Di mɛrɛsin dɛn we yu de tek de pwɛl yu yes? Mek wi tok abaut ototoxicity!

Yu dɔn ɛva tink se sɔm mɛrɛsin dɛn, mɔ di wan dɛn we dɛn kin yuz fɔ mɛn siriɔs sik, kin pwɛl wi yes, we min se wi kin yɛri ɛn balans? Dis na rial tin we pɔsin kin du. Insay mɛrɛsin, wi kin kɔl dis kɔndishɔn ɔtotoksisiti. Nɔ wɔri, i impɔtant fɔ no bɔt dis. Lɛ wi tɔk bɔt am ditayli.

Wetin na ɔtotoksisiti?

Fɔ tɔk am simpul wan, ɔtotoksisiti na damej pan wi insay yes as sayd ɛfɛkt fɔ sɔm mɛrɛsin dɛn. If wi luk di minin fɔ di wɔd "ototoxicity", "oto" min "ear" ɛn "toxicity" min "poisoning". Dat min se, wan kɔndishɔn lɛk pɔyzin na di yes. Wi insay yes gɛt rili dilik sɛns sɛl dɛn. Dɛn sɛl dɛn ya de ɛp wi fɔ yɛri ɛn mek wi balans na di bɔdi. Sɔm mɛrɛsin, fɔ ɛgzampul, mɛrɛsin fɔ siriɔs infɛkshɔn ɛn mɛrɛsin fɔ sik dɛn lɛk kansa, kin pwɛl dɛn sɛns sɛl ya. Na da tɛm de dis kɔndishɔn we dɛn kɔl ɔtotoksisiti kin apin.

Wetin na di sayn dɛm fɔ ɔtotoksisiti?

Dɛn sayn ya nɔ kin apin di sem we fɔ ɔlman. Sɔntɛnde, di sik kin kam wantɛm wantɛm afta yu dɔn bigin fɔ tek di mɛrɛsin. Fɔ ɔda pipul dɛn, di sayn dɛn kin kam smɔl smɔl ɛn smɔl smɔl. I sɔprayz fɔ no se sɔm mɛrɛsin dɛn kin mek dɛn sik ya kin apin te to fayv ia afta dɛn dɔn bigin fɔ tek di mɛrɛsin. Bɔku tɛm, di fɔs sayn na we yu yɛri sawnd we de ring na yu yes. I kin tan lɛk se pɔsin de tɔk to ɔda pɔsin, ɔ i kin jɔs bi "ringing" sawnd ɔ "whooshing" sawnd. Dɔktɔ dɛn kin kɔl dis tinnitus . Tinnitus kin bi bak di fɔs sayn fɔ mek yu nɔ yɛri fayn. Ɔda sayn dɛn we de sho se yu gɛt dis sik na:

• Yu nɔ de yɛri fayn (insay wan ɔ ɔl tu di yes dɛn).
• Fɔ fil lɛk se yu de lɔs yu balans we yu de waka, mɔ we yu de klaym stej.
• I nɔ kin izi fɔ waka na nɛt ɔ na say dɛn we dak.
• Fɔ waka wit yu fut dɛn apat fɔ mek yu balans.
• Oscillopsia na di sɛns we pɔsin kin fil we i tan lɛk se tin dɛn we nɔ de muv de spin. Dɛn kɔl dis oscillopsia .
• Fɔ fil diziz, lɛk se yu ed de spin, lɛk se yu an dɛn de spin, ɔ fil taya.

Imajin aw i nɔ go fil fayn if yu gɛt diziz wantɛm wantɛm we yu de du yu wok dɛn we yu de du ɛvride, ɔ if yu bigin fɔ fɔdɔm we yu de waka? Dis na di sayn dɛn we wi nid fɔ pe atɛnshɔn to.

Aw dis kin afɛkt yɔŋ pikin dɛn?

If dis sik kin apin to yɔŋ pikin dɛn, mɔ di wan dɛn we dɔn ol fɔ lan fɔ tɔk, i kin bi big tin we kin mek dɛn nɔ ebul fɔ lan ɛn tɔk to ɔda pipul dɛn. As mama ɛn papa, wi fɔ rili pe atɛnshɔn to dɛn sayn ya:

• I nɔ kin izi fɔ mek yu pe atɛnshɔn, ilɛksɛf na skul ɔ we yu de stɔdi ɔda tin.
• Fɔ taya kwik kwik wan we yu gɛt fɔ lisin fɔ lɔng tɛm.
• I nɔ kin izi fɔ ɔndastand wetin ɔda pipul dɛn de tɔk, nɔ kin fred fɔ tɔk, ɔ nɔ kin tɔk atɔl. Sɔntɛnde dis kin bi rizin bak we kin mek pikin in tɔk nɔ de tɔk.

If pikin rili want fɔ lan sɔntin, bɔt i nɔ intres igen wantɛm wantɛm, ɔ if dɛn de tɔk ɔltɛm se dɛn taya, yu fɔ tink bɔt dis smɔl pas fɔ jɔs tink se na bad tin.

Wetin mek dis ɔtotoksisiti kin apin?

Dɔktɔ dɛn se i pas 200 kayn mɛrɛsin dɛn we kin pwɛl wi insay yes (ototoxic drugs). Sɔm pan dɛn mɛrɛsin ya nid fɔ gɛt prɛskrishɔn frɔm dɔktɔ. Bɔt sɔm, fɔ ɛgzampul, sɔm mɛrɛsin dɛn we de mek pɔsin fil pen, yu kin bay am na famasi we yu nɔ gɛt prɛskrishɔn.

Di impɔtant tin na dat bɔku pan di mɛrɛsin dɛn we dɛn kin se kin ambɔg di yes na rili impɔtant mɛrɛsin dɛn we de sev pɔsin in layf. Fɔ ɛgzampul, mɛrɛsin fɔ kansa, ɔ mɛrɛsin fɔ siriɔs baktriyal infɛkshɔn. Insay dɛn kayn tin ya, di bɛnifit we pɔsin kin gɛt we i tek di mɛrɛsin, we na fɔ sev pɔsin in layf , kin pas di smɔl bad tin dɛn we i kin du to di yes.

כlso, sכm `(ototoxic)` dכg dεm de כnli kכz harm if dεn tek dεm insay rili hכy dos. Wi nɔ kin tek dɛn kayn ay dos dɛn de. Bɔku men klas dɛn de fɔ drɔgs we kin ambɔg di yes:

Aminoglycoside antibayɔtik dɛn

Dis na wan kayn antibayɔtik we dɛn kin gi fɔ mɛn baktriyal infɛkshɔn. along wit di antikansa dכg dεm, dεn kin kכnsidr dis klas fכ dכg dεm (aminoglycosides) as di men kכz fכ ototoxicity. Na sɔm ɛgzampul dɛn ya:

• `(Amikasin)`
• `(Jɛntamisin)`
• `(Kanamycin)`
• `( Niomaysin )`
• `(Netilmisin)`
• `(Streptomycin)`
• `(Tobramaysin)`
• `(Vancomycin)` (Dis kin inklud bak sɔmtɛm insay dis kategori)

Di mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn pipul dɛn we gɛt kemotɛrapi

Mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn difrɛn kayn kansa. Sɔm pan dɛn tin ya kin ambɔg di yes:

• `(Kaboplatin)`
• `( Sisplatin )`

Loop diuretics - "wata pils".

Dis na mεdikeshכn dεm we de εp di kidni dεm fכ pul di εksyכs sכlt εn wata na di bכdi tru di urine. Sɔm pipul dɛn kin kɔl dɛn bak "wata pils." Sɔm pan dɛn tin ya na:

• `(Bumetanide)`
• `(Etakrinik asid)`
• `( Furosemide )` (Dis na mɛrɛsin we bɔku pipul dɛn sabi)
• `(Tɔrsemide)`

Ɔda mɛrɛsin ɛn kemikal dɛn

Pan ɔl we i nɔ kin apin so ɔltɛm, ɔtotoksisiti kin kam bak bikɔs ɔf:

• Kwinin: .Mɛrɛsin dɛn we dɛn kin gi fɔ mɛn malaria.
• Salicylates : Dɛn tin ya na tin dɛn we dɛn kin yuz fɔ mɛn pen we dɛn nɔ kin bay . Aspirin, we wi ɔl no, na wan kayn salicylate. Bɔt na we dɛn tek am bɔku bɔku wan ɛn fɔ lɔng tɛm, na in prɔblɛm kin apin.
• Kεmikכl dεm we de na di envayroment: Sɔntɛnde, dis kכndyushכn kin kכz fכ tin dεm lεk mεkkyuri , tin, lid, εn kabon monoksayd we de na di envayroment.

Wetin na di tin dɛn we kin mek pɔsin gɛt dis sik?

di risk fכ divεlכp dis kכndyushכn fכ ototoxicity nכto di sem fכ כlman. Dipen pan di mɛrɛsin we yu de tek, yu dɔktɔ go ɛksplen to yu dɛn tin ya we kin mek yu gɛt prɔblɛm. Sɔm tin dɛn we kin apin na:

• De kayn mɛrɛsin wae yu de tek: Sɔm mɛrɛsin kin gɛt bɔrku risk fɔ dis pas ɔda wan dɛm.
• Doz fɔ di mɛrɛsin: Aw bɔku fɔ tek.
• Aw lɔng fɔ tek di mɛrɛsin.
• If fɔ tek sɔm mɛrɛsin dɛn we kin ambɔg di yes togɛda. If na so i bi, di prɔblɛm kin bɔku mɔ ɛn mɔ.

Apat frɔm dat, sayɛnsman dɛn dɔn kam fɔ no se sɔm pipul dɛn jin (DNA) kin gɛt ɛfɛkt bak . Na patikyula, sɔm pipul dɛn jɛnɛtik mek-ap (ɔ strɔkchɔ) kin inkrisayz di risk fɔ ɔtotoksisiti we dɛn de tek sɔm aminoglycoside antibayɔtiks.

Kɔmplikɛshɔn dɛn we kin apin bikɔs ɔf ɔtotoksisiti

di damej we di insay yes we dεn ``ototoxic`` dכg dεm ya kin mek kin bi ``irrεvεrsibl`` . Dat min se prɔblɛm kin apin fɔ lɔng tɛm we i de yɛri ɛn balans. Ɛspɛshali pan yɔŋ pikin dɛn, dɛn prɔblɛm ya we dɛn kin yɛri kin mek dɛn nɔ ebul fɔ tɔk, lan langwej, ɛn ivin gɛt di skil dɛn we dɛn nid fɔ tɔk to ɔda pipul dɛn. Imajin, if pikin nɔ ebul fɔ yɛri wɔd dɛn fayn, aw dɛn go lan fɔ yuz dɛn wɔd dɛn de fɔ tɔk? Bɔt ivin if dɛn nɔ ebul fɔ chenj di damej, dɔktɔ dɛn kin wach yu sik, trit di sayn dɛn if dɛn kam, ɛn gi yu di sɔpɔt we yu nid.

Aw fɔ no dis sik?

If yu gɛt dɛn kayn sik ya, yu go nid fɔ go to dɔktɔ we de mɛn yu yes, nos, ɛn trot (ɔtolaryngologist ɔ ENT spɛshal) ɔr ɔdiɔlɔjis. Dɛn go du difrɛn tɛst fɔ chɛk yu insay yes, i go dipen pan di sayn dɛm we yu gɛt. Di tin we impɔtant pas ɔl na dat yu dɔktɔ kin tɛst yu fɔ yɛri ɛn balans bifo i gi yu mɛrɛsin we dɛn tink se na ototoxic.Dɔn bak, yu kin mek dɛn du dɛn tɛst ya wan wan tɛm we yu de tek di mɛrɛsin. Da we de, if ɛni chenj de as sayd ɛfɛkt fɔ di mɛrɛsin, yu kin no am kwik kwik wan.

Us tɛst dɛn dɛn kin du?

Fɔ si aw yu insay yes de wok, yu dɔktɔ kin du tɛst dɛn lɛk dis:

• Odiogram: Dis de tɛst aw yu de yɛri difrɛn sawnd dɛn, i.e. sɔft sawnd, lawd sawnd, ay ɛn lɔw sawnd (pitch), ɛn aw yu ɔndastand wɔd dɛn fayn fayn wan.
• di כditory Brainstem Response (ABR) tεst: Dis de tεst aw yu כditory nerve de rεspכnd to sawnd dεm εn aw da rεspכns de travul go na di bren.
• Otoacoustic Emissions (OAEs) test: vεri fayn fayn strכkchכ dεm we lεk ia na di insay yes (hεr sεl dεm na di kכklia) de mek vεri slo vaybreshכn (sawnd vaybreshכn) we de ansa to sawnd. dis tεst de mכsu dεn vaybreshכn dεm ya fכ si aw di sεl dεm de wok fayn fayn wan.
• Vestibular test battery: Dis nɔto wan tɛst, bɔt na siriɔs tɛst fɔ chɛk fɔ balans prɔblɛm. fכ egzampl, dis kin inklud tεst dεm lεk `(Videonystagmography - VNG)` (wach di ay muvmεnt dεm), `(Vestibular Evoked Myogenic Potentials - VEMPs)` (fכ wach di rispכns dεm fכ di nεv dεm we involv fכ bεlε), `(Rotary chair test)` (tεst we yu sidɔm na chia we de rכt), εn `(vidio Head Impulse Testing - vHIT)`.

Aw dɛn kin trit ɔtotoksisiti?

Bɔt i sɔri fɔ no se we pɔsin stɔp fɔ tek wan mɛrɛsin we gɛt ɔtotoksik, i nɔ de rivɛns di damej we dɔn ɔlrɛdi apin. Bɔt fɔ stɔp di mɛrɛsin ɔ fɔ ridyus di doz (if i pɔsibul) i kin ɛp fɔ mek yu nɔ pwɛl mɔ. Bɔt lɛk aw wi bin dɔn tɔk, bɔku tɛm dɛn mɛrɛsin ya we de mek pɔsin gɛt ɔtotoksik kin sev pɔsin in layf. So, nɔr kin pɔsibul ɔltɛm fɔ stɔp dɛm ɔr mek big chenj na yu tritmɛnt plan. If na so i bi, yu dɔktɔ go wach aw yu de tek di mɛrɛsin ɛn ɛp yu fɔ kɔntrol di sik dɛn we yu gɛt.

Tul ɛn we fɔ ɛp fɔ mɛn di sik dɛn

Pan ɔl we dɛn nɔ go ebul fɔ chenj di damej, we dɛn de fɔ ɛp yu fɔ liv wit di sayn dɛm:

• Ɛp fɔ yɛri: Dɛn tin ya kin ɛp pipul dɛn we nɔ de yɛri fayn, mɔ di wan dɛn we nɔ de yɛri fayn, fɔ yɛri tin fayn ɛn fɔ mek i izi fɔ tɔk to dɛnsɛf.
• Kɔklia implant: Dis na ilɛktronik tin dɛn we dɛn kin du ɔpreshɔn fɔ put insay di yes. Bɔrku tɛm dɛn kin yuse dɛn fɔ pipul dɛm wae nɔr de yɛri fayn fayn wan wae nɔr de ansa fayn fayn wan wae dɛn de gi dɛn tin wae de ɛp dɛn fɔ yɛri ɔltɛm.
• Vɛstibular rihabiliteshɔn: .Dis na spɛshal trenin. Yu go wok wit wan vestibular thɛrapist ɔr fyzikal thɛrapist fɔ lan ɛksɛsayz ɛn tɛknik dɛm wae go ɛp yu bɔdi fɔ adap to ɛn bia wit di prɔblɛm dɛm wae de kam wit balans prɔblɛm wae kin kam wit prɔblɛm wae de insay yu yes. Dis kin ɛp fɔ ridyus di sayn dɛm lɛk fɔ gɛt diziz ɛn fɔ mek i nɔ izi fɔ waka.

Yu tink se dɛn kin mek dɛn nɔ gɛt ɔtotoksisiti?

Nɔto ɔltɛm dɛn kin ebul fɔ avɔyd dis sik kpatakpata. Sɔntɛnde, i kin nid fɔ gi yu ɔtotoksik mɛrɛsin fɔ sev yu layf. Bɔt if yu no di sayn dɛn kwik kwik wan, yu dɔktɔ go ɛp yu kwik kwik wan ɛn sɔntɛm i go du sɔntin fɔ ridyus di prɔblɛm dɛn we yu gɛt mɔ. If yu de tek mɛrɛsin we go mɔs pwɛl yu yes, yu dɔktɔ go de wach yu ɔltɛm. I go tɛl yu bak us sayn fɔ wach ɛn us sayn fɔ go to dɔktɔ if yu notis dɛn.

Aw lɔng dis tin go las?

di damej na di insay yes we di ɔtotoksisiti kin mek nɔ kin chenj . Dis min se di damej de sote go. Bɔt, i go dipen pan yu kɔndishɔn, yu dɔktɔ kin ebul fɔ chenj yu tritmɛnt plan (if i pɔsibul) fɔ stɔp mɔ damej ɛn di sayn dɛm fɔ mek yu nɔ wɔs. Bɔt bikɔs bɔku tɛm i nɔ kin pɔsibul fɔ stɔp fɔ tek di mɛrɛsin, yu dɔktɔ go mek wan tritmɛnt plan fɔ lɔng tɛm fɔ ɛp yu fɔ kɔntrol yu sik dɛn. Dipen pan aw yu gɛt di sik ɛn di mɛrɛsin we dɛn gi yu, yu dɔktɔ go tɔk to yu bɔt di prɔblɛm dɛn we kin apin we yu tek wan mɛrɛsin we de mek yu gɛt ɔtotoksik.

Aw a go kia fɔ misɛf ɛn mi pikin?

• Tɔk to yu dɔktɔ bɔt di prɔblɛm dɛn ɛn di bad tin dɛn we kin apin to ɛni mɛrɛsin we dɛn gi yu. Nɔ fred fɔ aks kwɛstyɔn.
• If yu notis ɛni nyu chenj na yu yɛri, balans, ɔ ɛni ɔda sayn afta yu dɔn bigin fɔ tek mɛrɛsin we yu tink se na ototoxic, ivin if na smɔl, go to yu dɔktɔ wantɛm wantɛm.
• If yu na mama ɔ papa ɔ pɔsin we de kia fɔ yu pikin we de gi dis mɛrɛsin to yɔŋ pikin, tek tɛm wach ɛni chenj we de apin to yu pikin. E kin tranga fɔ no di sayn dɛm wae de kam pan yɔŋ pikin dɛm. Apat frɔm we yu de luk fɔ sayn dɛn we de sho se yu pikin nɔ de yɛri ɔ i nɔ de balans, na fɔ no ɛni sayn we de sho se yu pikin gɛt prɔblɛm fɔ pe atɛnshɔn ɔ i de taya ɔltɛm. I pɔsibul se di pwɛl at we yu pikin de gɛt kin bi bikɔs ɔf prɔblɛm we i gɛt fɔ yɛri. If yu gɛt ɛnitin we de mɔna yu, go to yu dɔktɔ fɔ advays.

Aw kwik ɔtotoksisiti kin bigin?

I kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Sɔm pipul dɛn kin gɛt sayd ɛfɛkt wantɛm wantɛm we dɛn bigin fɔ tek di mɛrɛsin. Fɔ ɔda pipul dɛn, dɛn sik ya nɔ kin apin te fayv ia afta dɛn dɔn bigin fɔ trit dɛn. Sɔm tritmɛnt ɛn mɛrɛsin dɛn kin gɛt dilay ɛfɛkt. Dis na di rizin we mek i impɔtant fɔ mek yu de du tɛst fɔ yɛri ɔltɛm we yu dɔktɔ se fɔ wach aw yu de yɛri.

Mɛmba se bɔku pan di mɛrɛsin dɛn we gɛt fɔ du wit ɔtotoksisiti, lɛk antibayɔtik ɛn kemotɛrapi drɔgs, impɔtant fɔ layf. Pan ɔl we dɛn kin mek di insay yes pwɛl, di bɛnifit dɛn we pɔsin kin gɛt we i tek dɛn, ilɛksɛf na fɔ mɛn di sik ɔ fɔ sev pɔsin in layf, pas di prɔblɛm dɛn we kin apin to am fa fawe.

If yu de tek mɛrɛsin we dɛn no se go ambɔg yu yes, tɔk to yu dɔktɔ bɔt ɛni wɔnin sayn we kin de na yu insay yes. Di kwik we yu no se chenj de apin, na di kwik we yu dɔktɔ go ɛp yu ɛn gi yu di rayt plan fɔ kia fɔ yu.

Di tin we impɔtant pas ɔl we wi nid fɔ mɛmba! (Mɛsej we dɛn kin tek go na os)

Okay, so lɛ wi luk sɔm pan di tin dɛn we wi dɔn tɔk bɔt fɔ ɛp yu fɔ mɛmba sɔm pan di impɔtant pɔynt dɛn:

• Ototoxicity na damej pan di insay yes we sɔm mɛrɛsin dɛn kin mek. Dis kin afɛkt di we aw pɔsin de yɛri ɛn balans.
• Yu fɔ no bɔt di sayn dɛm lɛk tinnitus (ring na yu yes), yu nɔ de yɛri fayn, ɛn yu de tɔn diziz.
• Pan ɔl we bad tin kin apin we pɔsin de tek mɛrɛsin we go sev in layf, bɔku tɛm di bɛnifit dɛn we di mɛrɛsin kin gɛt kin pas di prɔblɛm dɛn we i kin gɛt. Bɔt i impɔtant fɔ no bɔt di prɔblɛm dɛn we kin apin.
• If dɛn dɔn gi yu wan mɛrɛsin we de mek yu bɔdi wam, tɔk to yu dɔktɔ bɔt am ɛn atɛnd di tɛst dɛn we dɛn dɔn sɛtul fɔ du.
• If yu notis ɛni nyu sayn, ilɛksɛf na smɔl tin, tɛl yu dɔktɔ wantɛm wantɛm. If yu gɛt tritmɛnt kwik kwik wan, dat kin ɛp fɔ mek di sik nɔ wɔs.

Na yu wok fɔ kia fɔ yu wɛlbɔdi. Wi op se dis infɔmeshɔn go ɛp yu fɔ du dat!