Breast cancer tan targeted therapy chungchang i zir dawn teh ang.

"Cancer" tih thumal hian min ti hlauhawm deuh vek a ni lawm ni? Mahse medical science a lo thang chho zel a, cancer dona kawng thar leh hlawhtling tak tak tam tak a lo chhuak ta a ni. Vawiin hian enkawl dan hlawhtling tak kan sawi dawn a, a bik takin hnute cancer tan chuan sawi hlawh tak a ni. Hei hi Targeted Therapy an ti a . Eng nge a nih, engtin nge a hnathawh tih leh a chungchanga hriat tur i neihte hi han thlir ila.

A awlsam zawngin, Targeted Therapy chu eng nge ni?

Ngaihtuah teh, chemotherapy hian kan hriat tlangpui angin cell inthen darh chak tak takte chu a tichhia a ni. Hei hian cancer cell chauh ni lovin kan taksaa cell hrisel tak takte pawh a tichhe thei a ni. Chuvangin chemotherapy hian sam tlakchham leh nausea ang chi side effect a thlen fo thin.

Mahse he enkawlna dan Targeted Therapy tih hi chu chu a danglam hle. A dik tak chuan hei hi enkawlna ‘smart’ tak a ni. Cancer cell chauh a target a , a bei bawk . He enkawl dan hian kan taksa ngeia immune system hmangin cancer cells te chu a tichhia a, a nih loh leh cancer cells te thanlenna atana an mamawh signal te chu a block bawk. Hei hian cell hrisel tak takte a tichhe tlem hle. Hei hi a thatna chu chemotherapy aiin a side effect a tlem zawk tlangpui.

He enkawlna hian kawng lian pahnih a thawk a:

1. Antibodies hman dan: Heng antibody te hi kan taksa immune system-a cell bik (special cells) atanga siam a ni. Heng antibody te hi laboratory-ah artificial-a siam a ni a, damdawi atan taksaah pek a ni. Chungte chu cancer cell-ah an inzawm a, an lo thang lian emaw, an tihchhiat emaw a titawp a ni.

2. Small molecule drugs: Heng damdawi hi pill anga ei theih a ni. Cancer cell chhunga signaling pathways te chu block-in hna an thawk a, chu chuan an inthen darh a, an lo thang lian ta a ni.

I doctor chuan i hnute cancer chi dik tak a zirin eng targeted therapy chi nge i tan a tha tih a rel ang.

HER2-Positive Breast Cancer leh a enkawl dan

Hnute cancer vei zinga 20% vel, a nih loh leh mi panga zinga pakhat vel hian HER2 tih gene-ah chhiatna an nei a ni. He defect hian gene hian copy tam lutuk a siam thin. Cancer cell-a HER2 protein a tam lutuk chuan chu cancer chu "HER2-positive breast cancer" kan ti thin.

I cancer hi HER2-positive a nih chuan a tan targeted therapy treatment bik, tangkai tak tak a awm a ni.

• Trastuzumab hmanga damdawi hman tur : .Hei hi HER2-positive cancer enkawlna atana targeted therapy ber a ni. He damdawi hi brand hming hrang hrang Herceptin, Kanjinti, Ogivri hmanga lei theih a ni. Vein chhunga injection pek a ni. Kawngpui pathum hmangin cancer a control thei nia rin a ni a, chungte chu:
• Cancer cells te hi a chung lamah an innghat a, an lo thang lian thei lo.
• Kan taksa hriselna (immune system) signal pein cancer cells te tihchhiat nan a pui thin.
• Chemotherapy nena pek a nih chuan chutiang enkawlna hlawhtlinna a tipung a ni.

• Pertuzumab: He damdawi hi Perjeta brand name hmanga siam a ni a, HER2-positive cancer dotu antibody dang pek a ni bawk. Trastuzumab leh chemotherapy damdawi docetaxel nen pek dun a ni fo. Amaherawhchu, naupai tan chuan a tha lo hle a, nausen piang lai chu a tichhe thei a ni.

• Damdawi dang: Ado-trastuzumab emtansine (Kadcyla), Margetuximab (Margenza), leh Fam-trastuzumab deruxtecan-nxki (Enhertu) te pawh hi tunlai damdawi chi hrang hrang tan hian pek an ni a, a bik takin cancer a darh (advanced) emaw, enkawlna dang a hlawhchhamna emaw a nih chuan.

• Pills: Lapatinib (Tykerb) leh Neratinib (Nerlynx) te hi HER2-positive cancer tan targeted drug a ni a, pill anga ei theih a ni. Hengte hi enkawlna dang zawhah pawh pek a ni fo bawk.

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HER2-Negative Breast Cancer enkawl dan tur

I cancer cell-te hian a chunga kan sawi tak HER2 gene defect, HER2 protein a tam lutuk lo tihna a nih chuan chu cancer chu "HER2-negative breast cancer" an ti a ni. Tichuan enkawlna chi dang pek i ni ang.

Hetiang cancer chi hrang hrang tan pawh hian targeted therapy damdawi bik a awm bawk.

• Damdawi Everolimus (Afinitor), Palbociclib (Ibrance), leh Ribociclib (Kisqali) te hi hormone therapy nen an ei dun thin. Hengte hi hmeichhia, a bik takin menopause hnua an cancer natna a darh tawhte enkawlna pek thin a ni.
• PARP Inhibitors: I cancer chu HER2-negative a nih a, BRCA gene mutation i neih chuan damdawi class bik PARP inhibitors an tih, Olaparib (Lynparza) leh Talazoparib (Talzenna) te pek i ni thei. Hengte hi cancer cells bik targeted therapies an ni bawk.

A pawimawh ber chu heng enkawlna zawng zawng hi i cancer genetic leh cellular level atanga teh a ni. Chuvangin he thu hi i doctor nen uluk taka sawiho a, i tana tha ber tur enkawl dan tur thlan a pawimawh.

Side effects awm fo chu engte nge ni?

Sawi tawh ang khan chemotherapy aiin side effect tlem zawk awm mahse targeted therapy hian side effect thenkhat a la nei thei tho. Chungte chu damdawi hrang hrangah a inang lo. Side effect i neih chuan doctor hnenah hrilh nghal rawh . A tam zawkah chuan thunun theih an ni.

Engtin nge emergency kan hriat theih ang?

A hnuaia chhinchhiahna pakhat emaw a aia tam emaw i neih chuan emergency a ni thei. Anmahni chu ngaihthah ngai suh. Doctor call nghal rawh. Amah i thlen theih loh chuan damdawi in hnai ber Emergency Department (ETU) ah kal la.