Cholangiocarcinoma hi i hria em? A awlsam zawngin sawi ila.

I pum dinglam, i ruh hnuaiah, i vun leh mit a sen (jaundice ang) emaw, chak lohna tlangpui chauh emaw, natna mak tak i nei tawh em? Chûngte chu thil pangngai ang maia lang mah se, a châng chuan chhan lian tak a awm thei a ni. Vawiin hian cancer chi khat hmuh tur awm lo mahse hlauhawm tak tak ni thei tur chungchang kan sawi dawn a ni. Chu chu bile duct cancer a ni a, damdawi lam chuan Cholangiocarcinoma tia hriat a ni.

A awlsam zawngin, cholangiocarcinoma chu eng nge ni?

Okay, heng bile duct te hi eng nge an nih kan en hmasa ang. Ngaihtuah teh, kan thin hian "bile" tih tui a siam chhuak thin. Hei hian chaw thau tak tak ei chhuahna kawngah nasa takin a pui a ni. Chuvangin, he bile hi liver atanga kan intestine tenau thlenga phurtu tube te tak te system chu bile ducts an ti a.

Cholangiocarcinoma hi cancer a ni a, bile duct system cell atanga intan a ni.

Hei hi cancer chi khat aggressive deuh a ni. Thil lungchhiatthlak tak chu a tam zawkah chuan he cancer hi hmuhchhuah a nih meuh chuan bile ducts piah lamah a darh tawh a ni. Chutiang hunah chuan enkawl a harsa hle a, prognosis pawh a tha lo hle. Mahse lungngai suh u, doctor leh scientist te chuan he cancer darh zel tur thunun thei tur leh damlote nun tha zawk pe thei tur damdawi thar an zawng chhuak fo thin.

He cancer chi hrang hrangte hi engte nge ni?

Bile duct cancer hi a awmna hmun a zirin chi thum ah then a ni a:

1. Intrahepatic cholangiocarcinoma: Hei hi liver chhunga bile duct te te ah a lo awm thin .

2. Perihilar/hilar cholangiocarcinoma: Hei hi a tam ber a ni. Hilum bulah a lo thang lian a, chutah chuan bile duct te chu liver atanga chhuak a ni. Klatskin tumor an ti bawk .

3. Distal cholangiocarcinoma: Hetiang chi hi liver pawn lama awm, small intestine hnaih taka awm bile duct-ah a lo awm thin.

Type 2 leh 3 pahnih hi an vaiin extrahepatic bile duct cancer an ti a . Chu chu cancer "liver pawn lama lo awm" tihna a ni.

He natna lan chhuah dan hi eng nge ni thei ang?

A tam zawkah chuan cancer hi a lian tawk a, bile duct a block hma loh chuan symptoms a awm lo. Symptoms a lan tak tak chuan hetiang thil hi i hmu mai thei.

A tir lamah chuan he cancer hian natna a thlen lo. Mahse, tumor a lo lian chhoh zel chuan pum dinglamah natna a awm thei. Mi thenkhatah chuan he natna hi pum chhung hmun dangah emaw, hnungzang thlengin a darh thei a ni.

He cancer vei theihna chhan leh a hlauhawmna te chu engte nge ni?

He cancer thlen chhan dik tak hi hriatchhuah a la ni lo. Mahse, bile duct-a chronic inflammation , a nih loh leh inflammatory conditions, chu a chhan lian ber a ni thei niin an ngai.

A awlsam zawngin sawi ila, chhiatna kal zel hian bile duct cells DNA a tichhe thei a ni. DNA hi kan cell te hnathawh dan tur hrilhtu "master plan" ang a ni. He DNA hi a chhiat chuan cell te chu thunun theih lohvin an inthen tan thei a, chu chuan cancer tumor a siam thei a ni.

Hei hi a thlen theihna tipungtu thil engemaw zat a awm a:

• Bile ducts nena inzawm natna: Gallstones, bile duct stones, leh `Primary sclerosing cholangitis` (bile ducts te a zim a, a block nana natna) te ang chi natna.
• Liver natna: Cirrhosis (liver a hliam), Hepatitis B emaw Hepatitis C viral infection te.
• Damdawi lam natna dang: Chronic ulcerative colitis, Inflammatory bowel disease (IBD), Zunthlum.
• Nunphung hrang hrang: zu in tam lutuk, thau lutuk, meizuk.
• Parasitic infection: Parasitic infection `Clonorchiasis` an tih hi Southeast Asia ramah a tam hle.
• Chemical tha lo tak tak nena inzawmna: Chemical thenkhat, a bik takin rubber emaw motor siamna hmuna hman thin te.

He natna hi engtin nge doctor hian a hriat theih ang?

Doctor i hmuh chuan i natna lan chhuah dan chu ngun takin a ngaithla hmasa ang a, i medical history a la ang a, taksa enfiahna a nei hmasa ang. Tichuan, cancer rinhlelh a nih chuan test engemaw zat an rawt thei a, chungte chu:

Thisen Test neih a ni

• Liver function test: Hengte hian liver hnathawh that dan tur ngaihtuahna a pe thei a ni. Bile ducts a block chuan thisenah enzyme thenkhat (`liver enzymes`) level a sang chho ang.
• Tumor marker test: Cancer a awm laia thisena thil engemaw zat (tumor marker) pung zat tehna test. `CA 19-9` leh `CEA` te hi he cancer chi hrang hrangah hian a pung thei tih hriattirna pahnih a ni.

Imaging Test te pawh a awm

• Abdominal ultrasound scan hi tih hmasak a ni tlangpui.
• Tin, CT scan emaw MRI scan emaw pawh tih theih a ni bawk. Magnetic resonance cholangiopancreatography (MRCP) hi MRI chi khat bik a ni a, bile duct system chiang takin a hmu thei a ni.

Endoscopic hmanga test neih a ni

Hei hian i hmui atanga camera dahna tube te tak te, flexible tak (endoscope) dah a, i pum chhungah leh i intestine te tak te chhungah pass a, chutah chuan bile duct a inhawng a, chu hmun chu uluk taka enfiah a ni. Hetiang tih lai hian sedated i ni ang a, chuvangin engmah hrehawmna i nei lovang. Endoscopic retrograde cholangiopancreatography (ERCP) hi test hman tlanglawn tak a ni.

Biopsy tih a ni

Hetah hian rinhlelhna hmun atang hian tissue te tak te tak te chu lakchhuah a ni a, microscope hmangin an enfiah thin. He tissue piece hi ERCP procedure neih chhung hian hmuh theih a ni. He tissue sample hi cancer cell-a genetic change (biomarkers) awm leh awm loh pawh test theih a ni. Hei hian mi thenkhat chu "targeted therapy" bik pek theih an nih leh nih loh hriat nan a pui thei bawk.

Cancer hi eng stage leh enkawl dan nge ni?

Natna hi kan hriat chian veleh kan taksaah eng chen nge a darh tawh tih hriat nan cancer stage kan ruat a. Hei hi enkawl dan tur ruahmanna siam nan a pawimawh hle. Stage 0 atanga 4-ah then a ni tlangpui a, Stage 4 tih awmzia chu cancer chu bile duct kaltlangin taksa hmun hla tak takah a darh (metastatic) tihna a ni.

Enkawl dan tur chu cancer awmna hmun, a stage leh damlo hriselna zawng zawng a zirin a innghat a ni.

• Surgery: Cancer a darh loh chuan surgery hi cancer leh a chhehvel tissue te chu a taka paih chhuah theihna tur enkawlna tha ber a ni. A châng chuan operation hmangin bile duct block tawh chu a inhawng reng theih nan stent dah a ni bawk.
• Liver transplant: Liver transplant hi a tir lama perihilar cancer thenkhat tan chuan tihdam theihna chance tha tak a ni.
• Radiation therapy: Cancer cell tihchhiat emaw, tumor tihtlem emaw nan high-energy rays a hmang.
• Chemotherapy: Taksa hnena cancer cell thattu damdawi pek.
• Targeted therapy: Hei hian cancer cell te tihpun leh an hnathawh titawp thei protein bik target tu damdawi pek a ni.
• Immunotherapy: Kan taksa ngeia immune system tichaktu leh cancer cells dona atana pui thei damdawi pek.

He natna laka inven dan tur a awm em?

He cancer hi 100% in ven theih a ni lo. Mahse, kan liver leh bile duct te hrisel taka vawn reng hian a hlauhawmna chu kan ti tlem thei a ni.

• Hepatitis B, Hepatitis C, leh HIV ang chi virus lakah inveng rawh (e.g., Hepatitis B vaccine la la, himna dan zawm rawh)
• Zu in tam lutuk hi pumpelh tur a ni.
• Taksa rihna hrisel tak vawng reng rawh.
• Meizial zuk loh vek tur a ni.

Cholangiocarcinoma hi natna khirh tak a ni tih hi a dik a ni. Amaherawhchu, a hriat chian a, a awm a nih chuan a hlauhawmna hriat chian a, natna lan chhuah dan danglam tak a lo lan veleh Doctor kan hmuh hian he natna do turin chakna nasa tak min pe a ni. I doctor chu thurawn leh enkawlna tha ber pe theitu che a ni.