Di men tin we kin apin na wi bɔdi na dat di it we wi de it kin gi wi trɛnk. I tan lɛk se yu put gas na motoka. Na ya, wi bɔdi kin gɛt ɛnaji frɔm shuga (glukɔs). Wan ɔmon we dɛn kɔl
insulin de kɔntrol dis wan ol tin . Na dis insulin de tɛl di shuga we de na di blɔd fɔ sɛn insay di sɛl dɛn we nid ɛnaji. I tan lɛk we yu opin di domɔt dɛn na di sɛl dɛn ɛn mek di shuga kam insay Bɔt insay pɔsin we gɛt Rabson-Mendenhall Syndrome in bɔdi, dis prɔses nɔ kin apin fayn fayn wan. Dat min se dɛn bɔdi nɔ kin ebul fɔ yuz insulin fayn fayn wan. Dis na wan sik we kin rili, rili rare.
So wetin rili na dis sik?
We insulin nɔ ebul fɔ du in wok fayn, i kin afɛkt di pikin in gro dairekt wan. Imajin, di ifɛkt we dis kin gɛt kin bigin ivin bifo dɛn bɔn di pikin, dat na we i stil de na di mama in bɛlɛ. Bebi dεm we gεt dis kכndyushכn kin sכm sכm. Ivin afta dɛn bɔn dɛn, dɛn
kin gɛt wet ɛn dɛn bɔdi kin gro smɔl smɔl. We wi de tɔk bɔt mɛrɛsin, Rabson-Mendenhall syndrome na wan sik we de pan wan big grup we dɛn kɔl siriɔs insulin resistance syndromes. Donohue syndrome ɛn tayp A insulin resistance syndrome na tu ɔda sik dɛm wae de pan dis grup.
Wetin na di rizin we mek dis kayn tin de apin?
Fɔ tɔk am simpul wan, dis na tin we pɔsin kin gɛt frɔm in jɛnɛtiks. Dat min se,
i kin gɛt frɔm di mama ɛn papa to di pikin . dis kin kכz fכ wan glitch na di jin we dεn kכl `INSR` na wi bכdi. Naw lɛ wi si aw dis kin apin. Insay ɛni sɛl na wi bɔdi, tu kɔpi dɛn de fɔ ɛni jin. Wan frɔm di mama, ɛn wan frɔm di papa. fכ mek di pikin gεt Rabson-Mendenhall syndrome, di tu kכpi dεm fכ di `INSR` jin we di pikin de gεt fכ gεt di sεf difεkt. If na wan kɔpi nɔmɔ gɛt di prɔblɛm, di sik nɔ go kam. In ɔda wɔd, fɔ mek pikin gɛt dis sik, di mama ɛn papa ɔl tu fɔ gɛt wan kɔpi fɔ dis jin we nɔ fayn ɛn wan kɔpi fɔ di jin we gɛt wɛlbɔdi. Dɔn, di pikin fɔ gɛt ɔl tu di kɔpi dɛn we nɔ fayn frɔm dɛn ɔl tu bay chans. Dis na di rizin we mek i nɔ kin apin so ɔltɛm bikɔs i nɔ kin apin tri tɛm pan 4 tɛm.
Wetin na di sayn dɛm fɔ dis sik?
Bɔrku tɛm, di sayn dɛm kin bigin fɔ sho
insay di fɔs ia na di pikin in layf. Dɔn bak, aw dɛn sik ya kin tranga kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin. Lɛ wi tek wan luk pan de men sayn dɛm wae yu kin si.
| Bɔdi pat/sistim | Di tin dɛn we pɔsin kin si |
|---|
| Hed ɛn fes | Raf skin, yay dɛn we wayd, dip grov dɛn na di tɔŋ, big pas avrej yes, lip, ɛn jaw. |
| Nɛl dɛn | Tik pas aw i kin bi. |
| Kanda | Dray skin. di dak εn tik fכ sכm εria dεm na di skin (especially na di fold dεm lεk di armpit dεm εn di nεk). Dɛn kin kɔl dis tin we dɛn kɔl acanthosis nigricans . Dɛn say dɛn ya kin fil lɛk velvet we yu tɔch yu. |
| Tit | Fɔ big pas aw i fɔ bi, fɔ krawd togɛda, ɔ fɔ gɛt tit bifo tɛm. |
| Ɔgan dɛn we de insay di bɔdi | di kidni, at, εn di sεks כgan dεm (penis na bכy pikin, vagina na gyal pikin) big pas nכmal. |
| Ɔda tin dɛn we pipul dɛn kin du | di ia dεm we de gro pasmak na di bכdi, i de gro sloslo bifo εn afta dεn bכn am, di bכdi de swel, di fεt we de כnda di skin bכku bכku wan, εn di mכsul dεm we de wik. |
Ɔda sik dɛn we kin apin bikɔs ɔf dis
Apat frɔm dɛn bɛsis sik ya, dis sik kin mek ɔda siriɔs sik dɛn bak.
- Sist dεm na di ovaria dεm fכ gyal pikin dεm.
- Shuga . Sɔntɛnde dis kin mek pɔsin gɛt wan sik we de mek pɔsin in layf de pan denja we dɛn kɔl ketoacidosis .
- Prɔblɛm dɛn na di kidni .
Aw dɛn kin du di diagnosis?
Wan pan di chalenj dɛm fɔ no dis sik na fɔ difrɛns am frɔm ɔda sik dɛm wae de luk lɛk (lɛk Donahue syndrome). Yu pikin in
dɔktɔ go du yu pikin in bɔdi ɛgzam gud gud wan, aks yu pikin in sik ɛn in famili wɛlbɔdi istri, ɛn i go mɔs tɛl yu fɔ du bɔku blɔd tɛst fɔ chɛk yu pikin in
blɔd shuga ɛn insulin lɛvɛl . Dis na di wangren we fɔ mek dɛn no di sik kɔrɛkt wan.
Aw dɛn kin trit am?
Bɔku tɛm, fɔ trit di sik we dɛn kɔl Rabson-Mendenhall syndrome, dɛn kin nid fɔ gɛt ɛp frɔm wan big tim, we gɛt difrɛn spɛshal pipul dɛn, dɔktɔ dɛn we de du ɔpreshɔn, ɛn dɔktɔ dɛn we de mɛn dɛnt. Kɔnsul kin rili impɔtant bak fɔ famili fɔ kɔntrol di strɛs ɛn filin we kin kam wit pikin we gɛt dis sik we nɔ kin apin so ɔltɛm.
Naw, no mɛrɛsin nɔ de fɔ dis sik we go de sote go. Di tritmɛnt na fɔ kɔntrol ɛn manej di sayn dɛm.
Bɔku tɛm, di tritmɛnt kin bi fɔ ɛni wan pan di sik dɛn. Fɔ ɛgzampul, ɔpreshɔn fɔ pul ovarian sist, dɛnt tritmɛnt fɔ dɛn tit prɔblɛm, ɛn ɔda tin dɛn Sɔntɛnde, dɔktɔ dɛn kin gi dɛn bɔku bɔku insulin ɔ ɔda mɛrɛsin dɛn we kin mek pɔsin yuz insulin, bɔt bɔku tɛm dɛn tin ya nɔ kin wok fɔ lɔng tɛm.
Nyu tritmɛnt dɛn we dɛn de chɛk
Di masta sabi pipul dɛn de kɔntinyu fɔ du risach bɔt bɛtɛ tritmɛnt opshɔn fɔ di ay blɔd shuga lɛvɛl (haypa glycemia) we gɛt fɔ du wit siriɔs insulin rɛsistɛns. Pan ɔl we dɛn tritmɛnt ya dɔn sho sɔm fayn fayn tin dɛn, dɛn nid fɔ du mɔ risach.
- Biguanides: Dis na wan kayn mɛrɛsin we de mek di bɔdi nɔ gɛt shuga ɛn i de mek pɔsin yuz insulin mɔ .
- Leptin: Dɛn dɔn si se dis prɔtin de ɛp fɔ kɔntrol di blɔd shuga ɛn insulin lɛvɛl.
- rhIGF-I (Recombinant insulin-like growth factor I): Dɛn kin yuz dis protin fɔ trit ketoacidosis, we na wan sik we kin mek pɔsin nɔ gɛt insulin .
Mɛsej we dɛn kin kɛr go na os
- Rabson-Mendenhall Syndrome na wan jεnεtik kכndyushכn we nכ kin apin we di bכdi nכ kin yuz insulin fayn fayn wan.
- dis de kכz fכ wan difεktiv jin (di `INSR` jin) we di pikin gεt frכm in mama εn papa tu.
- Di sayn dɛm kin bigin we dɛn smɔl ɛn kin afɛkt di bɔdi we de gro , di we aw in fes de luk , di skin, di tit, ɛn di ɔgan dɛm we de insay.
- Nɔr mɛrɛsin nɔr de fɔ dis fɔ ɔltɛm, ɛn dɛn de trit am fɔ kɔntrol di sayn dɛm. Dis nid fɔ gɛt sɔpɔt frɔm wan tim we gɛt spɛshal dɔktɔ dɛn.
- If yu pikin de sho ɛni wan pan dɛn sik ya, i rili impɔtant fɔ go to dɔktɔ (dɔktɔ) we sabi du am wantɛm wantɛm fɔ advays.
Rabson-Mendenhall Syndrome, insulin resistance, jenɛtik sik, pikin sik, acanthosis nigricans, ketoacidosis, dayabitis
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