He cancer hmuh tur awm lo tak hi i hria em? NUT Carcinoma chungchang hi han sawi ila

NUT Carcinoma tih hi i hre tawh em? A ni lo mai thei. A chhan chu cancer chi khat, a tlem hle a, a lo thang chak hle a ni. Mahse a chanchin hriat a pawimawh hle a, a chhan chu he dinhmun hi tu chungah pawh a lo awm thei a ni. Chuvangin vawiinah hian chipchiar deuhin kan sawi dawn a, kan thianpa nen kan inbia ang maiin.

NUT Carcinoma chu eng nge ni?

A awlsam zawngin, NUT Carcinoma hi cancer chi khat, a lo thang chak hle a, a na hle a ni . Squamous cell carcinoma zingah chuan a na ber nia ngaih a ni. Tunah chuan squamous cells hi eng nge ni tih i ngaihtuah mai thei. Hengte hi kan vunah cell chi khat a awm a. Chu mai a ni lo, kan taksa chhungril thenkhat pawh heng cell-te hian a khuh vek a ni.

He NUT Carcinoma hi kan genes-a genetic mutation avanga lo awm a ni. A dik zawka sawi chuan `NUTm1` an tih gene a chhiatna avanga lo awm a ni. I hria em, heng genes te hian kan cell te hnathawh dan tur hrilhfiahna an pe a ni. Chuvangin, heng thupekteah hian tihsual a awm a, chu chu `mutation` a nih chuan, cell hrisel tak takte pawh chu `cancerous cell`-ah an chang tan ta a ni. Tichuan heng cancer cell te hi an inkhawm a, `tumors` an siam ta a ni.

A tam zawkah chuan heng NUT carcinoma te hi kan taksa lai takah, a nih loh leh ``midline`` -ah te an lo awm thin. Chuvang chuan a hmain NUT-midline carcinoma tia koh an ni. Mahse, heng tumor te hi taksa peng dangah pawh a lo awm thei bawk.

Khawiah nge heng cancer natna hrik hi a lo awm theih ang?

NUT Carcinoma vei hmuhchhuah te hian an taksaah hian a hnuaia hmun hrang hrangah hian tumor an nei a:

• Lu, a bik takin sinus-ah (hei hi a tam ber) .
• Kawr chungah (hei hi hmuh tur a awm bawk) .
• Lung chhungah (hei pawh hi a awm fo) .
• A rilru chhungril lam, thinlung leh lung awmna hmun (`mediastinum`) (hei pawh hi a awm fo) .
• Pancreas a ni
• Kidney a ni
• Adrenal glands a awm a
• Pumpui
• Bladder a ni
• Ruh chhungah (`Bones`) .

He cancer hi NUT Carcinoma tia koh hi a lo thang lian thei a, a darh chak hle a, enkawl pawh ni se . Chu chu a hlauhawm ber a ni.

NUT Carcinoma hi engtiang chiahin nge a tlem?

Hei hi a takah chuan cancer hmuh tur awm lo tak anga ngaih a ni . Mahse, kan ngaihtuah aiin damlo an tam zawk mai thei. International NUT Midline Carcinoma Registry-ah kum khatah hri kai thar 20 chauh an awm.

Hetiang zat a tlem chhan pakhat chu he natna hi hriat chian a harsat vang a ni. Scientist te chuan he cancer ziarang ber, ``NUTm1`` gene-a ``mutation`` hi kum 2004 khan an hmuchhuak chauh a, chuvangin, damdawi in zawng zawng hian he gene hi hmuchhuak thei ``testing materials`` hi an nei vek lo.

Natna thar hmuhchhuah ang maiin han ngaihtuah teh. Test dik tak chu hmun tinah a awm theih nan hun rei tak a ngai a ni.

Tin, NUT Carcinoma hi cancer chi dang tlanglawn tak nen pawh awlsam takin a inzawm khawm thei bawk. Cancer chu NUT Carcinoma a nih leh nih loh dik taka hriat theih chu `NUTm1` gene mutation hmuhchhuah a nih chauhvin a ni. Mi thenkhat `lu leh kawng cancer`, `lung cancer`, leh cancer chi dang thenkhat hmuhchhuah te hian he gene mutation hi an nei tak tak thei a ni.

Mahse tunah chuan he cancer chi hi awareness a san chhoh avangin, leh he genetic mutation hmuhchhuahna technology a lo tha chho zel avangin cancer specialist te tan chuan NUT carcinoma hi a hma aia awlsam zawkin an hmuchhuak ta a ni.

Tuin nge NUT Carcinoma vei?

He cancer hi thalai zingah hmuhchhuah tam ber a ni . Diagnosis a nih lai hian kum median chu kum 24 vel a ni. Chumi awmzia chu natna hmuhchhuah zinga a chanve vel chu kum 24 hnuai lam an ni a, a chanve dang chu kum upa lam an ni tihna a ni.

Mahse, he cancer hi tu pawhah a awm thei . Nausen piang tharah hmuh a ni tawh a, kum 80 hnuai lam zingah pawh hmuh a ni tawh bawk. Chuvangin kum a zirin chauh a thleng dawn lo tih ngaihtuah theih a ni lo.

NUT Carcinoma natna lan chhuah dan chu engte nge ni?

Vawi tam tak chu, he cancer hian a tir lamah chuan chhinchhiahna a nei lo . Cancer hi a lo lian deuh a, tumor chhehvel tissue te a nghawng tan hnuah symptoms a lo lang tan thin. Chutih hunah chuan i chau a, i dam lo tlangpui mai thei.

Sinus cavities leh lung-ah tumor a lo awm fo avangin, a symptom report tam ber chu a inzawm tlat a ni.

A lan chhuah dan tlangpui:

• Chauhna/chau lutuk (`Chau lutuk`) .
• Sawifiah loha taksa rihna tlahniam
• Mass hrehawm tak a ni

Sinus cyst natna lan chhuah dan:

• Sinus pressure, tightness, emaw natna emaw
• Hnar thisen chhuak fo thin
• Hnar congestion emaw, hnar hring emaw
• I rim hriatna hloh

Lung tumor chhinchhiahna: 1.1.

• Thâwk harsa emaw, thawk harsatna emaw
• Chronic cough (khuh chhunzawm zel, a reh lo) .

Heng symptoms i neih vang mai mai hian NUT Carcinoma hi hlau suh. Mahse heng symptoms te hi a la awm reng a nih chuan .Doctor hmu ngei tur leh thurawn lak a pawimawh hle.

Eng thilin nge NUT Carcinoma hi a thlen?

He cancer hi gene hrang hrang pahnih inzawmkhawm avanga lo awm a ni a, hybrid gene mak tak (`hybrid gene` emaw `fusion gene`) a siam a ni. NUT Carcinoma vei zawng zawngah chuan gene `NUTm1` chu a inzawm tur ni lo gene dang nen an inzawm khawm a ni. `NUTm1` gene hian a mah chauhin cancer a thlen lo a, mahse he hybrid gene siam thar hi cancer cell tipungtu a ni.

NUT carcinoma vei zinga 75% vel ah chuan `NUTm1` gene hi `BRD4` gene nen an inzawm khawm a ni. 15% vel dangah chuan `NUTm1` gene chu `BRD3` gene nen an inzawm khawm a ni. A tlem hle a, gene dang nen pawh a inzawm thei.

Scientist-te chuan heng genetic mutations hi eng thil nge a thlen tih an la hre chiang lo. Mahse thil pakhat a chiang a, rochun an ni lo. Cancer hlauhawmna tlangpui, meizuk leh carcinogens nena inzawmna te pawh a inrawlh niin a lang lo. Heng genetic changes te hi eng thilin nge nghawng a neih tih hriat chian nan zirchianna tam zawk neih a ngai a ni.

Engtin nge NUT Carcinoma hi hmuhchhuah a nih?

Doctor ten he natna hi biopsy hmangin an hmuchhuak thin. Hei hian tumor atanga tissue sample te tak te chu special hollow needle hmanga lak a huam a ni. Chumi hnuah sample chu lab-ah thawn a ni a, cancer cell a awm leh awm loh endik a ni.

I doctor chuan special imaging procedure hmangin i taksa chhunga tumor awm chu a en ang a, a stage a hre bawk ang. Cancer staging chu cancer nasat zia hriat theihna a ni a, chu chu tumor lian leh te, a awmna hmun leh primary tumor atanga taksa peng dang a darh (metastasized) leh darh loh te a zirin a ni. Cancer metastasis hi cancer cells te chu a bul tanna atanga an inthen a, lymph fluid emaw thisen kal tlanga an kal a, hmun hla tak tak emaw tissue emaw ah tumor thar an siam hian a thleng thin.

CT scan leh MRI scan hmangin taksa chhunga tumor awmna hmun a hriat theih. PET scan hmangin cancer hi a darh tawh em tih hriat theih a ni.

He natna hi hriat chian nan eng test nge tih thin?

Laboratory-ah hian ‘NUTm1` gene hi biopsy sample-ah a awm em tih hriat nan special test `Immunohistochemistry` tih a ni. Sample-ah hian `NUTm1` gene a awm (`positive`) chuan NUT Carcinoma a ni tih hmuhchhuah a ni.

He gene hriat theihna tura test dang tih theih chu Fluorescence In Situ Hybridization (FISH) test emaw, special genetic test dang emaw a ni.

NUT Carcinoma hi engtin nge enkawl a nih?

Tumor chu i paih chhuak thei bawk.Surgery leh radiation therapy a ngai mai thei. Cancer hi tumor piah lamah a darh tawh a nih chuan chemotherapy pawh pek theih a ni. Vawi tam tak chu heng enkawlna zinga pakhat emaw a aia tam emaw hi pek khawm a ni.

Mahse, NUT carcinoma enkawl hi a harsa hle. Vawi tam tak chu, enkawlnain cancer chu a na zual zel loh nan a titawp a nih pawhin, a lo thang lian tan ang a, rei vak lo hnuah a darh leh ang.

Hetiang hunah hian a pawimawh ber chu chak taka awm hi a ni. Doctor-te thusawi ngaithla a, anmahni nen hian he thil hi kan hmachhawn dun a ngai a ni.

NUT Carcinoma i vei tih hmuhchhuah a nih chuan clinical trial hi enkawlna tha ber a ni thei . Clinical trial hi enkawlna thar emaw, enkawlna kawng thar emaw test na zirchianna a ni. Tunah hian scientist te chuan NUT Carcinoma tan targeted therapy an zirchiang mek a ni. Targeted therapy hi cell hrisel cancer thlentu genetic mutation target-a enkawlna a ni.

NUT carcinoma enkawlna atana targeted therapies pakhat chu `BET` inhibitors a ni. Heng damdawi te hian gene pahnih, `BRD4` leh `BRD3` te chu an target a, chungte chu `NUTm1` gene nena inzawm tlangpui an ni. Heng inhibitor te hian chu gene `NUTm1` nen an inzawm chuan cancer cell te chu an lo thang lian zel a titawp thin.

NUT Carcinoma hi tihdam theih a ni em?

Vanduaithlak takin NUT Carcinoma hi damdawi a awm lo. Cancer thang chak tak a ni a, taksa peng dangah pawh a darh chak hle. A vaiin enkawlna dawngtute chu he natna an vei tih hmuhchhuah a nih hnuah thla 10 vel an dam a ni. NUT Carcinoma vei mi sawm zinga pahnih atanga pathum chu kum hnih chhung an dam a ni.

Mahse, cancer dang ang bawkin, i hmalam hun tur emaw, enkawlna i dawn dan tur emaw chu thil tam takah a innghat a ni. Tumor awmna hmun, surgery emaw radiation therapy emaw hmanga lak chhuah vek theih a nih leh nih loh leh zirchianna thenkhatah chuan NUTm1 gene nena paired gene dang pawhin hmun an chang ve bawk.

I doctor chuan i natna hmuhchhuah a zirin enkawlna tumte a hrilhfiah ang che.

Engtin nge ka in enkawl ang?

Hemi hun chhung hian i rintlak leh i thlawp mi te nen in hual vel a pawimawh. He diagnosis-a harsatna lo awmte i hmachhawn theihna tura puitu tur resource awm zawng zawng hmang tangkai rawh.

I doctor hnen atangin palliative care a niService chungchang zir rawh. He diagnosis avang hian palliative care professional te hian i nun mamawh tharte chu an enkawl thei che a ni. Chemotherapy leh radiation hmanga enkawlna avanga nghawng tha lo awm thei te enkawl turin an pui thei che a, cancer natna avanga nitin mawhphurhna i hmachhawn theih nan an pui thei bawk che a ni.

Nangmah chauh i ni lo tih hre reng ang che. Ṭanpuina leh ṭanpuina dil hreh ngai suh.

Doctor hnenah eng zawhna nge ka zawh ang?

Hetiang hunah hian doctor zawh duhna tam tak a awm thei. Entirna thenkhat chu hetiang hi a ni:

• Cancer hi a darh tawh em?
• Specialist hmuh a ngai em, damdawi in bik pan a ngai em?
• Eng ang enkawlna nge i rawt?
• Enkawlna avanga hlawkna leh hlauhawm awm thei te chu engte nge ni?
• Enkawlna tumte chu engte nge ni?
• Palliative care te pawh tiamin support service dang ka hmuh theih nan min pui thei ang em?

NUT Carcinoma enkawlna hi a nasa thei hle. Oncologist appointment neih fo leh nitin nunah lungkhamna a awm avangin cancer hmuhchhuah tawhte hmachhawn chu a harsa thei hle. Palliative care ang chi medical resources te hian a pui thei a ni. Tin, i hmangaih takte hnena thlen chu chakna nasa tak a ni thei bawk. I diagnosis i dawn atang khan, hmalam pan zel tur chuan care option tha ber berte hriatthiam theih nan i cancer care team nen zalen taka inbiakna neih a pawimawh hle. Mi tinin cancer kan tawn dan hi a inang lo. He hun harsa tak karah hian i medical team te chu kaihruai turin an awm reng a ni.

Thil pawimawh hriat reng tur (Take-Home Message) .

Okay, chuvangin kan sawi tawh atang hian i hriat reng tur pawimawh ber berte chu khaikhawm ila:

• NUT Carcinoma hi cancer chi khat, a awm lo hle a, mahse a darh chak hle a, a nasat em em bawk.
• Hei hi gene ``NUTm1`` a mutation vang a ni. Hei hi rochun thil a ni lo.
• Cancer a lo zual deuh hnuah symptoms a lang fo thin. Ngaihsak suh la, natna lan chhuah dan danglam tak, a awm reng chuan damdawi lam thurawn zawng rawh.
• Diagnosis atan hian biopsy leh special genetic test neih a ngai a ni.
• Enkawlna hi a harsa hle a, mahse enkawlna thar chungchangah zirchianna kalpui mek a ni. Clinical trial hi duhthlan tur tha tak a ni mai thei.
• He zinkawngah hian palliative care leh i hmangaih tak takte puihna hi a pawimawh hle.
• I medical team nen engkim chungchang chu tlang takin sawi rawh.

He thu hi i tan a tangkai ngei ka beisei. He natna hi hriat chian chuan a hun a lo thlen hunah thutlukna dik siam turin a pui ang che.

` NUT Carcinoma, cancer, genetic mutations, cancer hmuh tur awm lo, squamous cell carcinoma, cancer symptoms, cancer enkawlna