I hlim lo em ni? Engkim i chau tawh em? Hetiang dinhmun hi depression kan ti a. Chuvangin, he rilru lam natna depression an tih hi enkawl nan hian damdawi chi hrang hrang pek thin a awm a. Vawiin hian damdawi pawl pakhat, a hlui deuh deuh, i hman hunah fimkhur hle a ngai tih kan sawi dawn a ni. Chungte chu MAOIs an ti a, chu chu Monoamine Oxidase Inhibitors tihna a ni. He hming hi a buaithlak deuhin lang mahse, a awlsam zawngin sawi ila.
Heng MAOI te hi eng nge ni tak tak?
A awlsam zawngin sawi ila, MAOIs hi damdawi chi khat a ni a, depression symptoms control na tur a ni. Hengte hi khawvela antidepressant hmuhchhuah hmasak berte an ni . Mahse, tunlai hian doctor ten awlsam takin he damdawi hi an pe lo. A chhan chu heng damdawi ei lai hian i ei leh in tur i fimkhur hle a ngai a, chubakah side effect leh himna thenkhat i ngaihven a ngai bawk.
A tlangpuiin doctor-te chuan MAOI hi antidepressant thar zawk dang (SSRI ang chi)-in a natna lan chhuahna a tihchangtlun loh chuan a tawp ber atan chauh an pe thin.
Eng damdawi nge he category-a tel?
Khawvela MAOI hman chi thenkhat chu hetiang hi a ni:
- Isocarboxazid (Marplan®) hmanga siam a ni.
- Phenelzine (Nardil®) hmanga siam a ni.
- Selegiline (Emsam®) hmanga siam a ni.
- Tranylcypromine (Parnate®) tih a ni.
Heng hmingte hi i hriat loh a ni mai thei, kan ramah hian hman tlanglawn a nih loh avangin. Mahse hriat a tha.
MAOI hmang hian eng dinhmun nge enkawl?
Heng damdawi te hi natna chi hrang hrang tan phalna pek a ni tawh a.
| Damdawi chi hrang hrang | A bik takin damdawi lam dinhmun hman a ni |
|---|---|
| Isocarboxazid leh Tranylcypromine hmanga siam a ni | Major Depressive Disorder a ni a, a rilru a hah hle |
| Phenelzine a ni | Treatment-resistant depression, panic disorder, leh social anxiety disorder te a ni |
| Selegiline a ni | Major depressive disorder leh Parkinson natna enkawlna adjunctive angin. |
"Off-label" hman hi eng nge ni?
A châng chuan, doctor-te chuan damdawi chu official-a pawm loh dinhmun atân an hmang ṭhin. Hei hi "off-label" hmanna an ti. Doctor thil tawn leh hriatnain damlo tan a hlawkpui dawn tih a hriat phawt chuan tih a ni. Entirnan, ADHD tan Selegiline hi a chang chuan an pe a, Tranylcypromine hi khawtlang lungkhamna atan an pe bawk.
He damdawi hian engtin nge hna a thawh?
Hei hi hriatthiam a awl hle mai. Kan thluak chhungah hian palai tlemte an awm tih han ngaihtuah teh. Neurotransmitter kan ti a . Serotonin, Norepinephrine, leh Dopamine te hi kan rilrua hlimna, mut leh hriatrengna ang chi thilte thununtu ber an ni.
Tunah chuan kan thluaka enzyme dang pakhat monoamine oxidase tih chu a awm ta a ni. He enzyme hna hi chu tirhkohte chu "tifai" hi a ni. Chu chu anmahni tihchhiat leh an level tihhniam tihna a ni.
MAOI hian a tih tur chu enzyme tifaitu (Monoamine Oxidase) hnathawh a titawp a ni . Chuti a nih chuan eng nge thleng? Chu thuchah hlim tak takte (serotonin leh dopamine ang chi) chu a chhe vek a, thluaka an pung khawm a ni. An level a sang chho zel. Tichuan kan mood a tha a, depression symptoms te pawh a tlahniam ta a ni.
Hetihlai hian chemical pakhat Tyramine tih pawh a awm bawk. Kan taksaa thisen sang control turin a pui a ni. MAOI damdawi hian he Tyramine hi a chhe vek bawk. Hei hi heng damdawi te nen hian risk lian ber a ni . Nakinah kan sawi leh ang.
MAOIs hian eng side effect leh risk nge a neih?
Heng damdawi hman hian side effect leh hlauhawmna lian tham engemaw zat a nei thei a ni. Chuvangin, damdawi lam thurawn tel lova hman hi a hlauhawm hle .
Side effect awm fo thin
- Luak chhuak emaw, lu hah emaw (thisen hniam vang) .
- Kawng a vawt (xerostomia) .
- Luhai
- Bloating emaw constipation emaw a awm thei
- Mutthilh theih lohna
- Mu thei lo
Risk leh complication na tak tak a awm thei
1. Serotonin Syndrome natna a ni
Hei hi natna khirh ber leh nunna atana hlauhawm ber a ni. Taksa a serotonin level a san lutuk chuan a thleng thin. He hlauhawmna hi MAOIs hi serotonin level tisang thei damdawi dang (e.g., SSRIs, natna tidamtu thenkhat) nen i ei chuan a nasa zawk a ni. Chuvang chuan i damdawi ei zawng zawng, vitamin lam thlengin doctor hnenah hrilh a pawimawh.
| Serotonin syndrome natna lan chhuah dan | |
|---|---|
| Thiltih dan tlangpui | Restlessness, luak chhuak, luak chhuak, pum na, mit hrual , thawk hah , khur, taksa ruh hring. |
| A lan chhuah dan na tak (damdawi inah dah nghal ngai) . | Buaina, tachycardia, thisen sang, khawsik, seizures, hriatna hloh. |
Heng natna khirh tak tak te hi i neih chuan damdawi in hnai ber Emergency Department (ETU) ah kal nghal rawh . Enkawlna tihkhawtlai hi nunna atana hlauhawm a ni thei.
2. Ei leh in lama harsatna (Tyramine interaction) .
Hei hi MAOI-te practical problem lian ber a ni. Kan sawi tawh ang khan MAOI hian ei tur thenkhata pianphung atanga awm chemical tyramine tihchhiatna chu a titawp a ni.
MAOI i ei laiin tyramine tamna ei tur i ei chuan i thisena tyramine level chu hlauhawm takin a sang thei a ni. Hei hian thisen sang a tisang nghal thei a . Hei hi "Tyramine Pressor Response" an ti a. A tlem berah chuan he thisen sang hian thluaka thisen a chhuah (cerebral hemorrhage) leh thihna thlengin a thlen thei a ni.
MAOI i ei hian eng ei tur nge i ei loh tur?
A hnuaia tarlan te hi he damdawi eitu ei loh tur chi hrang hrang list a ni a, hei hi tyramine a tam vang a ni.
| Chaw chi hrang hrang | Sawifiahna leh entirnan |
|---|---|
| Kum upa tawh Cheese | Cheddar, Swiss, leh Parmesan ang chi cheese (cheese thar zawk Cottage cheese leh Mozzarella te hi risky a tlem zawk). |
| Soy Sauce a ni | Soy atanga siam thil zawng zawng. |
| Sa/nga fermented emaw, vawn that emaw | Sausage, salami, sangha hring, leh thil dang dang. |
| Thin | Liver tharah hian tyramine awm lo mah se, a chhe thuai avangin tyramine level a sang thei hle. |
| Thei puitling tak tak | Banana, avocado, theipui ang chi thei rah te chu a puitlin chuan. |
| Beer fermented a ni | A bik takin tap beer a ni. |
Thil pawimawh ber: Chaw ei hi a upa chho zel a, a tyramine level a sang chho zel a. Chuvangin, he damdawi ei hian ei tur la awmte ei loh tur a ni a, chaw siam thar ei tur a ni .
3. Antidepressant Discontinuation Syndrome a awm thei
He damdawi hi kar 6 aia rei i ei hnua i ei loh thut chuan he natna hi a awm thei a ni. Khawsik, taksa na, lu na, luak chhuak, mut theih lohna, leh hahdam lohna te a awm thei. Chuvangin, doctor rawn hmasa lovin he damdawi hi ei kha titawp ngai suh . Damdawi i ei tawh loh chuan kar engemaw zat chhung zawi zawiin i ei tur a ni a, i doctor enkawlna hnuaiah chauh i ei tur a ni.
4. Mahni intihhlum tumna
Kum 25 hnuai lam thalaiten he damdawi hi an ei tan tirh hian mahni intihhlum duhna a pun theihna chance tlemte a awm. Nang emaw i fa emaw hian heng ngaihtuahnate hi i neih chuan damdawi petu doctor nen inbia nghal ang che.
Engtikah nge Doctor i hmuh ang?
MAOI i ei a nih chuan i doctor pan fo tur a ni a, damdawi hian hna a thawk em tih leh harsatna a awm leh awm loh enfiah tur a ni. Chu bakah, heng thilte hi i doctor nen pawh sawiho bawk ang che.
- I tuar theih loh side effect i neih chuan.
- I symptoms a lo tha lo a nih chuan, emaw, a zual zel a nih chuan.
- Damdawi ei kha bansan a ngai nia i hriat chuan.
Take-Home Thuchah a ni
- MAOIs hi antidepressant class hlui chak tak leh hlauhawm tak, tunlaia hman lar tak a ni lo.
- He damdawi hi i ei a nih chuan diet control hi tih ngei ngei tur a ni . Tyramine tamna ei tur hi ei loh vek tur a ni.
- Damdawi dang i ei lai i doctor hriattir a pawimawh hle a, chuti lo chuan serotonin syndrome hlauhawm tak i nei thei a ni.
- He damdawi hi eng thil vang pawha damdawi lam thurawn tel lovin ei tan emaw chawlhsan emaw suh.
- Serotonin syndrome natna lanchhuahna na tak emaw, mahni intihhlum tumna emaw i neih chuan damdawi in emergency room (ETU)-ah kal nghal rawh.
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