Wi no aw i nɔ izi fɔ fɛt bɔdi kansa. Bɔt we di sayɛns bɔt mɛrɛsin de go bifo, pipul dɛn kin gɛt nyu op ɔltɛm. Tide wi de tɔk bɔt wan mɛrɛsin we dɔn briŋ dis kayn nyu op, wan mɛrɛsin we de spɛshal fɔ tɔch ɛn trit kansa sɛl dɛn. Di nem fɔ dis drɔg na Truqap.
Wetin na Truqap? Yu tink se i difrɛn frɔm di mɛrɛsin we dɛn kin gi ɔltɛm?
Truqap (capivasertib) na wan tritmɛnt we dɛn kin yuz fɔ mɛn bɔdi kansa. Naw yu kin de wɔnda, "Wetin na dis targeted therapy?"
Fɔ tɔk am simpul wan, imajin wan gadin we gɛt bɔku gras. Kimotɛrapi ɔltɛm tan lɛk we yu de sprɛy di wan ol gadin wit ɛbisayd. Dɔn, wit di gras, dɛn kin pwɛl gud plant dɛn bak we gɛt wɛlbɔdi. Dis min se kemotɛrapi kin kil kansa sɛl dɛn, bɔt i kin mek sɔm damej bak pan wɛlbɔdi sɛl dɛn na wi bɔdi.
Bɔt targeted therapy tan lɛk fɔ fɛn wan gras ɛn sprɛy am nɔmɔ. I de no di patikyula protin dεm we de εp di kεnsar sεl dεm fכ gro kwik, εn i de stכp dεm fכ du dat. Dis min se di damej we di sɛl dɛn we gɛt wɛlbɔdi kin du nɔ kin bɔku.
Truqap na wan pan dɛn kayn tritmɛnt ya we dɛn kin tɔch. Di US FDA bin gri fɔ di mɛrɛsin insay 2023, spɛshal fɔ advans brɔst kansa we gɛt ɔmon-pɔzitiv (HR-positiv) ɛn we gɛt sɔm chenj dɛn na di jɛnɛtiks. Dɛn kin gi di mɛrɛsin togɛda wit ɔda ɔmon tritmɛnt we dɛn kɔl fulvestrant.
Aw Truqap de wok na di bɔdi?
Sɔm pipul dɛn we gɛt bɔdi kansa we dipen pan ɔmon (HR-positiv) kin gɛt chenj dɛn na di jin dɛn we dɛn kɔl PIK3CA, AKT1, ɔ PTEN . di mכtayshכn dεm na di AKT1 jin, spεshal wan, kin εp di kεnsar sεl dεm fכ gro εn divayd kwik kwik wan.
wetin Truqap de du na fכ blok di aktiviti fכ wan protin we dεn kכl AKT . I tan lɛk we yu ɔf wan swich we de mek di kansa sɛl dɛn gro kwik kwik wan.
Nɔto dat nɔmɔ. di kansa sel dεm we de dipεnd pan כmon dεm de dipכnt pan כmon dεm lεk εstrojen na wi bכdi fכ gro. Na dat mek dɛn kin gi Truqap togɛda wit wan ɔmon tritmɛnt we dɛn kɔl fulvestrant.
- Truqap: I de inhibit di AKT protin we de inkrεs di growth rεt fכ di kεnsar sεl dεm.
- Fulvestrant: I de mek di ɔmon ɛstrojen nɔ rich di kansa sɛl dɛn.
we yu atak frכm di tu say dεm dis we i de εp bכku fכ kכntrכl di kεnsar sεl dεm we de gro.
Aw a go no if dis tritmɛnt fayn fɔ mi?
Truqap tritmɛnt kin fayn fɔ yu pan dɛn kayn tin ya:
- Yu kansaIf i dɔn go bifo, ɔ i dɔn spre to ɔda pat dɛn na di bɔdi (mɛtastatik) .
- If spεshal tεst dεn dכn kכnfכm se yu kεnsar sεl dεm gεt di jεnεtik chenj dεm we wi bin dכn tכk bכt (PIK3CA, AKT1, PTEN) .
- If yu dɔn ɔlrɛdi gɛt ɔmon tɛrapi, ɛn di kansa dɔn kam bak di tɛm ɔ afta da tritmɛnt de.
Di tin we impɔtant pas ɔl na dat, yu dɔktɔ we de mɛn kansa go disayd if dis mɛrɛsin fayn fɔ yu. I go chɛk di chenj dɛn we yu gɛt pan yu kansa ɛn rivyu yu kɔmplit mɛdikal istri fɔ disayd fɔ du di las tin.
Wetin na di sayd ɛfɛkt dɛm fɔ Truqap? Aw dɛn go ebul fɔ kɔntrol dɛn?
Lɛk ɛni mɛrɛsin, Truqap kin mek yu gɛt sayd ɛfɛkt. Sɔm pan dɛn kin rili siriɔs. So i impɔtant fɔ no bɔt dɛn tin ya.
Dis dɔŋ ya na di men sayd ɛfɛkt dɛm ɛn wetin yu fɔ du if dɛn apin.
| Sayd ɛfɛkt we pɔsin kin gɛt | Wetin fɔ du |
|---|---|
| Di blɔd shuga we bɔku | If yu gɛt sɔm sayn dɛn lɛk fɔ tɔsti we yu nɔ kin tɔsti, yu kin pis ɔltɛm, ɔ yu kin lɔs yu wet pan ɔl we yu de it mɔ, tɛl yu dɔktɔ wantɛm wantɛm . I go de tɛst yu blɔd shuga ɔltɛm ɛn du ɛnitin we i nid fɔ kɔntrol di shuga we yu gɛt. |
| Rɔnbɛlɛ | Tɛl yu dɔktɔ jɔs afta yu bigin fɔ gɛt dayarɛa. Drink bɔku wata lɛk wata ɛn jus fɔ mek yu nɔ gɛt wata na yu bɔdi. Yu dɔktɔ go gi yu di rayt mɛrɛsin fɔ yu. |
| Di we aw di skin kin biev | If yu notis nyu skin lεsin, di lεsin dεm we de naw big, skin rεd, fiva, blista na yu lip/ay/mכt, skin blista כ skin de pilTɛl yu dɔktɔ wantɛm wantɛm. I go disayd if i fɔ kɔntinyu fɔ tek di mɛrɛsin ɔ chenj di doz. |
Apat frɔm dɛn tin ya, yu kin gɛt bak nɔys, vɔmit, taya, yu mɔt sɔri, ɛn chenj na sɔm blɔd tɛst rizɔlt.
Di tin we impɔtant pas ɔl: Nɔ ɛva stɔp fɔ tek yu mɛrɛsin ɔ chenj di doz if yu dɔktɔ nɔ advays yu. If yu gɛt ɛni sayn we de mɔna yu, tɔk to dɛn bɔt am.
Truqap de intarakt wit ɔda mɛrɛsin ɔ it dɛn?
Yɛs, dis na pɔynt bak we rili impɔtant. Truqap kin intarakt wit sɔm ɔda mɛrɛsin ɛn it dɛm. So, yu fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud di mɛrɛsin dɛn fɔ ɔda sik dɛn, vaytamɛn dɛn, ɛn ivin tin dɛn we dɛn kin yuz fɔ mɛn animal dɛn).
dis na biכs wi bכdi de yuz wan εnzym we dεn kכl CYP3A fכ brok dis dכg εn pul am kכmכt na di bכdi. sכm mεdikeshכn εn it dεm kin chenj di we aw dis CYP3A εnzym de wok.
- CYP3A Inhibitors: dεn ya de inhibit di akshכn fכ di CYP3A εnzym. Dis kin mek Truqap de na di bɔdi fɔ lɔng tɛm ɛn i kin mek di risk fɔ gɛt sayd ɛfɛkt dɛn go ɔp. Sɔm antibayɔtik ɛn antifɔngal dɛn de insay dis kategori. Na mɔtalman, yu fɔ avɔyd fɔ drink grep ɔ grep jus we yu de tek Truqap.
- CYP3A Inducers: dεn ya de wok bay we dεn de inkrεs di aktiviti fכ di CYP3A εnzym. Dis kin mek dɛn pul Truqap na di bɔdi kwik kwik wan, we kin mek i nɔ wok fayn . Sɔm antibayɔtik (lɛk rifampicin) ɛn sɔm mɛrɛsin fɔ HIV de insay dis kategori.
So, bifo yu bigin fɔ tek ɛni nyu mɛrɛsin, mek shɔ se yu tɔk to yu dɔktɔ we de mɛn kansa bɔt am.
Aw yu go no if di mɛrɛsin de wok?
Yu dɔktɔ go de wach yu kɔndishɔn ɔltɛm. I go du tɛst dɛn lɛk blɔd tɛst, CT skan, ɛn MRI skan fɔ no aw di mɛrɛsin de wok fayn. Na wetin yu fɔ du na fɔ tek di mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu.
Mɛsej we dɛn kin kɛr go na os
- Truqap (capivasertib) na wan tritmɛnt we dɛn kin yuz fɔ mɛn bɔdi kansa. I de tɔch di kansa sɛl dɛn spɛshal wan, so i nɔ de mek di sɛl dɛn we gɛt wɛlbɔdi nɔ pwɛl bɛtɛ.
- Dis tritmɛnt fayn fɔ kansa dɛn we dipen pan ɔmon (HR-positiv), agresiv, ɛn we gɛt spɛshal jɛnɛtik ɔltɛrayshɔn (PIK3CA, AKT1, ɔ PTEN).
- As sayd ɛfɛkt lɛk ay blɔd shuga lɛvɛl, dayarɛa, ɛn riakshɔn na di skin kin apin, ripɔt ɛni ɔda kayn sayn to yu dɔktɔ wantɛm wantɛm.
- Nɔ ɛva stɔp fɔ tek mɛrɛsin ɔ chenj di doz if yu dɔktɔ nɔ advays yu.
- I impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin ɛn it we yu de tek.
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