Chhungkaw zingah cancer vei an awm em? Lynch Syndrome chungchang hi han zir ila

A châng chuan, "Chhungkaw history-ah cancer vei ka nei a, chuvang chuan kei pawhin ka vei tam zawk ang em tih hi ka ngaihtuah ṭhin," tiin kan inzawt ṭhin. Dik tak chuan cancer chi thenkhat hi thlah khat atanga thlah khata thlah kal zel, genetic influence avanga lo awm thei a ni. Entirnan, Lynch Syndrome hi cancer vei theihna nasa takin a tipung a, mahse sawi tam a ni lo. Hei hi hriat chian a pawimawh hle. Chuvangin vawiin hian awlsam takin sawi ila.

A awlsam zawngin Lynch Syndrome hi eng nge ni?

Lynch syndrome hi nu leh pa atanga fa, a nih loh leh thlahtute hnena kai theih, genetic condition a ni. Hetiang natna vei hian cancer chi hrang hrang a vei theihna a sang zawk, a nih loh leh a hlauhawm hle bawk.

A bik takin, he natna vei hian kum 70 a tlin chuan colorectal cancer vei theihna chance 40% atanga 80% in a sang zawk a, uterus, ovaries leh stomach cancer vei theihna a sang zawk bawk. Hemi chungchanga thil danglam bik chu cancer hi cancer kum pangngai aiin a lo awm hma hle a , kum 30 emaw 40 emaw vel pawh a ni mai thei.

Hetiang dinhmun a lo awm chhan hi eng nge ni?

Hei hi hrethiam tur chuan kan taksa hi rei lo te han ngaihtuah ila. Kan taksa hi cell maktaduai tam tak atanga siam a ni. Heng cell te hi an inthen darh zel a, cell thar an siam chhuak zel a ni. Photocopy machine hmanga copy siam ang maiin han ngaihtuah teh. Chutianga cell inthen darh chuan a chang chuan tihsual tenau te a awm thin. Mahse vanneihthlak takin kan taksa DNA ah hian ‘mismatch repair genes’ bik a awm a, chu chuan heng thil tihsualte hi hrechiangtu leh siam thattu a ni.

Lynch syndrome vei chuan heng ‘checker genes’ zinga pakhatah hian chhiatna emaw, tihsual emaw a nei a ni . Tichuan, chu cell-te chu an inthen chuan tihsual dangte chu siam\hat a ni lo va, cell \ha lote chu an in\hen chhunzawm zel a, taksaah cell \ha lo tam tak an lo piang \an ta a ni. Hun a kal zel a, heng cell chhia te hi cancer a lo ni ta a ni.

I nu emaw i pa emaw hian he natna hi a neih chuan nang pawhin i rochun theihna chance 50% i nei a ni.

Lynch syndrome tih theihna tur symptoms te chu engte nge ni?

He dinhmun chungchangah hian ngaihtuahna tibuaitu tur thil pawimawh engemaw zat a awm. Chung zinga pakhat emaw, a aia tam emaw chu nangmah emaw, i chhungte tan emaw a hman chuan doctor nena inbiakna neih a pawimawh hle.

Engtin nge he dinhmun hi kan hriat theih ang?

Nangmah emaw, i chhungte zinga tu emaw cancer vei a nih a, i doctor-in Lynch syndrome vang a nih a rinhlelh chuan cancer sample tlemte chu test theih a ni. Chutianga tih theih dan tlangpui pahnih a awm a, chungte chu:

• Immunohistochemistry (IHC) test: Hei hian cancer cell-a protein chi hrang hrang awmte a enfiah thin. A hmaa kan sawi tawh ‘checker genes’ atanga protein siam chhuah kha chu cell-ah chuan a awm lo a nih chuan Lynch syndrome chhinchhiahna a ni thei.
• Microsatellite instability (MSI) test: Hei hian cancer cell DNA-a tihsual awm leh awm loh direct-in a enfiah thin.

Heng test-te hian Lynch syndrome i vei tih a nemnghet a nih chuan, emaw, i chhungte zinga mi pakhatin he natna hi a neih avangin hlauhawma i inhriat chuan, thisen sample-ah hian he genetic defect hi i nei em tih chiang taka hriat theih nan genetic test i ti thei ang.

Genetic Counselor pakhat hnen atanga tanpuina

Hetiang hunah hian i doctor chuan genetic counselor hnenah a refer thei che a ni. Hemi chungchangah hian thil tam tak an hrilhfiah ang che.

• Chhungkaw pakhatah Lynch syndrome hi rochun a nih dan.
• I genetic test report result hian eng nge a awmzia.
• Heng result te hian i cancer risk a nghawng dan.
• I fate’n he gene hi i hnen atanga an rochun theihna chance.
• Cancer laka invenna atana i duhthlan turte.

Lynch syndrome i neih chuan engtin nge enkawl theih ang?

Hetiang natna i nei tih i hriat huna tih tur tha ber chu cancer enfiah turin regular screening neih hi a ni. Tichuan, cancer lo awm tak tak pawh ni se, a tir lamah hmuh chhuah a nih theihna leh a dam vek theihna a sang zawk a ni . Entirnan, colon cancer hi a hmaa hmuhchhuah a nih chuan 90% velin a dam thei a ni.

I doctor chuan eng test nge i tih tur leh eng chen nge i mamawh tih a rel ang. Test atana rawtna awm tlangpui chu:

• Colonoscopies: Kum 20-25 a\angin kum khat emaw kum hnih emaw chhungin he test hi neih tir i ni thei. Hei hian intestine lianah polyp emaw cancer chhinchhiahna emaw a awm leh awm loh a enfiah thin.
• Endoscopies: Kum 30 vel atang khan hei hi kum 3-5 danah tih theih a ni a, pum leh intestines endik theih a ni.
• Hmeichhia tan test: Kum 30 an tlin hnuah kum tin pelvic exam, transvaginal ultrasound, uterine biopsy ang chi test neih a tha thei a, uterus leh ovary te enfiah thin a ni.

Mi thenkhat, a bik takin hmeichhia fa nei tawhte chuan cancer vei theihna tihziaawmna turin preventive surgery chungchang an doctor nen an sawi dun thin. Hei hian cancer a lo awm hmain colon, uterus emaw ovaries emaw surgery hmanga lakchhuah tihna a ni. Hei hi mimal thutlukna a ni vek.

Nun hrisel neih a pawimawhzia

Checkup neih fo rualin nun hrisel nun hian he hlauhawmna hi a tihziaawm bawk.

• Thlai, thei, legumes leh whole grains tamna diet ei rawh.
• Exercise tih fo thin ang che .
• I rihna control rawh.
• Zu in hi tihtlem rawh.

Zirna thenkhatah chuan nitin aspirin dose tlem ei hian he hlauhawmna hi a tihziaawm thei tih hmuhchhuah a ni a, mahse hemi chungchangah hian zirchianna tam zawk neih a ngai a ni. Chuvangin , doctor rawn hmasa lovin nangmah chauhin damdawi ei tan ngai suh.