I fa hian pum na a nei em? Hemolytic Uremic Syndrome (HUS) a ni thei!

I fa te hian ni engemaw zat chhung chu pum na nen ril\am a nei tawh em? A chhungah thisen pawh i hmu mai thei. Chutiang thil a thlen chuan nangmah, nu leh pa angin, i lungkham hle chu thil pangngai tak a ni. Hetiang symptoms i neih hian pum na mai mai ni lovin a tam thei hle. Vawiin hian kan sawi dawn a, natna khirh tak tak, mahse hriat hmasak a nih chuan enkawl theih tak a ni. Chu chu (Hemolytic Uremic Syndrome) , a tawi zawngin (HUS) a ni.

Hemolytic Uremic Syndrome (HUS) hi eng nge ni? A awlsam zawngin i hrethiam ang u.

Awle, tunah chuan hei (HUS) hi eng nge a nih i en ang u. A awlsam zawngin, kan kal chhunga thisen kalna kawng te tak te te chu a inkharkhip thinna dinhmun a ni . Tui pipe a inkhar a, tui a luang chhuak tawh lo ang maiin han ngaihtuah teh. He blockage hian thil pawimawh pathum a thlen a, chungte chu:

1. I thisen sen (red blood cells) a chhe vek: Damdawi lamah chuan hei hi hemolytic anemia an ti a. Thisen sen (red blood cells) te hi kan taksa pum puia oxygen phurtu an ni. Chuvangin an tihchhiat chuan taksain oxygen a mamawh zat a tlahniam a ni.

2. Thisen a platelet awm zat a tlahniam: Hetiang dinhmun hi thrombocytopenia an ti a. Platelets hi cell te tak te, thisen kan chhuah dawna kan thisen zam tura puitu an ni. Chungte chu a tlem chuan thisen chhuah tihtawp a harsa a, taksa pum puiah hliam a awm thei bawk.

3. Kal chhiatna: Hei hi thil hlauhawm ber a ni. Kidney-in hna a thawh that loh chuan taksaa bawlhhlawh awm khawmte chu a paih chhuak thei lo. Hei hi (Acute Kidney Injury - AKI) an ti bawk.

HUS hian tu pawh a nghawng thei a, mahse a tam zawk chu bacteria infection , a bik takin Escherichia coli , E. coli tia hriat lar vang a ni. He bacteria hi ril\amna thlentu a ni a, a bik takin thisen chhuak ril\amna thlentu a ni. Mahse, syndrome hi symptoms awmkhawm a ni a, HUS hi E. coli tih loh thil dang vang pawh a awm thei bawk.

Hetiang dinhmun (HUS) hian kal (kidney) chauh ni lovin, a chang chuan taksa peng dang, thinlung leh thluak te pawh a nghawng thei a ni. Mahse, kal (kidney) a nghawng tam ber.

A pawimawh ber: Nangmah emaw, i fain thisen chhuak emaw, ni thum aia rei riltam emaw i neih chuan Doctor pan ngei ngei tur a ni. Enkawl loh chuan HUS hi a na hle thei a, nunna pawh a tichhe thei bawk.

HUS chi hrang hrang a awm em?

Ni e, (HUS) hi chi hrang hrang lian tak tak a awm. An chanchin tlem han zir ila:

1. "Typical" (HUS): Hei hi a tam ber chi a ni . A tam zawk chu bacteria infection, a bik takin E. coli, kan small intestine leh colon a nghawng vang a ni.

2. "Atypical" (HUS) (aHUS): Hei hi a tlem zawk.Hei hi genetic reasons vang a ni fo thin a, chu chu nu leh pa atanga fate rochun a ni tihna a ni.

3. "Secondary" (HUS): Hetiang chi hi damdawi lam thil dang nena inzawm a ni. Entîr nân, damdawi ṭhenkhat, hri kai dang emaw, naupai emaw avânga lo awm thei a ni.

"Atypical" (HUS) (aHUS) chungchang tlem han zir belh leh ila.

(aHUS) hi a awm lo hle. A hmaa a lan chhuah dan ang chiah kha a thlen thei bawk:

• Thisen sen (red blood cells) a tlahniam.
• Platelet count a tlahniam.
• Kidney failure nghal (acute kidney failure) .
• Thisen sang (hypertension) emaw, thisen sang control theih lohna emaw.

Hetiang dinhmun (aHUS) hi a tlangpuiin genetic disorder a ni . Chu chu kan genes-a inthlak danglamna (mutations) engemaw zat avanga lo awm a ni tihna a ni. Mahse, he genetic condition hi awm mah se, infection, natna, a nih loh leh environment factor eng emaw avanga lo awm a ni.

Engtiang chiahin nge (HUS) hi a hluar?

Bacteria (E. coli) avanga ril\am vei zinga 5% leh 15% inkar chuan HUS an nei ang . (aHUS) an tih chi hi a tlem hle. Mi maktaduai khat velah a awm thin.

(HUS) natna lan chhuah dan ber berte chu engte nge ni?

Heng symptoms te hi i hriat chian a pawimawh hle.

A lan chhuah hmasak ber:

• Diarrhea: Thisenin a zui fo thin.
• Pum natna.
• Nausea leh luak chhuak.
• Lu na .
• Chills leh khawsik.

Thil hmuh theih dangte:

• Bruising awlsam tak.
• Pale skin (pallor): Hnar chhung lam leh ka chhung lam thlengin a sen thei.
• Rilru tibuai.
• Kaih.
• Stroke ang chi dinhmun.
• Lung natna (arrhythmia) chak tak.

(HUS) dinhmun a nasat chuan thisen zam (red blood cells) chhe tawhte hian thisen a tikhawlo thei a, kal ang chi taksa peng hrang hrangte a tichhe thei bawk. Tichuan kal (kidney) hian bawlhhlawh a filter tha thei lo. Hei hi (Acute Kidney Injury - AKI) kan tih chu a ni. A lan chhuah dan chu hetiang hi a ni:

• Zun chhunga thisen (hematuria) a awm.
• Thisenah toxins level sang: Hei hian lungawi lohna leh natna hriatna a thlen thei.
• Thisen sang a sang.
• Thâwk harsa (dyspnea).
• Edema: A hring thei a, a bik takin ke leh ke ruh ah a hring thei.
• Zun chhuah tlem (oliguria).

(HUS) awm chhan berte chu engte nge ni?

HUS vei tam zawk hi E. coli bacteria chi thenkhat avanga lo awm a ni. Heng bacteria te hian toxin pakhat Shiga toxin an siam chhuak thin . He toxin hian kan small intestine lining a tichhia a, diarrhea a thlen bawk. He toxin hian thisenah a lut bawk a, thisen sen (red blood cells) a tichhia a, kal (kidney) a tichhe bawk.

E. coli infection i vei theihna a sang zawk a, chu chu:

• Sa tui lo: a bik takin bawnghnute, bawnghnute hmin.
• Unpasteurized milk leh thei in tur: Pasteurization hi a lumna nem tak a ni a, bacteria ang chi thil tha lo tak tak a that a ni.
• Thlai leh thlai silfai loh, bawlhhlawh.

Heng toxin siamtu E. coli chi hrang hrangte hi Shiga toxin siamtu E. coli (STEC) an ti bawk. North America-a STEC chi awm tam ber chu E. coli O157:H7 a ni.

A tlem hle a, damdawi leh thil thenkhat hian "secondary (HUS)" a thlen thei bawk. Entirnan:

• Cancer dona damdawi (Chemotherapy damdawi): (bleomycin), (cisplatin), (gemcitabine) ang chi te.
• Immunosuppressant damdawi: (cyclosporine), (tacrolimus) ang chi te.
• Quinine: Malaria damdawi a ni.
• Ruihhlo thenkhat : (oxymorphone), (ecstasy), (cocaine).

(HUS) hi a kai theih em?

Ni lo, HUS hi a kai thei lo.

Mahse, E. coli bacteria hi a kai thei a ni. He bacteria hi ei leh in bawlhhlawh hmanga kai theih a ni a, E. coli vei, ril\am vei mi emaw ran emaw ek nena inzawm emaw a ni thei bawk. Chuvangin faina kawngah fimkhur hle a pawimawh hle.

Tute nge lo thanglian thei ber (HUS)?

Tu pawhin HUS hi an vei thei a, mahse a hnuaia mite hi an hlauhawm zawk a ni:

• Naupang kum 5 hnuai lam tan.
• Immune system chak lo (immunocompromised) nei tan chuan.
• I chhungkuaa mi tu emaw chuan HUS a lo nei tawh a nih chuan (a bik takin aHUS).
• E. coli infection i neih chuan: A bik takin sa tui lo leh pasteurized milk ang chi thil atang hian.
• (E. coli) vanga ril\am natna vei nen direct contact.

Engtin nge (HUS) i nei tih i hriat theih ang? (Diagnosis) tih a ni.

Doctor i hmuh hunah hengte hi a ti ang:

• I medical history zawt rawh .
• I chhungkaw damdawi lam chanchin zawt rawh .
• Taksa enfiahna (physical examination) neih a ni.

Heng thilte hian HUS condition rinhlelhna a siam a nih chuan doctor chuan test eng emaw zat a ti leh ang.

Eng ang test nge tih thin?

• Urinalysis: I zun sample lak a, protein emaw thisen emaw enfiah a ni.
• Thisen test: Thisen sample lak a ni a, chu chu red blood cell count, platelet level, leh i kidney leh liver hnathawh that dan te enfiah a ni.
• Stool test: Stool sample lak a, HUS thlentu bacteria, E. coli O157 awm leh awm loh enfiah a ni.
• Genetic testing: A chang chuan, i thisen sample chu genetic testing atan thawn a ni thei bawk. Hei hian aHUS ang chi genetic condition i neih leh neih loh leh eng enkawlna nge i tan a tha ber tih hriat nan a pui thei a ni.
• Kidney biopsy: Hei hi kal (kidney biopsy) te tak te lak a, microscope hmanga enfiah a, kal (kidney) tihchhiatna engzat nge a awm tih leh eng thilin nge a thlen tih hriat a ni. Hei hi mi zawng zawngin kan mamawh vek lo.

Engtin nge test hian HUS i nei tih a finfiah theih ang?

• Zun test atanga: Zun chhungah thisen emaw protein emaw a awm chuan.
• Thisen test: Thisen sen leh platelet level a hniam chuan, emaw, kal hnathawh tilangtu value (creatinine ang chi) a san chuan.
• Stool test: (E. coli O157) ang chi bacteria hmuh a nih chuan.
• Kidney biopsy: Kal chhiatna bik hmuh tur a awm.

Engtin nge (HUS) hi enkawl a nih?

HUS i vei tih hmuhchhuah a nih chuan damdawi inah dah a ngai dawn a, enkawl i ngai dawn a ni. Enkawlna kawng hrang hrangte chu:

• Intravenous (IV) fluids leh/ emaw tube feeding (enteral nutrition): Hei hian tui tlakchhamna a veng a, ei leh in mamawh a pe bawk.
• Damdawi hman tur: 1.1.
• Thisen sang tihhniamna damdawi (antihypertensives) pein kal chhiatna tihtlem tumin an bei thin .
• aHUS vei te hi damdawi bik eculizumab emaw ravulizumab emaw pek theih an ni. Heng damdawi ei tan hma hian meningococcal leh pneumococcal natna laka vaccine lak hmasak a pawimawh a, heng damdawi te hian chutiang natna vei theihna a tipung a ni.
• Kar hnih tal antibiotics i ei a ngai mai thei.
• Thisen pek: (HUS) vei tan thisen sen leh platelet pek hi a pawimawh hle. Thisen sen (red blood cells) hian thisen tlakchhamna (anemia symptoms) a tihziaawm a, chu chu thawk hah leh lungphu chak lutuk te hi a ni. Platelets hian thisen a tikhawlo tha thei a, thisen chhuah leh hliam a ti tlem a ni.

Kal a chhiat nasat chuan kal a dam leh hma loh chuan thisen tihfai nan dialysis a ngai mai thei. HUS avanga kal a chhiat vek chuan kal thlak a ngai mai thei.

HUS hi a dam kim thei ang em?

Ni e, mi tam tak chu HUS atang hian an hriselna tichhe vek lovin an dam leh thin.

Mahse, mi thenkhat, a bik takin naupang te te hian 20% atanga 50% velin mild chronic kidney disease (CKD) an vei thei a ni. End-stage kidney disease (ESK) hi 3% atanga 5% velin a vei thei a ni. Zirna hrang hrangah CKD hian puitling 45% vel a vei tih hmuhchhuah a ni.

HUS vei zinga 85% aia tam chuan an kal (kidney function) chu an ti tha leh vek a ni. Amaherawhchu, an dam kim vek a nih pawhin nakin lawkah thisen sang emaw, kal lama harsatna dang emaw an neih theihna chance a tlem hle.

HUS hi ven theih a ni em?

HUS thlentu lian ber E. coli infection laka invenna atana i tih theih thenkhat chu hetiang hi a ni. Hengte hi nang leh i chhungte tan a pawimawh hle a ni:

• Hmun bawlhhlawh (lake, lui)-ah tui chawi loh tur a ni a, a bik takin tuiah hian bacteria a tam hle nia i hriat chuan tui chawi loh tur a ni.
• Diarrhea i neih chuan tui chawi turin kal suh.
• Unpasteurized (raw) in tur (milk, thei tui) in loh tur.
• Kitchen hmanrua (knife, fork, spoon) leh ei tur buatsaihna hmun (counter, cutting board, dish) te uluk takin tifai fo ang che.
• Egg leh sa hmin chu a chhung lam temperature 71 degree Celsius (160 degree Fahrenheit) aia tlem loah uluk takin chhum la, vawk chu a chhung lam temperature 74 degree Celsius (165 degree Fahrenheit) tal chhum rawh.
• Sa defrost dawnin microwave emaw refrigerator emaw-ah dah tur a ni. Chaw buatsaihna hmunah emaw tui lum takah emaw defrost suh.
• Chaw raw leh cooked chu a hranin dah tur a ni.
• Chaw ei hma te, bathroom hman zawh te, naupang kawrfual te te thlak zawh te, leh lova ran i khawih hnuah te sahbawn leh tui lum hmangin uluk takin kut sil thin ang che.

Ngaihtuah teh, heng step awlsam tak takte hi zawm hian hetiang dinhmun khirh tak lakah hian i inveng thei ang.

(HUS) i neih chuan eng nge i beisei theih ang?

Diagnose leh treatment dik tak a awm chuan HUS vei tam zawk chuan an hriselna tichhe vek lovin an dam kim vek a ni. Mahse, nakin lawkah thisen sang emaw, kal (kidney) tichhe thei tur natna dang emaw a awm theihna a awm.

HUS natna khirh tak tak, a bik takin taksa peng dang, thluak ang chi a nghawng chuan enkawl loh chuan thihna a thlen thei a ni.

Damchhuah theihna chance (HUS) engzat nge awm?

Diagnosis leh enkawlna dik tak a awm chuan mi 90% aia tam chu HUS hi an damchhuak thei a ni. Chuvangin hlauthawng lo tur leh symptoms i neih chuan doctor thurawn lak vat a pawimawh.

Engtin nge ka in enkawl ang?

Nangmah emaw, i fa emaw hian riltam na tak i neih chuan i taksaah tui (rehydrate) tum hi a pawimawh hle.Rehydration drinks, Jeevani ang chi hian electrolyte hloh chu a thlak danglam thei a ni. Nausen leh naupang tête chu nu hnute emaw, formula emaw pek a ngai mai thei. I fate tui a tihchak theih dan tur tha ber chu doctor zawt rawh.

Engtikah nge Doctor ka hmuh ang?

Heng symptoms te hi i neih chuan doctor pan nghal rawh:

• Thisen chhuak riltam.
• Ni thum aia rei diarrhea.
• Taksa a hring chhuak.
• Vun a hliam awlsam.
• Chauhna nasa tak a awm.

Doctor hnenah eng zawhna nge ka zawh ang?

Doctor hnenah heng zawhnate hi i zawt thei ang:

• Hemolytic Uremic Syndrome ka neih leh neih loh engtin nge i confirm ang?
• Engtin nge Hemolytic Uremic Syndrome hi ka neih?
• Hemolytic Uremic Syndrome ka neih loh chuan eng damdawi dang nge ka neih theih ang?
• Eng enkawlna nge i rawt?
• Ka kal (kidney) hi a chhe vek dawn em ni?
• Nakin lawkah thisen sang emaw, kal lama harsatna dang emaw ka nei ang em?

Hemolytic Uremic Syndrome triad hi eng nge ni?

Triad chu damdawi lam dinhmun engemaw tilangtu symptom lian pathum inzawmkhawm a ni.

Hemolytic Uremic Syndrome triad-ah hian:

1. I thisen sen (red blood cells) tihchhiat (microangiopathic hemolytic anemia) .

2. I thisena platelet awm zat tlahniam zauh zauh (thrombocytopenia) .

3. Kal hliam na tak (acute kidney injury) a awm.

Diarrhea ka neih chuan Hemolytic Uremic Syndrome ka nei tihna em ni?

Diarrhea i neih vang mai mai chuan Hemolytic Uremic Syndrome i nei tihna a ni lo. Mahse, thisen chhuak i riltam a nih chuan, emaw, i riltam a nasat (tui ang maia riltam emaw ni thum aia rei emaw) a nih chuan doctor pan ngei ngei tur a ni.

(Hemolytic Uremic Syndrome) leh (Thrombotic Thrombocytopenic Purpura - TTP) te hi eng nge an danglamna?

Hemolytic Uremic Syndrome (HUS) leh Thrombotic Thrombocytopenic Purpura (TTP) te hi natna inang pahnih an ni. TTP-ah chuan thisen kalna kawng te tak teah thisen zam (blood clots) a lo awm thin. Doctor-te chuan HUS leh TTP hi group-ah dah khawm mah se, tunah chuan condition hran anga ngaih an ni ta.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Diarrhea hi hun rei lote chhunga awm, mahse nuam lo tak a ni fo thin. Ni khat emaw ni hnih emaw chhungin a dam tlangpui. Mahse, thisen chhuak i riltam a nih chuan, emaw, ni thum aia rei i riltam a nih rualin, bathroom i kal dawna i chau, i sen loh emaw, i zun tlem zawk emaw i neih chuan doctor pan nghal a hun tawh.

Hemolytic Uremic Syndrome an tih hian i kal (kidney) nasa takin a tichhe thei a, taksa peng dangte pawh a nghawng thei bawk.Hei hi enkawlna i hmuh hma poh leh i kal (kidney)-ah hun rei tak chhung chhiatna i nei tlem zawk thin. Chuvangin, a natna lan chhuah dan hre reng la, faina tha tak nei la, ngaihtuahna i neih chuan doctor thurawn la rawh. I hriselna hi i tan a pawimawh em em a ni!

` Hemolytic Uremic Syndrome, HUS, Kidney Disease, Diarrhea, E. coli, Thisen sen, Platelets, Naupang hriselna