Cancer hmuh tur awm lo Chordoma tih hi i hre tawh em? Kan sawi dawn nia!

He hming "chordoma" hi i la hre ngai lo mai thei. Chu chu mak a ti lo, a chhan chu hei hi cancer chi khat, a tlem hle a ni. Amaherawhchu, a tlem hle nachungin, hei hi hriat chian a pawimawh hle. A chhan chu, he tumor chi hi kan ruhroah emaw, luruh bul lamah emaw a awm thei a ni. Chuvangin vawiin hian he chordoma hi eng nge a nih, engtin nge a lo awm tih, a symptoms te, eng treatment nge tih te hi chipchiar tak leh awlsam takin sawi ila.

Chordoma chu eng nge ni? A awlsam zawngin i zawng chhuak ang u!

A awlsam zawngin, chordoma chu ruh chhunga cancer natna lo awm a ni . I ruhroah emaw, i luruh bul emaw, i kawr chunglam leh i thluak hnuai lam ruhteah a lo thang lian ber. Doctor-te chuan cancer chi khat sarcoma an tih angin an dah a. Sarcoma hi ruh leh soft tissue (connective tissue)-a cancer lo awm tihna a ni.

Chordoma hi a lo thang zawi zawi tlangpui . Mahse, buaina chu kan nervous system, chu chu thluak leh ruhro hnaih takah an awm avangin enkawl a harsa deuh thei a, an chhehvela tissue nalh tak takte chu an rawn lut a ni.

Thil dang chu enkawl hnuah pawh heng tumor te hi a lo awm leh theihna chance a sang hle . A tam zawkah chuan hei hi a bul tanna tumor awmna hmunah a thleng thin. Tin, 30% atanga 40% velah chuan chordoma cancer cell hi taksa peng dangah a darh thei bawk. Doctor-te chuan hei hi ``metastasizing'' an ti.

Khawiah nge Chordoma hi taksa peng dangah a darh theih?

Chordoma metastasis, chu chu taksa peng dangah a darh chuan a darh theihna hmun tam ber chu:

• I lungphu chu
• Tumor bulah hian lymph nodes a awm
• Ruh dang
• Thin
• Vun

Khawiah nge chordoma hi a lo awm theih?

Chordoma hi i ruhro hmun apiangah a awm thei a, mahse hmun tam tak pathum a awm a:

1. The sacrum: Hei hi i hnute inkar ruh pathum (triangular bone) a ni. Hetah hian chordoma 35% vel a lo awm thin.

2. Skull base: A bik takin i luruh bul, i thluak thlawptu ruhteah. Hengte hi ``Clival chordomas'' an ti bawk a, a chhan chu hetah hian awm ``Clivus'' ruh-ah an lo awm tam ber a ni. Hetiang chi hi chordoma zawng zawng zinga 35% vel a ni bawk.

3. In the moving vertebrae of the spine (`vertebrae`): Chu chu i kawr, i rilru leh i hnungzang a vertebrae te a ni. Chordomas hi heng zinga 30% vel ah hian a awm thin. Cervical vertebra pahnihnaah an tam ber. Tin, hnungzang hnuai lam (lumbar spine) leh rilru (thoracic spine)-a vertebrae-ah te pawh an awm thei bawk.

Chordoma chi hrang hrangte chu engte nge ni?

World Health Organisation (WHO) chuan chordoma hi chi thum ah a then a. Heng classification te hi cancer cell te hi microscope (`histology`) hmanga an lan dan atanga siam a ni.

1. Classic/conventional chordoma: Hei hi a tam ber (chordoma zawng zawng zinga 80% atanga 90%) a ni. Hetiang chi cell te hi cell chi khat bik, "bubble" deuha lang an ni. Chondroid chordoma hi hetiang chi dang a ni bawk. Chordoma zawng zawng zinga 5% leh 15% inkar a ni. Chondroid chordoma hi luruh bul lamah a lo awm tam ber.

2. Dedifferentiated chordoma: Hei hi chi khat (5% aia tlem) a ni. Cell inzawmkhawm dan pangngai lo tak a ni. Hetiang chi hi chi dang aiin a thang chak zawk a, a na zawk a, taksa peng dangah pawh a metastasize duh zawk bawk .

3. Poorly differentiated chordoma: Hei pawh hi a tlem hle bawk . Tun thlengin medical record-ah damlo 60 aia tlem lo record an ni. Hetiang chi thil danglam bik chu `(SMARCB1)` emaw `(INI1)` emaw an tih gene chu inactivated (deletion) a ni. Hetiang chordoma hi naupang leh thalai zingah hmuh tur a tam ber.

Tute nge chordoma vei tam ber?

Chordoma hi kum eng pawhah, tu pawhah a awm thei. Mahse, puitling kum 50 leh 80 inkarah a tam ber a, naupangte hi mi tlemte chauhin an vei a, chu chu mi zawng zawng zinga 5% vel a ni.

Hmeichhia aiin mipa hian a let 1.5 velin chordoma an vei tam zawk tih hmuhchhuah a ni bawk.

Hei hi engtiang chiahin nge a hluar?

Chordoma hi cancer a awm lo hle a ni . Kum tin mi maktaduai khat zinga pakhat velin a nghawng a ni. Chumi awmzia chu, entirnan, United States-ah chuan kum tin mi 300 vel chauh hri kai thar hmuhchhuah an ni tihna a ni.

Chordomas hian primary bone tumor zawng zawng 1% leh 4% inkar a huam a ni.

Chordoma natna lan chhuah dan chu engte nge ni?

Chordoma a lo lian zel chuan a chhehvela spinal cord emaw thluak emaw chu pressure a siam thei a ni. He pressure hian symptoms a siam thin . Tin, ruh chhunga tumor awmna hmun a zirin symptoms pawh a inang lo thei bawk.

Chordoma natna lan chhuah dan tlangpui chu hnungzang, kut, emaw ke ruh natna, chak lohna, leh/ emaw, rilru hahna te hi a ni .

Skull base chordoma awm dan hrang hrang:

I lu ruh bul, i thluak hnuaia awm, chordoma i neih chuan:

• Mit pahnih hmuh theihna (Diplopia) .
• Mit hmuh a fiah lo
• Lu na
• Hmai hring emaw, na emaw

Tailbone/sacrum-a chordoma awm dan: 1.1.

I ruhro hnuai ber, sacrum bulah chordoma i neih chuan:

• Vun atanga lo chhuak lump emaw bump emaw
• Zun emaw, ek chhuah emaw harsatna (bladder emaw bowel dysfunction) .
• A hnungzang hnuai lam emaw, hnute lam emaw a na

Hriat reng tur chu, a chang chuan heng symptoms te hi damdawi lam natna tlanglawn dang nen pawh a inthlau thei hle. Chuvangin, natna lan chhuahna awm reng, danglam tak i neih chuan damdawi lam thurawn lak a pawimawh hle.

Engvangin nge Chordoma hi a lo awm? A chhante chu engte nge ni?

Researcher-te chuan chordoma thlentu hi eng nge ni tih chiang takin an la hre lo a , mahse TBXT an tih gene-a mutations hi a inrawlh niin an ngai.

Chhungkaw eng emaw zat chu chordoma vei nia hriat a ni. An test-naah chuan `(TBXT)` gene duplication an rochun tih hmuhchhuah a ni. Tin, ‘(TBXT)` gene inthlak danglamna chu chordoma vei mahse chhungkaw zingah tumah he natna nei lote zingah hmuhchhuah a ni bawk.

Chordoma hi ``notochord`` an tih structure-a cell atanga lo piang a ni.He ``notochord`` hi embryo a lo thanglian dawna a ruhro (spinal cord) lo thanglian zelna atana pawimawh tak a ni. A tlangpuiin he ``notochord`` hi naupai kar riat vel ah a bo thin. Mahse, mi tlemte takah chuan heng ``notochord`` cell thenkhat hi ruhro ruh emaw, luruh bul emaw ah an awm reng thei.

Chuvangin, tuna kan ngaihdan chu a hmaa kan sawi tawh `(TBXT)` gene-ah hian inthlak danglamna a awm chuan heng `(notochord)` cell la awmte hi a pangngai lo takin an lo thang lian tan thei a, chordoma an siam thei a ni.

Tin, ``Tuberous sclerosis`` tih hming pu genetic condition nei te chu chordoma vei theihna a sang hle bawk. He ``Tuberous sclerosis`` natna hian epilepsy a thlen thei a, hmasawnna a tikhawtlai thei a, taksa hmun hrang hrangah tumor a siam thei bawk. Hei hi gene pahnih ``TSC1`` leh ``TSC2`` tih te mutations avanga lo awm a ni.

Engtin nge chordoma chu kan hriat theih ang?

Chordoma symptoms i neih chuan doctor chuan i symptoms leh medical history a zawt hmasa ang. Tichuan physical exam leh neurological exam an nei ang.

Doctor chuan tumor a rinhlelh chuan X-ray, computed tomography (CT) scan, MRI scan ang chi imaging test a ti ang. He MRI scan hian chordoma hriatchhuahna kawngah a pui fo thin.

Tichuan, i doctor chuan ruh cancer specialist hnenah i natna hmuhchhuah chu nemnghet turin a refer ang che a, ngaihdan pahnihna a la ang che. Chordoma awmna dik tak hriat tumin imaging test dang an ti leh thei bawk a, taksa hmun dangah a darh tawh em tih an enfiah thei bawk a, test dang pawh an ti thei bawk.

Mahse, chordoma hi chiang taka hriat theihna awmchhun chu biopsy neih hi a ni . Hei hian lump sample tlemte lak a, a tlangpuiin needle biopsy hmanga microscope hmanga enfiah a huam a ni. Chutiang a nih chauh chuan specialist chuan chordoma a nih leh nih loh a hre chiang thei ang.

Chordoma hi eng enkawlna nge ni?

Chordoma enkawlna ber leh tha ber chu operation hmanga tumor pumpui lakchhuah hi a ni . Doctor-te chuan hei hi ``En bloc resection.`` tiin an sawi a, hetianga tumor hi lakchhuah vek a nih chuan damlo chu rei tak dam theihna chance tha ber a ni.

Mahse, tumor awmna hmun a zirin hei hi tih harsa tak a ni thei. A bik takin, luruh bul lama awm chordomas te hi paih vek theih a ni lo fo thin.

A chhan chu ruhroa chordoma awm hian i ruhro leh a chhehvela nerve leh thisen kalna kawng pawimawh tak takte a tichhe thei a ni. Hei hi zai laia a chhiat chuan hun rei tak chhung chak lohna emaw, thihna emaw pawh a thlen thei a ni. Tin, luruh bul lama chordoma awm chu thluak bul, cranial nerve leh spinal cord nena inhnaih em em avangin paih vek a harsa hle bawk. Neurosurgeon te chuan tumor hi a tam thei ang ber paih chhuah an tum a, chutih rualin a him thei ang bera an awm bawk.

Chordoma hian radiation therapy emaw chemotherapy emaw primary treatment atan an dawng tha lo tlangpui. Mahse, operation hnuah chuan i medical team chuan tumor chu a lo let leh tawh loh nan radiation therapy an rawt mai thei.

Tunah hian zirchiangtute chuan chordoma enkawlna thar, targeted therapy leh immunotherapy te an zirchiang mek a ni. Clinical trial i tel theihna tur pawh a awm thei.

Chordoma hi ven theih a ni em?

Dik tak chuan chordoma lo awm lo turin engmah tih theih a awm lo . A tam zawkah chuan random takin an lo thanglian thin.

Mahse, i chhungkuaa mi pakhatin Chordoma a vei tawh a nih chuan, emaw, ``Tuberous sclerosis'' tih natna i neih chuan, doctor hnenah checkup neih fo a pawimawh. Chumi hnuah chuan Chordoma chhinchhiahna i neih leh neih loh an enfiah thei ang che. Hei hi hriat chian a nih hma chuan enkawlna a hlawhtlin theihna a sang zawk.

Chordoma atanga dam leh theihna chance engzat nge awm? (Prognosis) tih a ni.

Chordoma prognosis, a nih loh leh outlook chu thil engemaw zatah a innghat a ni:

• Tumor awmna hmun leh engzat nge surgery hmanga lak chhuah theih: Tumor hi lak chhuah vek theih a nih chuan a dam leh theihna chance a sang hle. Surgery tel lova enkawlna dang chauh hman a nih chuan chance a tlem hle.
• Cancer hi taksa peng dangah a darh tawh em (metastasized): Hmun hla takah a darh tawh a nih chuan damchhuahna a tlahniam thei.
• I kum hriat chhuah hun: A tlangpuiin kum 60 chunglam tan damchhuahna hi a hniam deuh hlek a ni.
• Tumor hi dedifferentiated emaw ni lo emaw: ``Poorly differentiated chordoma`` ang chi chi hrang hrangte hian ``conventional chordoma`` aiin prognosis an nei chhe zawk.

I medical team te hian i dinhmun a zirin i beisei tur dik ber an pe thei che a, chuvangin zawhna zawh pawh hlau suh.

Hei hi thihna thlentu a ni thei ang em?

Ni e, chordoma hian thihna a thlen thei. A tam zawkah chuan thihna hi tumor a lo awm leh hnuah a thleng a, i spinal cord, thluak emaw thluak stem-a tissue te chu a tichhia a ni.

Chordoma vei 357 te zirchiannaah chuan damchhuah zat chu hetiang hi a ni:

• Kum thum hnuah: 80.5%
• Kum nga hnuah: 68.4%
• Kum sawm hnuah: 39.2%

Mahse, hengte hi averages chauh a ni tih hre reng ang che. I medical team chuan i dinhmun bik a zirin damchhuah zat chungchang chipchiar zawkin an pe thei ang.

Chordoma Cancer nge Normal Tumor a ni em?

Chordoma hi malignant (cancerous) a ni ngei ang. A subtype pakhat mah hi noncancerous anga ngaih a ni lo.

Engtikah nge Doctor ka hmuh ang?

Chordoma hi enkawl hnuah pawh a lo lang leh thei a , kum tam tak hnuah pawh a lo lang leh thei bawk. Chuvangin, hun rei tak chhung i medical team te nen follow-up neih a pawimawh hle.

Symptom thar i neih chuan, emaw, i symptoms awmsa chu a na zual a nih chuan , i doctor nen inbiakna neihpui ngei ang che.

A tawp berah chuan hriat reng tur tlemte (Take-Home Message) .

Ruh cancer hmuh tur awm lo tak i neih thu i hriat chuan hlauhna leh stress i neih hi thil pangngai a ni. Chordoma hi cancer a ni a, a awmna hmun avang hian enkawl harsa tak a ni.

Mahse, i medical team chuan i duh ang anga enkawlna ruahmanna chipchiar tak an siam ang a, i chordoma enkawl nan leh i nunphung tihchangtlun nan a pui ang che tih ring rawh

• A natna lan chhuah dan hriat hmasak a pawimawh: natna awm reng, rilru hahna, emaw mit hmuhna inthlak danglam emaw i neih chuan damdawi lam thurawn zawng rawh.
• Mithiam doctor thurawn zawng rawh: Chordoma hi natna hlauhawm tak a nih avangin damdawi lam team tawnhriat ngah tak atanga enkawlna lak a pawimawh hle.
• Enkawlna hnuah pawh check-up neih fo a ngai: Natna lo awm leh theihna a awm avangin doctor-te thupek angin check-up-ah tel ve rawh.

He thu hi i tanpui theih ka beisei. Zawhna i neih chuan doctor zawh hreh suh.

` Chordoma, cancer, ruh cancer, ruhro, luruh, sacrum, clivus