I chhungkuaah Down Syndrome vei i hmangaih tak tak i neih chuan an upat deuh deuh chuan an hriselna chungchangah zawhna hrang hrang, leh hlauhna tlemte pawh a awm mai thei, chu thil pangngai tak a ni. A bik takin "Alzheimer's Disease" tih hming hi i hre fo tawh ngei ang. Heng natna pahnih hi inzawmna a awm tak tak em tih hi i ngaihtuah nasa hle mai thei. Dik tak chuan a awm. Mahse i hlauh hmain chiang takin, awlsam tak leh awlsam takin sawi ila.
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Engvangin nge Down syndrome vei te hi Alzheimer’s vei an hlauhawm zawk nia sawi?
Hei hi hrethiam tur chuan kan taksa peng bulpui ber lam kan pan leh a ngai a ni. Chu chu kan chromosome te chu an ni . A awlsam zawngin sawi ila, heng chromosomes te hi kan taksa cell tinah ‘instruction’ ang mai an ni. Kan sam rawng atanga kan san zawng thlengin heng chromosome-a gene awmte hian a hril vek a ni. A tlangpuiin mi pakhat hian chromosome chi hrang hrang copy hnih a nei a.
Mahse, Down syndrome vei chuan chromosome 21 copy dang a nei a, chu chu copy pathum a ni . Hei hi Alzheimer natna nen a inzawm dan chu a ni: Alzheimer natna a lo awm huna thluaka protein tha lo (beta-amyloid) siam chhuah tura hriattirtu gene hi he chromosome 21-ah hian a awm a ni.
Chuvangin, chromosome 21 copy extra a awm avangin Down syndrome vei chuan an thluak ah he protein hlauhawm tak hi a siam tam zawk thin. Hun a kal zel a, heng protein te hi thluak cell vel ah an pungkhawm a, an dah khawm a, chu cell te chu an tichhia a, an tichhia tan ta a ni. Hei hi Alzheimer natnaah chuan a thleng thin.
Chu bakah, Down syndrome vei taksa leh thluak chu mi pangngai aiin a upa chak zawk (premature aging) . Chu chu, Down syndrome vei kum 45 mi taksa chu mipui zahawm tak zinga kum 65 emaw kum 70 emaw mi taksa nen a inang thei tihna a ni. Hetianga tar chak lutuk hi Alzheimer natna lo awm hma chhan lian tak a ni bawk.
Engtin nge a lan chhuah dan? Alzheimer natna lan chhuah dan pangngai nen an danglam em?
Ni e, hei hi thil pawimawh tak a ni. Down syndrome vei zinga Alzheimer natna lan chhuah dan hi mi pangngai natna lan chhuah dan nen a danglam deuh thei. Chuvangin a chang chuan he dinhmun hi hriat a harsa thei hle.
Alzheimer’s kan ngaihtuah hian hriatrengna hloh kan ngaihtuah tlangpui. Mahse Down syndrome vei tan chuan hriatrengna hloh hi a lan chhuahna hmasa ber a ni lo mai thei . Inthlâk danglamna dangte chu hriat hmasak a ni thei.
Chu inthlak danglamna chu a hnuaia table-ah hian eng nge ni tih i en ang u.
| Symptom a ni | Down syndrome vei miah chuan eng ang nge a nih |
|---|---|
| Nitin hnathawh | Tûn hmaa mahni chauha i tih theih thilte, inchei te, ei leh in te, inbual te, leh tea siam te hi ṭanpuina a ngai a ni. Chutiang thil tih duhna leh tih theihna chu a tlahniam zauh zauh a. |
| Nungchang a inthlak danglam thin | Vawilehkhatah chuan an rilru a na a, thil awmze nei lo takin an che a, an buai a, a nih loh leh ngawi rengin an ding tan a, a sir lehlamah ngaihvenna nei lovin, tawng lovin an ding ta a ni. |
| Seizures thar lo chhuak | Hei hi symptom pawimawh tak a ni. A dam chhunga seizure nei ngai lo mi pakhatin kum 40 a tlin hnuah seizure thar a neih tan chuan Alzheimer natna chhinchhiahna a ni thei. |
| Hriatrengna leh ngaihtuah thiamna | A tir lamah chuan hriatrengna hloh hi hriat theih loh mah se, hun kal zelah a thleng thei a ni. Thil thar hriat reng a harsa ta hle mai. Thil dik leh dik lo thlan thiamna leh thutlukna siam thiamna a tlahniam a. |
| Thusawi harsa | Thusawi tlem i tan thei a, thu i hmuh harsat phah thei a, i thusawi chu i sawisel lo thei bawk. |
A pawimawh ber chu i fa emaw chhungte emaw nungchang pangngai (baseline) atanga inthlak danglamna hmuh hi a ni . An pian tirh atanga zir lama harsatna engemaw zat an neih avangin hriatrengna lama inthlak danglamna hriat a harsa thei hle. Mahse, "He mi hi a hma chuan hetiang hi a ni lo va, tunah chuan an danglam ta," tia i inhriat chuan chu chu a pawimawh ber a ni.
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Alzheimer natna hi mipui zingah kum 65 hnuah a lo awm tlangpui a, mahse Down syndrome vei tan chuan he hlauhawmna hi a hma zawk hle.
- Kum 35 mi a niTun hnaiah zirchianna hrang hrangah Down syndrome vei zinga 25% vel (mi pali zinga pakhat) vel chuan Alzheimer’s symptoms an nei thei tih hmuhchhuah a ni.
- Mi tam tak tan chuan kum 40 bawr vel emaw, kum 50 hnuai lam emaw atang hian natna lanchhuahna hi a lang tan thin.
- A pum puia thlir chuan Down syndrome vei mi pakhatin Alzheimer natna a vei theihna hi mipui zawng zawng aiin a let thum atanga a let nga velin a sang zawk a ni.
Vengtu angin eng nge ka tih ang?
He thu hian a ti hlauhawm thei che a ni. Mahse, hlauthawng suh. Awareness hi ralthuam tha ber a ni. Thil pawimawh tak tak i tih theih a awm a.
1. Damdawi lam endik fo: I fa emaw chhungte emaw doctor hnena hruai fo a pawimawh. A bik takin kum 30 i tlin hnuah chuan Alzheimer’s natna hlauhawmna chungchang hi doctor nen zalen takin sawipui thin ang che.
2. Baseline Assessment: Kum 30 i tlin chuan i doctor nen thawk ho la, i fa hriatrengna, nitin hnathawh dan leh nungchang te endik rawh. Hei hian nakin lawka inthlâk danglamna eng pawh i hriat theih nân a ṭanpui ang che.
3. Hrilhfiahna tur fimkhur rawh: Amah chu nangmahin i hre chiang ber. Chuvângin, inthlâk danglamna tenau ber pawh i hriatte chu a ni leh hun ziakin lehkhabuah ziak rawh. "Vawiin khan a kekawrte chu a mah chauhin a ha thei lo," "Kar hmasa atang khan a lungawi lo hle a ni," tih ang chi note siam rawh. Hei hian doctor tan a \angkai hle ang.
4. Damdawi lam pan nghal rawh: A chunga kan sawi tak symptoms pakhat emaw a aia tam emaw i neih chuan doctor pan turin nakin lawkah nghak suh . Alzheimer natna hi tihdam kim theih a nih loh laiin, a natna lan chhuah dan enkawlna leh nunphung tihchangtlunna tur leh nangmah leh damlo tan pawh hahdamna pe thei tur enkawlna leh hmanraw hrang hrang a awm a ni.
Take-Home Thuchah a ni
- Down syndrome vei te hian mipui zawng zawng aiin Alzheimer natna vei theihna genetic risk an nei sang zawk hle.
- Symptoms hi kum 40s emaw 50s tir lam emaw atanga tan a ni tlangpui a, mipui zahawm tak aiin a hma zawk hle.
- Hriatrengna hloh ai chuan, a lan chhuah hmasak ber chu nungchang inthlak danglamna, nitin hna thawh theih lohna, emaw, seizure thar emaw a ni thei.
- I hmangaih tak nungchang, theihna, a nih loh leh nitin nunphungah danglamna langsar tak i hmuh chuan, chu chu i doctor hnenah sawipui ngei ang che.
- A hmaa hriatchhuah leh damdawi lam enkawlna dik tak chuan damlo nunphung a tichangtlung thei a, enkawltu i nih angin i tan hahdamna a pe thei bawk.
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