I naupan lai atang tawh khan hnungzang na i nei tawh em, zing i thawh tirh khan hnungzang na i nei tawh em? Rei vak lo kal hnuah emaw, ni khata hna i thawh tan tirh emaw hian natna chu a reh deuh niin a lang em? Hei hi hnungzang natna awlsam tak mai niin i ngai mai thei. Mahse a chang chuan heng symptoms te hi tunlaia kan sawi tur Ankylosing Spondylitis an tih natna chhinchhiahna hmasa ber a ni thei. Ngaihtuah buai suh, he thu hi chiang tak leh awlsam takin kan sawi dawn a ni.
Ankylosing Spondylitis (AS) hi eng nge ni tak tak?
A awlsam zawngin sawi ila, Ankylosing Spondylitis (AS) hi ruh natna chi khat a ni. Mahse kan ruhro (spine) a ruh ( joint ) te chu a bik takin a nghawng a ni . Kan ruhro hi ruh te tak te tam tak inzawm khawm atanga siam a ni a, chu ruh inkar ruh chu a hring a, a hring a, a na bawk. Hun a kal zel a, he inflammation hian ruh chhunga ruh (joint) te chu a inzawm khawm thei a, chu chuan ruhro (spine) a flexibility a ti tlem thei a ni.
He natna lan chhuah dan tlangpui chu:
- Back na leh stiffness: Hei hi zing thawh hmasak ber emaw, rei tak ding hnua i hriat chian ber a ni.
- Exercise neih laiin natna a tlahniam: Mak tak maiin, chawlh laiin natna a pung a, active laiin a tlahniam a, chu chu kea kal, tlan, emaw, zuang emaw te hi a ni.
- Ruh dang na: Mi thenkhat chuan ruh, hip, khup, leh kephah te pawh na an nei thei bawk.
- Chau lutuk nia inhria.
He natna hi thalai kum 15 leh 30 inkar ah a intan fo thin a, chuvang chuan mi tam tak chuan hnungzang natna awlsam tak angin an ngai sual mai thei.
Chuti a nih chuan hei hi genetic link a awm em?
Awle. Hei hi he thuziak thupui pawimawh ber a ni. Ankylosing Spondylitis hi natna a ni a, a pianphung atanga lo chhuak a ni a, chu chu genetic influence a nei tihna a ni . I chhungkuaa mi tu emaw, chu chu nu leh pa, unau te hian he natna hi an nei a nih chuan nang pawhin midang aiin he natna hi i vei theihna a sang zawk tihna a ni.
Scientist-te’n he thil hi an zirchian lai hian gene pakhat bik chu an ngaihven hle a, chu chu HLA-B27 gene a ni.
Ngaihtuah teh, Ankylosing Spondylitis vei hmuhchhuah zinga 85% aia tam chuan he gene HLA-B27 an tih hi an nei tih hmuhchhuah a ni. Chu chuan he gene leh natna inzawmna nghet tak a lantir lo em ni?
He HLA-B27 gene hian kan taksa immune system a pui a. A awlsam zawngin sawi ila, ramdang mi rawn lut, virus leh bacteria ang chi te chu a hre chiang a, a do thei bawk. Mahse a chang chuan he gene inthlak danglamna avang hian immune system chu haywire-in a kal a, kan taksa peng hrisel tak tak te, hetiang hunah hian kan ruhro (spine) ruh te chu a rawn bei tan thin. Scientist te chuan he inflammation hi hei vang hian a awm niin an ngai.
Hemi atan hian HLA-B27 chauh hian mawh a phur em?
Ni lo, chu chu zawhna pawimawh tak a ni. He thawnthuah hian HLA-B27 hi a changtu ber ni mahse, supporting actors dang tlemte an awm. Scientist te chuan he natna vei theihna tur genetic risk zawng zawng zinga 30% vel chu HLA-B27 gene atanga lo chhuak a ni an ti. A bak zawng chu gene tenau zawk engemaw zatin a nghawng a ni.
Heng gene-te nghawng hi a tlem avangin pakhat hnu pakhata hriat chian a harsa hle. Mahse, khawvel hmun hrang hranga scientist-te zirchianna hmangin gene eng emaw zat hmuhchhuah belh a ni a, an thawhhona leh thu hriatte insem darh a ni.
| Gene | Hrilhfiahna awlsam tak |
|---|---|
| HLA-B27 a ni | Hei hi gene bulpui ber a ni. Immune system nen a inzawm tlat a ni. AS vei tam zawk hian he gene hi an nei a ni. |
| ERAP1 tih a ni | Hei hi immune system hnathawhna atana inrawlh gene a ni bawk. HLA-B27 nena hman dun a nih chuan natna vei theihna a tipung a ni. |
| IL23R leh IL1A te a awm | Hengte hi taksaa inflammation lo awm leh control nana genes te pawh an ni. Heng gene hrang hranga danglamna hian AS vei theihna a tipung thei bawk. |
Researcher-te chuan gene dang, hriat loh, hei pawh hi nghawng thei tur an la zawng mek a ni.
Mi zawng zawng hian gene an neih vang mai maiin natna hi kan vei em?
No. Ni lo tak zet.Hei hi i hriat reng a ngai a ni. I taksaah HLA-B27 gene i neih chuan Ankylosing Spondylitis i vei dawn tihna a ni lo. Midang aiin natna vei theihna chance tlem a sang zawk tihna chauh a ni.
Hetiang hian han ngaihtuah teh. Zirchianna pakhatah chuan Ankylosing Spondylitis vei nu leh pa atanga HLA-B27 gene rochun naupang zinga 75% emaw, pali zinga pathum emaw chuan he natna hi an vei ngai lovang tih hmuhchhuah a ni.
He natna thlentu tur hian genes ringawt a tawk lo tihna a ni. Genetic influences bakah hian environment factors pawh a awm ngei tur a ni. Heng thilte hi eng nge an nih chiang taka hriat ni lo mah se, thil engemaw, hri kai thenkhat ang chi te hian hmun a chang thei niin an ngai. A awlsam zawngin, genes hi silai mu, kang thei tura inpeih ang mai a ni a, a kang thei tur chuan meialh a mamawh a ni.
Chuti a nih chuan engtin nge ka tih ang?
He thuziak-a kan sawi tawh ang chi symptoms i neih chuan (kum naupan lai atanga tan, zing lama na zawk, exercise hmanga tihdam theih) i neih chuan, emaw, i chhungte zinga mi pakhatin Ankylosing Spondylitis a vei a nih chuan i lungkham a ngai lo.
I tih theih tha ber chu doctor thiam tak, i GP hnenah hmuh nghal hi a ni . I natna lan chhuah dan a ngaithla ang a, a enfiah ang che a, a tul chuan thisen test leh X-ray ti turin a ti ang. HLA-B27 gene i neih leh neih loh enfiah turin test pawh an rawt thei bawk.
A pawimawh ber chu heng dinhmunte hi hriat hmasak leh enkawl hi a ni tih hre reng ang che . Chutianga i tih chuan a natna chu i thunun thei a, hnungzang natna chu i veng thei a, nun pangngai leh hlim takin i nung thei bawk.
Take-Home Thuchah a ni
- Ankylosing Spondylitis (AS) hi ruh natna chi khat a ni a, a bik takin ruhro a nghawng a ni. Thalaite zingah a tam ber.
- He natna hian genetic link nghet tak a nei a, a bik takin gene HLA-B27 hi a chhan lian ber a ni.
- Mahse, i taksaah HLA-B27 gene i neih mai mai chuan natna i nei dawn tihna a ni lo. Risk factor mai a ni.
- Genes bakah hian environmental factors hian he natna lo awm dan hi a nghawng bawk.
- Hun rei tak chhung hnungzang na, zing lama natna i neih emaw, chhungkaw history-a natna i neih emaw chuan hlauthawng suh la, i doctor hnenah thurawn dik tak zawt rawh .
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