I thisen var hi hlauhawm takin a tlahniam em? Chu chu agranulocytosis a ni em? Kan sawi dawn nia!

I damlo reng reng em? Hun rei lo te chhung pawh nise chak lo leh chau takin i inhria em? A chang chuan hei hi i taksa invenna, chu chu thisen var chi khat neutrophils tihhniam hlauhawm tak vang a ni thei. Vawiin hian natna khirh tak mahse enkawl theih tak agranulocytosis tih kan sawi dawn a ni . Lungngai suh, hei hi hriat chian a pawimawh.

Agranulocytosis hi eng nge ni tak tak?

A awlsam zawngin sawi ila, Agranulocytosis hi nunna atana hlauhawm tak a ni a, kan taksaa thisen var neutrophils an tih zat hi a tlahniam nasa hle a ni. Thisen var hi kan immune system-ah sipai ang a ni tih i hria em? Natna thlentu hrik laka min vengtu an ni. Heng neutrophils te hi a tlem chuan kan taksa hi natna hrik lakah a awlsam zawk thin. A tlangpuiin min tichhe vak lo hrik te pawhin min ti na thei a ni. Ngaihtuah teh, kan ram sipaiah hian special forces unit pakhat chu rang taka bo ta se, hmelma tenau tak pawh hi buaina lian tak a ni lo ang em? Hei pawh hi chutiang bawk chu a ni. "Agranulocytosis" tih hming hi granulocytes tih thumal atanga lo chhuak a ni. Granulocytes hi thisen var chi khat a ni bawk. An zingah hian natna hrik tichhe thei enzyme an awm a. Granulocyte hi chi thum a awm a, chungte chu Neutrophils , Eosinophils, leh Basophils te an ni. Neutrophils hi kan taksaa thisen var tamna ber a ni. Chuvangin doctor-te chuan neutrophil level an test a, agranulocytosis an nei tih an hmuchhuak a ni. Hei hi granulocytopenia an ti \hin .

Neutropenia leh Agranulocytosis hi eng nge an danglamna?

An pahnih hian neutrophils tlahniam nen an inzawm a ni. Mahse, agranulocytosis hi neutropenia natna na ber a ni .

• Neutropenia hi thisenah neutrophils awm zat chu a pangngai aia tlem a ni. Thisen microliter (mL) khata neutrophil 1,500 aia tlem nei te chuan neutropenia an nei nia sawi a ni.
• Agranulocytosis hi a hnuhnung ber, hlauhawm ber a ni a, thisen microliter khatah neutrophil count 100 aia hniam a tlahniam a ni. Hrethiam e? Hei hi neutropenia natna khirh ber a ni.

Agranulocytosis chi hrang hrang a awm em?

Ni e, hei hi kawng lian pahnih in a lo thleng thei a ni: 1. Inherited agranulocytosis:Hei hi genetic disorder avanga lo awm a ni. Chu chu kan taksain neutrophils siam tura puitu genes-ah harsatna a awm tihna a ni. He natna hian naute leh naupang te te a nghawng nasa ber a ni. 2. Acquired agranulocytosis: Hei hian chhan tam tak a nei thei. Mahse, a tam zawkah chuan (70% vel!) kan ei thin damdawi thenkhat side effect avanga lo awm a ni. Hetiang chi hi puitlingah a tam ber.

Hetiang dinhmun hi engtiang chiahin nge a awm?

Hei hi a takah chuan thil awm lo tak a ni. A vaiin kum tin mi sang za zinga mi pasarih velin he natna hi an vei thin. Chuvangin tul lovah hlau suh, mahse fimkhur a pawimawh.

Agranulocytosis natna lan chhuahna chu engte nge ni?

Hetiang a nih chuan a lan chhuah dan ber chu hri kai nen a inzawm a ni. Chungte chu a intan thut thei a, a nih loh leh hun kal zelah a pung zauh zauh thei bawk. Heng symptoms te hi i hriat lar angin a lang em tih en rawh:

• Khawsik nei, khawsik leh khur chhuak.
• Heart rate leh thawk chakna a sang.
• Nunna nei lo anga inhriatna leh hah lutuk.
• Thlarau na (pharyngitis), gingival recession, hmui thisen chhuak .
• Kawng leh kawchhunga hliam , ei leh in tur ei harsa.
• Thisen sang tlahniam nghal (hypotension), luak chhuak, muhil, leh hriatna hloh pawh a ni thei.

Hetiang symptoms i neih chuan, a bik takin a lo lang fo a nih chuan doctor thurawn i lak ngei ngei tur a ni.

Engvangin nge agranulocytosis hi a lo awm? A chhante chu engte nge ni?

Hei hi a chhan ber chu kan taksaa thisen var (white blood cells) neutrophils an tihte hlauhawm taka tlahniam vang a ni. Hei hi chhan pahnih awm thei a ni:

• Either kan taksa hian neutrophils a siam tling lo a, a thawk tha thei lo.
• Chutiang a nih loh chuan taksaa neutrophils te chu a chhe vek a, a nih loh leh a hun hmain an thi a ni.

Tunah chuan hei hi a chhan bik eng nge ni tih i lo en ang u.

Agranulocytosis rochun atanga lo chhuak a ni

Hemi kawngah hian neutrophils siamna atana puitu gene pakhatah harsatna a awm a. Hei hi pian tirh atanga awm (congenital) dinhmun a ni. Entîr nân, Kostmann syndrome , a nih loh leh congenital agranulocytosis , natna hlauhawm tak kan ei chuan, naute piang tharte chuan natna hrik, khawsik, inflammation, leh ruh lama harsatna an nei fo ṭhîn.

Agranulocytosis hmuhchhuah a ni

Hei hi chhan hrang hrang a awm thei. Eng nge an nih i en ang u:

• Damdawi thenkhat: Hei hi a chhan tam ber a ni . Antibiotics thenkhat , antipsychotic damdawi , leh thyroid damdawi te hian he natna hi a thlen thei a ni.
• Autoimmune diseases : Heng natnate hi immune system-in taksa cell a beih nasat em emna natna a ni. Entirnan lupus leh rheumatoid arthritis te hi a ni .
• Bone marrow natna leh bone marrow failure disorders: Entirnan , aplastic anemia . Ruhro (bone marrow) hi kan thisen cell siamna hmun a ni.
• Cancer: Ruhro (bone marrow) tichhe thei cancer, a bik takin leukemia .
• Cancer enkawlna (Chemotherapy): Heng enkawlnate hian cell hrisel bakah neutrophils te a tichhe thei a ni.
• Toxin emaw chemical emaw nena inzawmna: Hun rei tak chhunga lead emaw mercury ang chi thil nena inzawmna.
• Hri kai: Malaria , TB , leh Rocky Mountain spotted fever ang chi natna khirh tak tak te.
• Nutritional deficiencies: Vitamin B12 leh Folate ang chi nutrient pawimawh tak tak tlakchhamna.

Hetiang dinhmun hi tute nge hlauhawm ber?

Hmeichhia te hian mipa aiin he natna hi an vei tam zawk deuh. Tin, agranulocytosis hian kum eng pawh a nghawng thei bawk. Mahse, a hnuaia mite hi a bik takin an hlauhawm hle a ni:

• Cancer vanga chemotherapy la mekte.
• Autoimmune natna lupus leh rheumatoid arthritis te nei te .
• Mite damdawi thenkhat ei thin, chu chu Clozapine (Clozaril®) , antipsychotic , Trimethoprim/sulfamethoxazole (BactrimTM) , leh Methimazole (Tapazole®), thyroid damdawi te hi a ni.

Agranulocytosis avanga harsatna awm thei te chu engte nge ni?

Hetiang dinhmun hian natna kai fo emaw, hun rei tak emaw (chronic infections) a thlen thei a ni.

Agranulocytosis hi kar thum atanga kar li aia rei a awm chuan infection a awm theihna chance 100% a awm.

Sepsis hi enkawl loh chuan sepsis an tih, immune system reaction na tak, nunna atana hlauhawm tak a thlen thei a ni. Sepsis hi natna khirh tak a ni a, taksa pum puiah a darh a. Kum 65 chunglam emaw, hriselna lama harsatna dang nei emaw, thinlung natna, kal natna emaw, lung natna emaw nei te chuan heng harsatnate hi an vei theihna a sang zawk a ni.

Engtin nge hei hi i diagnose?

Engtin nge doctor hian agranulocytosis hi a hriat theih ang? A tlangpuiin hengte hi an zawm thin:

• Complete Blood Count (CBC) leh differential: He test hian i thisena cell chi hrang hrang, a bik takin neutrophils awm zat a en thin. Thisen microliter khatah absolute neutrophil count (ANC) 100 aia tlem a nih chuan agranulocytosis anga ngaih a ni. (Mi hrisel tan chuan value pangngai chu 1,500 aia tam a ni.)
• Bone marrow biopsy leh aspirate: A chang chuan, he test hi i bone marrow-in neutrophils a siam chhuah dan hriat nan tih theih a ni.
• Symptoms leh medical history: Doctor chuan i symptoms te, damdawi i ei te, tun hnaia hri kai te, leh chemicals i tawn dan te a zawt ang che.
• Genetic testing: Genetic condition rinhlelh a nih chuan genetic testing hmanga finfiah theih a ni. Hei hi vun biopsy emaw thisen test emaw a ni thei.

Hei hi eng enkawlna nge ni?

Thu lawmawm tak chu he natna hi enkawlna tur a awm a, agranulocytosis a ni. Enkawlna chu a chhanah a innghat.

• Causative Medication tihtawp: Damdawi pakhatin i symptoms a thlen a nih chuan i tih hmasak ber tur chu i doctor-in a tih angin him taka i ei loh tur a ni. Doctor rawn hmasa lovin damdawi ei kha bansan ngai suh.
• Antibiotics: Infection i neih chuan i doctor chuan a symptoms tihziaawm nan antibiotics leh damdawi dang \ha tak tak a pe ang.
• Granulocyte colony-stimulating factor (G-CSF): Hetiang injection hi taksain neutrophils a siam chhuah chak zawk nan pek theih a ni. Entirnan, damdawi Filgrastim (Neupogen®) , Pegfilgrastim (Neulasta®) , leh Lenograstim (Granocyte®) te hi a ni.
• Immunosuppressants: Autoimmune disorder avanga natna lo awm a nih chuan immune system titawp thei damdawi, Prednisone ang chi te chu pek theih a ni.
• Bone marrow transplant: Enkawlna dang a hlawhtlin loh chuan bone marrow transplant neih a ngai mai thei. Hetah hian donor hrisel tak hnen atangin ruhro (bone marrow) pek i ni ang. Hei hian i taksain neutrophils hrisel tak tak a siam leh thei dawn a ni.
• Infection ven dan: Hei hi a pawimawh hle. Hetiang natna vei te hian hri kai loh nan fimkhur hle a ngai a ni.
• I kut chu sahbawn hmangin uluk takin silfai fo ang che.
• Mipui tamna hmun a theih ang tawkin pumpelh rawh.
• Pawn chhuah dawnin hmai khuhna/mask vuah tur a ni.
• Natna laka invenna tur thil dang i tih theih dan tur chu i doctor nen sawiho rawh.

Engtiang chiahin nge enkawl hnuah ka dam leh thuai ang?

Recovery hun chhung hi i neutrophil count tlahniam chhan leh i natna nasat danah a innghat a ni. Damdawi pakhat avanga side effect a nih chuan damdawi i ei tawh loh hnuah i neutrophil count a normal leh theih nan kar khat atanga kar thum vel a ngai tlangpui.

Hei hi ven theih a ni em?

A chang chuan agranulocytosis hi a pumpelh kim thei lo. Mahse, i neutrophils tihhniam thei damdawi (e.g., chemotherapy, rilru lam damdawi thenkhat) i ei a nih chuan i doctor nen inbiakna neih a pawimawh a, i neutrophil level pawh enfiah fo a pawimawh. Cancer natna chemotherapy i dawng a nih chuan i doctor chuan neutrophil siam chhuah tihpunna tura pui turin G-CSF injection a rawt thei ang.

Agranulocytosis vei tan chuan eng nge a hmalam hun?

Hei hi enkawl theih ni mahse, a rah chhuah chu mi hrang hrangah a inang lo thei. Enkawlna dik tak pek a nih chuan, emaw, neutrophils tihtlemtu damdawi chu tihtawp a nih chuan, chu natna chu a reh fo thin.

Mahse, enkawl loh chuan natna khirh tak tak leh thihna thlengin a thleng thei a ni. Neutrophil count hi hlauhawm level-a a awm rei poh leh natna kai leh harsatna a thlen theihna a sang zawk. Hei hi kum 65 chunglam leh damdawi lam harsatna (kidney, heart, emaw lung natna ang chi) nei te tan chuan a dik hle.

Engtikah nge doctor i hmuh ang?

Agranulocytosis hi nunna atana hlauhawm tak a ni. Chuvangin diagnosis leh enkawl vat a pawimawh hle. Heng symptoms te hi i neih chuan doctor pan nghal rawh:

• Infection i neih fo chuan.
• Infection hi a dam theih nan hun rei tak a duh chuan.
• Infection symptoms i neih chuan khawsik, khawsik, emaw, rilru na emaw i neih chuan.

Autoimmune disease i neih emaw, i neutrophils tihhniam thei damdawi i ei a nih chuan i medical checkup te hi skip suh. Doctor hnena checkup neih fo hian i neutrophil level a enfiah thei a, infection venna kawngah a pui thei bawk.

Kan hriat reng tur pawimawh ber berte (Take-Home Message) .

Okay, chuvangin kan sawi tawh atang hian point pawimawh tak tak thenkhat chu han recap leh ila:

• Agranulocytosis hi natna khirh tak ni mahse enkawl theih a ni a, thisen var neutrophils an tih te chu nasa takin a tlahniam a ni.
• Hri kai fo thin, khawsik, kawr na ang chi symptoms i neih chuan doctor pan nghal rawh.
• Hei hi damdawi thenkhat, autoimmune natna leh cancer enkawlna avanga lo awm thei a ni.
• Enkawlnaah chuan damdawi tisualtu tihtawp te, antibiotics te, G-CSF injection te, leh ruhro thlak (bone marrow transplant) te pawh a tel thei.
• Infection laka inven hi a pawimawh hle. Kut sil fo leh vantlang hmuna mask vuah ang chi thil awlsam tak tak tih hmangin i inveng thei a ni.
• Hei hi i hlauhawm a nih chuan (e.g., damdawi thenkhat i ei chuan) doctor appointment hi skip suh.

He thu hi i tan a tangkai ngei ka beisei. Hrisel takin awm rawh!