Pwɛl hat nɔr kin izi lɛk aw i kin tan. Bɔku tɛm, i nɔ kin izi fɔ liv wit am. I kin tek sɔm pipul dɛn sɔm tɛm fɔ fɛn di rayt tritmɛnt fɔ dɛn. Sɔntɛnde, wan mɛrɛsin nɔ kin mek pɔsin fil fayn atɔl. Rizin de fɔ dat. Lɛ wi ɔndastand dis frɔm di biginin.
Wetin mek pwɛl hat kin apin? Aw mɛrɛsin lɛk Rexulti go ɛp?
Fɔ tɔk am simpul wan, pan Major Depressive Disorder (MDD), sɔm kayn kemikal dɛn we de na wi bren kin go dɔŋ. Wi kin kɔl dɛn nyurotransmitta ya. Yu go dɔn yɛri bɔt sɛrotonin ɛn dopamin . Dis na di men kemikal mɛsenja dɛm wae de kɔntrol tin dɛm lɛk aw wi de tink, plan, fil gladi, pe atɛnshɔn, ɛn slip. So we dɛn dɔn ridyus dɛn tin ya, di sayn dɛm fɔ pwɛl hat kin sho.
Dɛn kin gi mɛrɛsin fɔ mɛn pwɛl hat fɔ ɛp fɔ mek dɛn kemikal ya kam bak. Bɔt sɔntɛnde, pan ɔl we dɛn mɛrɛsin ya kin mek di sik nɔ bɔku, dɛn kin lɛf sayn dɛn we tu tranga fɔ mek dɛn ebul fɔ wok ɛvride. Sɔm pipul dɛn kin jɔs ansa sɔm pat pan di tritmɛnt. Dɛn kɔl dis pwɛl hat sik wae nɔr kin gɛt tritmɛnt.
Dis na we dɔktɔ dɛn kin ad ɔda mɛrɛsin to di mɛrɛsin we dɛn de yuz naw. Dɛn kɔl dis adjɔnt tritmɛnt . Dat min se, na mεdikeshכn we dεn gi fכ "εp" di tritmεnt we de naw, fכ "bכst" in ifektiv.
Rexulti (brexpiprazole) na wan pan dɛn kayn adjɔnt mɛrɛsin ya. Dɛn tin ya de pan wan klas ɔf drɔgs we dɛn kɔl sɛkɔn jɛnɛreshɔn antisaykotik. Dɛn nyu mɛrɛsin ya nɔ kin gɛt bɛtɛ sayd ɛfɛkt lɛk fɔ shek shek, fɔ mek yu mɔsul dɛn stif, ɛn fɔ mek yu bɔdi gɛt bɔku bɔku bɔdi pas di ol mɛrɛsin dɛn. Rexulti de wok bay we i de kɔntrol di kεmikכl dεm na di bren difrεn we, i de ridyus di simptom dεm we i de ridyus di risk fכ sayd ifekt dεm.
Aw Rexulti de wok insay di bɔdi?
rεxulti de wok mεntal wan bay we i de inkrεs di lεvεl dεm fכ dopamin εn sεrotonin na di bren. spεshal wan, dis mεdikeshכn de tay pan sכm rεsεpכta dεm na di bren εn i de εp fכ rilis di dopamin we dεn trכp. I kin mek bak di akshɔn fɔ sɛrotonin, we kin ɛp fɔ mek yu fil fayn ɛn fɔ ridyus di sayn dɛm fɔ pwɛl hat.
Aw a fɔ yuz dis mɛrɛsin?
Rexulti na wan pill we yu kin tek wan tɛm insay di de. Yu kin tek am wit it ɔ atɔl am. i kin stat wit wan rili lכw dכz, lεk haf miligram (0.5mg). Dɔn yu dɔktɔ go inkrisayz di doz smɔl smɔl bay aw yu bɔdi de ansa, ɔda mɛrɛsin dɛn we yu de tek, ɛn aw yu kidni ɔ liva de wok fayn. Di maksimal doz fɔ pwɛl hat na 3 miligram (3mg) fɔ wan de.
Di tin we impɔtant pas ɔl na fɔ fala yu dɔktɔ in instrɔkshɔn dɛn di rayt we. Fɔ tek yu mɛrɛsin di rayt tɛm ɛvride na di wangren we fɔ balans yu bren kemistri, kɔntrol yu sik dɛn, ɛn wok fayn fayn wan.
Mɛmba se dis mɛrɛsin nɔ de mɛn yu wantɛm wantɛm. E kin tek sɔm wiks fɔ notis se yu sik dɔn chenj. So, fɔ yuz di mɛrɛsin ɔltɛm na di men tin we go mek yu gɛt sakrifays.
Wetin stɔdi dɛn se bɔt aw dis mɛrɛsin kin wok fayn?
Dɛn dɔn du tu big stɔdi fɔ no aw Rexulti kin woke ɛn sef fɔ pwɛl hat. Insay dɛn stɔdi ya, dɛn gi wan grup pan pipul dɛn Rexulti ɛn dɛn gi di ɔda grup wan plesibo. Dis bin mek di wan dɛn we de du risach ebul fɔ no di tru tin dɛn we di mɛrɛsin de du.
Akɔdin to di rizɔlt fɔ dɛn stɔdi ya, afta 6 wik, bɔku pipul dɛm wae tek Rexulti apat frɔm dɛn ɔspitul antidipreshan mɛrɛsin bin gɛt mɔdaret to mild dipreshɔn simptom dɛm.
Di tebul we de dɔŋ ya jɔs de sho di tin dɛn we dɛn dɔn fɛn. Di mɔ di mak smɔl, na di mɔ di sayn dɛn kin rili bad.
| Tim | Dipreshɔn lɛvɛl na di stat (avɛrej skɔ) . | Dipreshɔn lɛvɛl afta 6 wik (avɛrej skɔ) . | Difrɛns pan di mak dɛn (impruvmɛnt) . |
|---|---|---|---|
| Stɔdi 1: Plɛsibo (dɔmi pil) . | 27.3 | 22.1 | -5.2.2 |
| Stɔdi 1: Rɛksulti 2 mg | 26.9 | 18.5 | -8.4 |
| Stɔdi 2: Plɛsibo (dɔmi pil) . | 26.5 | 20.2.2 | -6.3 |
| Stɔdi 2: Rɛksulti 1 mg | 26.5 | 18.9 | -7.6 |
| Stɔdi 2: Rɛksulti 3 mg | 26.5 | 18.2 | -8.3 |
As yu kin si frɔm dɛn stɔdi ya, di wan dɛn we tek Rexulti bin gɛt bɔku impɔtant improvement pan dɛn symptoms. Dɛn stɔdi ya bin kɔnfyus bak se dɛn ebul fɔ wok na ɛvride layf, wit famili, na sosayti, ɛn na wok/skul, bin impɔtant.
Aw a go no if di mɛrɛsin de wok?
Insay sɔm wik ɔ mɔnt, yu go bigin fɔ notis se yu sik dɔn bɛtɛ. Yu fambul ɛn padi dɛn bak go notis di difrɛns we de pan yu.
- Impruv di we aw pɔsin de fil
- Mɔ ɛnaji ɔ motiveshɔn
- Bɛtɛ slip
- Intres pan aktiviti dɛn we yu bin de ɛnjɔy trade.
- I nɔ de wɔri ɔ wɔri igen
- I de mek pɔsin want fɔ it mɔ ɛn mɔ
- Bɛtɛ kɔnsɛntreshɔn
Dɛn chenj ya nɔ kin apin wan de. Dɛn kin apin smɔl smɔl. So, e fayn fɔ kip trak fɔ di chenj dɛm wae de kam pan yu sayn dɛm. Aw lɔng yu nid fɔ tek tritmɛnt kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin. Sɔm pipul dɛn nid am fɔ shɔt tɛm, ɛn ɔda wan dɛn nid am fɔ lɔng tɛm.
De tin wae impɔtant pas ɔl na fɔ nɔr stɔp fɔ tek yu mɛrɛsin wae yu nɔr de tɔk to yu dɔktɔ bikɔs yu tink se yu sik de kam bɛtɛ. If yu du dat, yu sik kin wɔs bak. If yu nɔr fil fayn afta sɔm mɔnt, tɛl yu dɔktɔ bɔt dat bak.
Sayd ɛfɛkt ɛn aw fɔ mɛn dɛn?
Di sayd ɛfɛkt dɛm wae kin kam wit Rexulti na wae yu de gɛt bɔku bɔku bɔdi, yu de slip, yu de tɔn ed, yu gɛt sayn dɛm wae tan lɛk flu, ɛn yu nɔr de rɛst (we yu nɔr ebul fɔ sidɔm stil). Dɛn tin ya nɔ kin apin to ɔlman, bɔt bɔku tɛm dɛn kin stɔp as tɛm de go.
| Sayd ɛfɛkt we pɔsin kin gɛt | Wetin yu go ebul fɔ du |
|---|---|
| We yu de gɛt bɔku bɔku bɔdi, yu go gɛt bɔku bɔku kɔlɔstrel/shuga | Adopt layf we gɛt wɛlbɔdi. Ɛksesaiz, ad vɛjitebul, frut, ɛn mit we nɔ gɛt bɛtɛ bɔdi to yu it. Ridyus ɔyl, sɔl, ɛn shuga. Yu dɔktɔ go de chɛk yu wet, blɔd prɛshɔn, kɔlɔstrel, ɛn shuga ɔltɛm. |
| Fɔ slip ɔ fɔ gɛt diziz | If yu fil se yu de slip, tek di mɛrɛsin bifo yu go slip na nɛt. Grap sloslo frɔm we yu sidɔm ɔ ledɔm. Nɔ drayv te yu no aw di mɛrɛsin de afɛkt yu. |
| Nɔ rɛst (Akathisia) . | Dis kin min fɔ fil se yu nɔ ebul fɔ de na wan ples ɛn jɔs de waka waka. Layt ɛksesaiz lɛk fɔ waka ɛn fɔ strɛch kin ɛp. Kɔl yu maynd wit tin dɛn lɛk fɔ du ɛksɛsayz fɔ blo ɛn fɔ tink gud wan. Limit tin dɛm lɛk kɔfi, ti, ɛn kola, bikɔs dɛn kin mek dis filin bɔku. |
| Di we aw pɔsin nɔ kin gri wit ɔt | Dis mɛrɛsin kin mek di bɔdi nɔ ebul fɔ kol insɛf. Nɔ mek yu wam pasmak ɛn nɔ gɛt wata na yu bɔdi. Wear layt klos ɛn drink bɔku wata. |
| Bɛlɛ de at, kɔnstipɛshɔn, yu mɔt de dray | Tek di mɛrɛsin wit it. If yu mɔt dray, drink smɔl wata ɔltɛm, sok ays kiub, ɔ chuk gɔm we nɔ gɛt shuga. If yu gɛt kɔnstipɛt, drink bɔku wata ɛn it tin dɛn we gɛt bɔku fayv (wit bran, bins, frut). |
Dis na de tin wae kin apun pasmak. If ɛni wan pan dɛn tin ya we nɔ fayn nɔ de apin ɔ i de wɔs, mek shɔ se yu tɛl yu dɔktɔ.
Prɔblɛm kin de wit ɔda mɛrɛsin dɛn? (Drug Intarakshɔn) .
Yɛs. Sɔm mɛrɛsin dɛn kin mek di Rexulti wok fayn ɔ i nɔ kin wok fayn, ɔ i kin mek di risk fɔ gɛt sayd ɛfɛkt, we dɛn tek am wit Rexulti. Fɔ ɛgzampul, sɔm antifɔngal (e.g., ketoconazole), sɔm antibayɔtik (e.g., clarithromycin), sɔm antidipreshan (e.g., fluoxetine, paroxetine), ɛn ivin grepfruit jus kin chenj di ifɛkt dɛm we Rexulti gɛt.
So, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn, vaytamɛn dɛn, ɛn ɛbul prɔdak dɛn we yu de tek, so dat i go ebul fɔ ajɔst di doz fɔ Rexulti fɔ fit yu.
Us tɛst dɛn fɔ du we dɛn de trit am?
Yu dɔktɔ go du sɔm tɛst fɔ wach yu wɛlbɔdi bifo yu bigin fɔ tek di mɛrɛsin ɛn we yu de tek am.
- Yu wet, ayt, ɛn di say we yu wes de rawnd.
- Wan kɔmplit blɔd kɔnt (CBC).
- Fast blɔd kɔlɔstrel ɛn shuga tɛst (Fasting lipid profayl ɛn blɔd shuga).
- Blɔd prɛshɔn.
- AIMS tεst fכ chεk fכ abnכmal muvmεnt dεm (e.g., involuntary limb muvmεnt dεm).
Dɛn tɛst ya na di wangren we fɔ no ustɛm di mɛrɛsin go afɛkt yu bɔdi.
Mɛsej we dɛn kin kɛr go na os
- Rexulti na "ad-on" mεdikeshכn wae dεn kin gi apat frכm mεdikeshכn dεm wae dεn dכn כlrεdi de tek fכ diprεshכn, fכ εnhans dεn effektivεs.
- Dis kin wok bay we i de balans di kemikal dɛm na di bren we gɛt fɔ du wit gladi at ɛn gladi at.
- Tek di mɛrɛsin ɔltɛm, di doz we dɛn tɛl yu fɔ tek, lɛk aw yu dɔktɔ tɛl yu fɔ tek am.
- Ivin if yu sik dɛn dɔn bɛtɛ, nɔ stɔp fɔ tek di mɛrɛsin we yu nɔ go to yu dɔktɔ.
- Yu fɔ no bɔt di sayd ɛfɛkt dɛm lɛk fɔ gɛt bɔku bɔku bɔdi, fɔ slip, ɛn fɔ nɔr de rɛst. If dɛn de mɔna yu, tɔk to yu dɔktɔ.
- I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn, vaytamɛn dɛn, ɛn tradishɔnal mɛrɛsin dɛn we yu de tek.
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