dɛm fɔ dis?

Dɛn sayn ya kin apin we dɛn de du di ɔpreshɔn ɔ jɔs afta dɛn du di ɔpreshɔn we yu de wɛl. If yu gɛt dɛn sayn ya we yu de slip ɛn ɔnda anestezi, yu nɔ go fil dɛn. Bɔt yu dɔktɔ we de anestez go notis dɛn. Dɛn go tek tɛm wach yu impɔtant sayn dɛn ɔl di tɛm we dɛn de du di ɔpreshɔn. So dɛn go bigin fɔ trit dɛn jɔs afta dɛn notis dɛn sayn ya.

Wetin mek dis de apin? Wetin na di rizin?

Pipul dεm wae kin gεt Malignant Hyperthermia gεt jεnεtik chenj, dat na, jεnεtik mכtεshכn, insay sכm protin dεm na dεn mכsul sεl dεm. Imajin se wi mɔsul sɛl dɛn gɛt kalsiɔm we dɛn dɔn kip insay dɛn. di rilis fכ dis kalsiכm de kכntro bay sכmtin lεk get. We dɛn gi nɔmal pɔsin mɛrɛsin we de mek pɔsin nɔ fil fayn, dis get kin wok di we we dɛn kin kɔntrol. Dis kin mek di mɔsul dɛn kɔntrakt ɛn tayt, di bɔdi in mɛtabolism kin bigin fɔ spid, ɛn di bɔdi in tɛmpracha kin go ɔp bad bad wan. Afta sɔm tɛm, di mɔsul sɛl dɛn kin day, ɛn bɔku bɔku tin dɛn lɛk potashɔm kin gɛda na di blɔd. Ɔda siriɔs sayn dɛn kin apin bikɔs ɔf dɛn rizin ya.

Us drɔgs kin mek dis riakshɔn?

Dis sik kin kam mɔ pan tu grup dɛm fɔ drɔgs.

• Anestetik we dɛn kin inhal:
• Halothane we dɛn kɔl Halothane
• Desflurane we dɛn kɔl
• Sevoflurane we gɛt di sik
• Isoflurane we gɛt di sik
• Di mɛrɛsin dɛn we dɛn kin put insay di bɛlɛ : .
• Succinylcholine (dis na tin we de mek di mɔsul dɛn rilaks fast fast) .

Aw yu kin no ɛn kɔnfɔm dis?

Ditekshɔn we dɛn de du di ɔpreshɔn

Bɔku tɛm, dɛn kin no am we dɛn de du ɔpreshɔn. If yu nɔ no se yu gɛt dis sik, yu dɔktɔ we de anestez nɔ go no se yu gɛt dis sik. Bɔt i go de wach yu ɔl di tɛm we dɛn de du di ɔpreshɔn ɛn i kin sɔprayz se yu gɛt malignant hyperthermia if dɛn notis dɛn chenj ya:

• Hat rit we de go ɔp fɔ natin.
• Di tɛmpracha na di bɔdi kin go ɔp kwik kwik wan .
• Di bɔku bɔku kabon dayɔgzayd we dɛn kin pul kin bɔku.
• Di mɔsul dɛn we de stif.

Dɛn tren di wan dɛn we de anestez fɔ no dɛn chenj ya kwik kwik wan, so dɛn kin bigin fɔ trit dɛn kwik kwik wan.

Yu tink se i pɔsibul fɔ no bifo tɛm if prɔblɛm de?

If yu sɔspɛkt se yu gɛt dis risk bikɔs ɔf yu famili histri, sɔm spɛshal tɛst dɛn de fɔ kɔnfirm am.

• Caffeine Halothane Contracture Test (CHCT): Dis min se yu fɔ tek wan rili smɔl pat pan yu mɔsul (muscle biopsy) ɛn put am pan halothane gas ɛn kafin na lɛbɔtri. Dɛn kin yuz di we aw di mɔsul pat de riak fɔ no if yu kin gɛt dis sik.
• jεnεtik tεst: Dis tεst, we involv fכ tek bכdi sεmpl, kin no di jεnεtik mכtεshכn dεm (e.g., RYR1, STAC3, CACNA1S) we kכl Malignant Hyperthermia.

Bɔt dɛn tɛst ya dia smɔl, ɛn dɛn nɔ de ɔlsay na Sri Lanka. So, if yu nid fɔ gɛt ɔpreshɔn kwik kwik wan ɛn sɔmbɔdi na yu famili gɛt dis sik, dɔktɔ dɛn nɔ go wet fɔ di tɛst ɛn dɛn go jɔs yuz sef anestetik we nɔ go mek dis riakshɔn insay yu.

Aw dɛn kin trit am?

Di men ɛn we de sev layf we dɛn kin gi if pɔsin gɛt bad bad aypatɛma na dantrolene . As di dɔktɔ we de mɛn pipul dɛn we de anestezi tink se dis sik, dɛn kin gi dis mɛrɛsin wantɛm wantɛm insay dɛn bɛlɛ. Na di sem tɛm, .

• Di anestetik we de mek di riakshɔn de stɔp wantɛm wantɛm.
• Dɛn go tɛl di dɔktɔ we de du di ɔpreshɔn ɛn dɛn go dɔn di ɔpreshɔn kwik kwik wan.
• fכ ridyus di hכy bכdi tεmprachכ , dεn kin gi kol IV wata insay di vein dεm, εn dεn kin kol di bכdi wit tin dεm lεk ays pak.
• I de gi ɔksijɛn.
• I de trit di prɔblɛm dɛn we gɛt fɔ du wit di at ritm.

We dɛn dɔn kɔntrol di sik, dɛn go kip yu na di intensiv kia yunit (ICU) fɔ at le wan de, usay di mɛdikal tim go de wach yu. Insay dis tɛm, dɛn go du mɔ blɔd tɛst ɛn gi dɛn ɔda tritmɛnt as nid de.

Aw di tin go tan lɛk? Wetin na di prɔblɛm dɛn we kin apin?

If di mɛdikal tim no dis sik kwik kwik wan ɛn trit am kɔrɛkt wan, i pɔsibul fɔ mek i wɛl ful wan. Di kɔmplikɛshɔn dɛm wae kin kam wit dis na:

• Mɔsul dɛn we dɔn pwɛl.
• Kidni we nɔ de wok fayn.
• Liva nɔ de wok fayn.
• Blɔd we de kɔmɔt.
• Di at we de mek di at nɔ de wok.
• Di sik dɛn we kin mek pɔsin sik.
• Go insay wan kɔma.
• Day.

Malignant Hyperthermia na wan sik wae kin kil pɔrsin if dɛn nɔr trit am. Ivin wit di rayt tritmɛnt, di nɔmba fɔ pipul dɛn we de day de bitwin 3% ɛn 5%.

Yu tink se dɛn go ebul fɔ stɔp dis?

Yɛs, dɛn kin ebul fɔ stɔp am! Di bɛst we fɔ du dis na fɔ no bɔt di prɔblɛm we yu gɛt fɔ yusɛf ɛn yu dɔktɔ. If yu no se yu gɛt wan jenɛtik muteshɔn we gɛt fɔ du wit dis, ɔ if yu no se sɔmbɔdi na yu famili gɛt dis sik, yu fɔ tɛl di dɔktɔ we de anestez bifo dɛn du yu ɔpreshɔn. Dɔn we i gi yu anestezi, i go yuz mɛrɛsin dɛn we nɔ gɛt wan prɔblɛm instead fɔ yuz dɛn mɛrɛsin dɛn de we de mek yu gɛt prɔblɛm. Dɔn da denja riakshɔn de nɔ go apin. Bɔrku pipul dɛn kin no se dɛn kin gɛt dis risk afta i dɔn apin to dɛn. Na dat mek i rili impɔtant fɔ no yu famili mɛdikal istri. Malignant Hyperthermia, anestezi, ɔpreshɔn, anestezi riakshɔn, jenɛtik sik, dantrolene, famili istri, ɔpreshɔn sef, anestesia kɔmplikeshɔn, jenɛtik sik