We yu dɔktɔ tɛl yu se yu gɛt bɔdi kansa, yu si di nem ‘Taxane’ we dɛn tɔk bɔt na yu tritmɛnt plan? Yu go dɔn fred smɔl we yu yɛri dis nem. Na nɔmal tin fɔ mek tin kam na yu maynd we yu yɛri di wɔd ‘kimotɛrapi’ wit dis nem. Bɔt nɔ wɔri. Taxane na wan tritmɛnt we rili fayn we dɛn dɔn de yuz fɔ mɛn bɔdi kansa fɔ pas 40 ia. Lɛ wi tɔk bɔt am simpul wan we yu go ɔndastand.
Wetin na dɛn taksan ya? Aw dɛn kin wok?
Fɔ tɔk am simpul wan, taksan na wan kayn kemotɛrapi we de stɔp di kansa sɛl dɛn fɔ sheb, bɔku, ɛn fɔ skata ɔlsay na di bɔdi.
Jɔs tink bɔt dat, jɔs lɛk di sɛl dɛn we gɛt wɛlbɔdi na wi bɔdi, di kansa sɛl dɛn kin bɔku bay we dɛn de sheb. dis prכsεs we di sεl dεm de sheb de εp bay wan sistεm we de fכ sכm sכm tכb dεm (maykrotubul dεm) insay dεn sεl dεm. di taksan klas fכ dכg dεm, כ mכr prεsis ``antimikrotubul ejen dεm'', de go dayrekt to εn tכk to da vεri tכb sistεm de. Dɛn drɔgs ya kin ambɔg di wok we da tiub sistɛm de wok ɛn i kin mek i nɔ ebul fɔ du am. Dɔn di kansa sɛl dɛn nɔ kin ebul fɔ sheb, ɛn leta dɛn sɛl dɛn de day. Dis na di men prinsipul fɔ dis tritmɛnt.
Dis tritmɛnt kin bi wan we yu fɔ gɛt na yu tritmɛnt plan, mɔ if yu gɛt ``(HER2-positiv)`` kayn bɔdi kansa.
Taxane drɔgs (fɔ ɛgzampul, `(Docetaxel)` ɛn `(Paclitaxel)`) dɛn de yuz insay ɔl tu di kayn dɛn:
1. di brɔst kansa we kin bigin: Dɛn kin gi dis mɛrɛsin bifo dɛn du di ɔpreshɔn fɔ mek di tumbu smɔl ɛn mek i smɔl. Dɛn kin gi am bak afta dɛn dɔn du di ɔpreshɔn fɔ mek di kansa nɔ kam bak.
2. Metastatic breast cancer: Dɛn kin yuz dis tritmɛnt bak fɔ kɔntrol kansa we dɔn skata to ɔda pat dɛn na di bɔdi.
Aw dɛn kin gi Taxane drɔgs?
Naw dɛn de gi taksan drɔgs insay di bɛlɛ (IV) , we min se dɛn de gi dɛn as salin sɔlvushɔn insay wan vein. Dɛn kin du dis na ɔspitul ɔ kansa klinik.
Sɔntɛnde dɛn kin gi taksan dɛn wan (monotherapy). Ɔda tɛm dɛn, dɛn kin gi dɛn togɛda wit ɔda kemotɛrapi mɛrɛsin dɛn fɔ mek di tritmɛnt wok fayn. Fɔ ɛgzampul, dɛn kin gi dɛn togɛda wit drɔgs lɛk Capecitabine, Carboplatin, ɛn Cyclophosphamide.
Di gud nyus na dat sayɛnsman dɛn de du risach naw bɔt aw fɔ tek dis mɛrɛsin as pil, we go mek pipul dɛn nɔ go na ɔspitul tumara bambay.
Wetin yu fɔ ɛkspɛkt we yu de gɛt tritmɛnt?
Wae yu dɔktɔ disayd fɔ bigin fɔ trit yu wit taksan, dɛn go mek wan patikyula tritmɛnt fɔ yu. Dis inklud aw ɔltɛm yu nid fɔ kam na ɔspitul ɛn aw lɔng i go tek fɔ gɛt di mɛrɛsin.
- Di nɔmba fɔ di tritmɛnt dɛn: Dis kin difrɛn frɔm wan pɔsin to ɔda pɔsin. I dipen pan di kayn mɛrɛsin we dɛn gi yu (`(Docetaxel)` ɔ `(Paclitaxel)`), di doz fɔ di mɛrɛsin, ɛn aw yu bɔdi de ansa am.
- fכ egzampl, dεn kin gi `(Docetaxel)` wan tεm εvri 3 wik . Ɛni doz kin tek lɛk wan awa so.
- Dɛn kin gi paclitaxel smɔl mɔ. Sɔntɛm wan tɛm insay tu wiks . I kin tek lɛk tu awa so. Sɔm kayn tin kin de bak we dɛn kin gi smɔl doz wan tɛm insay di wik fɔ sɔm pipul dɛn.
- Doz: Di kayn mɛrɛsin we dɛn de gi yu kin dipen pan bɔku tin dɛn, lɛk di kayn ɛn stej we yu gɛt kansa, yu wet ɛn ayt, ɛn us ɔda mɛrɛsin dɛn de gi yu.
- Di tɛm we yu fɔ tek di tritmɛnt: Dis kin dipen bak pan aw di tritmɛnt go wok fayn ɛn if yu gɛt siriɔs sayd ɛfɛkt. Bɔrku tɛm, dɛn kin gi tri to siks saykl tritmɛnt fɔ kansa wae nɔr dɔn skata. Kansa we dɔn skata kin nid fɔ gɛt tritmɛnt fɔ lɔng tɛm.
Bɔt mɛmba se if yu gɛt bad bad sayd ɛfɛkt ɔ yu nɔ ebul fɔ bia wit di mɛrɛsin, yu dɔktɔ kin chenj yu to ɔda tritmɛnt.
Yu tink se Taxanes kin mek yu gɛt sayd ɛfɛkt?
Yɛs. I sɔri fɔ no se, lɛk ɔl di kemotɛrapi drɔgs, taksan kin mek pɔsin gɛt sayd ɛfɛkt. Dis na bikɔs dɛn mɛrɛsin ya nɔ kin afɛkt di kansa sɛl dɛn nɔmɔ, bɔt dɛn kin afɛkt di sɛl dɛn we gɛt wɛlbɔdi ɛn we kin sheb kwik kwik wan. Bɔt bɔku tɛm, di sayd ɛfɛkt dɛn we taksan kin gɛt kin smɔl ɛn dɛn kin telɛ am we yu kɔmpia am wit ɔda kemotɛrapi drɔgs.
Dɛn sayd ɛfɛkt ya kin kɔmɔt frɔm smɔl to siriɔs tin we go mek yu nid fɔ go na ɔspitul. Lɛ wi tek wan luk pan wetin na dɛn sayd ɛfɛkt ya.
| Sayd ifekt dɛm fɔ taksan tritmɛnt | |
|---|---|
| Kɔmɔn sayd ɛfɛkt dɛn | |
| Taya | Yu kin fil taya bad bad wan bɔku tɛm. |
| Di ia we de lɔs | Iɛ na di ed, ɛn ɔda bɔdi ia kin fɔdɔm. |
| Mɔsul ɛn jɔyn pen | Yu bɔdi kin fil pen. Dɔktɔ dɛn kin kɔl dis ``myalgia''. |
| Nɔs ɛn vɔmit | Di dɔktɔ go gi yu mɛrɛsin fɔ kɔntrol dis. |
| Pen ɛn swɛt na di an ɛn fut dɛn | Yu kin gɛt tingling, bɔn, ɔ pen na yu an, yu fut, ɛn yu finga dɛn. Dɛn kɔl dis periferik nyuropathy. |
| Sɔl dɛn na yu mɔt | Smɔl wund dɛn kin apin insay di mɔt. |
| Di risk fɔ gɛt infɛkshɔn kin bɔku | If di wayt blɔd sɛl dɛn go dɔŋ (nyutropenia) i kin mek yu gɛt sik mɔ ɛn mɔ. |
| Siriɔs sayd ɛfɛkt dɛm we dɛn fɔ ripɔt to di dɔktɔ wantɛm wantɛm | |
| Sivɛri dayarɛa (Dayrɛa) . | Wan kɔndishɔn fɔ dayarɛa we nɔ de stɔp. |
| I kin wik bad bad wan na di an ɛn fut dɛn | An tu wik fɔ ol sɔntin ɔ leg tu wik fɔ waka. |
| Fiva | I kin bi sayn fɔ se infɛkshɔn de na di bɔdi. |
| Vishɔn kin chenj | Yu nɔ de si fayn ɔ yu nɔ de si fayn igen. |
| Blɔd we nɔ de kɔmɔt fayn | Nos blɔd ɔ brus ɔlsay na di bɔdi. |
Bɔrku tɛm, dɛn sayd ɛfɛkt ya kin dɔn insay sɔm wik ɔr mɔnt afta dɛn dɔn stɔp di tritmɛnt. Bɔt sɔm kayn tin kin de wae de nyuropathy kin tranga ɛn nɔr kin dɔn fɔ sɔm pipul dɛm.
Di tin we impɔtant pas ɔl na dat, if yu gɛt ɛni ɔda sayn we nɔ kɔmɔn, nɔ ignore am ɛn tɛl yu dɔktɔ ɔ di nɔs we de trit yu wantɛm wantɛm.
Aw dis tritmɛnt kin wok fayn?
Taxane na tritmɛnt we rili wok, na dat mek dɛn dɔn de yuz am fɔ lɔng tɛm.
Fɔ di fɔs stej kansa:
Risach dɔn sho se if dɛn gi uman dɛn we gɛt bɔdi kansa we dɔn bigin fɔ du ɔpreshɔn, dat kin mek dɛn liv bɔku ɛn i kin mek di kansa kam bak.
Fɔ mɛtastas brɔst kansa:
Insay kes dɛm we di kansa dɔn skata, taksan tɛrapi nɔ kin ebul fɔ mɛn di kansa, bɔt i kin ɛp bad bad wan fɔ kɔntrol aw di sik de go bifo ɛn fɔ mek i liv lɔng.
Pan ɔl we dɛn kin yuz dis tritmɛnt fɔ HER2-positiv kansa, dɛn kin yuz am bak fɔ wan kayn kansa we at fɔ trit we dɛn kɔl Triple-Negative Breast Cancer (TNBC).
Tɛm de we Taxane tritmɛnt nɔ kin wok?
Yɛs, sɔntɛnde i kin ebul. Nɔto ɔl kansa kin ansa taksan di sem we. Sɔm kansa nɔ kin ebul fɔ tek dis mɛrɛsin frɔm di biginin. Ɔda tɛm, afta di tritmɛnt dɔn wok fɔ sɔm tɛm, di kansa kin yus to di mɛrɛsin ɛn i kin gɛt resistans. Dɔn di drɔg kin stɔp fɔ wok.
dis kכndyushכn kin kכmכn spεshal wan pan ``tripul-nεgεtiv'' kεnsar dεm. Sayɛnsman dɛn stil nɔ no di rayt tin we mek dis kin apin.
Dis tɛm ya, yu dɔktɔ kin chenj di kɔmbayn mɛrɛsin ɔ chenj yu to ɔda tritmɛnt we rili difrɛn.
Mɛsej we dɛn kin kɛr go na os
- Taxane na wan rili fayn tritmɛnt fɔ kimotɛrapi fɔ bɔdi kansa. Nɔ fred dis.
- Dɛn kin gi dis tritmɛnt tru wan layn we dɛn kin put insay di bɛlɛ (IV). Yu go nid fɔ go na ɔspitul pan wan patikyula tɛm.
- Sɔm bad tin dɛn lɛk we yu ia de lɔs, taya, ɛn bɔdi we de at kin apin. Bɔrku pan dɛn tin ya kin go wans dɛn dɔn stɔp di tritmɛnt.
- If yu gɛt siriɔs sik lɛk fiva, bad bad dayarɛa, ɔ yu an ɛn fut wik pasmak, tɛl yu dɔktɔ wantɛm wantɛm.
- Na yu rayt fɔ tɔk to yu dɔktɔ opin wan bɔt ɛni kwɛstyɔn, fred, ɔ dawt we yu gɛt.
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