Obujjanjabi obupya ku bulwadde bwa CAH! By’olina okumanya ku nsonga eno (Congenital Adrenal Hyperplasia) .

Waliwo omuntu yenna mu maka go naddala omwana alina obuzibu bw’obusimu obuzaalibwa nabwo? Oyinza okuba ng’omanyi ebizibu ng’okulwawo okukula, okukula amangu, n’okugenda mu nsonga ezitali za bulijjo mu bakyala. Embeera y’obuzaale etali ya bulijjo eyinza okuleeta bino eyitibwa ‘Congenital Adrenal Hyperplasia’. Tujja kugiyita CAH mu bufunze. Leero, tugenda kwogera mu bufunze ku nsonga eno n'obujjanjabi obupya obuzze ku nsonga eno.

Mu ngeri ennyangu, CAH kye ki?

CAH mbeera ya buzaale eremesa endwadde z’ekibumba (adrenal glands), obusimu obubiri obutono obusangibwa waggulu w’ensigo okukola obusimu obuyitibwa cortisol, obusimu obwetaagisa mu bulamu bwaffe.

Lowooza ku mibiri gyaffe ng’ekkolero. Ekimu ku bintu (cortisol) mu kkolero lino bwe kikendeera, ekifo ekifuga mu bwongo (pituitary gland) kitabuka ne kiweereza obubonero (ACTH) eri endwadde z’ekibumba okukola ennyo. Olw’okusikirizibwa kuno okuyitiridde, wadde ng’okukola cortisol tekweyongera, mu kifo ky’ekyo kutandika okukola obusimu bw’abasajja obusingawo obuyitibwa ‘androgens’ .

Obutakwatagana buno mu busimu buyinza okuleeta ebizibu bingi:

• Abalongo abakyala: Nga bazaalibwa, ebitundu by’ekyama eby’ebweru biyinza okufaanana eby’omwana omusajja.
• Ku njuyi zombi: ebizibu ng’okulwawo okukula, okukula amangu, n’obutazaala biyinza okubaawo mu bulamu obw’oluvannyuma.

Okugatta ku ekyo, abalwadde ba CAH abamu nabo bayinza okuba nga bakendedde ku kukola obusimu obulala obukulu obuyitibwa aldosterone. Awatali busimu buno, CAH esobola okufuuka ey’amaanyi ennyo, ekivaako okuwuniikirira, okukoma oba n’okufa.

Obujjanjabi obw’emyaka 70 n’essuubi eppya

Okumala emyaka mingi, obujjanjabi bwokka obwa CAH bwali bwa kukyusa busimu obuyitibwa cortisol obutono mu mubiri ne bassaamu eddagala eriweweeza ku bulwadde bwa steroids , gamba nga hydrocortisone. Wabula okumira eddagala lino ery’amaanyi okumala ebbanga eddene kiyinza okuvaako ebizibu ebiwerako. Ku bino ebisinga okubeerawo kwe kugejja, puleesa, amagumba okunafuwa, n’okulemererwa okukula mu baana.

Eddagala lino eppya (Crinecerfont) likola litya?

Kino kye kintu ekisinga obukulu. Obutafaananako bujjanjabi bukadde, eddagala lino eppya likola mu ngeri ya njawulo ddala.

‘Crinesurfont’ teyongera busimu buva bweru. Mu kifo ky’ekyo, eddagala lino ligenda butereevu mu kifo ekifuga obwongo (endwadde ya pituitary gland) ne liziyiza okufulumya akabonero akatayagalwa (ACTH) akasitula endwadde z’ekibumba.

Mu ngeri ennyangu, kino kiringa okuggyako ‘switch’ y’enkola eteetaagisa. Kino kifuga omubiri okukola obusimu bwa ‘androgen’ obuteetaagisa.

Ekirungi ekisinga obunene ekiri mu kino kiri nti okuva emiwendo gya androgen bwe gifugibwa, ddoozi ya steroids ezeetaagisa okukuuma bbalansi y’obusimu esobola okukendeezebwa ennyo . Kino kitegeeza nti ebizibu ebiva mu ddagala lya steroids nabyo bisobola okukendeezebwa ennyo.

Eddagala lino lisinga kukwatagana na ani?

'Crinesurfont' mu kiseera kino ekkirizibwa eri abalwadde ba CAH abasukka mu myaka 4 egy'obukulu . Si kifo kya steroids, wabula kyongera ku steroids.Obujjanjabi obw’okwongerako.

• Ku baana: Okuva bwe kiri nti abaana bakyakula, eddagala eriweweeza ku bulwadde buno liyinza okukosa ennyo enkula yaabwe. N’olwekyo, eddagala lino eriyinza okukendeeza ku ddoozi y’eddagala eriyitibwa steroids, liyinza okubayamba ennyo. Kino kikulu nnyo naddala mu myaka gy’obuvubuka, nga kizibu okufuga obusimu.
• Ku bantu abakulu: Obujjanjabi buno era busobola okuwa obuweerero eri abantu abakulu abatawaanyizibwa ebizibu ebiva mu kumira eddagala eriyitibwa steroids okumala ebbanga eddene, oba abafuna obuzibu okukuuma obusimu obutebenkevu.

Manya ku bizibu ebivaamu n’obukuumi

Mu kugezesebwa mu malwaliro, ebizibu ebitonotono ebitonotono, eby’akaseera obuseera bye bibadde bimanyiddwa n’eddagala lino.

• Ku bantu abakulu: obukoowu, okulumwa omutwe, okuziyira, okulumwa ennyondo.
• Ku baana: okulumwa omutwe, okulumwa olubuto, okukoowa, okuzibikira ennyindo.

Ekikulu, obubonero buno obusinga bwali butono, era omuwendo gw’abalwadde abaali balina okulekera awo okumira eddagala lino gwali mutono nnyo.

Okulabula okw'enjawulo: Beera mwegendereza ku buzibu bwa Adrenal Crisis!

Bw’oba ​​omira eddagala lino, kikulu nnyo okumanya embeera ey’amaanyi eyitibwa ‘adrenal crisis’. Mu ngeri ennyangu, embeera eno esobola okubaawo singa omubiri tegufuna bungi bwa ‘cortisol’ obwetaagisa mu kiseera eky’okunyigirizibwa okw’amaanyi (e.g., yinfekisoni ey’amaanyi, okulongoosebwa, akabenje).

Ntegeera ntya oba eddagala lino linsaanira/omwana wange?

Okusalawo kuno kulina okukolebwa nga weebuuzizza ku musawo wo naddala omusawo w’endwadde z’omu lubuto . Omusawo ajja kulowooza ku bintu bingi, omuli ebyava mu kukeberebwa omusaayi, omutindo gw’okukula, obuzito, puleesa, n’obusimu bw’olina mu kiseera kino, okuzuula oba eddagala lino likusaanira.

Lino si ddagala lya CAH, naye waliwo essuubi ddene nti lijja kuyamba okutumbula omutindo gw’obulamu bw’abalwadde, okukendeeza ku buzibu obuva mu steroid, n’okwanguyiza okuddukanya obusimu.