Sɔm mɛrɛsin dɛn kin mek pɔsin gɛt dis maynia sik? (Lɛ wi lan bɔt Anticholinergic Drugs).

Wi ɔl gɛt fred sɔmsay na wi at se wi mama ɛn papa, ɔ wisɛf, go bigin fɔ fɔgɛt tin as wi de ol. We wi tink se wi nɔ go ebul fɔ mɛmba tin ɛn nɔ ebul fɔ tink klia wan, dat kin rili mek wi fred. Pan ɔl we ol pipul dɛn na di men tin we kin mek pɔsin nɔ ebul fɔ mɛmba dis sik, ɔr kin gɛt dis maynia sik, naw dɛn de tɔk bɔt ɔda tin wae kin mek pɔrsin gɛt dis sik. Dat min se, sɔm pan di mɛrɛsin dɛn we wi kin yuz fɔ difrɛn sik dɛn.

Wetin na dɛn anticholinergic mɛrɛsin ya?

Fɔ tɔk am simpul wan, anticholinergics na wan klas fɔ drɔgs. Dɛn mek dɛn wit wan plant we dɛn kɔl Bɛlɛdɔna. Dis plant kin rili bi pɔyzin insay sɔm dos dɛn. Bɔt di kɔmpawnd dɛn we de insay dis plant kin ebul fɔ kɔntrol, ɔ stɔp di wok we wi nervɔs sistɛm de du to sɔm mak, so dɛn kin yuz dɛn fɔ mek mɛrɛsin dɛn we dɛn kin kɔntrol.

Imajin, wi nervɔs sistɛm tan lɛk wan nɛtwɔk we de skata ɔlsay na di bɔdi. Wi bren na di men tin we de mek wi de. di kכmand dεm we dεn gi frכm de go to di כl bכdi tru dεn nεv sεl dεm ya. Ɔltin frɔm di we aw wi de waka, we wi de tink, aw wi at de bit, aw wi de blo, aw wi de slip, ɛn aw wi fayv sɛns dɛn de wok, na dis nervɔs sistɛm de kɔntrol am.

Kεmikכl mεsenja dεm de we de kכri mεsej tru dis nεv sεstem. Wi kin kɔl dɛn nyurotransmitta. Asɛtilkolin na wan pan dɛn kayn mɛsenja dɛn de we rili impɔtant. So, wetin anticholinergic drugs de du na fɔ blok dis mɛsenja we dɛn kɔl acetylcholine. tru dat, dεn kin kכntro sכm pan di tin dεm we di nεv sεstem de du.

Dɛn kin yuz bɔku pan dɛn mɛrɛsin ya fɔ mɛn sik dɛn we pɔsin kin gɛt.

Sɔm mɛrɛsin dɛn we dɛn kin yuz bɔku tɛm

Dɛn mɛrɛsin ya kin kam lɛk pils, ay drɔp, ɛn injɛkshɔn. Sɔm ɛgzampul dɛn na:

• Diphenhydramine: Dis na wan kayn mɛrɛsin we dɛn kin yuz fɔ mɛn alɛji. Di mɛrɛsin we dɛn kin yuz na Sri Lanka we dɛn kɔl Piriton gɛt wan tin we tan lɛk dis we dɛn kɔl klorfeniramin. Dɛn wan ya kin fɔdɔm bak insay di sem klas we dɛn kɔl anti-cholinergics.
• Benztropine: Dɛn kin yuz am fɔ di sik dɛn we de sho se pɔsin gɛt Pakinsin.
• Dicycloverine: Dɛn kin yuz am fɔ bɛlɛ pen, mɔ pan tin dɛn lɛk Irritable Bowel Syndrome (IBS).
• Oxybutynin: Na mɛrɛsin we dɛn kin gi pipul dɛn we nɔ kin izi fɔ kɔntrol dɛn urine.
• Hyoscyamine: Dɛn kin yuz am fɔ pen na di bɛlɛ ɛn blad mɔsul.

Fɔ tɔk am simpul wan, wetin na dis maynia sik?

Dimɛns na wan jɛnɛral wɔd wae dɛn kin yuse fɔ difrɛn kayn sik wae kin afɛkt pɔrsin in ebul fɔ tink, mɛmba, ɔr disayd. E kin bɔrku pan pipul dɛm wae dɔn ol.

Dis sik kin afɛkt pɔrsin in:

• Abiliti fɔ pe atɛnshɔn
• Fɔ tɔk to ɔda pipul dɛn (kɔmyunikeshɔn) .
• Di ebul fɔ pik wetin rayt frɔm wetin rɔŋ (discretionary intelligence) .
• Mɛmba
• Ebul fɔ tink di rayt we ɛn sɔlv prɔblɛm dɛn

Sɔmtɛm, kayn dis maynia sik lɛk Alzaima kin ivin mek pɔrsin in pasɔnaliti ɛn bihayvya chenj.

Udat kin gɛt bɔrku risk fɔ gɛt dis maynia sik?

• Ej: We pɔsin de ol na in na di men tin we kin mek i gɛt prɔblɛm.
• At sik: Pipul wae gɛt histri wae gɛt ay blɔd prɛshɔn, ay kɔlɔstrel, ɛn strok kin gɛt bɔrku risk fɔ gɛt dis maynia sik.
• Jɛnɛtiks: If pɔsin we de nia yu fambul dɔn gɛt Alzaima, yu risk fɔ gɛt am kin go ɔp bay lɛk 10% - 30%.
• Traumatik Bren Injury: Siriɔs ɔr we de kɔntinyu fɔ wund yu ed kin mek yu gɛt mɔ prɔblɛm bak.

Bɔt sɔntɛnde dis we aw pɔsin kin mɛmba tin kin apin fɔ sɔm tɛm. Sɔm mɛrɛsin dɛn, we pɔsin nɔ gɛt bɛtɛ vaytamɛn, ɛn we di tayroyd ɔmon nɔ balans kin mek bak i nɔ ebul fɔ mɛmba fɔ sɔm tɛm.

So yu tink se dis mɛrɛsin kin rili mek yu gɛt dis maynia sik?

Risach pipul dɛn bin du wan big stɔdi fɔ no. Dis na bin tɛn ia stɔdi. Na lɛk 3,500 pipul dɛn we dɔn pas 65 ia bin tek pat pan dis. Nɔn pan dɛn pipul ya nɔ bin gɛt dis maynia sik we dɛn bigin fɔ du di stɔdi.

Di wan dɛn we du di risach bin kip rɛkɛd fɔ ɔl di mɛrɛsin dɛn we di wan dɛn we tek pat bin tek, di wan dɛn we dɔktɔ gi dɛn ɛn di wan dɛn we dɛn kin bay we dɛn nɔ bay na kɔt, lɛk piridin. Dɛn bin de tɛst di patisipan dɛn mɛmori ɛn tink skil ɛvri tu ia.

We di stɔdi dɔn, 797 pan di wan dɛn we tek pat bin dɔn gɛt dis maynia sik. Pan dɛn wan ya, 637 pan dɛn bin gɛt wan sik we dɛn kɔl Alzaima.

We di wan dɛn we du di risach bin de stɔdi dis data, dɛn bin fɛn wan tin we bin mek dɛn sɔprayz. Dɛn bin fɛn wan impɔtant asosieshɔn bitwin pipul dɛm wae de yuse anticholinergic mɛrɛsin ɛn dɛm wae gɛt dis maynia sik . Dɛn bin kam fɔ no bak se di mɔ we pɔsin de yuz dɛn mɛrɛsin ya fɔ lɔng tɛm, na di mɔ i go gɛt dis maynia sik .

Wetin mek dis de apin?

Wan pan di men tiori dɛm na dat i gɛt fɔ du wit di nyurotransmitta asɛtilkolin, we natin nɔ de na di bren fɔ pipul dɛm we gɛt Alzaima sik. Infakt, sɔm mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn Alzaima sik kin wok bay we dɛn kin mek di asɛtilkɔlin bɔku na di bren.

So, anticholinergic drugs de blok di acetylcholine messenger, so risechar dem tink se dat kin bi di rizin. Bɔt dɛn nid fɔ du mɔ risach bɔt dis.