I doctor-in i chhungkuaa mi tu emaw, i nu emaw, i pa duh tak emaw pawhin Parkinson’s Disease a vei tih a hrilh che chuan hlauhna leh lungkhamna nasa tak i neih chu thil pangngai a ni. He natna hi damdawi la awm lo mah se, a natna lan chhuah dan thunun thei tur leh nunphung tha tak vawng reng thei tur damdawi tha tak tak a awm nual. Chuvangin vawiinah hian heng damdawi te hi eng nge an nih, engtin nge an thawh tih leh kan fimkhur a tul tih te han sawi ila.
Engvangin nge Parkinson natna hi a lo awm? Damdawi ei hian eng nge thleng?
A awlsam zawngin sawi ila, Parkinson natna hi thluak lam natna (progressive neurological condition) a ni a, taksa chetna a nghawng a ni. A chhan chu thluaka nerve cells te, a bik takin thluaka chetna control tu substantia nigra an tih hmuna nerve cells te a bo zauh zauh vang a ni. Heng nerve cell te hian neurotransmitter dopamine an tih chu an siam chhuak thin .
Ngaihtuah teh, chemical pakhat dopamine an tih hi kan taksa kal tluang taka a kal theih nan a pawimawh hle a, traffic jam awm lohna kawngpuiah lirthei khalh ang maiin. Parkinson natnaah chuan he dopamine siam chhuah hi a tlahniam a, chu chuan a natna lan chhuah dan chu a che slow, a khur leh a nghet lo.
Chuvangin Parkinson natna damdawi tam tak thil tum ber chu engtin emaw tak thluaka dopamine level hniam tak control hi a ni.
Damdawi hman ber ber
Doctor-te chuan Parkinson vei tan damdawi engemaw zat inzawmkhawm an pe tlangpui a, pakhat chauh ni lovin. Damdawi chi hrang hrang hi han thlir ila.
| Ruihhlo Class | A Hnathawh Dan | Thu pawimawh tak tak |
|---|---|---|
| Levodopa leh Carbidopa te a awm bawk | Levodopa hi thluaka kal a, dopamine-ah a chang a ni. Mahse thluak a thlen hmain taksaah a chhe vek tawh avangin, a tihtawp nan damdawi carbidopa an tih nen an inzawm khawm a ni. | Hei hi Parkinson natna damdawi ber leh tangkai ber a ni. Incheina slowness (bradykinesia), rigidity, leh tremors tihziaawmna atan a tangkai hle. |
| Dopamine Agonist te hi an ni | Hengte hian thluaka dopamine receptor te a tichak a, dopamine angin "a thawk" bawk. Chu chu heng damdawi te hian dopamine tih ang bawk hian an ti tihna a ni. | Natna bul tan tirh lamah emaw, damlo naupang zawkah emaw hman fo thin a ni a, levodopa hman tangkai dan hi hun rei zawk vawng reng turin a pui bawk. |
| Enzyme inhibitor (MAO-B & COMT) hmanga siam chhuah a ni. | Heng damdawi te hian thluaka dopamine tichhe thei enzyme te hnathawh a ti tlem a, chu chuan dopamine chu thluaka rei zawk a awm tir thei a ni. | Hengte hi levodopa thiltihtheihna tihpun leh rei zawka a awm theih nan pek a ni. |
| Amantadine a ni | Dyskinesia control nan a pui a, hei hi control loh taka che leh chetna, levodopa ang chi damdawi avanga lo awm thei a ni. | A tir chuan antiviral anga hmuhchhuah ni mahse, chetna lama harsatna dang Parkinson natna tan pawh a tangkai hle. |
| Anticholinergic damdawi te pawh a awm | Dopamine a tlahniam chuan chemical dang acetylcholine an tih hian nghawng a nei nasa hle. Heng damdawi te hian a nghawng a tikhawlo a, khur leh taksa ruh (muscle stiffness) a ti tlem a ni. | Damlo khur nasa lutuk tan chuan a hlawkthlak thei hle. |
A pawimawh ber chu heng damdawi zingah hian eng damdawi nge pek tur tih leh eng dose nge pek tur tih chu i doctor chauhvin a rel thei a ni. Damlo kum, a natna lan chhuah dan leh thil dang tam takah a innghat a ni.
Damdawi ei hian side effect a neih dan pawh kan hre tur em ni?
Damdawi dang ang bawkin Parkinson damdawi hian side effect a nei thei a ni. Chungte chu damdawi chi hrang hrang a zirin a inang lo. Ngaihtuah buai suh, mi zawng zawng hian heng side effect zawng zawng hi an nei vek dawn lo. Mahse, anmahni fimkhur a pawimawh.
- Levodopa: Enkawlna hmasa berah luak chhuak, luak chhuak, luak chhuak, lu na, nitin mutthilh, leh postural hypotension te hi a awm thei. Kum upa lamteah chuan buaina, thil hmuh theih loh, rilru lam natna (psychosis) a awm thei.
- Dopamine Agonists: Hengte hian i ei tan tirh hian rilru hahna, mutthilh, hmui a vawt, buaina, leh thil hmuh loh (hallucinations) a thlen thei a ni. Mahse, heng symptoms te hi ni rei lo te chhungin a reh tlangpui.
- Damdawi dang: Damdawi thenkhat hian side effects a thlen thei a, chu chu riltam, rilru na, mut theih lohna, ke na, chaw ei kham, emaw hmui vawt te hi a ni.
Vaukhânna pawimawh tak: Doctor rawn hmasa lovin levodopa ei kha titawp ngai suh, a dose pawh tihtlem nghal suh. Chutianga tih chuan natna hlauhawm tak, nunna atana hlauhawm tak, Parkinsonism Hyperpyrexia Syndrome tih chu a thlen thei a ni. Neuroleptic Malignant Syndrome ang chi natna khirh tak a ni. Eng thil vang pawha damdawi ei kha i chawlhsan a ngai a nih chuan i doctor nen inbia ngei ang che.
Symptom dang, chetna nena inzawm lo damdawi a awm em?
Awle. Parkinson’s hi chetna tichhe thei natna mai a ni lo. Mahse a kaihhnawih harsatna dang tam tak a awm a. Chu chu doctor pawhin a enkawl thei bawk.
| Symptom a ni | Enkawlna awm thei te |
|---|---|
| Ek khal | Damdawi bawlhhlawh tihziaawmna tura puitu, polyethylene glycol (MiraLax ang chi) te hi a ni. |
| Nitin Mutthilh theihna | Damdawi chi hrang hrang Modafinil (Provigil ang chi) te. |
| Depression emaw, Lungkhamna emaw | SSRI chi hrang hranga antidepressant damdawi. |
| Psychosis/Hallucinations te a awm thei | Antipsychotic damdawi bik pimavanserin ang chi te. |
| Erectile Dysfunction a awm a, a rilru a buai em em bawk | Sildenafil (Viagra ang chi) damdawi. |
Damdawi tih loh chu eng nge tih theih dang?
Damdawi hi he indonaah hian a tel ve pakhat chauh a ni. Tin, damlo nunphung tichangtlung thei thil dang tam tak a awm bawk.
Parkinson natna enkawl nan hian exercise leh physical therapy hi a pawimawh hle. Dik tak chuan exercise hi natna zual zel tur tikhawtlai theitu a ni tih finfiah a ni.
- Physical therapy: Parkinson vei te tana ruahman bik physical therapy programme hian balance, gait, leh stability a ti tha thei a ni.
- Exercise: Kar khatah minute 150 tal cardiovascular exercise neih a pawimawh hle. Cycle leh boxing ang chi thiltih te hi a hlawkthlak hle tih hmuhchhuah a ni.
- Rilru hriselna: Parkinson ang natna khirh tak nena nun hi rilru lama harsatna a ni thei. Chuvangin i lungngaih emaw, i lungkham emaw a nih chuan rilru lam hriselna lama mithiam, psychologist ang chi te biak hreh suh.
Engtikah nge doctor ka hmuh leh ang?
Parkinson damdawi i ei hian doctor pan fo a pawimawh a, damdawi hian hna a thawk em tih leh symptom thar i neih leh neih loh enfiah a pawimawh. I doctor nen inbia ngei ang che, a bik takin hetiang dinhmunah hian.
- I tuar theih loh side effect i neih chuan.
- I symptoms a lo tha lo emaw, a na zual emaw chuan.
- Damdawi ei kha tihtawp duh i neih chuan.
Take-Home Thuchah a ni
- Parkinson natna hi tihdam kim theih ni lo mah se, a natna lan chhuah dan chu a thunun thei hle a, nun tha tak i hmang thei bawk.
- Levodopa hi he natna damdawi atana hmanraw pawimawh leh tha ber a ni.
- Doctor thurawn tel lo chuan damdawi ei kha bansan suh emaw, a dose pawh thlak danglam suh.
- Exercise leh physical therapy hi damdawi ang bawkin a pawimawh a. Exercise hian natna kal zel dan tur a thunun thei a ni.
- Side effect emaw, harsatna dang emaw i neih chuan doctor nena inbiakna neih hi hlau suh. I tanpui turin a inpeih reng a ni.
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