Yu kin fil fɔ gɛt anestezi? Lɛ wi lan bɔt (Pseudocholinesterase Deficiency)?

Yu dɔn ɛva fil fɔ fred smɔl fɔ di anestezi we dɛn kin gi yu fɔ ɔpreshɔn? Na nɔmal tin fɔ mek sɔm pipul dɛn fil da we de. Bɔt imajin wetin go apin if sɔm pan di mɛrɛsin dɛn we dɛn kin gi yu fɔ anestez nɔ bin rili rayt fɔ yu bɔdi. Tide wi go tɔk bɔt wan pan dɛn kayn tin ya we nɔ kin apin so ɔltɛm, bɔt we rili impɔtant fɔ no bɔt. dat na wan kכndishכn we dεn kכl `(Pseudocholinesterase Deficiency)`.

Wetin na `(Pseudocholinesterase Deficiency)`? Lɛ wi ɔndastand am simpul wan, nɔto so?

Okay, dis nem de soun likl long, no bi so? Mek wi kip am simpul. `(Pseudocholinesterase)` na spεshal εnzym `(Enzyme)` insay wi bכdi. wan pan di men wok dεm we dis `(Enzyme)` de du na fכ brok dכn (dat na, `(metabolize)`) insay di bכdi sכm pan di dכg dεm we dεn gi fכ rilaks mכsul dεm , spεshal wan we dεn anεsthεz wi (wi de kכl dεn ya `(Choline esters)`). Imajin se we dɛn de du ɔpreshɔn, yu mɔsul dɛn nid fɔ paralayz fɔ sɔm tɛm. Dis na di drɔgs we dɛn kin gi fɔ dat.

naw, insay wan kכndishכn we dεn kכl `(Pseudocholinesterase Deficiency)`, wetin de apin na dat dis `(Enzyme)` we dεn kכl `(Pseudocholinesterase)` na yu bכdi n כ de prodyuz inof , כ i nכ de wok fayn . Wetin kin apin da tɛm de? di dכg dεm we dεn gi fכ rilaks di mכsul dεm (`(Succinylcholine)` εn `(Mivacurium)` na tu εgzampl fכ dis) dεn nכ de kכmכt na di bכdi kwik kwik wan. Dɛn kin de na di bɔdi fɔ lɔng tɛm.

Dis kin mek yu mɔsul dɛn nɔ de wok fɔ lɔng tɛm afta dɛn dɔn anestez yu, ɛn yu kin ivin gɛt prɔblɛm fɔ blo. Dis min se yu nɔ go ebul fɔ muv ɔ blo yusɛf te di tin dɛn we di mɛrɛsin de du to yu dɔn.

Aw dis sik kin kɔmɔn?

fכ tru, dis kכndyushכn we dεn kכl `(Pseudocholinesterase Deficiency)` nכto so kכmכn . Na avrej, na lɛk wan pan ɔl 3,200 ɔ 5,000 pipul dɛn nɔmɔ kin gɛt dis sik. Dat min se, na rili smɔl nɔmba.

Wetin na di sayn dɛm we de sho se yu gɛt dis sik? Aw yu no dis?

Bɔrku pipul dɛm wae gɛt dis sik nɔr kin no am te dɛn gɛt di kayn anestetik drɔg wae a bin dɔn tɔk bɔt, we dɛn kɔl ``Choline esters.'' Na da tɛm de di men sayn dɛm kin apia:

• di mכsul dεm we rilaks pasmak (i.e., we nכ gεt layf) fכ lכng tεm pas aw dεn go εkspεkt nכmal wan.
• Ivin di mɔsul dɛn we de ɛp yu fɔ blo nɔ kin wok fɔ sɔm tɛm .

I kin tek sɔm awa fɔ mek dɛn sik ya nɔ de igen. Dis tɛm kin difrɛn frɔm wan pɔsin to ɔda pɔsin. insay dis tεm, yu mεdikal tim go kip yu כnda anεsthεsia εn εp yu fכ brith tru ``ventilator'', we na atifishal brith mashin, te yu ebul fכ brith yu wan.

Wetin na di tin dɛn we kin mek i apin? Aw dis kin apin?

dis kכndyushכn (Pseudocholinesterase Deficiency) kin kכmכt (i.e. inhεrit), כ i kin divεlכp leta insay layf..

Di tin dɛn we kin mek pɔsin gɛt dis sik

Pipul dεm we dεn bכn wit dis kכndyushכn gεt chenj, כ mכtεshכn, insay wan jin we dεn kכl `(BCHE)`. dis `(BCHE)` jin na in de tεl wi bכdi fכ mek di εnzym `(Pseudocholinesterase)`. So, we chenj de na dis jin, yu bɔdi de mek smɔl pan dis ɛnzaym, ɔ i nɔ go mek am atɔl.

Kכz dεm we de divεlכp we yu de liv (Acquired) .

Sɔmtɛm, dis kɔndishɔn (Pseudocholinesterase Deficiency) kin apin ɔlsay na yu layf. Na difrɛn sik dɛn ɛn sɔm mɛrɛsin dɛn kin kam wit am.

Sɔm sik dɛm wae kin mek yu gɛt dis sik:

• Malnutrishɔn
• Bɔku bad bad injuri dɛn we pɔsin kin gɛt we i bɔn
• Kidni sik
• Liva sik
• Hypothyroidism (tayroyd we nɔ de wok fayn) .
• Kansa
• We uman gɛt bɛlɛ

Sɔm mɛrɛsin wae kin mek yu gɛt dis sik na:

• MAO inhibito dεm (e.g. Fεnεlzin (Nardil®)) .
• Pils fɔ kɔntrol bɔn pikin (Oral contraceptives) .
• Echothiophate ay drɔp dɛn
• Mɛtɔklɔpramid
• Sayklɔfosfamid
• Piridostigmin we dɛn kɔl Piridostigmin

Aw dɔktɔ dɛn kin no bɔt dis?

If yu gɛt prɔblɛm fɔ kɔntrol yu mɔsul dɛn ɔ fɔ blo afta yu dɔn tek jenɛral anestezi, yu dɔktɔ kin tink se yu nɔ gɛt pseudocholinesterase. fכ kכnfכm dis, dεn kin du bכdi tεst f כ chεk yu lεvεl dεm fכ di εnzym pseudocholinesterase.

If pɔsin na yu famili gɛt dis sik, dɔktɔ kin du jenɛtik tɛst fɔ no if yusɛf gɛt am. Dis involv fɔ tek blɔd sɛmpul ɛn chɛk fɔ si if yu gɛt di (BCHE) jin muteshon.

if yu dכkta saspek se yu gεt dis kכndyushכn, dεn go yuz כda kayn mכsul rilaksant dεm we nכ de dip pan di εnzym ``Pseudocholinesterase''.

Wetin na di tritmɛnt?

If yu gɛt sayn dɛm fɔ `(Pseudocholinesterase Deficiency)` afta dɛn dɔn gi yu jenɛral anestezi, yu kin nid fɔ go na dɔktɔ kwik kwik wan. Di mɛdikal tim go wach yu gud gud wan te yu wɛl. If nid de, dɛn go kip yu ɔnda anestezi ɛn yuz `` mɛkanikal ventileshɔn`` mashin fɔ ɛp yu fɔ blo te yu ebul fɔ blo yusɛf.

Wetin yu fɔ ɛkspɛkt if yu gɛt dis sik?

If dɛn no se yu gɛt `(Pseudocholinesterase Deficiency)`, di bɛst tin we yu kin du na fɔ tɛl yu dɔktɔ dɛn bɔt am – mɔ di dɔktɔ dɛn we go de si yu fɔ ɔpreshɔn .

Dɔn bak, yu nid fɔ tɛl yu famili bɔt dis bak., den dεn kin tεst dεm bak fכ si if dεn gεt di `(BCHE)` jin mכtεshכn. If na so i bi, dɛn fɔ tɛl dɛn dɔktɔ dɛn bak bifo dɛn du ɛni ɔpreshɔn.

I fayn bak fɔ wɛr mɛdikal ID breslɛt so dat dɔktɔ dɛn go no if yu nid fɔ du ɔpreshɔn pan yu kwik kwik wan.

Yu tink se dɛn go ebul fɔ stɔp dis?

Pseudocholinesterase deficiency na wan sik we dɛn bɔn wit we dɛn nɔ kin ebul fɔ avɔyd. Bɔt if pɔsin na yu famili gɛt am, dɛn kin tɛst yu fɔ di BCHE jin muteshɔn bifo dɛn du jenɛral anestezi. Dis kin ɛp fɔ mek dɛn nɔ gɛt prɔblɛm dɛn we dɛn de du ɔpreshɔn.

If yu gɛt di jenɛtik muteshon, yu dɔktɔ go mɔs skip di Choline esters ɛn pik difrɛn anestetik. Rokuronium na di anestetik wae dɛn kin yuse fɔ pipul dɛm wae gɛt Pseudocholinesterase Deficiency.

Yu kin ebul fɔ ridyus yu risk fɔ gɛt Acquired Pseudocholinesterase Deficiency leta na yu layf bay we yu de trit di ɔndalayn kɔndishɔn dɛn, lɛk we yu nɔ de it fayn ɔ we yu nɔ gɛt bɛtɛ kidni sik (CKD). Dɔn bak, if yu de tek ɛni mɛrɛsin we de mek di ɛnzaym we dɛn kɔl Pseudocholinesterase nɔ bɔku, yu kin tɔk to yu dɔktɔ bɔt aw fɔ chenj yu mɛrɛsin.

Wetin na de tin wae nɔr fayn fɔ yu, dat na, us mɛrɛsin nɔr fayn fɔ yuse fɔ pipul dɛm wae gɛt dis sik?

If dɛn dɔn no se yu gɛt `(Pseudocholinesterase Deficiency)`, yu fɔ avɔyd dɛn kayn anestetik mɛrɛsin ya :

• Suksinilkolin `(Suksinilkolin)`
• Mivakuriɔm we dɛn kɔl Mivacurium
• Prokɛyn we dɛn kin yuz
• Kloroprokɛyn we dɛn kin yuz
• Benzocaine we gɛt di sik
• Tetracaine we gɛt di sik

Kwɛstyɔn dɛn we yu fɔ aks yu dɔktɔ

If yu gɛt wan sik we dɛn kɔl ``Pseudocholinesterase Deficiency'', ilɛksɛf dɛn bɔn yu wit am ɔ yu gɛt am leta, yu kin aks yu dɔktɔ sɔm kwɛstyɔn dɛn lɛk:

• Wetin na di ɛksaktɔl kɔntraindikshɔn fɔ mi, dat na, us mɛrɛsin dɛn a fɔ avɔyd?
• Dis sik na sɔntin we dɛn bɔn mi wit ɔ na ɔda sik kin kam wit am?
• I fayn fɔ mek dɛn du tɛst fɔ mi famili?

Fɔ go na ɔpreshɔn kin mek yu strɛs smɔl. Bɔku pan wi kin so pe atɛnshɔn pan di ɔpreshɔn dat wi nɔ kin ivin tink bɔt di pɔsibul fɔ mek bad tin apin to di anestezi. No mɛrɛsin nɔ de fɔ Pseudocholinesterase Deficiency. Bɔt if yu no if yu gɛt am, dat kin ɛp yu fɔ avɔyd di mɔsul dɛn we kin wik fɔ sɔm tɛm ɛn di prɔblɛm we kin apin to yu fɔ blo afta dɛn dɔn du yu ɔpreshɔn. If yu gɛt Pseudocholinesterase Deficiency, tɛl yu famili bɔt am. Dɛn kin gɛt tɛst bak fɔ di jin ɛn avɔyd ɛni prɔblɛm we nɔ nid fɔ apin we dɛn de travul wit wɛlbɔdi biznɛs.

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

So, `(Pseudocholinesterase Deficiency)` na smɔl nem we de mek pɔsin fred, bɔt i rili impɔtant fɔ no bɔt am. Ɛspɛshali if yu go gɛt ɔpreshɔn, ɔ if pɔsin na yu famili dɔn gɛt sɔntin lɛk dis , i go fayn fɔ mek yu tɔk to yu dɔktɔ dɛn bɔt dis. Mɛmba se bɔku tɛm, fɔ no na di bɛst shild we go sev wi frɔm prɔblɛm dɛn we wi nɔ nid!

` Anestesia, pseudocholinesterase, enzym dεfisiεns, כspitul komplikashכn, jεnεtik kכndishכn, mכsul dεm we nכ de wok fayn, anεsthεtik drog dεm