Parkinson natna chungchanga hriat tur thilte!

Kum upat ruala natna lo thlengte hi i ngaihtuah fo thin em? Chutiang natna pakhat chu Parkinson natna a ni. I hre tawh mai thei. Thil pawi tak ni mah se, hriatthiamna dik tak neih a pawimawh hle. Chuvangin vawiinah hian Parkinson natna hi eng nge a nih, engtin nge a lo awm, a lan chhuah dan te, a enkawl dan tur a awm em tih te i sawi dawn nia.

Parkinson natna hi eng nge ni? A awlsam zawngin...

A awlsam zawngin sawi ila, Parkinson natna hi i thluak hmun thenkhat chu zawi zawiin a chak lo va, hun kal zelah a symptoms a zual zel thin. Mi tam zawk chuan he natna hi an hriat chhan chu taksa ruh control, kal, balance, leh che vel a nghawng vang a ni. Mahse thil dang tam tak a nghawng thei bawk a, chung zingah chuan i hriatna te, i ngaihtuahna te, leh i rilru hriselna te pawh a tel. Machine tar ang maiin i thluak hmun thenkhat chu a thawk tha tawh lo.

He natna hian tute nge a tuar ber?

Kum upat deuh deuh hian Parkinson natna vei theihna a sang chho zel a ni. He natna vei tan kum zat chu kum 60 vel a ni. Hmeichhia aiin mipaah ​​a tam deuh niin a lang bawk.

Mahse, kum nena inzawm fo mah se, a chang chuan puitling naupang, kum 20 hnuai lam te zingah a lo awm thei a ni. Mahse, a tlem hle. Tlangval pakhatin a vei chuan chu mi nu leh pa emaw, a unaupa emaw, a farnu emaw, a fa emaw pawhin he natna hi a vei a rinawm.

Parkinson natna hi engtiang chiahin nge a hluar?

Parkinson natna hi a takah chuan i ngaihtuah aiin natna tlanglawn zawk a ni. Kum upat ruala thluaka neurodegenerative disease awm tam ber pahnihna a ni. Motor thluak natna awm tam ber a ni bawk. Mithiamte chuan khawvel pumah kum 60 chunglam zinga 1% tal chuan he natna hi an vei niin an chhut.

He natna hian engtin nge i taksa a nghawng?

Parkinson natna hian i thluak hmun bik , basal ganglia an tih chu a tichak lo zauh zauh thin. He hmun hi a chak lo deuh deuh chuan thunun theihna i hloh zauh zauh thin. Zirchiangtute chuan Parkinson natna hian i thluak chemistry-ah danglamna lian tak a thlen tih an hmuchhuak a.

A tlangpuiin i thluak hian thluak cell (neurons) te inbiak dan tur control nan neurotransmitters an tih chemical a hmang thin. Parkinson natna i neih hian i thluak hian heng neurotransmitters zinga pakhat, chemical pawimawh tak dopamine tih hi a nei tlem hle.

I thluak hian i taksa ruhte chu che turin signal a thawn hian, chu chetna chu dopamine mamawh cell hmangin a ti tha hle a ni. Dopamine a tlem chuan Parkinson natna lan chhuahna ber chu che zawi leh khur hi a ni.

Parkinson natna a zual zel chuan a natna lan chhuah dan chu a darh zau zel a, a na zual zel bawk. Natna hnuhnung zawkah chuan thluak hnathawh a nghawng bawk a, chu chuan dementia ang chi symptoms leh depression ang chi condition te a thlen thin.A thleng thei.

Parkinson natna leh Parkinsonism hi eng nge an danglamna?

"Parkinsonism" tih hi thumal tlangpui a ni a, Parkinson natna leh natna dang engemaw zat, a lan chhuah dan inang lo tak takte pawh a huam tel a ni. Chu chu, he thumal hi Parkinson natna tan chauh ni lovin, Multiple System Atrophy emaw Corticobasal Degeneration emaw ang chi natna dang tan pawh hman theih a ni tihna a ni. A awlsam zawngin, Parkinsonism hi umbrella lian tak ang a ni a, Parkinson natna hi chu umbrella hnuaia awm pakhat chauh a ni.

Parkinson natna lan chhuah dan chu engte nge ni?

Parkinson natna lan chhuah dan hriat lar ber berte chu taksa ruh (muscle control) chak lohna nena inzawm te hi a ni. Mahse, tunah chuan mithiamte chuan taksa ruh (muscle control) lama harsatna awm chu natna lan chhuahna awmchhun a ni lo tih an hre ta.

Motor nena inzawm natna lan chhuah dan

Chungte chu motor symptoms an ti a, chu chu chetna nena inzawm tihna a ni.

• Slowness of movement (Bradykinesia): Hei hi Parkinson natna hriat theihna atana symptom neih ngei ngei tur a ni. Hetiang natna vei te hian an taksa ruhte chu chak lo angin an sawi mai thei a, mahse a takah chuan taksa ruh control lama harsatna a ni a, chakna hloh vang a ni lo. I ke leh ke te a tang ang mai a ni a, zawi zawiin hna i thawh a ngai a ni.
• Resting tremor: Hei hi rhythmic tremor a ni a, taksa ruh hman loh lai pawhin a awm thin. Parkinson’s vei zinga 80% vel ah a awm thin. Hei hi essential tremor an tih condition nen a danglam a ni . Essential tremor-ah chuan taksa ruhte hi chawlh laiin an khur lo tlangpui.
• Muscle rigidity emaw stiffness: Lead-pipe rigidity leh cogwheel rigidity hi Parkinson natna lan chhuah dan tlangpui a ni. Lead-pipe rigidity hi taksa peng pakhat a inthlak a, a nghet lo, a danglam ngai lo. Cogwheel rigidity hi tremor leh lead-pipe rigidity te inzawmkhawm hian a awm thin. A hming hi a chhan chu a chetnate chu a jerky leh stop ang maia a lan vang a ni (clock hlui chunga seconds hand ang maiin ngaihtuah rawh).
• Unstable posture emaw walking gait: Incheina slow leh stiffness, chu chuan stooped, stooped posture a thlen thin. Hei hi natna a zual zel angin a lang chhuak tlangpui. Hei hi mi a kal hian a hriat theih a, ke pen te tak te hmanga kal a nih avangin leh a kut a vawrh vak loh avangin. Tin, an inher dawnin step engemaw zat an zawh a ngai bawk.

Movement dang nena inzawm symptom dang pawh a awm thei bawk:

• Mit mit khap tamna tlahniam: Hei hi hmai ruh control tlahniam chhinchhiahna a ni bawk.
• Kutziak te tak te, scrunched-up (Micrographia): Hei hi taksa ruh control lama harsatna avanga lo awm a ni.
• Drooling: Hei hi hmai ruh control hloh vang a ni bawk.
• Hypomimia: Hei hian hmêl lan dan a danglam tlem hle tihna a ni a, a nih loh leh a danglam ngai lo tihna a ni.
• Chaw ei harsa (Dysphagia): Hei hi kawr chhunga thau (muscles) chunga thununna hloh vang a ni. Hei hian pneumonia emaw choking emaw ang chi harsatna a thlen theihna a tipung a ni.
• Abnormally low speaking voice (Hypophonia): Hei hi kawr leh rilru chhunga thau control tlahniam vang a ni.

Motor lam ni lo symptoms a awm

Tin, chetna leh taksa ruh control nena inzawm lo symptom engemaw zat a awm bawk. Tun hma chuan mithiamte chuan heng non-movement symptoms te hi movement-related symptoms hmaa lo lang a nih chuan natna thlen theihna tur risk factor niin an ngai thin. Mahse, tunah chuan heng symptoms te hi natna bul tan tirh lamah pawh a lang thei tih finfiahna a pung zel a ni. Chumi awmzia chu heng symptoms te hi kum tam tak, kum sawm tam tak pawh nise, movement-related symptoms hmaa vaukhânna chhinchhiahna a ni thei tihna a ni.

Incheina nena inzawm lo symptoms (chu chu early warning sign a ni thei a, bold-in tarlan a ni ):

• Autonomic nervous system symptoms: Chung zingah chuan orthostatic hypotension , constipation leh gastrointestinal problems, urinary incontinence, leh sexual dysfunction te a tel.
• Lungngaihna.
• Hriak hriatna hloh (anosmia).
• Mut lama harsatna: Entirnan , periodic limb movement disorder (PLMD) , rapid eye movement (REM) behavior disorder, leh restless legs syndrome te hi a ni.
• Ngaihtuahna leh ngaihtuahna seng harsa (Parkinson’s-related dementia).

Parkinson natna hi stage hrang hrang a awm em?

Parkinson natna hian natna lan chhuahna na tak a thlen theih nan kum tam tak, kum sawm tam tak pawh a ngai thei. Kum 1967 khan specialist pahnih Margaret Horn leh Melvin Yar te chuan Parkinson natna chi hrang hrang classification system an siam a. Mahse, chu classification system chu hman a ni tawh lo. Natna chi hrang hrang thliar hran ai chuan, natnain mi tinte a nghawng dan hriat chian a, chumi ang zela enkawl chu a \angkai zawk.

Tunah hian Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) hi doctor-te’n natna chi hrang hrang an thliar hrang dan ber a ni. MDS-UPDRS hian Parkinson natnain a nghawng dan chi hrang hrang pali a teh a:

• Part 1: Nitin nunah thil tawn hrang hrang, non-movement aspects.He section hian rilru hriselna leh rilru lama theihna nena inzawm symptoms, dementia, depression, leh anxiety te, chetna nena inzawm lote a en a ni. Tin, natna, chaw ei kham, zun insum theih lohna, leh hahna ang chi thilte zawhna a zawt bawk.
• Part 2: Nitin nun tawn hrang hranga chetna nena inzawm thil. He part hian movement nena inzawm hna leh theihna a nghawng dan a en a ni. Hei hian thusawi thiamna te, ei dan te, ei dan te, i ei dan te, i inchei theih leh theih loh, i inbual theih leh theih loh, leh khur i neih leh neih loh te a huam a ni.
• Part 3: Incheina test. Doctor chuan he part hi Parkinson natnain chetna nena inzawm nghawng a neih dan hriat nan a hmang thin. Heng test te hian i thusawi, i hmel lan dan, i rilru khauh lutuk, i kal dan leh i tlan chak dan, i balance dan, i che chak dan leh i khur dan te a teh thin.
• Part 4: Incheina lama harsatna awm. He hmun hi i doctor-in i Parkinson natnain i nun a nghawng dan a hriatna hmun a ni. Hei hian ni khata symptom thenkhat i neih hun chhung leh i hun hman dan a nghawng em tih te a huam a ni.

Eng thilin nge he natna hi a thlen?

Parkinson natna thlen thei tur risk factor engemaw zat hmuhchhuah ni mah se (entir nan, pesticides nena inzawmna), a chhan finfiah awmchhun chu genetic influences a ni. Parkinson natna hi genetic a nih loh chuan mithiamte chuan "idiopathic" tiin an classified. Chumi awmzia chu a lo thanlen chhan chiah an hre lo tihna a ni.

A tam zawkah chuan Parkinson natna thlen chhan chiang tak hmuh a harsa a, mahse zirchianna erawh a la kal zel a ni.

Chhungkaw Parkinson natna

Parkinson natna hi chhungkaw hrang hrangah a kal thei a ni. Chumi awmzia chu i nu leh pa pakhat emaw, pahnih emaw hnen atangin i rochun thei tihna a ni. Mahse, hei hi case zawng zawng zinga 10% vel chauh a ni. Mithiamte chuan Parkinson natna nena inzawm gene pasarih tal an hmuchhuak tawh a ni.

Idiopathic Parkinson natna a ni

Mithiamte chuan Parkinson’s disease, a chhan hriat loh hi i taksain protein alpha-synuclein tih a hman danah harsatna a awm niin an ngai. Protein hi chemical molecule a ni a, a pianzia bik tak a nei a. Protein thenkhatin an pianzia dik tak an hloh chuan – hei hi protein misfolding an ti a – i taksa chuan a hmang thei lo va, a ti chhe thei lo bawk.

Khawiah mah kalna tur a awm loh avangin heng protein te hi hmun hrang hrangah emaw, cell thenkhatah emaw an pung khawm a (heng protein te hi an inzawm khawm a, Lewy body an tih aggregate an siam thin ). Heng Lewy taksa pungkhawm hian cell-ah toxic effect a siam a, a tichhia bawk. Hetianga heng protein-te hi a fold dik loh hi natna engemaw zatah hmuh a ni a, chu chu Alzheimer natna leh Huntington natna te hi a ni .

Parkinsonism natna thlentu a ni

Parkinsonism nena inzawm nia sawi condition emaw cause thenkhat a awm. Hengte hi Parkinson natna nen inang lo mah se, a lan chhuah dan inang an nei a, chuvangin doctor-te chuan Parkinson natna an hriatchhuah hunah heng chhante hi an ngaihtuah thin.

• Damdawi: Damdawi thenkhat hian Parkinson’s ang chi a thlen thei. Heng nghawngte hi damdawi ei tihtawp a nih chuan rei lo te chhung atan a ni fo thin.
• Encephalitis: Thluak hring, encephalitis tia hriat bawk hian a chang chuan Parkinsonism a thlen thei.
• Toxins: Manganese dust, carbon monoxide, welding fumes, leh pesticides thenkhat ang chi thila inhnimhnawihna hian Parkinson natna a thlen thei bawk.
• Traumatic brain injury: Boxing, football, leh hockey ang chi infiamna avanga lu hliam nawn fo hian thluak a tichhe thei a ni. Hei hi "post-traumatic parkinsonism" an ti a.

Hei hi natna hrik kai theih a ni em?

Ni lo, Parkinson natna hi kai theih a ni lo. Midang hnen atangin i man thei lo.

Engtin nge natna hi kan hriat theih ang?

Parkinson natna hriatchhuah hi clinical process a ni fo thin. Chumi awmzia chu doctor chuan i natna lan chhuah dan enfiahin, zawhna zawtin, leh i damdawi lam chanchin enfiahin diagnosis a siam fo ang tihna a ni. Diagnostic leh laboratory test thenkhat chu tih theih a ni a, mahse a tlangpuiin natna dang emaw, a chhan dang emaw hriat loh nan a ngai thin.

Parkinson natna enkawlna i chhan loh chuan lab test tam tak i mamawh lo mai thei. I chhân lêt loh chuan, chu chuan dinhmun dang i nei tih a târ lang thei a ni.

Natna hriat theih nan eng test nge hman thin?

Doctor-te chuan Parkinson natna an rinhlelh emaw, natna dang an paih chhuah a ngai emaw chuan imaging leh diagnostic test hrang hrang an ti thei a ni. Chung zinga ṭhenkhat chu:

• Thisen test (hengte hian Parkinson’s chi dang a awm loh nan a pui thin).
• Computer tomography (CT) hmanga enfiah a ni.
• Genetic testing neih a ni.
• Magnetic resonance imaging (MRI) hmanga enfiah a ni.
• Positron emission tomography (PET) hmanga tihchhuah a ni.

Laboratory test thar a awm bawk.

Zirchiangtute chuan Parkinson natna chhinchhiahna thenkhat hmuhchhuah dan tur an hmuchhuak a. Heng test thar pahnihte hi protein alpha-synuclein nen an inzawm a, mahse kawng thar, danglam takin an test a ni.

• Spinal tap/lumbar puncture: He test hian thluak leh ruhro vel cerebrospinal fluid-a alpha-synuclein proteins fold dik lo awmte a zawng thin.
• Vun biopsy hmanga tihchhuah: 1.1.Test dang pakhat chu i vun chunglam atanga nerve tissue (biopsy) sample lak a ni. Hei hian alpha-synuclein protein-a chhiatna i neih leh neih loh a enfiah thei a, chu chuan Parkinson natna vei theihna a tipung a ni.

Engtin nge enkawl a nih? A dam kim thei ang em?

Tunah hian Parkinson natna hi a dam kim thei lo. Mahse, a natna lan chhuah dan thunun dan tur tam tak a awm. Mi hrang hrangah enkawl dan a inang lo thei a, an natna lan chhuah dan leh enkawlna a thawh that dan azirin a inang lo thei. Damdawi hi he natna enkawl dan ber a ni.

Enkawlna pahnihna chu i thluak hmun khatah electrical current nem tak pe thei tur hmanrua (hei hi Deep Brain Stimulation an ti) implant turin operation tih hi a ni. Research-based option thenkhat pawh a awm a, stem cell hmanga enkawlna te pawh a awm a, mahse mi zawng zawng tan a awm lo.

Eng damdawi leh enkawl dan nge hman?

Parkinson natna damdawi hmanga enkawlna hi chi hnih ah then a ni a, chungte chu direct treatment leh symptomatic treatment te an ni. Direct treatment hian Parkinson natna ngei pawh hi a target a ni. Symptomatic treatment hian natnain a nghawng thenkhat chauh a enkawl a ni.

Damdawi chi hrang hrang

Parkinson natna enkawltu damdawi te hian kawng hrang hrangin hna an thawk a.

• Dopamine supplementation: Levodopa ang damdawi hian i thluaka dopamine a tipung thei a. He damdawi hi a hlawk ber mai. A thawk lo a nih chuan Parkinson natna dang chhinchhiahna a ni tlangpui a, Parkinson natna a ni lo. Levodopa hi rei tak hman a nih chuan side effect a nei thei a, a thatna pawh a tlahniam thei bawk.
• Dopamine ang chi hnathawh: Dopamine agonists hi damdawi dopamine ang chiaha nghawng nei damdawi a ni. Levodopa tan hun tikhawtlai turin damlo naupangte hnenah pek an ni fo.
• Dopamine inhibitors: I taksa hian natural process a nei a, chu chuan dopamine ang chi neurotransmitters a tichhia a ni. Hetiang breakdown titawp thei damdawi hian thluaka dopamine tam zawk a awm theih nan a pui thei a ni.
• Levodopa inhibitors: Heng damdawi te hian i taksain Levodopa a process dan a ti hniam a, rei zawk a thawk thei a ni.
• Adenosine blocking drugs: Cell thenkhatin adenosine an hman dan tikhawlo thei damdawi hi levodopa nena pek a nih chuan additive effect a nei thei a ni.

Parkinson natna lanchhuahna bik enkawlna damdawi engemaw zat a awm bawk. Entir nan:

• Mipat hmeichhiatna hmansualna.
• Chauhna emaw, mutthilh emaw.
• Ek khal.
• Mut harsatna a awm.
• Lungngaihna.
• Dementia natna (dementia) a awm.
• Hlauhthawnna.
• Hallucinations leh psychotic symptom dangte pawh a awm thei.

Thluak thuk tak tihchakna

Tun hma chuan Parkinson natna avanga thluak hnathawh that lohna hmun chu tumruh taka tihchhiat leh hliam tuar surgery a awm thin. Tûn laiah pawh hetiang bawk hian Deep Brain Stimulation hmang hian a awm thei a ni. Chutah chuan taksaa dah hmanrua pakhat chuan thluak hmun hrang hrangah electric current nem tak a pe chhuak a ni.

Hei hi a thatna lian ber chu Deep Brain Stimulation hi reversible a ni. Mahse, tumruh taka hliam (intentional scarring) chu tihdanglam theih a ni lo.

Experimental hmanga enkawlna te

Researcher-te chuan Parkinson natna tidam thei tur enkawlna dang an zirchiang mek a, chung zingah chuan stem cell transplant , neuron-repair treatment , leh gene therapies te pawh a tel.

Ka in enkawl loh chuan engtin nge ka symptoms te hi ka enkawl theih ang?

Parkinson natna hi nangmah ngeiin i hriat chian theih loh natna a ni lo. Doctor nen inbiakna nei lovin i symptoms te hi enkawl tum suh.

Engtiang chiahin nge enkawl hnuah ka dam leh thuai ang?

Hei hi thil tam takah a innghat a, enkawl dan chi leh natna nasat danah te a innghat a ni. Hemi chungchangah hian i doctor hi a tha ber a ni.

He natna hi ka neih chuan eng nge ka beisei ang?

Parkinson natna hi a degenerative condition a ni. Chumi awmzia chu thluaka a nghawng chu hun kal zelah a na zual tihna a ni. Mahse, natna a zual zel theih nan hun a duh tlangpui. Mi tam zawk chuan he natna vei hian nun pangngaiin an hmang thei a ni.

A tir lamah chuan tanpuina i mamawh tlem thei a, mahni inrintawkna neiin i nung thei bawk. A nghawng a na zual zel chuan i natna lan chhuah dan control nan damdawi i mamawh mai thei. Damdawi tam tak, a bik takin Levodopa hi i natna lan chhuahna atana tha ber dose tlem ber i hmuh chuan eng emaw chen emaw, a hlawk hle emaw a ni.

Parkinson natna hi eng chen nge a awm?

Parkinson natna hi tihdam theih a nih loh avangin, dam chhung zawnga natna awm reng a ni.

Parkinson natna hi eng nge a nih?

Parkinson natna hian thihna a thlen lo. Mahse, a natna lan chhuah dan leh a nghawng dan chu a chang chuan thihna thlen thei a ni. Amaherawhchu, enkawlna lama hmasawnna a awm chhoh zel avangin he natna vei te dam rei zawng hi nasa takin a pung ta a ni.

Engtin nge he natna vei theihna hi ka tihziaawm theih ang emaw, ka ven theih ang?

Parkinson natna hi genetic factors vang emaw, beisei loh thil thleng vang emaw a ni. Chung zinga pakhat mah chu ven theih a ni lo va, a hlauhawmna pawh tihziaawm theih a ni lo. Agriculture emaw welding lama thawkte chu an hlauhawm zawk nia sawi ni mah se, mi zawng zawng hian Parkinson natna hi an vei vek lo.

Engtin nge ka in enkawl ang?

Parkinson natna i vei a nih chuan i tih tur tha ber chu i doctor-in a tih angin i in enkawl hi a ni.

• I damdawi ei tur chu a sawi angin ei rawh: I damdawi ei dik chuan Parkinson natna lan chhuahnaah danglamna nasa tak a thlen thei a ni.
• I doctor duh angin hmu rawh: Heng appointment te hi i dinhmun enkawl nan leh damdawi leh dose dik tak zawn nan a pawimawh hle.
• Symptoms ngaihthah suh: Parkinson natna hian symptoms chi hrang hrang a thlen thei. Chung zinga tam tak chu enkawl theih a ni.

Zawhna zawh fo thin thenkhat (FAQ) .

Engtin nge mi pakhatin Parkinson natna a neih theih?

Mithiamte chuan Parkinson natna tam zawk hi a chhan an hre lo. 10% vel chu genetic a ni. A bak 90% chu idiopathic an ni.

Parkinson natna vei theihna tur hriattirna hmasa berte chu engte nge ni?

A lan chhuah hmasak ber chu motor (slow movement, tremor, rigidity) emaw non-motor emaw a ni thei. Motor symptoms ni lo (e.g., rimchhia (anosmia) , constipation , mut harsatna , orthostatic hypotension ) te hi motor symptoms a lan hma kum tam takah a intan thei.

Parkinson natna hian thihna a thlen thei em?

Ni lo, Parkinson natna hi a mah chauhin a thihpui thei lo. Mahse, thihna thlen thei dinhmun dang a thlen thei a ni.

Parkinson natna hi tihdam theih a ni em?

Ni lo, Parkinson natna hi tihdam theih a ni lo. Amaherawhchu, enkawl theih a ni a, enkawlna tam tak chuan a hlawk hle. Natna zual zel tur leh a lan chhuah dan na tak tak lo awm tan pawh tihkhawtlai theih a ni.

A tawp berah chuan hriat reng tur (Take-Home Message) .

Parkinson natna hi natna khirh tak, hun rei tak chhung a ni a, mahse hlauh tur a ni lo. Tuna enkawlna hman mek hmang hian mi tam tak chuan an natna lan chhuah dan chu uluk takin an enkawl thei a, nun pangngaiin an hmang thei bawk.

A pawimawh ber chu nangmah emaw, i hnaih ber emaw pawhin heng symptoms te hi an neih chuan doctor thurawn la nghal mai tur a ni. Natna hi hriatchhuah thuai a, enkawl tan a nih chuan a rah chhuah a tha zawk. Doctor thupek dik taka zawm a pawimawh hle bawk.

Hemi chungchanga zawhna dang i neih chuan doctor nen inbiakna neih hreh suh. An lawm hle ang che.

` Parkinson’s, thluak natna, thluak lam natna, chetna lama harsatna, dopamine, levodopa, tar hriselna