Hereditary risk of colon cancer (HNPCC) - hei hi han sawi ila

I chhungkaw member engemaw zatin colorectal cancer an vei tih i hre tawh em, a bik takin kum 50 an tlin hmain? A nih loh leh i chhungkuaa hmeichhia zingah uterine cancer vei an tam em? Hetiang thil kan hriat hian hlauthawng leh lungkham deuh deuh hi thil awmdan pangngai a ni. Mahse hei hi hriat chian hlauh ai chuan a pawimawh zawk. Vawiin hian cancer hlauhawmna bik, thlah khat atanga thlah danga inthlau thei tur kan sawi dawn a ni. Hei hi HNPCC kan ti a.

HNPCC hi eng nge ni tak tak?

A awlsam zawngin sawi ila, HNPCC hi Hereditary Nonpolyposis Colorectal Cancer tih acronym a ni. Sinhala tawng chuan "Hereditary Nonpolyposis Colorectal Cancer" tih ang chi tihna a ni. Mahse, chu thute chu a buaithlak hle a ni lawm ni? Chuvangin HNPCC tiin i hre reng ang u.

Hei hi cancer hlauhawmna a ni a, kan genes-a inthlak danglamna (mutations) engemaw zat avang hian thlah khat atanga thlah dangah kan rochun theih a ni. Hei hian a bik takin large intestine a nghawng a, chu chu i intestine a tawp ber a ni. Mahse "Nonpolyposis" tih hming hi "non-polyposis" tihna a ni. A chhan chu, a tlangpuiin, colon cancer a lo awm hmain intestine-ah hian "polyps" tih hming pu thil te te a lo awm thin a ni. Mahse, HNPCC vei chuan hetiang polyp hi a nei tam lo va, cancer vei theihna a sang zawk.

Chuti a nih chuan Lynch syndrome pawh hi HNPCC a ni em?

Ni e, heng hming pahnih hi dinhmun inangah hman a ni fo. Mahse technical lama danglamna tlem a awm. Lynch syndrome hi a thlentu genetic condition a ni. Chu chu, mi pakhatin Lynch syndrome nena inzawm gene mutation a neih chuan cancer natna HNPCC an tih chu a vei theihna a sang zawk tihna a ni.

A tlangpuiin kum 50 hnuai lam chuan Lynch syndrome nena inzawm cancer, colon cancer, endometrial cancer, small intestine cancer, emaw ureteral cancer te a neih chuan chhungkua hian HNPCC an tih natna an nei niin an sawi. Heng cancer te hi a tam ber chu intestine dinglam a ni.

Hetiang dinhmun hi engtiang chiahin nge a awm? Eng nge a lan chhuah dan?

Khawvel puma colorectal cancer zawng zawng zinga 2% atanga 4% vel chu HNPCC hian a ni. Chumi awmzia chu colorectal cancer 100 zinga 2 atanga 4 vel chu he genetic factor vang a ni tihna a ni. Tu pawh a nghawng thei a, mahse kum 50 hnuai lam atanga hmuhchhuah tam ber a ni.

A tir lamah chuan HNPCC hian symptom a nei lo fo thin. Chu chu a hlauhawm ber a ni. Mahse cancer a lian chhoh zel chuan heng ang symptoms hi i nei tan mai thei.

Engvangin nge HNPCC hi a lo thanglian? Hri kai theih a ni em?

Hei hi a chhan ber chu kan genes a ni. Kan taksa hi lehkhabu lian tak ang mai a ni ang tih han ngaihtuah teh, chu lehkhabuah chuan genes chu thupek inziak a ni. Kan taksaa cell tin hian heng thupek ang hian hna an thawk vek a. A châng chuan, heng instruction-ah hian spelling tihsual (mutations) a awm ṭhin.

Kan taksa hian a tlangpuiin heng tihsualte hi hre thei leh siamthat thei gene bik a nei a. Mi pakhatin lehkhabu a proofread ang maiin. Lynch syndrome-ah chuan hengte hi MLH1, MSH2, MSH6, PMS2, leh EPCAM te an ni.Heng "corrective" an tih gene te hi an chhiat chuan cell inthen darh hian tihsual dang an siam tha thei lo. Hun a kal zel a, heng cell chhia te hi an pungkhawm a, cancer cell an lo ni ta zawk a ni.

Hei hi natna hrik kai theih a ni lo. Chaw ei emaw, HNPCC vei bula awm emaw chuan i man thei lo. Mahse, a thlentu gene mutation hi thlah khat atanga thlah dangah a kal zel thei a ni. Nu emaw, pa emaw hian he gene mutation hi a nei tih han ngaihtuah teh. Tichuan an fate zinga pakhatin chu gene chu a rochun theihna chance 50% a awm. Chumi awmzia chu fa pahnih an awm chuan pakhatin he risk gene hi a rochun thei tihna a ni. Chuvang chuan chutiang chhungkaw zinga mi engemaw zatin cancer an vei a ni.

Doctor hian engtin nge HNPCC hi a hriat theih ang?

A chunga i sawi tak symptoms neia doctor i pan hunah chuan a tih hmasak ber tur chu i symptoms te ngun taka ngaithla a, taksa enfiahna a neih hmasak ber tur a ni. Tichuan, i chhûngte damdawi lam chanchin chungchâng zawhna tam tak an zâwt ang .

• "I nu, i pa, i unaute hian cancer an vei tawh em?"
• "A nih chuan eng ang cancer nge a nih? Eng kum nge a lo awm?"
• "I chhungkuaah hian mi engzat nge cancer vei tawh?"

Heng zawhnate hi a pawimawh hle a, a chhan chu chhungkaw member engemaw zatin colon emaw uterine emaw cancer an vei tawh a nih chuan, a bik takin kum naupang takah doctor chuan HNPCC hi a ringhlel thei a ni.

A dawtah chuan, colon cancer i neih leh neih loh finfiahna atana test ber chu colonoscopy . Hei hian camera te tak te dahna tube hmanga i colon pumpui enfiah a huam a ni. Thil rinhlelh awm tak tak hmuh a nih chuan tissue te tak te chu la in lab-ah test (biopsy) turin an thawn thin.

HNPCC dinhmun finfiah nan hian special test engemawzat neih a ngai a:

1. Genetic Testing: I thisen sample lak a ni a, Lynch syndrome nena inzawm genetic mutations a awm leh awm loh test a ni.

2. Tumor tissue testing: Cancer a awm chuan cancer cell te chu HNPCC nena inzawm marker bik an awm leh awm loh enfiah thin a ni.

3. Thil dang awm lohna: Hriselna dang a awm bawk a, chu chu Familial Adenomatous Polyposis (FAP) tih a ni. FAP-ah chuan colon-ah polyp za tam tak emaw, sang tam tak emaw a lo awm a. Hei hi HNPCC-ah a thleng lo. Chuvangin, i doctor chuan heng condition pahnih zingah hian eng condition nge i neih tih a enfiah ang.

HNPCC enkawlna tur engte nge ni?

HNPCC avanga colon cancer a lo awm chuan a enkawlna ber chu cancer leh a chhehvel tissue lakchhuahna surgery a ni. He surgery hi colectomy an ti a . Kawng hrang hrangin tih theih a ni.

• Partial Colectomy: Colon chhunga cancer awmna hmun chauh lakchhuah a ni.
• Colectomy zawng zawng: 1.1.Colon pumpui chu a chhuak vek a ni. He surgery hi HNPCC vei tan chuan nakin lawka cancer dang a vei theihna tur tihtlem nan a tha fo thin.
• Proctectomy: Rectum chu intestine lian tak nen lakchhuah a ni.

Enkawlna dang

Cancer hi taksa peng dangah a darh (metastasized) a nih chuan surgery bakah hian enkawlna dang a ngai mai thei.

• Chemotherapy: Cancer cell tichhe thei damdawi chak tak tak pek.
• Immunotherapy: Cancer cells do turin kan taksa ngeia immune system tichaktu. He enkawlna hi HNPCC vanga cancer awmte tan chuan a hlawhtling fo thin.

HNPCC nena khawsa mi pakhatin a hriat tur thilte

HNPCC i vei tih hmuhchhuah a nih chuan mi pangngai aiin bowel cancer chauh ni lovin, cancer chi dang engemaw zat vei theihna i nei sang zawk tihna a ni. Chuvangin medical check-up neih fo hi i nunah a tel ve tur a ni.

I doctor chuan heng cancer te hi screening neih fo turin a fuih thei che a ni:

• Nausen pum (uterus) a ni
• Ovarian a ni
• Pumpui
• Kidney leh urinary system
• Thluak
• Vun

Hei hi hlauhawm takin a ri mai thei. Mahse hetah hian a tha ber chu early detection hi a ni . Screening neih fo chuan cancer hi a lo awm tan a nih pawhin a hma deuhin a man thei a ni. Tichuan enkawl leh dam vek theihna chance a sang zawk hle.

Lynch syndrome hi kan genes-a awm thil a nih avangin tihdam theih a ni lo. Amaherawhchu, HNPCC avanga cancer awmte chu tihdam theih a ni. Total colectomy ang chi surgery hian colon cancer a veng thei bawk.

Engtin nge ka risk hi ka enkawl ang?

Chhungkaw history-a HNPCC emaw Lynch syndrome emaw i neih chuan i tih hmasak ber tur chu i doctor nen inbia ang che. Genetic testing neih a ngai em tih a rel ang.

Lynch syndrome gene mutation i nei tih finfiah a nih chuan i doctor chuan kum 20 vel atanga colon cancer screening, colonoscopy ang chi screening tan turin a fuih mai thei che a ni.

Chu bakah, nunphung hrisel tak i neih chuan cancer vei theihna i tihziaawm belh thei bawk:

• Meizial zuk loh vek tur a ni.
• Ei leh in inthlau tak, ei tur tha tak ei rawh (thlai, thei leh fiber tamna ei tur tam zawk telh bawk ang che).
• Exercise neih fo thin ang che.
• Zu in hi tihtlem rawh.
• Taksa rihna hrisel tak vawng reng rawh.
• Doctor-in a rawt test zawng zawng chu a hun takah tih vek rawh.