Omwana wo omuto alina kookolo ono atatera kulabika? Ka twogere ku Rhabdoid Tumor!

Ba maama ne ba taata, mugugu munene ku mutima gwo era ekintu ky’otayagala na kulowoozaako ng’omwana wo omuto akizudde nti alina kookolo. Naye oluusi, abaana basobola okufuna endwadde ze tutasuubira. Leero tugenda kwogera ku kika kya kookolo atatera kulabika nnyo, asaasaana amangu, akwata abaana naddala abaana abato. Kino kiyitibwa Rhabdoid Tumor . Oyinza okuwulira nga weewuunya katono ng’owulira erinnya lino, naye ka tulinnyonnyole mu ngeri ennyangu.

Ekizimba kya Rhabdoid kye ki? Mu ngeri ennyangu...

Rhabdoid Tumor kika kya kookolo ekitali kya bulijjo, ekikula amangu . Businga kubeera mu baana abato n'abaana abawere . Obutoffaali bwa kookolo buno bwe butunuulirwa mu microscope, bufaanana ne rhabdomyoblasts , ekika ky’obutoffaali obukola ebinywa. Eno y'ensonga lwaki kiyitibwa "rhabdoid." Kookolo ono asobola okukula mu nsigo z’omwana, mu bitundu ebigonvu oba mu busimu obw’omu makkati (obwongo n’omugongo). Ebyembi kookolo ono asobola okusaasaana amangu ennyo, ekizibuwalira okumujjanjaba.

Waliwo ebika bya Rhabdoid Tumor eby’enjawulo?

Yee, waliwo ebika bya kookolo ono ebikulu ebiwerako okusinziira ku kifo w’abeera. Ka tulabe kye bali.

1. Ekizimba ky’ekibumba ekiyitibwa Rhabdoid Tumor (RTK) .

Kino kizimba kya rhabdoid mu kibumba mu mwana. Oluusi kifunzibwa nga ``(RTK)``.

2. Ebizimba bya Rhabdoid ebizibu eby’ebweru w’omutwe oba eby’ebweru w’ekibumba

Kookolo ow’ekika kino asobola okukula mu bitundu by’omwana ebigonvu n’ebitundu ebirala, gamba ng’ekibumba, amawuggwe n’olususu. Era kiyitibwa ebizimba ebiyitibwa malignant rhabdoid tumors (MRT) . "Ekizibu" kitegeeza kookolo.

3. Ebizimba ebitali bya bulijjo ebiyitibwa Teratoid Rhabdoid Tumors (ATRT) .

Ekika kino ekya kookolo wa rhabdoid akula mu busimu bw’omwana obw’omu makkati, obwongo n’omugongo. Mu kookolo ow’ekika kino, obutoffaali bwa kookolo busooka kutondebwa mu bwongo bw’omwana oba mu mugongo. Ebitundu nga 50% ku kookolo zino (ATRT) zikula mu cerebellum (ekifuga entambula n’okutebenkera) oba mu kikolo ky’obwongo ( ekifuga ebintu ng’okussa n’okukuba kw’omutima).

Ani asinga okulwala ebizimba bya Rhabdoid Tumors?

Businga kukwata baana bawere n'abaana abato ennyo naddala abali wakati w'emyezi 11 ne 18 . Abantu abakulu tebatera nnyo kukwatibwa bulwadde buno.

Kino tekitera kubaawo nnyo, okunoonyereza okumu kugamba nti kibeerawo mu bantu abatakka wansi wa muntu omu ku buli bukadde.Kigambibwa nti kookolo ono abeera mu bungi obutono. Ekyo kitegeeza nti mbeera ya bbula nnyo.

Lwaki ebizimba bino ebya rhabdoid bikula? Kiki ekivaako?

Ebiseera ebisinga, ekisinga okuvaako kookolo wa rhabdoid y’enkyukakyuka mu buzaale mu ggiini ya SMARCB1 . Teebereza nti mu mubiri gwaffe mulimu akakuumi akatono akafuga okukula kw’obutoffaali. Ensengekera eno eya SMARCB1 ye ggiini eziyiza ebizimba . Kikola puloteyina efuga okukula kw’obutoffaali. Okufaananako omuserikale w’ebidduka, kiyimiriza obutoffaali obutagabanya mangu. Kale, singa wabaawo ekikyamu, kwe kugamba, enkyukakyuka, mu ggiini eno eya SMARCB1, okufuga okwo kubula era obutoffaali ne bwawukana mangu nnyo, ekivaako kookolo . Tekitera kubaawo, kookolo ono era asobola okukula olw’enkyukakyuka mu ggiini endala eziyiza ebizimba eyitibwa SMARCA4. Wadde ng’abaana abamu basobola okusikira obuzaale buno obukyusiddwa okuva mu bazadde baabwe, ebiseera ebisinga kookolo ono abaawo olw’enkyukakyuka empya ey’obuzaale ebaawo nga tewali byafaayo bya maka . Kino kitegeeza nti ne bwe kiba nti tewali muntu yenna mu maka abaddeko nkyukakyuka eno emabegako, obutoffaali bw’omwana buyinza okuba n’enkyukakyuka eno mu butanwa. Nga bajjanjaba omwana, okwekenneenya obuzaale kuyinza okukolebwa okunoonya enkyukakyuka eno ey’obuzaale.

Bubonero ki obulaga ekizimba kya Rhabdoid Tumor?

Obubonero buyinza okwawukana okusinziira ku myaka gy’omwana n’ekifo kookolo w’ali . Obubonero butera okutandikira mu kitundu kookolo w’akula. Mu bino biyinza okuli okwonooneka kw’obusimu, okukaluubirirwa okussa oba ekizimba mu lubuto lw’omwana. Olw’okuba kookolo ono asaasaana mangu nnyo, obubonero busobola okulabika amangu. Obubonero obulala buyinza okuli:

• Omusujja ogutera okubeerawo.
• Okulumizibwa omutwe .
• Omusaayi mu musulo ( Hematuria ) .
• Okuziyira n'okusiiyibwa .
• Ennywanto z’omusaayi ezizimba .
• Obusungu buli kiseera, obutawummula (Irritability).
• Emmere tewooma .
• Otulo obutali bwa bulijjo.
• Mu balongo, obunene bw’omutwe buba bunene.
• Okubulwa bbalansi oba okukaluubirirwa okutambula.

Omwana wo bw’aba n’obubonero bumu oba obusingawo ku buno, kikulu nnyo okugenda ew’omusawo mu bwangu.

Tya?Ekizimba kino ekya Rhabdoid Tumor kizuulibwa kitya?

Omusawo akebera omwana wo ajja kusooka kwekebejja omubiri n’akubuuza ku bubonero bw’omwana wo. Olwo bagenda kulagira okukeberebwa okuwerako okukakasa nti obulwadde buno buzuuliddwa. Mu bino biyinza okuli:

• Ultrasound scan: Kino kikozesa amaloboozi ag’amaanyi amangi okukola ekifaananyi (sonogram) eky’ebitundu by’omwana eby’omunda.
• CT scan: Kino kikozesa X-ray ne kompyuta okukola ekifaananyi eky’ebitundu bisatu (3D) eky’ebitundu ebigonvu n’amagumba g’omwana.
• MRI scan: Kino kikozesa magineeti, amayengo ga leediyo, ne kompyuta okukola ebifaananyi ebikwata ku bitundu ng’obwongo bw’omwana n’omugongo.
• Okukebera obusimu: Kino kikebera obwongo bw’omwana, omugongo n’enkola y’obusimu.
• Lumbar puncture / Spinal tap: Mu kino, sampuli y’amazzi g’omu bwongo (CSF) aggyibwa mu mugongo gw’omwana ne yeekebejjebwa wansi wa microscope okulaba oba waliwo obutoffaali bwa kookolo.

Wabula sikaani zino zisobola okulaga ebizimba bya rhabdoid ebifaanana ebika bya kookolo ebirala. N’olwekyo, abasawo batera okutwala sampuli z’ebitundu by’omubiri ne balagira okwongera okukeberebwa. Ebigezo bino mulimu:

• Okukebera obuzaale: Sampuli y’omusaayi oba ebitundu by’omwana etwalibwa ne ekeberebwa oba waliwo enkyukakyuka mu buzaale bwa `SMARCB1` ne `SMARCA4`.
• Biopsy: Mu nkola eno, omusawo akozesa empiso okuggya akatundu akatono ku kizimba. Olwo omukugu mu by’endwadde n’agitunuulira ng’akozesa microscope okulaba oba waliwo obutoffaali bwa kookolo. Singa obutoffaali bwa kookolo buzuulibwa, ekizimba ekinene nga bwe kisoboka kiyinza okuggyibwawo nga balongoosebwa oba mu kulongoosebwa oluvannyuma.
• Immunohistochemistry: Kino kigezo kya njawulo nnyo. Ekozesa obuziyiza okunoonya obubonero/obuziyiza obumu mu sampuli y’ebitundu by’omwana wo. Obubonero buno busobola okuyamba okuzuula oba kookolo wa rhabdoid oba kookolo ow’ekika ekirala.

Rhabdoid Tumor ejjanjabwa etya?

Omusawo wa kookolo w’abaana y’akulembera mu kujjanjaba omwana. Akolagana ne ttiimu y’abakugu abalala okukola enteekateeka y’obujjanjabi esinga okukwatagana n’omwana. Enzijanjaba ez’enjawulo eziwerako ziyinza okukozesebwa awamu okujjanjaba kookolo wa rhabdoid. Olw’okuba kookolo ono asaasaana mangu nnyo, okunoonyereza kulaga nti okukozesa obujjanjabi obuwera awamu kitera okutta obutoffaali bwa kookolo okusinga okukozesa emu yokka.

• Okulongoosa: Singa okukebera kookolo tekuggyawo kookolo, ekisooka, bwe kiba kisoboka, kwe kulongoosa okuggyawo kookolo omungi nga bwe kisoboka, oboolyawo nga yenna.
• Chemotherapy (Chemo): Kino kizingiramu okuwa eddagala okukomya okukula kw’obutoffaali bwa kookolo. Eddagala lino litta obutoffaali bwa kookolo obumu ate obulala ne bulemesa okwawukana. Kyokka eddagala lino teriyinza kumanya njawulo eriwo wakati w’obutoffaali obulungi n’obutoffaali bwa kookolo, n’olwekyo liyinza okuvaako ebizibu.
• Eddagala erya dose ennene ng’okyusa obutoffaali obusibuka mu mubiri: Obujjanjabi obw’amaanyi busobola okutta obutoffaali bwa kookolo obusingawo. Kyokka era kitta obutoffaali obulamu, gamba ng’obutoffaali obukola omusaayi mu busimu bw’amagumba. Okusobola okukola ku kino, obusimu bw’amagumba bw’omwana obumu butwalibwa ne buterekebwa nga tebannaba kumuwa bujjanjabi bwa ddagala lya dose ennene. Oluvannyuma lw’okujjanjabwa, obusigo bw’amagumba buddizibwa omwana okudda mu kifo ky’obutoffaali obusaanyeewo.
• Obujjanjabi bw’amasannyalaze: Buno bukozesa X-rays ezirina amaanyi amangi okukendeeza oba okusaanyaawo obutoffaali bwa kookolo. Kyokka olw’okuba obujjanjabi bw’amasannyalaze busobola okukosa enkula y’omwana n’enkula y’obwongo, ddoozi ekyusibwa okusinziira ku myaka gy’omwana n’obunene bwe.
• Okugezesa mu malwaliro: Omusawo ayinza n’okuteesa ku kugezesebwa okupya (ebika ebipya eby’eddagala, obujjanjabi obugendereddwamu, oba eddagala eriweweeza ku busimu obuziyiza endwadde) okujjanjaba kookolo w’omwana wo.

Biki ebiyinza okuva mu bujjanjabi buno?

Obujjanjabi bwa kookolo naddala obw’eddagala eriweweeza ku bulwadde bwa kookolo buyinza okuvaako ebizibu. Kino kiri bwe kityo kubanga eddagala erikozesebwa okutta obutoffaali bwa kookolo nalyo litta obutoffaali obulamu. Kyokka, ebizibu ebisinga biggwaawo oluvannyuma lw’obujjanjabi okuyimirizibwa . Osobola okukolagana ne ttiimu y’abasawo b’omwana wo okuddukanya ebizibu bino. Ebizibu ebitera okuvaamu mulimu:

• Okugwa kw'enviiri `(Alopecia)` .
• Emmere tewooma.
• Obuteeyabya.
• Embiro.
• Okuziyira n’okusiiyibwa.
• Amabwa mu mumiro ne mu kamwa.
• Okuzimba `(Edema)` .
• Ebbula ly'otulo.
• Okukoowa okuyitiridde .
• Obuzibu mu kujjukira.

Ebizimba bya Rhabdoid Tumors bisobola okuziyizibwa?

Ebyembi, kookolo ono ava ku nkyukakyuka mu buzaale, n’olwekyo tewali ngeri yonna gye tuyinza kumuziyiza . Kyokka, singa omuntu mu maka go abadde alina kookolo wa rhabdoid oba kookolo omulala, era ng’osuubira omwana, kiba kirungi okwogera n’omusawo wo ku kubuulirira ku buzaale . Okubuulirira ku buzaale kuyinza okukuyamba okutegeera akabi k’olina okubeera n’embeera y’obuzaale mu mwana wo.

Rhabdoid Tumor esobola okuwona? Ebiseera by’omwana eby’omu maaso binaaba bitya?

Omusawo ajjanjaba omwana wo asobola okukuwa eky’okuddamu ekituufu mu kibuuzo kino. Naye,Ebyembi, abaana abasinga obungi abalina ekizimba kya rhabdoid ekizibu tebawangaala myaka mitono. Kyokka singa omwana azuulibwa ng’amaze emyaka 2 , okuteebereza kuyinza okuba okulungiko katono. Omuwendo gw’okuwangaala kwa kookolo ono gusinziira ku bintu ebiwerako:

• Emyaka gy'omwana.
• Awali kookolo mu mubiri gw'omwana.
• Oba kookolo asaasaanidde mu bitundu by’omubiri ebirala.
• Bungi bwa kookolo obwaggyibwawo nga balongooseddwa.
• Engeri omwana gy’anaakwatamu obujjanjabi bwa kookolo.

Olw’okuba kookolo omubi ennyo owa rhabdoid tatera nnyo, ebibalo by’obulamu bwesigamiziddwa ku muwendo omutono ennyo ogw’abalwadde. N’olwekyo, obulamu bw’omwana obw’amazima buyinza okwawukana. Okunoonyereza kulaga nti omuwendo gw’abantu abawangaala emyaka etaano ku kookolo w’ekibumba (RTK) guli wakati wa 20% ne 25% . Kino kitegeeza nti wakati wa 20% ne 25% ku bantu abazuuliddwa nga balina RTK bakyali balamu nga wayise emyaka etaano bukya bazuuliddwa. Omuwendo gw’emyaka etaano egy’okuwangaala ku kookolo w’ekika kya atypical teratoid rhabdoid carcinoma (ATRT) guli wakati wa 32% ne 50%.

Kya bulijjo okuwulira omugugu omunene n’ennaku ng’owulira ekintu nga kino. Naye jjukira nti toli wekka.

Kiki kye nsaana okubuuza omusawo?

Kya bulijjo okuba n’ebibuuzo bingi ng’okizudde nti omwana wo alina kookolo. Bino bye bimu ku bibuuzo by’olina okujjukira okubuuza mu kiseera ekyo:

• Omwana wange alina kookolo wa ngeri ki?
• Kookolo w’omwana wange ali ku mutendera ki?
• Omwana wange alina kukeberebwa ki?
• Bujjanjabi ki bw’oyinza okukozesa ku kookolo w’omwana wange?
• Emikisa ki egy’obujjanjabi buno okubeera obulungi?
• Kugezesebwa ki okw’obujjanjabi omwana wange kw’ayinza okwetabamu?
• Tumanya tutya oba obujjanjabi buno bukola bulungi?

Okugoberera kukolebwa kutya mu kiseera ky‟obujjanjabi n‟oluvannyuma lw‟obujjanjabi?

Mu kiseera kyonna omwana wo ng’ajjanjaba kookolo, ebimu ku bigezo ebikozesebwa okuzuula obulwadde buno bijja kwetaaga okuddibwamu. Ebigezo bino bikozesebwa okupima engeri obujjanjabi gye bukola obulungi. Okusinziira ku bivudde mu kukeberebwa kuno, ttiimu yo ey’abasawo ejja kukolagana naawe okusalawo emitendera egiddako gy’osaanidde okukola. Kino kiyinza okuzingiramu okugenda mu maaso, okukyusa oba okulekera awo okujjanjaba. Omwana wo bw’amala okujjanjaba kookolo, ajja kwetaaga okuddayo okukeberebwa n’okukeberebwa okugoberera buli luvannyuma lwa kiseera . Mu kugoberera kuno, omusawo ajja kukebera okulaba oba embeera y’omwana wo eteredde oba obulwadde buzzeemu. Okugoberera kuno kuyinza okumala emyaka egiwerako oluvannyuma lw’okujjanjabwa.

N'ekisembayo, jjukira... (Obubaka bw'okutwala awaka)

Tukimanyi nti kimenya omutima okuwulira amawulire nti omwana wo alina kookolo. Naye kikulu okujjukira nti toli wekka.. Ttiimu yonna ejjanjaba omwana wo omuli abasawo ne ba nurse eri wano okukuyamba n’ab’omu maka go mu kiseera kino ekizibu. Waliwo obujjanjabi bw’ebizimba bya rhabdoid, era waliwo essuubi eri omwana wo . Yogerako n’omusawo w’omwana wo ku ky’okwegatta ku kibiina ekiyamba abazadde oba amaka agayamba kookolo . Osobola okufuna okubudaabudibwa n’okuzzibwamu amaanyi okw’amaanyi ng’ogabana emboozi yo n’okuwulira ku by’ayitamu abantu abalala.