Chhungkaw member emaw, thian hnai tak emaw chuan zawi zawiin engkim a theihnghilh a, nitin hna pawh mahni chauha thawk thei lo an nih lai i hmuh hian i lungngaihna chu thuin sawi chhuah a harsa hle. Alzheimer natna hi chutiang rilru ti na tak chu a ni. Tun thleng hian a natna lan chhuah dan control thei damdawi chauh a awm tawh a, mahse tunah chuan khawvelin he natna thlentu direct-a target tur damdawi thar chungchang a sawi ta a ni. Vawiin hian he beiseina thar kan sawi dawn a, chu chu Anti-Amyloid therapy a ni.
A awlsam zawngin sawi ila, he Anti-Amyloid treatment hi eng nge ni?
Alzheimer natna vei thluak ah hian protein chi khat `beta-amyloid` an tih chu a tul lovah a pungkhawm thin. Electrical wire kal tlanga current kal ang maiin han ngaihtuah teh, chu chu kan thluaka neuron inkara information kal dan a ni. Chu `beta-amyloid` protein chu a pungkhawm a, heng nerve cells inkarah hian rust ang chi `plaques` a siam thin. Chu chuan thu leh hla kal dan a tibuai a ni. Hei hi hriatrengna hloh leh ngaihtuah chian theih lohna chhan ber a ni.
He damdawi class thar, anti-amyloid tia koh hian thluaka `beta-amyloid` plaque awmkhawmte chu paih chhuakin hna a thawk a ni. Chu chu natna lan chhuah dan tihtawp mai ai chuan natna thlentu bulpui ber a bei tihna a ni. Beiseina chu heng plaque te hi paih chhuah a nih chuan thluak cell te hian hun rei zawk chu hrisel zawkin an thawk thei dawn a ni.
Hengte hi a takah chuan `immunotherapy` tih treatment category-ah an tel a ni. A dik zawka sawi chuan heng damdawi te hi laboratory-a a bik taka siam antibody chi khat (monoclonal antibody) anga pek a ni. Heng antibody te hi kan taksaa an luh chuan chu `beta-amyloid` protein tha lo tak takte chu an hmuchhuak a, an inzawm a, an tichhia a ni.
Tuna anti-amyloid damdawi pawmpui ber pahnih chu `donanemab (Kisunla)` leh `lecanemab-irmb (Leqembi)` te an ni. Damdawi pakhat `aducanumab (Aduhelm)` tih pawh a awm a, mahse tunah chuan a siamtu company chuan market atangin an la chhuak ta a ni.
Engtin nge he enkawlna hi ka hmuh theih ang? Side effect a awm em?
He damdawi hi saline solution (IV infusion) hmangin vein pakhatah pek a ni. Hei hian darkar khat vel a awh a ni. `Leqembi` hi kar hnih danah pek thin a ni tlangpui a, `Kisunla` hi kar li danah pek thin a ni. Dose tlemte hmangin i tan a, zawi zawiin i doctor-in a pek angin i tipung a.
Mahse he enkawlna nena inzawm hlauhawm ber chu i hriat a ngai a ni. A hmingah chuan `ARIA (Amyloid-Related Imaging Abnormalities)` tih a ni.
A awlsam zawngin, hei hian thluaka a hring deuh emaw, thluak chhunga thisen chhuahna hmun te te a thlen thei a ni. Hei hi a mah chauhin a reh fo thin nachungin, hei hi en reng a pawimawh hle. Chuvangin he enkawlna chhung zawng hian thluak MRI scan neih reng a ngai a ni.
| Side effect chi hrang hrang | Hrilhfiahna |
|---|---|
| ARIA (risk lian tak) 1.1. | Thluak a hring emaw thisen chhuak te te. Hei hian lu na, luak chhuak, luak chhuak, buai, leh mit lama harsatna a thlen thei a ni. |
| Side effect dang a awm bawk | - Allergy avanga natna awm thei - Tlu tla - Kawthalo |
| A bik takin ngaihven rawh | Scientist-te chuan he damdawi hi thisen tithianghlimtu damdawi ei thin hnenah pek a nih chuan thluak thisen chhuah theihna a tipung thei niin an ring. Hemi chungchangah hian i doctor nen in inbia ngei tur a ni. |
He damdawi hi engtiang chiahin nge a hlawk tak tak?
Hetah hian a tricky part chu a awm. Zirna atanga a lan dan chuan heng damdawi te hian thluaka `beta-amyloid` plaques te chu a paih chhuak thei a ni. Chu chu thil tha tak a ni.
Mahse, chu plaque te chu lakchhuah a nih hnuah chuan damlo hriatrengna leh nitin hna a thawh theihna chu eng chen nge a lo \ha tak tak ang tih chungchangah ngaihdan inang lo a la awm tho. Zirchianna thenkhatah chuan hengte hian natna kal zel dan chu tlem a ti hniam thei tih an hmuchhuak. Chu chu natna chu a dam kim tihna a ni lo va, natna a zual zel tur chu a tikhawtlai zawk tihna a ni.
Scientist-te chuan he enkawlna hi natna bul tan tirh atanga tan a nih chuan result ropui ber beisei theih a ni tih an ring , thluaka chhiatna nasa tak a thlen hmain.
He enkawlna hi tute nge dawng thei ang?
Hei hi Alzheimer vei zawng zawng tan pek theih a ni lo. Tunah hian hengte hi mi tlemte tan chauh hman tur a ni.
- Natna hmasa lama awmte tan: Chu chu Alzheimer natna lo awm tan tirh emaw, ‘mild cognitive impairment’ tih natna nei emaw tan a ni. Hei hian natna zual zawk nei te tan a hlawkpui dawn em tih hriat a la ni lo.
- Amyloid plaques neia finfiah tawhte tan chuan:I doctor-in he damdawi a pek hma hian heng plaque te hi i thluaka a awm tak tak em tih an finfiah hmasa tur a ni. Hei hi PET scan emaw, spinal tap emaw a ni thei.
He enkawlna hi tuin nge dawng thei lo?
He damdawi hi clinical trial tam takah zirchian a la ni lo a, chuvangin a hnuaia hriselna lama harsatna nei te tan he damdawi hi pek hi a hlauhawm thei hle:
- Mite thisen zam tur venna damdawi ei thin (aspirin tih loh chu).
- Tun hmaa heart attack emaw stroke emaw vei tawhte.
- Thisen chhuahna lama harsatna nei te.
- Kidney emaw liver natna nei te.
Thil dang chu, heng enkawlna te hi a man to hle a ni . Sri Lanka ang ramah chuan mi tam tak tan chuan hengte hi hmuh a harsa thei hle. Hengte hi tun dinhmunah chuan chutiang chuan a awm lo.
Take-Home Thuchah a ni
- Anti-amyloid hi damdawi chi thar a ni a, thluaka `beta-amyloid' plaques awm khawm te chu a paih chhuak a , Alzheimer natna a thlen thei a ni.
- Hei hian natna lan chhuah dan aiin a chhan bulpui ber enkawl a tum a ni.
- Hei hi damlo natna hmasa ber , thluaka plaque awm tih finfiah tawhte tan chauh pek theih a ni.
- ARIA-ah hian thluak a hring emaw thisen chhuah emaw a awm theih avangin enkawl chhung hian MRI scan hmanga enkawl reng a pawimawh hle.
- He enkawlna hi zirchianna stage-ah a la awm a, a man a to hle a, mi tlemte chauh tan a awm tih hrethiam rawh.
- I hmangaih tak pakhatin Alzheimer’s symptoms a neih chuan a tha ber chu i doctor nen thu belhchian dawl zawk leh i tana tha tur enkawl dan tur chungchang sawipui hi a ni.
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