MUTYH-Associated Polyposis (MAP) hi i hre tawh em? I sawi dawn nia!

He hming (MUTYH-Associated Polyposis) tih hi i hre tawh em? A ni lo mai thei. A rare, mahse a pawimawh hle thei, hereditary condition a ni. Chumi avang chuan taksa peng thenkhatah chuan thang te te, (polyps), an tih te hi a lo thang lian thei a ni. Chuvang chuan hei hi hriat chian a pawimawh hle.

MUTYH gene-associated polyposis (MAP) hi eng nge ni?

A awlsam zawngin, (MUTYH-Associated Polyposis) emaw (MAP) emaw hi kan genes kaltlangin thlah khat atanga thlah dangah kan kal zel a ni. Hemi a thil thleng chu kan taksaah, a bik takin colon leh rectum-ah hian tissue te te, duh loh zawng (polyps) an tih te a lo awm thin a ni. Heng (polyps) te hi cancer vei an ni lo. Amaherawhchu, a then chu lakchhuah a nih loh chuan hun kal zelah cancer vei theihna chance a sang zawk. Heng (polyps) te hi colon-ah chauh ni lovin, a chang chuan small intestine leh stomach-ah pawh a lo thang lian thei a ni.

He MAP condition hian cancer vei theihna a keng tel em?

Ni e, a dik tak zet. (MAP) i neih chuan, colorectal cancer vei theihna chu a vei lo aiin a sang zawk tih a chiang hle. Ngaihtuah teh, (MAP) vei zinga a chanve vel chuan (MAP) an vei tih hmuhchhuah a nih hian colorectal cancer an nei tawh a ni! A tam zawkah chuan heng cancer te hi kum 40 leh 60 inkar vel a ni a, mahse a chang chuan a hmain a lo lang thei bawk. Chu mai ni lovin, duodenal cancer leh digestive system pawn lama cancer chi dang (gastrointestinal (GI) tract) vei theihna i nei thei bawk.

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MAP vei dam rei zawng chu engzat nge ni ang?

He thu hi hre hlau suh. (MAP) vei tam zawk chuan nun pangngaiin an hmang thei a, mahse dinhmun pakhat a awm. Chu chu cancer screening tan hma leh tih fo tur tihna a ni . A pawimawh ber chu heng (polyps) te hi cancer-a an chan hmain zawn chhuah leh paih chhuah hi a ni. Chumi hnuah chauh chuan hrisel takin kan awm thei ang.

MUTYH gene-associated polyposis (MAP) natna lan chhuahna chu engte nge ni?

Hetah hian buaina chu a awm. MAP symptoms engmah i hmu lo va, i hre lo tlangpui bawk. I chaw ei kawngah polyp i nei a nih pawhin symptom engmah a awm lo fo. Chuvangin, polyp awm ringawt hi MAP i nei tih chhinchhiahna rintlak a ni lo. Avang:

• Mi tam takin polyp nei mahse MAP an nei lo mai thei.
• Genetic condition dang, Familial Adenomatous Polyposis (FAP) te pawhin colon chhungah polyp a siam thei bawk. Genetic test chauh hian FAP, MAP emaw, genetic condition dang emaw i neih leh neih loh a chiang thei.
• A châng chuan MAP an vei tih hriat a nih pawhin mi ṭhenkhat chuan polyp an nei lo mai thei.

Hetiang MAP dinhmun hi eng nge ni?

MAP hi kan MUTYH gene (MYH tia hriat bawk) a mutation vang a ni. Autosomal recessive angin a inherit a ni. Chumi awmzia chu he natna hi lo awm tur chuan i nu leh pa pahnih hnen atangin mutation hi i rochun a ngai tihna a ni. I nu leh pa pakhat chauh hnen atanga mutation i rochun chuan MAP i nei dawn lo. Mahse, MAP phurtu i ni. Carrier nih awmzia chu i biological parent dang pawh carrier a nih chuan i fa hnenah i pe thei tihna a ni.

Tunah hian mipui 1% leh 2% inkar chu (MAP) phurtu an nih thu an chhut. Carrier te pawh hian colon cancer vei theihna a sang deuh a, mahse (MAP) vei te angin a sang lo.

Engtin nge he (MAP) dinhmun hi thlah khat atanga thlah dangah rochun a nih?

Nu leh pa pahnih hi (MAP) carrier ni ta se. Chutiang a nih chuan an fate’n he natna hi an rochun theihna chance chu hetiang hi a ni:

• (MUTYH) gene mutation hi rochun loh theihna chance pali zinga pakhat (25%) a awm. Chumi awmzia chu naupangin natna a vei dawn lo tihna a ni a, chu naupang chuan mutation chu an fate hnenah a pass thei dawn lo tihna a ni.
• Carrier nih theihna chance pali zinga pahnih (50%) a awm. Chumi awmzia chu naupang chu a lo thanglian dawn lo (MAP), mahse genetic mutation chu an fate hnenah an pass thei tihna a ni.
• Nu leh pa pahnih hian he mutation hi an rochun theihna chance pali zinga pakhat (25%) a awm. Tichuan naupang chuan (MAP) condition a nei ang. Tin, naupang chuan an fate hnenah (MUTYH) gene mutation pakhat tal a pe chhuak ang.

Engtin nge a dinhmun (MAP) hi kan hriat theih ang?

MAP i neih leh neih loh hriat nan hian step tlemte a ngai tlangpui. I doctor chuan i chhungkaw chanchin chipchiar takin a zawt hmasa ang che. I nu leh pate, i pi leh pute, leh unaute cancer emaw, hriselna lama harsatna dang emaw an neih tawhte chu a zawt ang.

I doctor chuan genetic condition i nei thei tih a rinhlelh chuan genetic test neih a rawt thei ang. Heng test te hian (MUTYH) gene mutation leh cancer vei theihna tipungtu genetic condition dangte a hriat theih a ni.

Doctor chuan a hnuaia thil thlengah hian genetic test neih a rawt thei ang:

• I chhungkuaa tu pawhin (FAP), (MAP) emaw, genetic condition dang emaw an neih chuan.
• I chhungte hian colon cancer an vei tawh a nih chuan.
• I unau pakhat emaw a aia tam emaw chuan an colon-ah polyp tam tak an nei a, mahse i nu leh pate chuan an nei lo a nih chuan (chu chu i nu leh pate hi carrier an ni thei tihna a ni).

I genetic testing-in (MAP) i nei tih a finfiah emaw, carrier i ni tih a finfiah chuan i doctor chuan cancer screening neih dan tur a sawipui ang che.Tin, i chhungkaw dangte pawh he thil hi hriattir a pawimawh hle a, chutiang chuan an duh chuan genetic testing pawh an nei thei ang.

MAP hi engtin nge enkawl a nih?

Dik tak chuan he natna (MAP) hi damdawi a awm lo. Mahse, cancer venna atana pui thei tur test leh enkawlna tam tak a awm a, cancer a lo awm tak tak a nih chuan a tir lamah hmuhchhuah leh enkawl theih a ni.

(MAP) i neih chuan cancer screening neih hma leh a hma aia tam zawk i neih a ngai mai thei. Chung zingah chuan:

• Colonoscopy: Colonoscopy i tih lai hian i doctor chuan i colon leh rectum chhung chu a en theih nan camera dahna tur special lighted tube a hmang thin. Colonoscopy hi i colon chhunga polyp awmte hmuh leh paih chhuah dan tha ber a ni. Kum 20 vel atang khan i colonoscopy hi i ti tan tur a ni a, a nih loh leh i chhungkaw zinga mi pakhatin colon cancer a vei tawh a nih chuan, cancer an vei kum (a hmasa ber pawh ni se) aiin kum 10 hmain i ti tan tur a ni.
• Upper endoscopy: Upper endoscopy hmangin i doctor chuan i pum leh i small intestine (duodenum) chunglam polyp te chu a hmu thei a, a paih chhuak thei bawk. I colon-ah polyp i nei tih hmuhchhuah a nih chuan kum 25 i tlin hmain upper endoscopy i nei tan tur a ni a, a hma pawhin i nei tan tur a ni.

Condition hi ven theih a ni em?

(MUTYH) gene mutation lo awm tur hi ven theih a ni lo. Chu chu kan rochun thil a ni tihna a ni. Mahse, assisted reproductive techniques a awm a, chu chuan nakin lawka naupangin (MAP) a rochun theihna tur a ti tlem thei a ni. Entirnan, (Preimplantation Genetic Diagnosis - PGD) tih hi (In Vitro Fertilization - IVF) nen hman a ni a , hei hian he thlahtu natna nei lo fa neih theihna a tipung thei a ni. Hetiang method hmang hian embryo chu nausen pum chhunga dah hmain a genetic condition test a ni.

Mahse, IVF'' hmanga PGD'' i tih chuan sum tam tak a seng a, rilru lam thil ngaihtuah tur tam tak a awm. Hemi chungchang hi hriat belh duh chuan reproductive endocrinologist thiam tak nen inhmukhawm a tha ber.

(MAP) ka neih chuan eng nge ka beisei ang?

(MAP) i neih chuan midang aiin cancer screen hmasa leh tam zawk i mamawh mai thei. Chu chu a dik a ni. Mahse, damdawi lam enkawlna leh enkawlna dik tak nen chuan nun hrisel tak i hmang thei a ni. Chuvang chuan doctor hmu fo a, cancer laka inven dan tha ber berte sawiho a pawimawh.

Engtin nge (MAP) nei mi angin ka in enkawl ang?

Cancer vei theihna a sang tih i hriat chuan rilru lam harsatna, lungkhamna emaw, lungngaihna emaw a thlen thei a ni. Hei hi thil pangngai a ni. Chutiang rilru lama harsatna i neih chuan khawngaihin amah chauhva hmachhawn tum suh ang che. Enkawlna leh puihna chi hrang hrang a awm a, talk therapy atanga damdawi thlengin.

Thlamuanna leh kaihhruaina pe thei khawtlang thilte pawh i zawng thei bawk. Midangte nena inbiakna neih theihna tur support group-ah pawh i tel thei bawk. Hetiang hmunah hian nangmah ang bawka thil tawn tawhte i biak theih avangin chakna nasa tak a ni thei.

Cancer vei theihna tipung thei genetic condition neih hi a buaithlak tak zet a ni. Mahse, nangmah chauh i ni lo. I healthcare team te chu i tanpui turin an awm a ni. Tunlai cancer screening hmanraw changkang tak takte hian cancer vei theihna nasa takin a tihziaawm thei a, a hmaa i hmuh theih nan a pui thei bawk.

A tawp berah chuan thil hriat reng tur

Okay, chuti a nih chuan tunah chuan kan sawi tawh (MUTYH-Associated Polyposis - MAP) kha i hrethiam zawk tawh ang. Hriat reng tur pawimawh thenkhat chu hetiang hi a ni:

• MAP hi genetic condition a ni a, rochun a ni. Intestines-ah polyp a siam a, colon cancer vei theihna a tipung bawk.
• Symptom lian tham a thlen lo. Chuvangin chhungkaw history-a cancer vei an awm chuan damdawi lam thurawn hmanga genetic test neih a pawimawh hle.
• (MAP) i vei tih hmuhchhuah i nih chuan hlauthawng suh. A hun takah (Colonoscopy) leh (Upper endoscopy) ang chi test neih a nih chuan cancer hi a tir lamah ven theih emaw, hriatchhuah theih a ni.
• Rilru hriselna pawh a pawimawh hle. I mamawh chuan tanpuina dawng hreh suh.
• I medical team te nen inzawmna nei reng la, i hriselna pawh enkawl rawh.

He thu hi i tan a tangkai ngei kan beisei. Nang leh i chhungte hriselna tha kan duhsakna kan hlan e!