Engvangin nge Alzheimer natna hi damdawi a la awm loh? Hemi chungchang hi han sawi ila

I nu, i pa, a nih loh leh i hmangaih upa tawh tak pakhatin thil a theihnghilh tih i hre ngai em? A châng chuan hming, address theihnghilh, a nih loh leh i glasses awmna hmun pawh hriat reng chu i tar chhoh zêl chuan thil pangngai a ni. Mahse he theihnghilhna hi a lo pung zauh zauh a, nitin hna pawh nangmah chauhin i thawk thei lo a nih chuan Alzheimer’s Disease chhinchhiahna a ni thei. Tichuan kan rilrua zawhna lian ber chu, ‘Engvangin nge hetiang khawvel changkang hian he natna damdawi hi a la hmuh loh?’ tih hi a ni. Vawiin hian thuk takin sawi ila.

Engtin nge he natna hi an hmuhchhuah hmasak ber?

He thawnthu hi kum 100 chuang kalta, kum 1901 atang khan a intan a, German doctor pakhat Alois Alzheimer chuan hmeichhe pakhat, dementia vanga thi thluak chu a enfiah a. Thil mak tak mai a hmu a. Thluak chhunga neurons inkarah chuan protein chi khat chu a sticky leh tangled tawh a, plaque ang maiin a lo awm tawh bawk. Chungte chu a hnuah "plaques" an ti ta a ni. Protein chi dang chu neurons chhunga thread ang maia inzawm leh inzawmkhawm a ni tih a hmu bawk. Chungte chu "tangle" an ti a.

Hun a kal zel a, scientist-te chuan hliam ang chi plaque-te chu protein pakhat beta-amyloid -a siam a nih thu an hmuchhuak ta a ni. Tin, thread ang chi tangles te hi protein dang tau -a siam a nih thu an hmuchhuak bawk. A tawpah chuan he natna hi a hmuchhuaktu doctor chawimawina atan "Alzheimer's disease" tiin an vuah ta a ni.

"Amyloid Hypothesis" chanchin lian tak chu.

Chuvangin, kum 1990 chhoah chuan zirchiangtute zingah ngaihtuahna lian tak a lo piang ta a ni. Chu chu, he natna thlentu ber chu thluaka beta-amyloid plaques awmkhawm a ni. He ngaihdan hi "Amyloid Hypothesis" an ti a. A awlsam zawngin sawi ila, heng amyloid plaque te hi thluak cell te thihna leh hriatrengna tichhetu a ni tih an ngaihtuah a.

Mahse hei hi a hlawhtling em? A tak tak lo. Heng amyloid plaques te hi paih chhuah tumin damdawi za tam tak hman a ni tawh a, mahse pakhat mah hian damlo nunah danglamna lian tham a thlen lo. Thluaka amyloid awm zat tihtlemtu damdawi hian damlo hriatrengna hloh chu a titawp lo va, an nitin nun pawh a titha lo. Tun hnaia damdawi pawmpui `lecanemab` pawh hian natna zual zel chu tlem a thunun thei chauh a, mahse a damdawi erawh a ni lo.

Kawng khatah kan tang tlat em?

Heng result hlawhtling lo tak tak avang hian tunah hian zirchiangtu tam tak chuan, "Kawng dik lo lamah kan kal em?" Dik tak chuan science hi vawi khata danglamna lian tak thlen thei thil a ni lo. Lawng lian tak ang mai a ni a, vawi khatah a herh kual thei lo. Zirchiangtute chuan kum tam tak chhung chu thupui inang an zir a, chutah chuan thupui inangah zirchianna tam zawk an nei leh thin. Tichuan, mipui leh hriatna pawl lian tak chu ngaihtuahna khat velin an din ta a ni. Ngaihtuahna thar nen hnathawh tur i kal chuan a kaihhnawih hmanrua leh tawnhriat a tlachham thin. Chuvangin, Alzheimer natna chungchangah chuan he lawng lian tak hi "amyloid" lam hawiin a kal a ni. Chuvangin, thil dang, inflammation, infection hrang hrang, autoimmune illnesses te chu ngaihven a ni lo hle.

Mahse, he amyloid thawnthu hi a dik lo vek lo. Buaina chu damdawiah a awm mai thei. A nih loh leh, damdawi ei hun chu a dik lo thei bawk. Heng damdawi te hi natna lan chhuah hma kum tam takah ei tan tur a ni mai thei.

Harsatna dang a awm leh bawk. Kum sawm vel kalta thleng khan mi pakhat dam laiin Alzheimer natna hi 100% a finfiah theih dan a awm lo a, an thih hnua an thluak enfiah mai loh chu. Chuvangin, zirchianna hluiah hian mi thenkhat chuan Alzheimer natna an nei tak tak lo. Chuvangin chu zirchianna atanga data chu a dik lo a ni lawm ni?

Mahse tunah chuan thil awmdan a danglam ta. Technology thar, a bik takin PET scan leh cerebrospinal fluid test hmangin mi nung thluaka amyloid leh tau protein awm leh awm loh hriat theih a ni.

Thluak chhunga ‘Traffic Jam’ leh zirchianna thar

Tunah chuan chu plaque te chu lak chhuah mai mai ai chuan zirchiangtute chuan buaina bulpui ber chu an en tan ta a, "Engvangin nge heng plaque te hi an lo awm?" Buaina chu khawiah nge a awm tih chiang taka hre lovin i chinfel theih loh ang mai a ni. Tunah chuan, hemi chungchangah hian theory thar engemaw zat a awm ta. Eng nge an nih i en ang u.

Chuti a nih chuan kan tih theih a awm lo em ni? Invenna chungchang hi han sawi ila.

Heng zawng zawng i hriat hian, ‘Aw, kan tih theih tur a awm lo’ tih i ngaihtuah mai thei. Mahse, chutiang chuan ngaihtuah suh. Thu lawmawm tak chu Alzheimer natna hi a lo awm theih nan hun rei tak a ngai a, kum 20 atanga kum 30 vel a ngai a ni. Chumi awmzia chu natna kal zel tur tihtawp emaw, tihkhawtlai emaw turin hun tam tak kan nei tihna a ni.

Genetic influence awm mahse, Alzheimer natna lo awm theihna tur tichhe thei risk factors modifiable tam tak a awm a. Chungte chu:

• Thau lutuk
• Zunthlum
• Lung leh thisen zam natna
• Cholesterol sang tak a ni
• Thisen sang a sang
• Hriatna hloh
• Depression leh mahni chauha awm

Heng thilte thatna lian ber chu risky a tlem a, a man a to lo va, kan hriselna zawng zawng atan a tha zawk bawk. Damdawi thar lei nan kum khata dollar maktaduai tam tak seng ai chuan kan nunphung thlak danglam hi engzat nge a hlut zawk?

Nakin lawkah chuan Alzheimer enkawlnaah hian cancer enkawlna ang bawkin, damdawi pakhat ni lovin, hmanraw leh damdawi hrang hrang, "cocktail" hmanga enkawl a ni thei. Amaherawhchu, he natna dona kawnga beiseina lian ber chu scientist-te’n an rinna hlui an zawtfiah a, kawng thar an zawn hi a ni.