I chhungkaw member pakhat, pahnih emaw pathum emaw pawh nise, colon cancer an vei tih i hre ngai em? A nih loh leh chhungkaw history-a cancer vei i neih avangin tlem i hlau em? Dik tak chuan cancer chi thenkhat hi thlah khat atanga thlah dangah a kai darh thei a ni. Vawiin hian kan genes kaltlangin colon cancer chi khat bik kan sawi dawn a ni. Hei hi HNPCC kan ti a.
HNPCC chu eng nge ni?
A awlsam zawngin sawi ila, HNPCC (Hereditary Nonpolyposis Colorectal Cancer) hi colon cancer chi khat a ni a, genes inthlak danglamna (mutations) thenkhat, thlah kal zel atanga lo awm thin a ni. Hei hi kan intestine lian (colon)-a awm cancer a ni.
Chuti a nih chuan hei hi Lynch Syndrome nen a inang em?
HNPCC aiin Lynch Syndrome hi i hre tam zawk ngei ang. An pahnih hian an inzawm tlat a, mahse an inang chiah lo. Hetiang hian han ngaihtuah teh. Lynch Syndrome hi kan taksaah hian genetic defect a ni. Genetic condition a ni a, cancer vei theihna a tipung a ni.
HNPCC tih hming hi Lynch Syndrome vei miin colon cancer emaw, a kaihhnawih cancer dang (uterine emaw small bowel cancer ang chi) a neih chuan a bik takin kum 50 a tlin hmaa a vei tihna a ni a, HNPCC cancer hi a tam ber chu large intestine dinglamah a lo awm thin.
A tawi zawngin, Lynch Syndrome hi genetic cause a ni. Chumi avanga cancer natna lo awm chu HNPCC a ni.
HNPCC hi engtiang chiahin nge a hluar? Eng nge a lan chhuah dan?
Khawvel puma colorectal cancer report zawng zawng zinga 2% leh 4% inkar chu HNPCC hian a ni. Kum eng pawhah he natna hi awm thei mah se, kum 50 hnuai lam zingah a awm tam ber.
HNPCC hian a tir lamah chuan symptom bik a nei lo mai thei a, mahse cancer a zual zel chuan heng symptoms te hi a lo lang thei a ni.
| Symptom a ni | A awlsam zawngin sawifiah a ni |
|---|---|
| Pum na emaw, pum na emaw | Pum natna, natna, emaw, pum na lutuk emaw hriat reng reng. |
| Chaw chakna | Ei duhna a tlahniam. |
| Thisen chhuak chu stool ah a awm | Toilet kal dawnin stool-ah emaw, black stool-ah emaw thisen a awm. |
| Chhan awm lovin chau tih hriatna | Hna pangngai pawh tih theih loh khawpa chau lutuk anga inhriatna. |
| Chhan awm lovin taksa rihna tihtlem | Diet leh exercise nei lovin taksa rihna tlahniam nghal. |
Engvangin nge HNPCC hi a lo thanglian? Hri kai theih a ni em?
Hei hi a chhan ber chu kan genes a ni. Kan taksa hi ruahmanna lian tak anga in sak angin han ngaihtuah teh. Chu ruahmanna awmna lehkhabu chu kan DNA a ni. He DNA-a instruction awmte hi genes kan ti a.
Lynch Syndrome vei te hian DNA-a tihsual siam thattu genes bik engemaw zat (`MLH1`, `MSH2`, `MSH6`, `PMS2` leh `EPCAM`)-ah chhiatna an nei a. Heng genes te hian hna an thawh that loh chuan kan cell inthen darh huna DNA-a tihsual (`DNA replication errors`) te chu siamthat a ni lo. Hun a kal zel a, heng tihsualte hi a pungkhawm a, cell pangngai chu cancer cell a nih theihna a sang chho zel a ni.
A pawimawh ber chu HNPCC hi natna hrik kai theih a ni lo. Chu chu khawsik angin mi pakhat atanga mi dangah a darh lo tihna a ni. Amaherawhchu, a thlentu gene dik lo chu thlah khat atanga thlah dangah a kal zel thei a ni. Chumi awmzia chu nu leh pa zinga pakhatin Lynch Syndrome an neih chuan naupang pakhatin chu gene chu a rochun theihna chance 50% a nei tihna a ni. Chu gene chu an rochun chuan chu naupang chuan nakin lawkah HNPCC emaw, a kaihhnawih cancer dang emaw a vei theihna a sang zawk a ni.
Engtin nge doctor hian hei hi a hriat chhuah?
A chunga kan sawi tak symptoms i neih chuan, a bik takin i chhungte zingah mi pakhatin colon cancer a vei tawh a nih chuan doctor pan ngei ngei tur a ni.
Doctor in a enfiah hmasa ang che. Tichuan, colon cancer rinhlelh a nih chuan test hman tlanglawn ber chu colonoscopy . Hei hian hnute chhunga tube te tak te dah luh a, camera hmanga intestine lian chhung lam enfiah a huam a ni.
HNPCC hmuhchhuah a nih leh nih loh finfiah nan doctor chuan a hnuaia mite hi a zawng bawk ang:
- Chhungkaw cancer chanchin: 1.1.I chhungte hnai ber, i nu, i pa emaw, i unaute emaw pawhin kum 50 an tlin hmain colon cancer emaw, Lynch Syndrome nena inzawm cancer dang emaw an vei tawh em tih zawhna i dawng ngei ang.
- Genetic Testing: HNPCC thlentu genetic mutations i neih leh neih loh hriat nan thisen test bik neih a tha.
- Condition dang paih chhuah: HNPCC ang bawkin, hereditary colon cancer condition dang FAP (Familial Adenomatous Polyposis) tih a awm bawk. An pahnih inkarah hian danglamna a awm avangin test pawh tih a ni ang a, FAP ni lovin HNPCC i nei tih finfiah a ni ang.
HNPCC leh FAP hi eng nge an danglamna?
An pahnih hian colon cancer natna (hereditary condition) ni mah se, a thlentu genes erawh a inang lo. A danglamna ber chu colon chhunga polyp lo awm zat hi a ni.
| Mihring ziarang | HNPCC (Lynch Syndrome) natna hrik pai a ni. | FAP a ni |
|---|---|---|
| Polyp lian leh te | Thei rah tlem hle emaw, a chhuak lo emaw (a tlangpuiin 10 aia tlem) a chhuak. | Nut za tam tak, sang tam tak pawh ni thei, a lo piang chhuak thin. |
| Cancer a lo ni ta | Tlemte lo thang lian chu cancer a ni nghal thei. | Enkawl loh chuan heng tumor zinga pakhat hi cancer a nih theihna chance 100% a awm. |
HNPCC enkawlna tur engte nge ni?
HNPCC enkawlna ber chu surgery (colectomy) a ni. Hei hian cancer awmna colon hmun emaw, a pum emaw chu surgery hmanga lak chhuah a ngai a ni. Hei hi kawng hrang hrangin tih theih a ni.
- Partial colectomy: Cancer awmna colon hmun chauh lakchhuah.
- Total colectomy: Intestine lian zawng zawng lakchhuah.
- Protectomy: Intestine lian leh rectum pahnih lakchhuah.
Cancer hi taksa peng dangah a darh (metastasized) a nih chuan i doctor chuan surgery bakah enkawlna dang a rawt thei bawk.
- Chemotherapy: Damdawi hmanga enkawlna, cancer cell tichhe thei.
- Immunotherapy: Cancer cells do turin kan taksa ngeia immune system tichaktu.
Thil tam takah chuan HNPCC cancer tan immunotherapy hi a hlawhtling zawk thei a ni.
HNPCC nei mi pakhat hmalam hun chu eng nge ni?
Lynch Syndrome hi genetic condition a ni a, tihdam theih a ni lo. Nun chhung zawnga dinhmun a ni. Mahse, surgery hian HNPCC cancer a tidam thei a, nakin lawkah colon cancer a veng thei bawk.
HNPCC vei chuan colon cancer bakah cancer chi dang a vei theihna a hlauhawm hle. Chuvangin i doctor chuan screening neih fo turin a hrilh ang che.
- Endometrial cancer a ni
- Ovarian cancer a ni
- Pum cancer a ni
- Kidney, thluak, thin leh vun cancer a ni
A pawimawh ber chu early detection a ni . A hun taka test i neih chuan heng cancer zinga eng pawh hi a hmain hriatchhuah theih a ni a, hlawhtling taka enkawl theih a ni bawk.
A vaiin HNPCC vei hmuhchhuah zinga 60% vel chu kum 5 chhung an dam thei a ni. Tin, Lynch Syndrome vanga bowel cancer vei zinga 70% leh 88% inkar chu kum 10 chuang an dam thei bawk. Heng statistics te hian a hmaa hmuhchhuah leh enkawl a pawimawh zia a tarlang a ni.
He hlauhawmna hi pumpelh leh enkawl dan tur eng nge tih theih ang?
Hei hi a thlentu genetic mutation hi ven theih a ni lo. Kan rochun thil a ni. Amaherawhchu, cancer laka invenna tur emaw, a hmaa hriat chian nan emaw thil tam tak tih theih a awm.
- I chhungkaw chanchin hre reng ang che: I chhungkuaa mi tu emaw chuan Lynch Syndrome emaw HNPCC emaw a vei a nih chuan i doctor nen sawiho la, i genetic testing pawh neih a ngai em tih zawt rawh.
- Screening tan hma: Lynch Syndrome i vei tih hmuhchhuah a nih chuan i doctor chuan kum 20 hnuai lam atanga colon cancer screening (colonoscopy) neih tan turin a rawt ang che.
- Nunphung hrisel: Heng thilte hian cancer vei theihna tihziaawmna kawngah nasa takin a pui a ni:
- Meizial zuk loh vek tur a ni.
- Zu in hi tihtlem rawh.
- Thlai leh thei chi hrang hrang tamna ei leh in hrisel ei rawh.
- Exercise neih fo thin ang che.
- Taksa rihna hrisel tak vawng reng rawh.
- Symptoms fimkhur rawh: Symptom thar i neih chuan ngaihthah lo la, doctor pan nghal rawh.
Take-Home Thuchah a ni
- HNPCC hi hereditary colon cancer condition a ni a, genetic defect Lynch Syndrome an tih avanga lo awm a ni.
- I chhungte zinga pakhat emaw, a aia tam emaw chuan kum 50 an tlin hmaa colon cancer an vei tawh a nih chuan, nang pawh hi i hlauhawm em tih hriat tumin doctor nen inbia ang che.
- He natna hi kai theih a ni lo a, mahse naupangte hian a hlauhawmna thlentu gene hi an rochun theihna chance 50% a awm.
- A hun takah screening neih a nih chuan cancer hi a tir lamah hmuhchhuah theih a ni a, nunna chhanchhuah theih a ni bawk.
- HNPCC hi surgery leh enkawlna dang hmanga hlawhtling taka enkawl theih a ni.
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