I chhungkuaah Down Syndrome vei i hmangaih tak tak i neih chuan an upat deuh deuh chuan an hriselna chungchangah zawhna hrang hrang, leh hlauhna tlemte pawh a awm mai thei, chu thil pangngai tak a ni. A bik takin "Alzheimer's Disease" tih hming hi i hre fo tawh ngei ang. Heng natna pahnih hi inzawmna a awm tak tak em tih hi i ngaihtuah nasa hle mai thei. Dik tak chuan a awm. Mahse i hlauh hmain chiang takin, awlsam tak leh awlsam takin sawi ila.
Engvangin nge Down syndrome vei te hi Alzheimer’s vei an hlauhawm zawk nia sawi?
Hei hi hrethiam tur chuan kan taksa peng bulpui ber lam kan pan leh a ngai a ni. Chu chu kan chromosome te chu an ni . A awlsam zawngin sawi ila, heng chromosomes te hi kan taksa cell tinah ‘instruction’ ang mai an ni. Kan sam rawng atanga kan san zawng thlengin heng chromosome-a gene awmte hian a hril vek a ni. A tlangpuiin mi pakhat hian chromosome chi hrang hrang copy hnih a nei a.
Mahse, Down syndrome vei chuan chromosome 21 copy dang a nei a, chu chu copy pathum a ni . Hei hi Alzheimer natna nen a inzawm dan chu a ni: Alzheimer natna a lo awm huna thluaka protein tha lo (beta-amyloid) siam chhuah tura hriattirtu gene hi he chromosome 21-ah hian a awm a ni.
Chuvangin, chromosome 21 copy extra a awm avangin Down syndrome vei chuan an thluak ah he protein hlauhawm tak hi a siam tam zawk thin. Hun a kal zel a, heng protein te hi thluak cell vel ah an pungkhawm a, an dah khawm a, chu cell te chu an tichhia a, an tichhia tan ta a ni. Hei hi Alzheimer natnaah chuan a thleng thin.
Chu bakah, Down syndrome vei taksa leh thluak chu mi pangngai aiin a upa chak zawk (premature aging) . Chu chu, Down syndrome vei kum 45 mi taksa chu mipui zahawm tak zinga kum 65 emaw kum 70 emaw mi taksa nen a inang thei tihna a ni. Hetianga tar chak lutuk hi Alzheimer natna lo awm hma chhan lian tak a ni bawk.
Engtin nge a lan chhuah dan? Alzheimer natna lan chhuah dan pangngai nen an danglam em?
Ni e, hei hi thil pawimawh tak a ni. Down syndrome vei zinga Alzheimer natna lan chhuah dan hi mi pangngai natna lan chhuah dan nen a danglam deuh thei. Chuvangin a chang chuan he dinhmun hi hriat a harsa thei hle.
Alzheimer’s kan ngaihtuah hian hriatrengna hloh kan ngaihtuah tlangpui. Mahse Down syndrome vei tan chuan hriatrengna hloh hi a lan chhuahna hmasa ber a ni lo mai thei . Inthlâk danglamna dangte chu hriat hmasak a ni thei.
Chu inthlak danglamna chu a hnuaia table-ah hian eng nge ni tih i en ang u.
| Symptom a ni | Down syndrome vei miah chuan eng ang nge a nih |
|---|---|
| Nitin hnathawh | Tûn hmaa mahni chauha i tih theih thilte, inchei te, ei leh in te, inbual te, leh tea siam te hi ṭanpuina a ngai a ni. Chutiang thil tih duhna leh tih theihna chu a tlahniam zauh zauh a. |
| Nungchang a inthlak danglam thin | Vawilehkhatah chuan an rilru a na a, thil awmze nei lo takin an che a, an buai a, a nih loh leh ngawi rengin an ding tan a, a sir lehlamah ngaihvenna nei lovin, tawng lovin an ding ta a ni. |
| Seizures thar lo chhuak | Hei hi symptom pawimawh tak a ni. A dam chhunga seizure nei ngai lo mi pakhatin kum 40 a tlin hnuah seizure thar a neih tan chuan Alzheimer natna chhinchhiahna a ni thei. |
| Hriatrengna leh ngaihtuah thiamna | A tir lamah chuan hriatrengna hloh hi hriat theih loh mah se, hun kal zelah a thleng thei a ni. Thil thar hriat reng a harsa ta hle mai. Thil dik leh dik lo thlan thiamna leh thutlukna siam thiamna a tlahniam a. |
| Thusawi harsa | Thusawi tlem i tan thei a, thu i hmuh harsat phah thei a, i thusawi chu i sawisel lo thei bawk. |
A pawimawh ber chu i fa emaw chhungte emaw nungchang pangngai (baseline) atanga inthlak danglamna hmuh hi a ni . An pian tirh atanga zir lama harsatna engemaw zat an neih avangin hriatrengna lama inthlak danglamna hriat a harsa thei hle. Mahse, "He mi hi a hma chuan hetiang hi a ni lo va, tunah chuan an danglam ta," tia i inhriat chuan chu chu a pawimawh ber a ni.
Kum engzat nge a nih chuan a hlauhawmna a pung?
Alzheimer natna hi mipui zingah kum 65 hnuah a lo awm tlangpui a, mahse Down syndrome vei tan chuan he hlauhawmna hi a hma zawk hle.
- Kum 35 mi a niTun hnaiah zirchianna hrang hrangah Down syndrome vei zinga 25% vel (mi pali zinga pakhat) vel chuan Alzheimer’s symptoms an nei thei tih hmuhchhuah a ni.
- Mi tam tak tan chuan kum 40 bawr vel emaw, kum 50 hnuai lam emaw atang hian natna lanchhuahna hi a lang tan thin.
- A pum puia thlir chuan Down syndrome vei mi pakhatin Alzheimer natna a vei theihna hi mipui zawng zawng aiin a let thum atanga a let nga velin a sang zawk a ni.
Vengtu angin eng nge ka tih ang?
He thu hian a ti hlauhawm thei che a ni. Mahse, hlauthawng suh. Awareness hi ralthuam tha ber a ni. Thil pawimawh tak tak i tih theih a awm a.
1. Damdawi lam endik fo: I fa emaw chhungte emaw doctor hnena hruai fo a pawimawh. A bik takin kum 30 i tlin hnuah chuan Alzheimer’s natna hlauhawmna chungchang hi doctor nen zalen takin sawipui thin ang che.
2. Baseline Assessment: Kum 30 i tlin chuan i doctor nen thawk ho la, i fa hriatrengna, nitin hnathawh dan leh nungchang te endik rawh. Hei hian nakin lawka inthlâk danglamna eng pawh i hriat theih nân a ṭanpui ang che.
3. Hrilhfiahna tur fimkhur rawh: Amah chu nangmahin i hre chiang ber. Chuvângin, inthlâk danglamna tenau ber pawh i hriatte chu a ni leh hun ziakin lehkhabuah ziak rawh. "Vawiin khan a kekawrte chu a mah chauhin a ha thei lo," "Kar hmasa atang khan a lungawi lo hle a ni," tih ang chi note siam rawh. Hei hian doctor tan a \angkai hle ang.
4. Damdawi lam pan nghal rawh: A chunga kan sawi tak symptoms pakhat emaw a aia tam emaw i neih chuan doctor pan turin nakin lawkah nghak suh . Alzheimer natna hi tihdam kim theih a nih loh laiin, a natna lan chhuah dan enkawlna leh nunphung tihchangtlunna tur leh nangmah leh damlo tan pawh hahdamna pe thei tur enkawlna leh hmanraw hrang hrang a awm a ni.
Take-Home Thuchah a ni
- Down syndrome vei te hian mipui zawng zawng aiin Alzheimer natna vei theihna genetic risk an nei sang zawk hle.
- Symptoms hi kum 40s emaw 50s tir lam emaw atanga tan a ni tlangpui a, mipui zahawm tak aiin a hma zawk hle.
- Hriatrengna hloh ai chuan, a lan chhuah hmasak ber chu nungchang inthlak danglamna, nitin hna thawh theih lohna, emaw, seizure thar emaw a ni thei.
- I hmangaih tak nungchang, theihna, a nih loh leh nitin nunphungah danglamna langsar tak i hmuh chuan, chu chu i doctor hnenah sawipui ngei ang che.
- A hmaa hriatchhuah leh damdawi lam enkawlna dik tak chuan damlo nunphung a tichangtlung thei a, enkawltu i nih angin i tan hahdamna a pe thei bawk.
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