If yu ɔ pɔsin we yu sabi gɛt bɔdi kansa, i nɔmal fɔ mek yu fil bad ɛn shɔk. Semweso, as wi de ol, di bon dɛn kin wik ɛn ivin we wi fɔdɔm smɔl, i kin brok dɛn. Bɔt bikɔs di mɛrɛsin dɔn go bifo, dɛn gɛt fayn tritmɛnt fɔ dɛn sik ya. Tide, wi go tɔk bɔt wan pan dɛn kayn patikyula tritmɛnt dɛn de.
Fɔ tɔk am simpul wan, wetin na dɛn SERM ya?
SERM dεm na sכt fכ Sεlektiv εstrojen Risεptor Mכdulεta dεm . Dis na wan kayn ɔmon tritmɛnt. Dis min se wi fɔ kɔntrol di we aw di ɔmon we dɛn kɔl ɛstrojen na wi bɔdi de wok. Tink bɔt am lɛk smat manija. i de blok di ifekt dεm we εstrojen de gi na sכm pat dεm na di bכdi, εn i de wok lεk εstrojen na כda pat dεm fכ εp di bכdi.
Tu pan di men drɔgs dɛn we de insay dis klas na Tamoxifen ɛn Raloxifene . Naw dɛn de yuz dɛn tin ya as tritmɛnt we rili wok fɔ sɔm kayn bɔdi kansa ɛn ɔstioporosis.
Aw dɛn SERM drɔgs ya de wok insay di bɔdi?
Dis kin tan lɛk se i nɔ izi fɔ ɔndastand, bɔt fɔ tru, i rili simpul. Lɛ wi ɔndastand dis wit ɛgzampul.
Tink bɔt ɛstrojen as di men tin. di sεl dεm na wi bכdi gεt rεsεpכta dεm we de mach dis ki. We yu put dis ki na di domɔt, di domɔt opin ɛn dɛn kin sɛn mɛsej to di sɛl.
- insay brεst kεnsar: sכm brεst kεnsar sεl dεm (dεn kכ l dεm Hכmכn Risεptor positifu כ ER-positiv kεnsar) nid di mεsej frכm di ki we dεn kכl εstrojen fכ gro εn divayd. SERM dכg dεm de wok bay we dεn de blכk di do (rεsεptor) pan dεn kεnsar sεl dεm ya. I tan lɛk se yu put ɔda tin na di ki ol na domɔt. Dɔn di rial ɛstrojen nɔ kin ebul fɔ rich na di ki ɛn opin di domɔt. Dis kin mek di kansa sɛl dɛn nɔ kin gɛt di mɛsej fɔ gro, ɛn dɛn kin stɔp ɔ slo.
- insay di bon dεm: Na di sem tεm, we dis SERM dכg go na wi bon dεm, i de wok lεk εstrojen de. Dat min se i de go na di domɔt dɛn we de na di bon dɛn ɛn opin dɛn domɔt dɛn de, ɛn i de ɛp fɔ mek di bon dɛn strɔng ɛn kip di kalsiɔm. Dis kin mek yu nɔ gɛt ɔstioporosis.
Yu dɔn si di wɔndaful we aw dis mɛrɛsin ebul fɔ du? Di sem mɛrɛsin de wok tu kɔmplit difrɛn we dɛn na tu ples. Na dat mek dɛn kɔl am "Selective".
Wetin na di men yus dɛm fɔ SERM dɛm?
Dɔktɔ dɛn kin advays dis tritmɛnt mɔ pan tu tin dɛn.
1. Fɔ bɔdi kansa
SERM na rili impɔtant tritmɛnt, mɔ fɔ ɔmon-sɛnsitiv (ER-positiv) brɔst kansa.
- Fɔ di wan dɛn we gɛt bɔku kansa: If sɔmbɔdi na di famili dɔn gɛt bɔdi kansa, ɔ if dɛn dɔn du di jenɛtik tɛst fɔ no se dɛn gɛt jɛnɛtik muteshɔn we de mek dɛn gɛt kansa mɔ, dɛn kin gi dɛn dis mɛrɛsin fɔ mek kansa nɔ kam.
- Afta di kansa ɔpreshɔn: Afta dɛn dɔn ɔpreshɔn di kansa, dɛn kin yuz SERM fɔ mek di kansa nɔ kam bak (`recurrence`) ɛn fɔ mek kansa nɔ kam bak na di ɔda bɔdi.
- insay DCIS: fכ mek di Ductal Carcinoma in Situ (DCIS) nכ kam bak, we na wan εli stej kεnsar we de apin na di brεst dakt dεm.
- Fɔ kansa we dɔn skata ɔlsay na di bɔdi: Fɔ kɔntrol kansa we dɔn skata to ɔda ɔgan dɛn na di bɔdi (Metastatic Breast Cancer).
- Fɔ man dɛn bɔdi kansa: Pan ɔl we i nɔ kin izi fɔ mek man dɛn gɛt bɔdi kansa, dɛn kin yuz dis tritmɛnt bak fɔ am if i apin.
2. Fɔ ɔstioporosis
Dɛn kin yuz wan SERM we dɛn kɔl Raloxifene fɔ kɔntrol di bon dɛn we de lɔs, fɔ mek di bon dɛn strɔng, ɛn fɔ mek di bon dɛn nɔ brok, mɔ pan uman dɛn we dɔn pas 40 ia.
Aw dis tritmɛnt kin wok fayn?
Yɛs, dis na tritmɛnt we rili fayn. Stɔdi dɔn sho se di mɛrɛsin we dɛn kɔl Tamoxifen mɔ kin ridyus di risk fɔ gɛt bɔdi kansa bay lɛk 40% .
- If pɔsin we dɛn dɔn ɔpreshɔn fɔ gɛt kansa na wan bɔdi tek Tamoxifen, di risk fɔ gɛt kansa na di ɔda bɔdi kin ridyus bay 50% .
- Fɔ pɔsin we dɔn gɛt kansa bifo i menɔpauz, di risk fɔ gɛt kansa bak kin ridyus bitwin 30% ɛn 50% .
- Dɛn dɔn si bak se raloxifene kin ridyus di risk fɔ mek yu spɛnal fraktrɔs we ɔstioporosis kin mek afta yu dɔn menɔpauz.
Wetin kin apin we dɛn de trit am?
Dɛn kin gi dis tritmɛnt as pil ɔ wata we dɛn kin tek ɛvride. Di tɛm we yu go tek di tritmɛnt kin difrɛn difrɛn wan bay aw yu sik ɛn wetin yu dɔktɔ tɛl yu fɔ du.
- Tamoxifen: Pipul dɛn we de tek am fɔ protɛkt ɔ trit bɔdi kansa kin tek dis mɛrɛsin fɔ 5 ia insay wan row. Yu dɔktɔ kin ɛkstɛnd dis tɛm to 10 ia. Dɛn kin chenj yu bak to ɔda mɛrɛsin (lɛk aromatase inhibitor) afta sɔm ia.
- Raloxifene: Di wan dɛn we de tek am fɔ ridyus di risk fɔ gɛt bɔdi kansa ɔ fɔ gɛt ɔstioporosis fɔ tek am as pil fɔ ɛvride fɔ lɔng tɛm lɛk aw dɛn dɔktɔ se.
Di tin we impɔtant pas ɔl na fɔ tek dis mɛrɛsin fɔ di ful tɛm lɛk aw di dɔktɔ tɛl yu fɔ tek am. If yu stɔp am af-af, dat nɔ go mek yu gɛt di tin dɛn we yu want.
Wetin na di sayd ɛfɛkt dɛm we dis tritmɛnt kin gɛt?
Jɔs lɛk ɛni tritmɛnt fɔ kansa, SERM kin mek sɔm sayd ɛfɛkt. Bɔt nɔto ɔlman go ɛkspiriɛns dɛn ɔl. Bɔku pan dɛn tin ya, dɛn kin ebul fɔ kɔntrol dɛn.
| Kɔmɔn ɛn rare sayd ɛfɛkt dɛm fɔ Tamoxifen | |
|---|---|
| Sayd ɛfɛkt we pɔsin kin gɛt | Tɔk bɔt |
| Kɔmɔn sayd ɛfɛkt dɛn (uman dɛn) . | |
| Hot flash dɛn we de shayn | Semweso lɛk wan sayn we de sho se pɔsin dɔn lɛf fɔ gɛt bɛlɛ. |
| Nayt swet dɛn | Sɔntɛm dɛn kin ambɔg di slip. |
| Menstrueshɔn we nɔ de ɔltɛm/blɔd we de kɔmɔt na di vagina | di mεnstral saykl fכ uman dεm we dεn mεnopos kin chenj. |
| Vagina dray, it, dischaj | I kin gɛt prɔblɛm wit mami ɛn dadi biznɛs. |
| Rare bɔt siriɔs sayd ɛfɛkt dɛn | |
| Blɔd we de klɔt | i kin apin na di vein dεm na di leg dεm (Deep Venous Thrombosis) כ na di lכng dεm (Pulmonary Embolism). |
| Risk fɔ gɛt kansa na di uterin | Rismɔl risk de. If yu gɛt ɛni blɔd we nɔ kɔmɔn, yu fɔ tɛl yu dɔktɔ. |
| Katarakt we pɔsin kin gɛt | Tek tɛm if chenj de na di vishɔn. |
| Strok | Na wan sik we nɔ kin apin so ɔltɛm bɔt i kin rili siriɔs. |
Raloxifene kin gɛt di sem kayn sayd ɛfɛkt (e.g. hot flash, leg pen), bɔt di risk fɔ gɛt uterin kansa smɔl pas wit Tamoxifen. Yu dɔktɔ go ɛksplen dis to yu mɔ.
Wetin a kin du fɔ mek a ebul fɔ kɔntrol di bad tin dɛn we kin apin to mi?
Sɔm tin dɛn de we yu kin du yusɛf fɔ mek i izi fɔ liv wit dɛn sayd ɛfɛkt ya.
- Fɔ hot flash: Ridyus di drink dɛn we gɛt kafin lɛk kɔfi ɛn ti. Sɔm pipul dɛn kin gɛt fridɔm we dɛn it tin dɛn we gɛt faytoɛstrojen lɛk soya bin, chikip, ɛn lentil.
- Fɔ inshɔmnia: We yu de du ɛksɛsayz ɔltɛm, dat kin mek yu slip fayn.
- di vagina dray: Sεf spεshal vagina mכstizayza dεm de we dεn kin yuz fכ dis. Aks yu dɔktɔ bɔt dɛn tin ya.
Ustɛm yu fɔ go to dɔktɔ wantɛm wantɛm?
If di kɔmɔn sayd ɛfɛkt dɛn kin rili bad, tɛl yu dɔktɔ. Bɔt if yu gɛt ɛni wan pan dɛn sayn ya, go na ɔspitul in imejensi dipatmɛnt (ETU) wantɛm wantɛm ɔ kɔl 1990. Dɛn tin ya kin bi sayn fɔ se yu gɛt siriɔs sik lɛk we yu gɛt strok ɔ blɔd we de rɔtin na yu lɔng (pulmonary embolism).
- Wan say na di bɔdi ɔ in fes kin swɛla ɔ wik.
- I nɔ izi fɔ tɔk, fɔ tɔk smɔl smɔl.
- Di ed we kin at bad bad wan wantɛm wantɛm.
- I nɔ kin izi fɔ yu fɔ blo wantɛm wantɛm.
- Shap pen na di chɛst, an, sholda, ɔ jaw we nɔ gɛt ɛni rizin fɔ no.
Nɔ ignore dɛn sayn ya. If wi du sɔntin wantɛm wantɛm, dat kin sev pipul dɛn layf.
Mɛsej we dɛn kin kɛr go na os
- SERM na spɛshal klas fɔ drɔgs we de kɔntrol aw di ɔmon ɛstrojen de wok. Dɛn na tritmɛnt we rili ɛp fɔ mɛn bɔdi kansa ɛn ɔstioporosis.
- Dɛn mɛrɛsin ya kin stɔp di bɔdi kansa sɛl dɛn we de gro ɛn i kin ɛp bak fɔ mek di bon dɛn strɔng.
- Tamoxifen ɛn Raloxifene na tu pan di SERM dɛm we dɛn kin yuz mɔ.
- Jɔs lɛk ɔl di mɛrɛsin dɛn, sɔm kayn bad bad tin dɛn de we kin apin to pɔsin, bɔt dɛn kin ebul fɔ kɔntrol bɔku pan dɛn. Tɔk opin wan wit yu dɔktɔ bɔt dɛn.
- Yu fɔ no bɔt siriɔs bɔt rare sayd ɛfɛkt lɛk blɔd we de klɔt ɛn strok. If dɛn kayn sayn dɛn de apin, go to dɔktɔ wantɛm wantɛm.
- Na yu dɔktɔ nɔmɔ go gi yu di bɛst advays fɔ no if SERM tritmɛnt rayt fɔ yu, ɛn wetin na in gud ɛn bad tin dɛn. So nɔ fred fɔ aks ɛni kwɛstyɔn we yu gɛt.
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