I doctor-in nangmah emaw, i hriat mi emaw tan Larotrectinib tih damdawi a pek hian, chu chu zawhna tam tak neih hi thil pangngai a ni. Hei hi eng ang damdawi nge ni? Eng nge thleng ang? Side effect a awm em? I ngaihtuah mai thei. Lungngai suh. He damdawi chungchang hi awlsam takin, i hriatthiam theih angin sawi ila.
Larotrectinib chu eng nge ni?
A awlsam zawngin sawi ila, larotrectinib hi damdawi chi khat bik a ni a, cancer cells te tihpunna a titawp a ni. Hei hi ‘targeted therapy’ an ti a. Chumi awmzia chu he damdawi hian cancer cell-a protein bik chauh a pan nghal a, a nghawng a, chu cell-te chu an lo thang lian thei lo tihna a ni.
Mahse hei hi cancer chi hrang hrang tan damdawi a ni lo. I cancer cells te chu NTRK (neurotrophic receptor tyrosine kinase gene fusion) tih gene ah mutation bik an nei em tih enfiah thin a ni. Chu genetic mutation nei te chauhvin he damdawi hi an hlawkpui ang. Chuvangin i doctor-in he damdawi hi a rawn pe che a nih chuan i cancer chi hian a chhang tha hle mai thei tihna a ni.
Damdawi ei tan hmaa doctor hnena hrilh tur thil
He damdawi hi i tan hma hian i hriselna dinhmun kimchang takin doctor hnenah i sawi hmasak phawt a pawimawh hle. A bik takin a hnuaia mite hi hrilh ngei ang che:
| Nihna | I hriattir tur chu |
|---|---|
| Liver natna | Liver natna eng emaw i neih chuan. |
| Nerve natna a awm | I kut leh ke a tingling emaw, nerve problem dang i neih emaw chuan. |
| Allergy nei te pawh a awm | He damdawi, damdawi dang, ei tur emaw, dye emaw allergy i neih chuan. |
| Naupai lai | Naupai, nau pai tum emaw, rinhlelhna emaw i neih chuan. |
| Nau hnute pek | I naute hnute i pek chuan. |
He damdawi hi engtin nge ka hman ang?
A pawimawh ber chu Doctor-in a sawi ang chiaha damdawi ei hi a ni.
- He capsule hi tui glass khat nen a pumin ei rawh .
- Capsule chu tichhia suh, tikehsawm suh, chew suh .
- Hei hi chaw ei hma emaw ei zawhah emaw i ei thei. Mahse, nitin hun khatah ei tum ang che .
- Pawimawh tak: He damdawi hi grapefruit tui nen ei ngai suh.
- Doctor thurawn tel lo chuan i damdawi ei kha bansan suh.
Naupangte hnena pek a nih chuan: He damdawi hi a chang chuan naupang tê tête tan pawh pek theih a ni. Mahse, fimkhur bik a ngai a ni. Hemi chungchang hi i pediatrician nen inbia ang che.
Dose a san chuan (overdose) eng nge tih tur?
He damdawi hi i ei tam lutuk nia i hriat chuan hlauthawng suh. Colombo National Hospital a National Poisons Information Center ah phone nghal rawh . A nih loh leh damdawi in hnai ber Emergency Treatment Unit (ETU)-ah kal rawh.
Ka damdawi ka ei theihnghilh a nih chuan engtin nge ni ang?
Dose i miss a nih chuan i hriatreng veleh ei nghal rawh. Mahse, i dose leh tur thleng darkar 6 aia rei lo a nih chuan missed dose kha skip la, i dose leh tur chu a hun ruatah ei rawh. Vawi khatah vawi hnih ei ngai suh.
He damdawi nena inzawm thei thil dang (Interactions) .
He damdawi hian damdawi leh ei tur dang nen a inzawm thei a ni. Chuvangin i ei zawng zawng chu i doctor hnenah hrilh la. Hei hian damdawi prescription, over-the-counter damdawi, herbal products, vitamin leh supplement te a huam a ni. Tin, zu i in emaw, zu i in emaw chuan doctor hnenah hrilh bawk ang che.
A hnuaia tarlan te hi he damdawi nena inzawm thei thil thenkhat an ni.
- HIV emaw AIDS emaw damdawi
- Antibiotics thenkhat (clarithromycin ang chi) .
- Fungal infection damdawi (ketoconazole ang chi) .
- Epilepsy natna damdawi (carbamazepine, phenytoin ang chi) .
- Lung natna damdawi thenkhat
- Immunosuppressant damdawi (cyclosporine, tacrolimus ang chi) te hi a tha hle.
- Cancer dona damdawi thenkhat (chemotherapy) .
- A thinghnah chu St. John’s Wort a ni
- Grapefruit tui tak a ni
He list hi a kim lo a, chuvangin i damdawi ei zawng zawng hi doctor hnenah hriattir a pawimawh.
Damdawi ei huna ngaihtuah tur thil
- Thisen test: He damdawi hi i ei lai hian i doctor chuan a chang chuan thisen test turin a ti ang a, i liver function ang chi thilte a enfiah ang.
- Hnathawh ngaihven ngai: He damdawi hian i lu a ti buai thei a, i muhil thei a, i rilru a ti buai thei bawk. Chuvangin, hei hian i taksa a nghawng dan chiang taka i hriat hma loh chuan ngaihven ngai hna, lirthei khalh emaw, machinery hman emaw te chu pumpelh rawh.
- Naupai leh nau hnute pek (a pawimawh hle): .
- Hmeichhia: He damdawi ei lai leh damdawi ei khap hnu kar khat tal naupai loh tur. Naupai i tum emaw, naupai nia i rinhlelh emaw chuan doctor hnenah hrilh nghal rawh.
- Mipa: He damdawi ei lai leh damdawi ei tawh loh hnu kar khat tal fa neih loh tur.
- He damdawi hi i ei lai leh i ei zawh hnu kar khat chhung chu naute hnute pek loh tur a ni .
- Fertility: He damdawi hian fa neih theihna a nghawng thei a ni. Hemi chungchanga zawhna i neih chuan doctor nen inbia ang che.
Damdawi hmansualna (side effects) te
Damdawi dang ang bawkin he damdawi hian side effect a nei thei bawk. Ṭhenkhat chu tenau deuh an ni a, ṭhenkhat erawh chu ngaihven vat a ngai thung.
| Side effects te chu doctor hnenah hriattir nghal tur a ni | |
|---|---|
| Allergy natna a awm thei | Vun vun rawng, hnim hring, hmai, hmui emaw lei emaw a hring. |
| Liver hliam chhinchhiahna | Dark yellow/brown urine, mit emaw vun emaw yellowing, pum dinglam chunglam na, luak chhuak, ei duhna hloh, pale stools. |
| Nervous system lama harsatna a awm | Luak chhuak, buai, balance hloh, ke ruh natna emaw, bengchheng emaw, tawng harsa. |
| Common side effects te chu a awm reng chuan doctor hnenah hriattir tur a ni | |
| Luak chhuak | Kawthalo |
| Ek khal | Khuh |
| Chau lutuk | |
He list-a tarlan loh symptom dang danglam tak i neih chuan i doctor nen pawh chutiang lam chu sawipui rawh.
Take-Home Thuchah a ni
- Larotrectinib hi NTRK gene fusion nei cancer tan bik targeted therapy a ni.
- Damdawi dang zawng zawng, herbal product leh supplement i ei zawng zawngte chu i doctor hnenah hrilh vek a pawimawh hle.
- He damdawi hi i ei lai hian grapefruit tui in vek loh tur a ni.
- Damdawi ei lai leh ei zawh hnu kar khat chhung chu naupai, nau hnute pek leh nau neih chungchangah fimkhurna khauh tak zawm tur a ni.
- Liver chhiatna emaw, thluak lama harsatna nasa tak emaw a awm chuan damdawi lam pan nghal rawh.
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