Nangmah emaw, i hnaih ber emaw hnute cancer vei nia hriat chuan doctor-te’n ‘ HER2-Positive ’ emaw ‘HER2-low’ tih ang chi thumal an hman i hre tawh mai thei. Hengte hi a takah chuan cancer cell chi hrang hrang sawina atana hman hming an ni. Tunah chuan heng cancer chi hrang hrangte enkawlna tur damdawi thar, hmasawn tak tak a awm ta. Chutiang damdawi bik pakhat chu Enhertu a ni. Vawiin hian he thu hi awlsam tak, hriatthiam awlsam takin kan sawi dawn a ni.
Enhertu hi eng damdawi nge a nih? Engtin nge a thawh?
A awlsam zawngin Enhertu hi targeted therapy a ni . A dik tak chuan damdawi chi khat `Antibody-Drug Conjugate (ADC) an tih a ni.` A hming hi a buaithlak deuhin a lang thei a, mahse a hnathawh dan erawh a mak khawp mai.
He damdawi hi smart missile angin han ngaihtuah teh. A then thum atanga siam a ni a:
1. Target-finding part (Antibody): He part hian cancer cell chung lamah protein bik `HER2` an tih chu a hmu a, chutah chuan a inzawm tlat a ni. He part hna chu cancer cell chauh thlan chhuah leh venhim a ni a, cell hrisel te tichhe lovin.
2. Payload: Hei hi cancer cell thattu damdawi a ni. A dik tak chuan hei hi chemotherapy chi khat chak tak a ni.
3. Heng pahnih inzawmtu part (Linker): A chunga kan sawi tak part pahnih hi he linker hmang hian a inzawm khawm a ni.
Chuvangin, he damdawi hi i pek hian a antibody part chu `HER2` protein nei cancer cell-ah a kal nghal a ni. Tichuan, damdawi chu cell chhungah a lut ta a ni. Cell chhunga a luh chuan chemo part chu a chhuak a, cancer cell chu a tichhia a ni. Cancer cell te an thih chuan cancer cell te chu an lo tlem a, an lo thang lian tawh lo.
Hetiang hmanraw thatna lian ber chu damdawi hian cancer cell chauh direct-in a target a, chuvangin cell hriselte tihchhiatna chu nasa takin a tlahniam a ni.
Engtin nge Enhertu hi pek a nih?
Enhertu damdawi hi thisen kal tlanga pek thin a ni. Chumi awmzia chu taksaah saline solution (IV infusion) angin pek a ni tihna a ni. He enkawlna hi damdawi in, clinic, emaw specialized treatment center-a healthcare professional-in a pe ang che.
- Hun chhung: He enkawlna hi kar 3 danah vawi khat pek thin a ni tlangpui .
- Dosage: Damdawi i mamawh zat hi i taksa rih zawng a zirin a innghat a ni. I doctor chuan a chhut chiang ang a, a pe ang.
- Hun bituk:I cancer hian he damdawi hi a chhang tha a nih chuan i doctor chuan he damdawi hi a rei thei ang bera chhunzawm turin a fuih ang che. Mahse, side effect engemaw zat i neih chuan damdawi dose i thlak a ngai mai thei a, rei lo te chhung atan i chawlhsan a ngai mai thei a, a nih loh leh i tihtawp vek a ngai mai thei bawk. I doctor chuan heng zawng zawng hi a sawipui ang che a, thutlukna a siam ang.
Enhertu damdawi hi engtiang chiahin nge a thawh tak tak?
Enhertu damdawi hman tangkai dan zirchianna clinical trial pahnih an neihah result tha tak an nei a ni.
1. Enhertu leh Kadcyla te khaikhin dan (DESTINY-Breast03 trial) .
He trial-ah hian Enhertu hi Kadcyla (ado-trastuzumab emtansine) nen khaikhin a ni a, hei hi damdawi dang ``HER2'' target a ni.A result chu a hnuaia table-ah hian tarlan a ni.
| Inthlauhna point | Enhertu enkawl dan tur | Kadcyla enkawlna a ni |
|---|---|---|
| Hmasawnna nei lova dam khawchhuahna (Hei hi damlo zinga a chanve velin an cancer an neih leh theih nan emaw, a darh loh nan emaw hun an mamawh hun a ni) | Thla 28.8 a ni | Thla 6.8 chhung a ni |
| Thla 12 hnua hri kai lo damlo za zela | 75.2% a ni. | 33.9% a ni. |
| Thla 24 hnu lama hri kai lo damlo za zela | 53.7% a ni. | 26.4% a ni. |
2. Enhertu leh chemotherapy tehkhin dan (DESTINY-Breast04 trial) .
He trial hian Enhertu hi standard chemotherapy nen an khaikhin a ni.
| Inthlauhna point | Enhertu enkawl dan | Chemotherapy hmanga enkawl a ni |
|---|---|---|
| Hmasawnna nei lova dam khawchhuahna | Thla 9.9 chhung a ni | Thla 5.1 a ni |
| Survival zawng zawng (Hei hi damlo enkawl tawh zinga a chanve an damchhuah hun a ni) | Thla 23.4 a ni | Thla 16.8 chhung a ni |
He data hian Enhertu hi tuna enkawlna thenkhat aiin a hlawk zawk hle tih a tarlang .
Engtin nge ka dam lehna hi ka enkawl ang?
Enhertu hian i dose hmasa ber i dawn veleh hna a thawk tan nghal a ni. I doctor chuan i taksain damdawi a dawn dan tur test hrang hrang a ti ang.
- Scans: Enkawl tan atanga kar 6 vel hnuah cancer kal zel dan enfiah nan scan hi tih thin a ni tlangpui. Hei hi a hma emaw, a hnu emaw pawhin tih theih a ni.
- Thisen test: I thisen var, neutrophil, leh platelet count te enfiah nan thisen test mumal tak neih thin a ni. Hei hian damdawi hi him taka i ei chhunzawm theih leh theih loh hriat nan a pui ang. Side effect, khuh ang chi i neih chuan, chu chu enfiah turin special test dang pawh i ti thei bawk.
Side effects leh engtin nge kan enkawl ang?
Cancer enkawlnaah hian side effect a awm fo thin. Hei hi Enhertu tan pawh a dik a ni. A pawimawh ber chu i doctor hnenah side effect i neih apiang hrilh hi a ni. An serious em tih a rel ang a, an chunga i tih tur a hrilh ang che.
I doctor chuan damdawi a pek hmaa i ei tur damdawi dang a pe thei ang. Chu thupekte chu dik taka zawm a pawimawh hle.
Chu bâkah, rilṭâm, rilṭâm, leh rilṭâm tihtlem nân heng ang thil awlsam tak takte pawh i ti thei bawk:
- Chaw tui tak tak, oil leh chili tlem zawk ei thin ang che.
- Chaw lian pathum ei ai chuan ni khatah chaw te te eng emaw zat ei thin ang che.
Side effect thenkhat nasat dan azirin i doctor chuan i damdawi ei zat tihtlem a, rei lo te atan enkawlna tihtawp emaw, tihtawp vek emaw a tum thei a ni. Ngaihtuah buai suh. I himna tur a ni vek.
Vaukhânna bik ka hriat tur a awm em?
Awle. Enhertu hian black box warning na tak a nei a . Hei hi FDA (US Food and Drug Administration)-in a vaukhânna sang ber a ni.
1. Nausen piang lai tana chhiatna: He damdawi hi i ei lai hian naupai hi i pumpelh vek tur a ni. Hei hian nausen piang lo chu nasa takin a tichhe thei a ni. Nangmah emaw i kawppui emaw chuan naupai i tum a nih chuan i doctor hnenah hrilh ngei ang che . I doctor chuan enkawlna hun chhunga hman tur birth control dan dik tak a hrilh ang che.
2. Lung chhiatna: He damdawi hian lung natna khirh tak `Interstitial Lung Disease (ILD)` tih a thlen thei a, chuvangin i doctor chuan i enkawl chhung zawngin hei hi a lo en reng ang che. Khuh leh thawk harsa ang chi symptom i neih chuan doctor hnenah hriattir nghal tur a ni.
Hengte avang hian doctor nena inbiak reng reng leh a thupek dik taka zawm a pawimawh hle.
Take-Home Thuchah a ni
- Enhertu hi damdawi hmasawn tak a ni a, hnute cancer-a HER2 protein a target a , cancer cell chauh a that a ni.
- Hei hi kar 3 danah vein (IV) hmanga enkawlna a ni.
- Clinical trial-ah he damdawi hi tuna hman mek enkawlna dang aiin a hlawk zawk tih hmuhchhuah a ni.
- Enkawl lai hian side effects, nausea leh vomiting te a awm thei a, chu chu enkawl dan tur a awm bawk. I doctor hnenah harsatna i neih chuan hriattir nghal rawh.
- Naupai laia he damdawi ei hian nausen piang lai tan harsatna nasa tak a thlen thei a, chubakah lungpui tichhe thei side effect na tak a awm theihna a awm bawk. Hemi chungchang hi i doctor nen inhawng takin sawi rawh.
💬 Comments (0)
Comment a la awm lo. Hetah hian i comment hi a vawikhatna atan add rawh.
I comment kha add rawh