I thisen kalna kawngte pawh a chhe thei em? Fibrinoid Necrosis chungchang hi han sawi ila!

Kan taksa pum puia thisen kalna kawng te tak te te hi tui phurtu pipe ang mai a ni. Hengte hi kan taksa peng tinah thisen phurtu an ni. Chuti a nih chuan, eng thilin nge heng thisen kalna kawngte hi a tihchhiat chuan eng nge thleng ang? Vawiin hian natna khirh tak thei tak kan sawi dawn a, chu chu Fibrinoid Necrosis tih natna a ni. Hlau suh, hei hi awlsam takin i hrethiam ang u.

Fibrinoid necrosis tih hi eng nge ni?

A awlsam zawngin, fibrinoid necrosis hi kan taksa chhunga thisen kalna kawng te tak te, a bik takin thisen kalna kawng te te chhungril bang tihchhiatna a ni . Tui pipe puak ang maiin han ngaihtuah teh. Chutianga thisen kalna kawng a chhiat chuan a chhe thei a, a hliam thei a , thisen a chhuak thei a, taksa chhungah pawh a hliam thei bawk.

“Necrosis” tih thumal hian cell thihna a kawk a ni . Accident emaw, hliam emaw, thisen supply hloh avanga cell thihna tihna a ni. Fibrinoid necrosis hi chutiang bawk chu a ni a, thisen kalna kawng bang chhunga cell awmte chu an thi tihna a ni.

Engtin nge he dinhmun hi a lo chhuah?

Hei hi a buaithlak deuhin a lang thei a, mahse hetiang hian han ngaihtuah teh. Kan taksaah hian immune system kan nei a. Kan taksa chhunga defence force awm ang mai a ni. He system hian natna lakah min venghim a ni . Mahse a chang chuan he immune system hi a overactive emaw, a buaithlak emaw thin.

Fibrinoid necrosis-ah chuan immune system chu a overactive a, thil thenkhat a chhuah tir thin. Heng thilte hi kan thisen kalna kawng chhungril bang-ah hian a innghat tlat a ni. Tichuan inflammation , a awm bawk a, chu chu a hring leh a sen tihna a ni. He inflammation hian thisen kalna kawng bang chhunga cell awmte chu a thi ta a ni. Phên dangin sawi ila, kan invenna hian kan cell ngei pawh a rawn bei ang mai a ni.

Eng thilin nge fibrinoid necrosis hi a thlen?

Thisen kalna kawng tichhe thei dinhmun eng pawh hian hei hi a thlen thei a ni. A chhan lian tak tak engemaw zat a awm a:

• Thisen sang tak : Hei hi (Malignant Hypertension) emaw (Hypertensive Crisis) emaw an ti a. A tlangpuiin mi hrisel thisen sang hi 130/80 mmHg aia hniam a ni tur a ni. Mahse, he dinhmun (Malignant Hypertension) an tih hian thisen sang chu 180/120 mmHg emaw a aia sang emaw thlengin a sang chho thin. Hei hi a lo thlen chuan kan...Fibrinoid necrosis hi thisen kalna kawng pawimawh tak tak, thinlung , thluak, leh kal (kidney)-a thisen phurtu thisen kalna kawngte a tihchhiat avangin a lo awm thei a ni. Hei hi emergency pawi tak a ni a, damdawi lam pan vat a ngai a ni.

• Autoimmune diseases : A hmaa kan sawi tawh ang khan heng natnate hi keimahni taksa chakna (immune system) ngeiin kan taksa ngei a beih nasat em emna natna a ni. Entir nan:
• (Rheumatoid Arthritis natna a ni ) .
• (Lupus) (Lupus natna – taksa peng tam tak a nghawng a, vun, ruh, kal)
• (Rheumatic Fever – rilru natna hnua lo awm thei leh thinlung tichhe thei)

• Preeclampsia: Hei hi nu thenkhatin naupai laia an neih thin a ni. Thisen sang leh symptom dang a awm tih hriat a ni .

• (Subacute Bacterial Endocarditis): Hei hi thinlung chhungril lam natna hrik kai a ni.

• Vasculitis: A awlsam zawngin sawi ila, thisen kalna kawng a inflammation a ni a, chu chu a hring tihna a ni. Hei hi entirnan:
• (Polyarteritis Nodosa) tih hi a awm a.
• (IgA Vasculitis) (hmanlai chuan Henoch-Schönlein purpura tia hriat thin) .

Tunah chuan he natna hi chhan pakhat chauh avanga lo awm a ni lo va, natna chi hrang hrang nen a inzawm thei tih i hrethiam tawh mai thei.

Hetiang natna lan chhuah dan hi engte nge ni?

Fibrinoid necrosis hian thisen kalna kawng a tihchhiat avangin a lan chhuahna ber chu thisen chhuah a ni . Hei hi kawng hrang hrangin a thleng thei a:

• Gums thisen chhuak.
• Thluak chhunga thisen (black emaw dark red emaw).
• Zun chhunga thisen – hei hi (Hematuria) kan ti a ni.
• Taksa hmun hrang hranga hliam (khawiah mah vuak loha hliam ang maia).
• Taksa chhunga thisen chhuak (hei hi pawn lam atanga hmuh theih a ni lo, mahse symptom dang atanga hriat theih a ni).
• Hnar thisen chhuak.

Hetianga thisen chhuak i neih chuan ngaihthah suh . Damdawi lam thurawn lak a pawimawh hle.

Fibrinoid Necrosis avanga harsatna awm thei te chu engte nge ni?

He natna avanga harsatna lo awm thin hi a chhan natna bulpui (underlying disease) ah a innghat tlangpui. Entîr nân:

• Kan sawi tawh kha (Malignant Hypertension) , chu chu thisen sang avanga kal thisen kalna kawngah fibrinoid necrosis a awm a nih chuan kal chak lohna a thlen thei tihna a ni.
• Hetiang dinhmun hi lupus ang chi natna avanga lo awm a nih chuan vun natna leh thinlung natna a awm thei.

Chumi awmzia chu complications chu fibrinoid necrosis chauh ni lovin, a hnuaia natna awm pawhin a hril tihna a ni.

He natna hi engtin nge an hriat chhuah? (Diagnosis) tih a ni.

Cell-te an thih chuan fibrin tih hming pu thil pakhat an chhuah chhuak a ni. He natna fibrin an tih hi he natna hriat theihna atana finfiahna ber a ni.

Pathologist , natna hriatchhuahna lama mithiamte chuan tissue chhia sample an la a, microscope hmangin an en thin. Chumi hnuah chuan he thil (Fibrin) hi a awm em tih an hmu thei ang.

Tissue sample lak hi biopsy an ti a . He biopsy tih dan hi natna awmna hmun azirin a inang lo:

• Skin biopsies: Vun chunglam atanga vun layer te tak te chu hrual theih a ni a, a nih loh leh hmanraw bik (punch tool) hmangin a te te pawh lak theih a ni bawk. A chang chuan thuk zawk atanga sample lak nan incision te tak te siam theih a ni.
• Internal biopsies: Taksa chhunga taksa peng pakhat atanga tissue sample lak nan doctor-te chuan needle emaw, endoscope an tih hmanrua emaw an hmang thin. Endoscope chu tube te tak te, a tawp khatah camera leh instrument te te dahna a ni. Hei hi taksa chhungah kaltlangin tissue sample lak theih a ni.

Engtin nge enkawl ang? (Tihdamna)

Dik tak chuan fibrinoid necrosis hi enkawlna bik, standard a awm lo. Mahse, doctor-te chuan thisen chhuahna chu an thunun thei a ni . Thisen chhuahna hmun leh a nihnaah a innghat.

Chu bakah, a pawimawh ber chu fibrinoid necrosis thlentu natna hnuaia awm chu enkawl hi a ni .

Entirnan, thisen sang hi a chhan a nih chuan a thunun theih nan damdawi pek thin a ni. Immune system lama harsatna a nih chuan a control theihna tur leh thisen kalna kawng tichhe zual zel tur tihtawp nan damdawi a awm a ni.

Chuvangin, enkawlna ngaih pawimawh ber chu a chhan bulpui enkawl hi a ni .

Fibrinoid necrosis lakah engtin nge i inven theih ang? (Invenna) 1.1.

Hemi laka inven vek tum ai chuan i tih theih tha ber chu a chhan bulpui (underlying conditions) i neih theihna tur tihtlem hi a ni.

• Checkup turin doctor hmu fo ang che. Chutiang chuan hriselna lama harsatna a awm chuan a nasat hmain hriatchhuah leh enkawl theih a ni.
• Chutianga thlen thei dinhmun (e.g. thisen sang, zunthlum, autoimmune disease) i neih tawh chuan i doctor thupek dik takin zawm rawh . I damdawi ei turte chu a hun takah ei la, i nunphung chu a tih angin vawng reng rawh.

Hetiang natna vei tan hian eng nge hmalam hun tur? (Prognosis) tih a ni.

Hei hi fibrinoid necrosis thlentu underlying condition nasat danah a innghat tak zet a ni. Thil awm dan ṭhenkhat chu dam chhung zawng a ni thei a, nunphung a ti tlahniam thei a, a hun hmaa thihna pawh a thlen thei bawk.

Entirnan, a chunga kan sawi tak natna (Malignant Hypertension) hi enkawl vat a nih loh chuan damlo dam rei zawng chu kum hnih velin a tlahniam thei a ni. Chuvang chuan natna lanchhuahna a lan veleh damdawi lam thurawn lak a pawimawh hle.

Engtikah nge doctor i hmuh ang?

Thisen kalna kawng a chhia tih i hriat a nih chuan, emaw, a hmaa kan sawi tawh ang chi (a bik takin sawifiah theih loh thisen chhuak) i neih chuan, doctor pan a, uluk taka enkawl a pawimawh hle.

I doctor-in a pek che treatment plan dik taka zawm chuan i dinhmun chu i control thei a, chhiatna dang i veng thei bawk.

Fibrinoid necrosis hi thisen kalna kawng a tichhe thei a ni. A thlentu dinhmunte chu a na thei hle a, chuvangin doctor-in uluk taka enkawl a ngai a ni. I doctor i hmuh fo chuan i hriselna i enkawl tha zawk thei a, a hnuaia dinhmun atanga harsatna lo thleng tur pawh i veng thei bawk.

Take-Home Thuchah a ni

• Fibrinoid necrosis hi thisen kalna kawng te te a tichhia a ni.
• Hei hi a chhan ber chu thisen sang leh autoimmune diseases ang chi natna te a ni.
• A lan chhuahna ber chu thisen chhuah chi hrang hrang a ni.
• Natna hriat theih nan biopsy lak a ngai mai thei.
• Enkawlna hi a chhan bulpui ber lam a ni ber.
• Symptoms emaw risk factors emaw i neih chuan doctor advice lak a pawimawh hle a, ngaihthah a nih chuan a pawi thei hle.

He thu hi i tan a tangkai ngei ka beisei. Hrisel takin awm rawh!