I chhungkuaa mi tu emaw, nu duh tak, pa, pi leh pi, pi leh pu duh tak pawh ni se, Alzheimer natna a vei a nih chuan a hrehawm theih zia kan hria. I hriatrengna a bo zauh zauh a, i inhriatthiamna i hloh tih i en hian i hrehawmna chu thuin sawi chhuah a harsa hle. Tuna he natna damdawi hman mekte hian a natna lan chhuah dan hi eng emaw chen chu thunun thei mah se, damdawi erawh a la awm lo. Mahse, medical science hian a beidawng ngai lo. Tunah chuan khawvel hmun hrang hranga scientist-te chuan he natna hi tidam thei, control thei leh venhim thei tur vaccine an zirchiang mek a ni. Chuvangin vawiinah hian he beiseina thar hi han sawi ila.
Eng vaccine nge Alzheimer natna tanpui thei?
Dik tak chuan zirchianna thenkhatah chuan puitlingte chuan natna chickenpox (entir nan, shingles vaccine) leh natna chi hrang hrang, measles ang chi vaccine an dawng a, Alzheimer natna vei theihna an nei tlem zawk tih an hmuchhuak. Mahse hengte hi Alzheimer natna vei bik vaccine an ni lo.
Alzheimer natna vaccine bik an siam hian scientist-te chuan he natna avanga thluaka inthlak danglamna lian pathum an ngaihtuah ber a ni. A awlsam zawngin, Alzheimer vei thluak chhungah hian "culprits" lian pathum an awm a.
1. Tau protein tangles: Chungte chu thluaka nerve cell chhungah an khawlkhawm thin.
2. Beta-amyloid plaques: Chungte chu nerve cell inkarah, chu chu cell pahnih inkar hmunah a awm khawm thin.
3. Thluaka inflammation: Heng misual pahnih hian thluaka inflammation, a nih loh leh inflammation an siam reng a.
Tuna vaccine siam mek zawng zawng hian heng misual pakhat emaw a aia tam emaw control hi a tum ber a ni. Vaccine chi hrang hrang hi a hranin han thlir ila.
| Vaccine chi leh target | A kalphung leh a nghawng dan |
|---|---|
| Tau proteins target tu vaccine te | I thluak nerve cell chhungah hian rel kawng ang chi, ei tur tha tak takte phurh chhuah leh kal leh tur a awm tih han ngaihtuah teh. He protein ‘tau’ an tih hian chu ‘rel kawng’ chu a nghet tlat a ni. Alzheimer natnaah chuan heng tau protein te hi an pianzia a dik lo a, track ang ni lovin an inzawm khawm a, ‘balls of thread’ ang mai an ni. Tichuan cell chhunga transport chu a tawp a, cell te chu an thi tan ta a ni. Heng vaccine te hian he tangle hi tihtawp an tum thin. Tuna vaccine test mek hi AADvac1 leh ACI-35.030/JACI-35.054 te an ni. |
| Beta-amyloid-a target-na vaccine siam a ni | Hei hi thluaka nerve cell inkara ‘bawlhhlawh’ emaw ‘glue ang chi bawlhhlawh’ emaw a awm khawm ang a ni. Heng protein pakhat beta-amyloid an tih chi hrang hrangte hi an pungkhawm a, ‘plaques’ an tih deposit an siam thin. Hei hian nerve cell te chu an inbiakpawhna tha tak a tikhawlo a, chu chu ‘signal’ an thawn thei lo tihna a ni. Heng vaccine te hian an tih tur chu taksa immune system tichakin he ‘bawlhhlawh’ hi a paih chhuak a ni. Vaccine ALZ-101, ABvac40, leh UB-311 te hi he category-ah hian an tel a ni. |
| Thluak inflammation target tu vaccine te | Thluak hrisel takah chuan microglia an tih cell bik a awm a. Thluak ‘cleaning crew’ ang an ni. An hna chu bawlhhlawh leh toxin duh loh zawng paih chhuah hi a ni. Mahse Alzheimer natnaah chuan heng hnathawkte hi an kal lo. Bawlhhlawh paih ai chuan thluaka inflammation awm reng thei chemical tha lo tak tak an siam chhuak thin. Hei hian nerve cell hrisel tak takte pawh a tichhe bawk. Heng vaccine te hian he ‘messy cleaning system’ hi siam that leh an tum thin. Heng experimental vaccine pahnih zinga GV1001 leh Protollin te hi an ni. |
Chuti a nih chuan engtikah nge Alzheimer vaccine kan hmuh ang?
Hei hi mi zawng zawng rilrua zawhna lian ber a ni. Dik tak chuan hei hian hun engemaw chen a la ngai dawn a ni. Heng vaccine kan sawi tawh zawng zawng hi clinical trials stage-ah an la awm vek a ni. Chumi awmzia chu mi hnena pek an him em tih leh engtiang chiahin nge an thawh hlawk tih hriat tumin an la test reng tihna a ni.
A pawimawh ber chu he zirchianna hi a hlawhtlin chuan nakin lawkah Alzheimer natna hi a tir lamah pawh ven theih emaw, enkawl theih emaw a ni thei a ni.
Tuna kan hriat dan chuan a chunga kan sawi tak vaccine zingah hian GV1001 a awmHe vaccine hi clinical trial-ah chuan a hmasawn deuh hlek a, mahse hengte hi final result a la ni lo.
Chumi hma chuan engtin nge kan tih ang?
He vaccine thar atana beiseina neih hi a tha khawp mai. Mahse chumi hma chuan nangmah emaw, i chhungte zinga tu emaw hian he natna hi i vei a nih chuan, a tha ber chu tuna i doctor-in a rawtna hi zawm hi a ni.
Tuna damdawi hman mek, Aducanumab leh Lecanemab te hian natna hi a hmaa hmuhchhuah a nih chuan eng emaw chen chu a ti hniam thei tih hmuhchhuah a ni. Chuvangin doctor nen inbiak reng a, a thupek zawm a pawimawh hle.
Hetiang clinical trial-a tel duh i nih chuan i doctor nen pawh i sawipui thei bawk. I tâna hun remchâng ṭha a awm leh awm loh leh chu mi tâna i tlin leh tlâk loh chungchânga kaihhruaina dik tak a pe thei ang che.
Take-Home Thuchah a ni
- Alzheimer natna hi thluaka inthlak danglamna (tau protein tangles, beta-amyloid deposits, inflammation) avanga lo awm a ni.
- Scientist-te chuan heng inthlak danglamnate hi target thei tur vaccine siam chhuah tumin nasa takin hma an la mek a, natna hi a veng thei a, a tidam thei a, a control thei bawk.
- Heng vaccine te hi research stage-a an la awm avangin mipui tam zawka hman theih turin hun engemaw chen a la ngai dawn a ni.
- Hetih laia tih tur tha ber chu i doctor-in a rawt angin enkawl chhunzawm zel a, a thupek zawm hi a ni.
- Nakin lawkah vaccine hlawhtling taka siam a nih hunah chuan i medical team te chuan an hriattir ang che.
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