Cancer i vei tih i hriat chuan i rilru put hmang chu thumal hmanga sawi a harsa hle. Mahse doctor-in inenkawl chungchang a sawi a, ‘chemotherapy’ tih ang chi tawngkam i hriat chuan hlauhna, hriat duhna leh buaina nasa zawka inhriat chu thil pangngai a ni. Cancer enkawlna atana chemo damdawi hman tlanglawn ber pakhat chu ‘Taxane’ a ni. Vawiin hian he thu hi awlsam takin, i hriatthiam theih tur angin, i thian hnai tak nen in inbia ang maiin kan sawi dawn a ni.
Taxane hi eng nge ni tak tak?
A awlsam zawngin sawi ila, taxanes hi chemotherapy damdawi chi khat a ni a, cancer cell a that a, tumor lian tham a titawp bawk. Chemotherapy-ah hian heng damdawi te hi kan thisenah kan dah tel a, chu chuan taksa pum puiah cancer cell zawngin a tichhia a ni.
Heng taxane damdawi te hi a danglam bikna chu thing atanga lo chhuak an nih vang a ni. A hmasa berin ‘Yew’ thing hnah atanga lakchhuah an ni . Dik tak chuan taxanes hi thlai atanga siam chemo damdawi chi hnih zinga pakhat a ni. A chi dang chu ‘Vinca alkaloids’ an tih damdawi pawl pakhat a ni a, ‘Mella’ thlai atanga lak chhuah a ni.
Tunah chuan scientist-te chuan heng thlai atanga taxanes an hmuhte chemical structure an zirchiang a, laboratory-ah pawh synthetically-a siam chhuah tumin hma an la mek a ni.
Engtin nge he damdawi hian cancer cell te hi a tihlum?
Hei hi hrethiam tur chuan cancer cells in darh dan hi kan hriatthiam hmasak a ngai a ni. Cancer chu cancer cell pakhat chu pahnih-ah a then a, chu chu paliah a inthen a, chutah chuan a pung chak hle a ni. Damdawi lamah chuan cell pakhat chu pahnih a inthen dan chu mitosis an ti a.
Taxane damdawi hian a tih chu cell inthen darh dan a tibuai a ni.
Cell pakhat a inthen chuan, chu cell chhunga genetic material chu chi hnih-ah chiang takin a in\hen a, cell thar pahnih hnenah thawn a ngai ang tih han ngaihtuah teh. Cell chhungah hian he hna thawk tura puitu structure a awm a, cable tie te te ang chi te hi a ni. Chungte chu microtubules an ti a . Hengte hian cell thar pahnih tana mamawh part hrang hrangte chu a hruai hrang a ni.
Taxane damdawi hi taksaah a luh chuan heng cable microtubules an tih te hi a tul lovah a tikhauh a ni . Tichuan an fold tha thei lo va, an unfold tha thei lo bawk. Chuvangin, cell pahniha then dan chu a chanve vel a tawp ta a ni. He inthenna hi tih theih a nih loh chuan nu leh pa cell chu rei vak lo hnuah a thi ta a ni.
Taxane damdawi hian cancer cell te inthen darh leh thanlen theihna a tichhia a, cancer a control a ni.
Taxane damdawi hi eng cancer chi hrang hrangah nge hman a nih?
Taxanes hi cancer chi hrang hrang enkawlna atana hman thin damdawi class pawimawh tak a ni. Chung zinga ṭhenkhat chu cancer ṭhenkhat tan first-line treatment atan hman a ni a, ṭhenkhat chu metastatic cancer atan hman a ni bawk.
| Taxane hmanga enkawl cancer chi hrang hrang | |
|---|---|
| A bik takin cancer hman a ni | |
| Ovarian cancer a ni | Hnute cancer a ni |
| Cancer chi dang enkawl dan | |
| Bladder cancer a ni | Cervical cancer a ni |
| Chaw ei leh in cancer a ni | Lu leh kawng cancer te |
| Prostate cancer a ni | Lung cancer (Non-small cell lung cancer) 1. A rilru a hah lutuk chuan a rilru a buai em em a. |
| Uterine cancer a ni | Lymphoma natna (Lymphoma) a ni |
A then phei chuan taxanes hi chemotherapy damdawi dang nen pek dun a ni. I doctor chuan i dinhmun atan eng enkawlna nge tha ber tih a rel ang.
Engtin nge he enkawlna hi pek a nih? Tin, a side effects te chu engte nge ni?
Enkawlna pek dan tur
Taxanes hi thisen kaltlangin pek thin a ni (IV) . Cannula (catheter) hmanga pek an ni a, chu chu saline solution ang chiah a ni. He enkawlna hian darkar khat emaw darkar engemaw zat emaw a daih thei. He enkawlna hi kar khatah vawi khat, emaw, kar tlemte chhungin vawi khat emaw i dawng a ngai mai thei. I doctor chuan i dinhmun a zirin enkawl dan tur a rel ang.
Side effect hmuh tur awm fo
Chemotherapy damdawi hian cancer cell inthen chak tak takte chu target mahse, a chang chuan kan taksaa cell hrisel, rang taka inthen darh thei te pawh a nghawng thei bawk. Entirnan, kan sam zungpui cell te, vun cell te, thisen cell te ang chi thil te. Hei vang hian side effect a awm thin.
| Side Effect a awm thei | A sawifiahna awlsam tak |
|---|---|
| Neutropenia (Neutropenia) a awm thin | Taksa chhunga natna hrik dotu thisen var chi khat neutrophils a tlem chuan natna hrik kai theihna a tipung a ni. |
| Peripheral neuropathy a awm a | Kut leh kea nerve chhiatna. Hei hian kut leh ke a ti na thei a, a ti na thei a, a tichak lo thei bawk . |
| Sam tlakchhamna | Hei hi side effect awm fo a ni a, mahse enkawlna zawh hnuah sam a sei leh ang. |
| Luak chhuak leh luak chhuak | Enkawl ni-ah a awm fo thin. Hei hi thunun nan damdawi pek a ni. |
| Muscle leh ruh natna | Taksaah na a awm thei a, ruh ruh a nghet lo thei bawk. |
| Thisen sang a inthlak danglam thin | Thisen sang a sang thei a, a tlahniam thei bawk. |
| Thisen cell a tlahniam | Thisen sen tlahniam chuan thisen tlakchhamna a thlen thei a, platelet tlahniam (thrombocytopenia) chuan thisen chhuah theihna a thlen thei bawk. |
Heng side effects te hi mi zawng zawngah a awm lo. Tin, tam tak chu thunun theih a ni bawk. I harsatna i neih apiang i doctor emaw nursing staff emaw hriattir a pawimawh hle.
He enkawlna hian hlauhawmna a nei em?
Taxanes hi enkawlna tha tak a ni a, cancer vei te dam chhung a ti rei hle. Mahse, enkawlna zawng zawng ang bawkin hlauhawmna engemaw zat a awm.
A châng chuan, a chunga kan sawi tak side effects hi a na hle thei bawk. Chutiang hunah chuan i doctor chuan i enkawl hun tûr chu thlak danglam emaw, rei lo tê chhûnga tihtawp emaw chu a rel thei a ni.
Thil pawimawh dang chu hun kal zelah cancer cell te hian he damdawi hi ‘an thiam’ tan thei a ni. Chu chu, chemoresistance an nei tihna a ni . Tichuan damdawiin a nghawng chu a tlahniam thei a ni. Mahse chutiang a nih chuan i doctor chuan damdawi chi hrang hrang inzawmkhawm emaw, enkawlna dang rawt emaw ang chi duhthlanna lam a hawi ang.
Take-Home Thuchah a ni
- Taxane hi chemotherapy damdawi chi khat chak tak a ni a, thlai atanga siam, cancer cell inthen darh theitu a ni.
- Hei hian cancer chi hrang hrang, hnute, ovarian leh lung te pawh hlawhtling takin a enkawl thei a ni.
- Side effects, sam tlakchham, bengchheng, taksa na te pawh a awm thei a, mahse a tam zawk chu enkawl theih a ni.
- Enkawlna hun chhunga harsatna tenau i neih apiang chu doctor emaw nurse emaw hnenah hrilh a pawimawh hle.
- Cancer enkawlna hi kan zinkawng a ni. He zinkawngah hian nangmah chauh i ni lo tih leh i tanpui tur medical team thiam tak tak i nei tih hre reng ang che.
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