I chhungkuaa mi tu emaw, i nu emaw, i pa emaw, i pi emaw pawhin thil tenawm tak tak an theihnghilh em? Thil tenau ber pawh i hriat reng theih loh chang chuan kan lungngai hle a, kan hlauthawng hle bawk. Hei hi a chhan ber chu Alzheimer natna a ni thei. Dik tak chuan he natna hi damdawi a la awm lo. Mahse, natna darh chak lutuk control thei tur leh a kal zelna tikhawtlai thei tur enkawlna thar a awm a ni. Kisunla hi chutiang damdawi pakhat, beiseina thar thlentu a ni. Hemi chungchang hi vawiinah hian awlsam tak leh chiang takin sawi ila.
Alzheimer natna leh Kisunla hnathawh dan
A awlsam zawngin sawi ila, Alzheimer’s hi thluak natna a ni a, hun kal zelah a lo thang zauh zauh a. Puitling kum upa zawkte zingah hriatrengna hloh natna a ni tih i hre tawh mai thei. He natna hi a lo awm chuan kan thluaka thil pawimawh tak tak, hriatrengna, hriatthiamna, tawngkam, ngaihvenna leh ngaihtuahna te thununtu te chu a chhe vek a ni. A chhan ber chu thluak cell inkara amyloid an tih protein tha lo (toxic protein) a awm khawm vang a ni.
Kan in chhunga tui pipe chu bawlhhlawhin a khuh a, tui luang tur a titawp ang bawkin, he amyloid protein hi thluak cell inkara a awm khawm chuan thluak cell te chu an inbiakpawhna leh an thawk tha thei lo.
Alzheimer natna hi dementia chi khat a ni tih i hre tawh mai thei. Dementia hi nitin hna thawk thei lo khawpa ngaihtuahna fiah harsatna thlen thei dinhmun sawina tlangpui a ni.
Doctor-te chuan natna hi stage hrang hrangah an ṭhen tlangpui. A tir lamah chuan hun rei lote chhunga hriatrengna hloh hi a lan chhuahna ber a ni. Natna a lo zual zel chuan nitin hna, ei tur buatsaih te, i kawng zawn te, sum enkawl dan te pawh a harsa ta hle. A hnu lamah chuan rilru lam natna lan chhuahna, social withdrawal, eng thil pawh ngaihven lohna, leh agitation te pawh i nei thei bawk.
Chuti a nih chuan, he damdawi thar Kisunla an tih hian eng nge a tih? Antibody bik donanemab-azbt tih a awm a. A tih chu a hmaa ka sawi tawh ang khan thluaka amyloid proteins pungkhawmte chu a target a, thluaka a paih chhuak thin. Chutiang chuan Kisunla hian thluak chhiatna a tihziaawm bakah natna a zual zelna rate a ti hniam bawk.
Kisunla damdawi hman dan tur?
Kisunla hi pill a ni lo. Intravenous (IV) infusion angin pek a ni . Saline kan hmuh ang bawkin, he enkawlna hi damdawi in emaw, clinic emaw-ah i dawng a ngai dawn a, minute 30 vel a ni.
Enkawlna i tan hunah chuan kar li danah milligram 700 (700 mg) vawi thum pek i ni ang. Chumi hnuah chuan i doctor chuan kar li danah milligram 1400 (1400 mg) thlengin a tipung ang.
He enkawlna hi i tan hmain i doctor chuan thluak scan bik , tau positron emission tomography (PET) tih chu a order ang. Hei hian i thluaka amyloid engzat nge a awm tih a enfiah thin. Scan-a i thluaka amyloid level a tlahniam nasa hle tih a hriat chuan i doctor chuan enkawlna tihtawp a rel mai thei.
Fimkhur tur thil bik leh a side effects te
Kisunla enkawlnaah hian side effect na tak a awm a, a bik takin kan fimkhur a ngai hle. A hming chu ARIA (amyloid-related imaging abnormalities) an ti a ni. A awlsam zawngin sawi ila, he damdawi hian thluak MRI scan-ah danglamna danglam tak a siam a. Hei hian symptoms a thlen ngai lo.
Mahse, a tlem berah chuan mi thenkhat chuan hetiang symptom hi an nei thei a ni:
- Lu na
- Rilru tibuai
- Luak chhuak
- Vision a danglam thin
- Kal laiin balance hloh
A chang chuan ARIA symptoms hi stroke symptoms nen a inang thei hle. Chuvangin, i damdawi ei zawng zawng hi doctor hnenah hrilh vek a pawimawh hle a , chutiang chuan ARIA vang nge thil dang vang a ni tih a hriat theih nan.
Tute nge ARIA vei theihna sang zawk?
Mi thenkhat chuan an genetic makeup a zirin ARIA vei theihna a sang zawk. Apolipoprotein E e4 (ApoE e4) an tih gene copy pahnih nei te hian thluak a hring emaw thisen chhuah emaw ang chi side effect na tak tak an nei thei a ni. Chuvangin, i doctor chuan Kisunla hmanga enkawl i tan hmain ARIA i vei theihna tur genetic test a ti mai thei. Enkawl lai hian he dinhmun hi enfiah turin MRI scan neih fo a ngai bawk ang.
Kisunla damdawi hlawhtlinna chu engtin nge an zirchian?
He damdawi hi engtiang chiahin nge a thawh tih hriat tumin clinical study lian tak neih a ni tawh bawk. Hemi kawngah hian Alzheimer natna hmasa ber vei tam tak an tel tawh a ni.
Hêng mite hi zirchiangtute chuan pâwl hnihah an ṭhen a.
1. Pawl khat pek an ni: Kisunla damdawi.
2. Pawl dang: chu damdawi ang deuh, mahse active ingredient nei lo (hei hi placebo kan ti a) pek an ni.
A rah chhuah chu a fuh tak zet a ni. Chu result chu a hnuaia table atang hian i hrethiam mai ang.
| Chhawr tangkai | Zirnain a hmuhchhuah chu |
|---|---|
| Natna darh zel tur titawp | Kisunla dawngtu zingah natna zual zel dan chu placebo dawngtu aiin 20% velin a hniam zawk a ni. |
| Symptoms a na zual lo | Kisunla dawngtu zinga zaa 47 chuan kum khat chhungin an natna a zual lo a, placebo group-a mi zaa 29% chauh an awm thung. |
| Thluaka amyloid tlahniam | Zirchianna tawp lamah chuan Kisunla dawngtu zinga 76% chuan an thluaka amyloid deposit a hniam hle a ni. |
Heng result te hian Kisunla hian Alzheimer natna a zual zelna chu nasa takin a tikhawtlai thei tih a tarlang.
Damdawi hian eng chen nge hna a thawh theih a, damdawi dang nen pawh inzawmna a awm em?
Kisunla dose hmasa ber i dawn veleh thluaka amyloid target-in hna a thawk tan ta a ni. Mahse, nang leh i enkawltute leh i doctor-te tan chuan i natna lan chhuah dan a tlahniam a, natna kal zel dan pawh a tlahniam tih hriat nan thla engemaw zat a la ngai thei.
Damdawi dang nena inzawmna
ARIA hmanga thluaka thisen chhuah theihna a nih avangin Kisunla hi thisen tithianghlimtu nena hman hian fimkhur bik tur a ni . Finfiahna chiang tak a la awm lo nain, thisen tithianghlimtu i ei a nih chuan Kisunla enkawlna i tan hmain i doctor nen he thu hi i sawipui ngei tur a ni.
A pawimawh ber chu i damdawi ei tur zawng zawng - i doctor-in a pek emaw, over-the-counter damdawi emaw, vitamin emaw, Ayurvedic emaw Sinhala damdawi emaw pawh nise, i doctor hnenah hriattir vek tur a ni.
Enkawl laiin lu na ang chi symptoms i neih chuan ngaihthah suh. ARIA chhinchhiahna a ni thei a, chuvangin i doctor hnenah hriattir nghal rawh .
Take-Home Thuchah a ni
- Kisunla hi damdawi thar, Alzheimer natna hmasa ber enkawlna atana hman a ni.
- Hei hian thluaka protein tha lo (toxic protein) amyloid an tih chu a paih chhuak a, natna zual zelna rate a ti hniam a ni.
- Hei hi intravenous (IV) infusion treatment a ni a, damdawi in emaw clinic emaw-ah pek a ngai a ni.
- ARIA tih hming pu side effect na tak hi hriat a pawimawh hle. Hei hian enkawl hma leh enkawl lai hian MRI scan neih fo a ngai a ni.
- Damdawi i ei zawng zawng (thisen tithianghlimtu te pawh tel) leh i natna lan chhuahna thar i neih apiang chu i doctor nen zalen taka inbiakna neih a pawimawh hle.
- Hei hi damdawi ni lo mah se, natna kal zel dan chu nasa takin a tikhawtlai a, damlote leh an chhungte tan beiseina thar a pe a ni.
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