Cancer enkawl hnuah natna hi a lo lang leh em? DLI (Donor Lymphocyte Infusion) chungchang hi han sawi ila

Thisen cancer enkawlna tur ruhro (bone marrow transplant) ang chi enkawlna lian tak nei la, "Tun dinhmunah chuan engkim a tha vek tawh," tiin i ngaihtuah a, chutah chuan cancer chu a lo kir leh tawh tih i hriat chuan engtin nge i awm ang? A lungchhiatthlak takzet a, a lungchhiatthlak hle bawk. Mahse, beiseina bansan suh. Vawiin hian hetiang dinhmunah hian tanpui thei tur enkawlna bik kan sawi dawn a ni. DLI tih a ni a, chu chu Donor Lymphocyte Infusion tihna a ni.

A awlsam zawngin DLI chu eng nge ni?

Okay, hei hi a awlsam zawngin han sawi ila. Lymphocytes hi i thisena thisen var chi khat a ni. Kan taksa chhunga sipai awm ang mai an ni. Kan taksa hriselna atana pawimawh tak an ni a, ram dang natna hrik, natna hrik leh cancer cell te an do thin.

Tunah chuan DLI (Donor Lymphocyte Infusion) hi heng lymphocyte thenkhat hi a hmaa i ruhro (stem cells) pe tawhtu hrisel tak atanga lak chhuah a ni a, i taksaah inject a ni. Heng ‘sipai’ thar, hrisel leh chak tak takte hian i taksaa cancer cell la awm zawng zawng chu an zawng chhuak a, an tichhe vek a ni. Chu chu he enkawlna tum ber a ni.

Eng case-ah nge DLI enkawl hi a tha?

I thisen cancer chu bone marrow transplant hnua a lo let leh (a lo let leh) chuan i doctor hian he enkawlna chungchang hi a hrilh tam ber che a ni.

DLI enkawlna atana hman tlanglawn tak takte chu hetiang hi a ni:

• Acute Myeloid Leukemia (AML) natna a awm avangin a chhuak thei lo.
• Chronic Lymphocytic Leukemia (CLL) hi a awm thei lo.
• Chronic Myeloid Leukemia (CML) natna hi a awm thei lo.
• Multiple Myeloma natna a awm
• Myelodysplasia (MDS) natna a awm thei.
• Non-Hodgkin Lymphoma natna a ni

He enkawlna atan hian engtin nge i inbuatsaih?

DLI enkawlna i tan hmain i doctor chuan uluk takin a enfiah ang che a, i natna lan chhuah dan tur a sawipui ang che a, test eng emaw zat a order ang.

• Bone marrow biopsy: Bone marrow sample tlemte lak a, cancer cell la awm leh awm loh enfiah a ni.
• Thisen chhiar tling (CBC): 1.1.Thisen chhunga cell awm zat enfiah mek a ni.
• Kidney leh liver function test neih a ni.

Biopsy-a cancer cells level a sang hle tih a hriat chuan i doctor chuan DLI hmain chemotherapy pek che a rel mai thei. Hei hi cancer cell tih tlem nan leh DLI enkawlna hlawhtlinna tihpun nan a ni.

Engtin nge lymphocyte cells hi donor hnen atanga lak chhuah?

Hei hi thil danglam bik tak a ni. Nunna petu che, chu chu ruhro petu che pawh hian hemi kawngah hian a pui bawk. A kut vein pakhatah tube te tak te (catheter) dahin thisen engemaw zat lak a ni. He thisen hi machine bik kaltlangin a kal thin. Chu machine chuan a tih chu kan mamawh lymphocyte cells chauh a thliar hrang a, thisen la awm chu thisen petu kut dang vein hmangin taksaah a thawn kir leh a ni. Hetiang kalphung hi apheresis an ti a . A châng chuan ruhro (bone marrow) i pek hmasak ber ṭumin heng lymphocyte cell ṭhenkhat hi la in, a hnua hman tûrin a vawt thei bawk.

Engtin nge DLI enkawlna i dawn?

Hei hi saline solution pek ang maia thil awlsam tak angin a lang.

1. Doctor emaw nurse emaw chuan i kut emaw, i rilru emaw chhunga vein pakhatah tube te tak te (catheter) a thun ang.

2. Tichuan, donor atanga lymphocyte cell inthen awmna packet chu chu tube ah chuan connect in i thisenah inject a ni.

3. He hna hi minute 30 vel a ni .

4. Hna thawh zawh chuan tube chu lakchhuah a ni.

A châng chuan kar emaw thla engemaw zat emaw chhungin hetiang hi dose engemaw zat i pe thei bawk.

Chutianga taksaa cell thar luhtir a nih chuan thil pawimawh ber pakhat chu graft vs. tumor effect (GvT) tih hi a ni. Chumi awmzia chu, donor atanga heng cell hrisel (graft) te hian i taksaa cancer cell (tumor) la awmte chu an zawng chhuak a, an bei a, an tichhia tihna a ni. Hei hi cancer chu a bo vek dan chu a ni.

DLI enkawlna hian eng hlawkna leh hlauhawmna nge a neih?

Hei hian a hlawkna ber chu

Tun hma chuan bone marrow transplant hnua cancer hi a lo let leh a nih chuan a tih theih awmchhun chu bone marrow transplant dang neih leh a ni. Mahse, second transplant a nih chuan complication awm theihna chu a sang zawk hle. DLI hi immunosuppressant tel lova cancer remission-a dah theihna kawng tha tak, risk hniam tak a ni.

Risk leh complication awm thei te

Enkawlna zawng zawng ang bawkin, hlauhawmna engemaw zat a awm. I medical team chuan hengte hi uluk takin an lo enfiah ang che.

Harsatna a awm chuan engtin nge tih tur?

Lungngai suh. Heng zawng zawng hi enkawlna a awm vek a ni.

• GvHD a awm chuan: I doctor chuan immunosuppressants a pe ang che .
• I thisen cell a hniam chuan: Thisen var hniam te hi a mah chauhin a bo fo thin. A nih loh chuan enkawl tur damdawi a awm. Thisen sen (red blood cells) leh platelets hniam te enkawl nan a tul chuan thisen pek theih a ni.

Enkawlna hnuah leh hlawhtlinna chungchang

Enkawlna hnua a dinhmun pangngaia a awm leh theih nan eng chen nge a mamawh dawn tih i doctor nen sawiho rawh. Follow-up leh thisen test reng reng i mamawh ang.

He enkawlna hlawhtlinna hi mi hrang hrangah a inang lo thei. A nghawngtu thil engemaw zat a awm a:

• Cancer stage a ni.
• I immune system hriselna.
• Tun hmaa transplant tih tawh chi.
• DLI hmaa chemotherapy tih a nih leh nih loh.

DLI hi immunotherapy a ni em?

Ni e, DLI hi immunotherapy a ni.Enkawlna chi khat a ni. A chhan chu i thil tih hi nangmah ngeiin i immune system chu pawn lam atanga T-cell hrisel tak tak pek a ni a, chu chuan cancer dona kawngah a pui a ni. Chu chu a beisei awm tak zet a ni.