I chau fo em, chaw ei lama harsatna awm reng i nei fo em, a nih loh leh sawifiah theih loh riltam i tawk fo em? Vun danglamna danglam tak i hmu em, a nih loh leh hriatrengna lama harsatna i tawk em? Hêng chhinchhiahnate hi dinhmun hrang hrang nêna inzawm thei a nih laiin, a pum puiin hrisêlna chungchânga ngaihtuahna bik, ngaihthah fo ṭhin chu a târ lang thei a ni. Vawiin hian Pellagra tia hriat natna pakhat kan sawi dawn a ni.
Pellagra chu eng nge ni?
A awlsam zawngin sawi ila, Pellagra hi Niacin , Vitamin B3 tia hriat bawk ei tlem avanga natna a ni. Hei hi a bul berah chuan ei leh in lama harsatna (malnutrition) chi khat a ni—a bik takin, micronutrient tlakchhamna a ni. I taksa hian cellular function tha ber tur chuan Niacin a mamawh a ni. Level a tlahniam chuan a nghawng chu i system pumpuiah a lang a, a bik takin vun, hmui, chaw ei kawng leh thluak-ah te a awm a ni. Damdawi lam inrawlhna mumal tak tel lo chuan Pellagra hian nerve a tichhe vek thei a, a nasat chuan thihna a thlen thei bawk.
Hei hian mi zawng zawng a nghawng em tih i ngaihtuah mai thei. A tlangpuiin ei leh in inthlau tak ei thinte hian Niacin tling tak an dawng thin. Primary Pellagra—ei leh in ei tlem avanga lo awm—chu ei tur mamawh lohna hmunah hmuh tur a tam ber. Mahse, Sri Lanka telin ram changkang zawkah chuan Niacin tlakchhamna hi secondary cause atanga lo chhuak a ni fo thin. Hei hian a awmzia chu hriselna dinhmun dang emaw thil dang emaw hian i taksain i Niacin i ei thin chu a hip lut thei lo va, a hmang thei lo tihna a ni.
Niacin chu eng nge ni a, engvangin nge i mamawh?
Niacin hi i taksa “engine” tha taka a kal theihna tura fuel additive angin ngaihtuah teh. Engine pakhatin hna a thawh theih nan refined fuel a mamawh ang bawkin, i taksa pawhin i ei calorie te chu hman theih tur energy-a siam turin Niacin a mamawh a ni.
I intestine te tak te hmanga a insiam hnuah Niacin hi coenzyme pawimawh takah a chang a, chu chu Nicotinamide Adenine Dinucleotide (NAD) tih a ni. NAD hian i taksaa enzyme 400 chuang a support a ni. A awlsam zawngin sawi ila, NAD hi Adenosine Triphosphate (ATP) tia hriat cellular energy siam chhuahna atan a pawimawh hle. Energy siamchhuahna piah lamah NAD hi DNA siamthatna leh cellular communication atan a pawimawh hle.
Niacin tlakchhamna hian engtin nge i taksa a nghawng?
NAD hi cellular energy atana pawimawh tak a nih avangin, tlakchhamna hian energy mamawhna sang tak emaw, cell turnover chak tak nei system-te a rawn nuai a: i vun, i gastrointestinal tract lining leh i thluak. Doctor-te chuan Pellagra natna chhinchhiahna langsar tak chu “3 Ds” tiin an sawi fo thin: Diarrhea, Dermatitis, leh Dementia. Ṭhenkhat chuan “D” palina an belh leh a: Thihna . Hun rei tak enkawl loh chuan a rah chhuah chu thihna thlen thei a ni.
1. Luak chhuak (Gastrointestinal mucositis) .
Diarrhea hi i chaw ei kawng (digestive tract) venhimna (protective lining) a lo piang tha lo a nih chuan a lo awm thin. He protective barrier hi awm lo se chuan i gut hian ei tur a digest nasa hle a, infection leh injury lakah a inveng nasa hle bawk. Hei hian chaw ei kawng zawng zawngah natna khirh tak a thlen a, chu chu pum na, chaw ei loh, hmui natna, leh lei hring, sen hring angin a lang chhuak thin.
2. Dermatitis (Vain êng hriat theihna) .
Pellagra hian vun natna danglam tak a siam a, a bik takin ni ênga awmna hmunah , hmai, kawr, kut leh keah te a awm a ni. Cellular energy tling lo chuan vun cell te chu UV light lakah an hypersensitive ta a ni. A tir lamah chuan vun chu a sen leh ni zungin a kang thei a, a tawpah chuan a hring, a hring a, hyper-pigmented plaques (darkened patches) a lo awm thei a ni. Hallmark sign chu a kawrfual dum, “Casal’s collar” tia hriat a ni a, chu chu kum 1735-a he natna hi a hriatchhuah hmasak bertu doctor Don Gaspar Casal hming chawia sak a ni.
3. Dementia (Thluak leh nerve tihchhiatna) .
Pellagra hian cell tina energy siamchhuahna a nghawng avangin a tawpah chuan thluak leh nervous system a nghawng a ni. A hmaa chhinchhiahnate chu a fiah lo thei hle a, chu chu hah reng, ngaihsak lohna (ngaihsak lohna), a nih loh leh ngaihtuahna seng harsatna te hi a ni. Lungkhamna emaw, lungngaihna emaw i nei thei bawk.Hun a kal zel a, heng symptoms te hi buaina leh delusions ah a lo zual thei a ni. A nasat chuan permanent dementia a awm thei a, chubakah neurological impairment , balance tha lo, kal dan tihbuai, taksa ruh natna, leh khur te pawh a awm thei bawk.
Khawiah nge Pellagra hi a tam ber?
Tunhma atang tawh khan Pellagra hi ei leh in tlemte nei population zingah a hluar hle a, a bik takin protein tamna supplement dawng thei lo, ei tur atana corn (maize) rinchhan nasa tak takte zingah a hluar hle. Corn-ah hian Niacin awm mah se, mihring taksain awlsam taka a lakluh theih loh “bound” form-ah a awm a ni.
Central leh South America-ah chuan corn chu tortilla-a siam dan hluiah chuan a buh chu lime tuiah an hnim a ni. Hetiang hian Niacin bound chu a chhuah tir a, chu chuan bioavailable a siam ta a ni. Chuvangin, chutiang hmunah chuan Pellagra ( Pellagra ) hi hmuh tur a awm tlem hle.
Tunah chuan flour leh rice ang chi staples fortification hian khawvel hmun tam takah primary Pellagra nasa takin a tihtlem phah a ni. Mahse, a tlem hle laiin, Pellagra vei chhan pahnihna chungchangah hian kan fimkhur reng a ngai a ni. Heng symptoms te hi i nei nia i rinhlelh chuan i hnai ber hospital emaw emergency services emaw hnenah zawh nghal rawh.
Pellagra natna lan chhuahna chu engte nge ni?
Pellagra natna lan chhuah dan tlangpui chu hetiang hi a ni:
- Persistent diarrhea , a chang chuan thisen chhuak thei.
- Pum natna leh chaw ei loh .
- Chaw ei chak lohna , luak chhuak leh luak chhuak .
- Vun na tak emaw vun natna nei emaw .
- Kawng natna leh lei sen hring, hring hring.
- Chauhna nasa tak, chak lohna, leh malaise tih hriatna tlangpui.
- Mood inthlak danglam leh depression.
- Neurological symptoms – entirnan, taksa peng hrang hranga khur emaw, rilru hahna emaw.
- Delirium leh dementia natna lan chhuah dan.
Pellagra hi engte nge ni?
A chhan ber chu niacin (Vitamin B3) tling lo ei leh in vang a ni. Chaw chi hrang hrang atanga niacin kan hmuh laiin, mimal, ei leh in inthlau tak nei lote chu an tlachham thei a ni.
Tin, a chhan pahnihna avang hian pellagra i vei thei bawk . Hei hian i taksain niacin a hip thei lo va, a hmang thei lo tihna a ni a, hei hi hriselna lama harsatna awm vang a ni. Entirnan:
- Gastrointestinal natna, malabsorption thlentu – Inflammatory Bowel Disease (IBD) emaw liver cirrhosis emaw ang chi te.
- Zu hmansualna: Zu in tam lutuk hian liver ang chi taksa peng hrang hrang a tichhia a, niacin ang chi ei tur pawimawh tak takte lakluhna a tichhe a, ei leh in tha lo tlangpui a thlen thin.
- Gastric bypass surgery: Surgery hnuah intestinal lining a chhiat chuan micronutrient pawimawh tak tak, niacin te pawh lakluhna a tibuai thei a ni.
- Iron deficiency anemia: I taksa hian niacin hi tha taka a thlak danglam theih nan leh a hman tangkai theih nan iron a mamawh a ni.
- Hartnup disease: Taksain vitamin siamna atana mamawh amino acid thenkhat a lakluh theih nana a beih nasat em emna genetic condition a ni.
- Carcinoid natna (carcinoid syndrome) a ni.Tumor cell thenkhat hian taksain niacin a siam chhuah a tihtlem thei a ni.
- Damdawi thenkhat: A bik takin niacin metabolism tibuai thei antispasmodics leh chemotherapy damdawi thenkhat.
- HIV hrik kai: HIV hian taksaah niacin a ti hniam thei a.
Engtin nge Pellagra hi hmuhchhuah a nih?
Doctor i tlawh hunah an enfiah ang che, i natna lan chhuah dan te, i damdawi lam chanchin te, leh ei leh in dan te an enfiah ang che. I doctor chuan pellagra a rinhlelh chuan chemical level bik tehna atan zun test a ti thei a, chu chuan i taksain niacin a dawng tlem em tih hriat nan a pui thei a ni. I doctor chuan i natna lan chhuah dan a ṭhat leh ṭhat loh en turin niacin supplement a pe thei bawk a; he therapeutic trial hi Nirogi Lanka leh clinic dangtea hman tlanglawn diagnostic approach dang a ni.
Pellagra damdawi hi engte nge ni?
Pellagra hi niacin (Vitamin B3) tlakchham vang a nih avangin enkawlna tha ber chu niacin supplement hmanga ei tur awm lo chu tihpun leh hi a ni. Mi tam zawk chuan enkawlna an tan veleh an dam nghal vat thin. Mahse, vun emaw, hmui emaw natna ang chi secondary symptoms te tan chuan enkawlna dang i mamawh mai thei.
A pawimawh ber chu, i pellagra hi secondary condition avanga lo awm a nih chuan, chu underlying medical issue atan chuan enkawlna dik tak i dawng tur a ni.
Enkawlna hian side effect a nei em?
I doctor-in a tih angin niacin supplement hian side effect lian tham a nei tlem hle. Adverse effects hi overdose chauhvin a thleng tlangpui a, hei hi deficiency vei mi pakhatah chuan a awm theih loh. An lo awm tak tak a nih chuan:
- Vun a rawn sen chhuak.
- Itching emaw rashes emaw a awm thei.
- Bloating leh indigestion.
- Lu na leh luak chhuak.
Engtin nge Pellagra hi i ven theih ang?
Ei leh in inthlau tak neih hi ei leh in tha tak neih theihna kawng awlsam ber a ni. Chaw ei tur tlem i neih chuan enriched foods leh dietary supplement te hian a pui thei a ni. Puitling hrisel tak chuan nitin niacin 15mg vel a mamawh tlangpui a, hei hi a tlangpuiin B-complex vitamin supplement hmanga pek a ni.
Niacin tamna ei tur zingah hian:
- Bawngsa thin a ni
- Beets a ni
- Brewer-a yeast a ni
- Chhang leh buhfai enriched
- Nga hriak nei, salmon leh tuna ang chi
- Peanuts a ni
- Alu (Alu) a ni
- Vawk vulh
- Buhfai
- Sunflower chi a ni
- Spaghetti sauce hmanga siam a ni
Pellagra vei theihna tipungtu hriselna lama harsatna rei tak i neih chuan, hun rei tak chhunga invenna tur ruahmanna i doctor nen sawiho la, chu chu i ei leh in, supplement, a nih loh leh tuna damdawi i hman danah siamthat a ni thei.
Pellagra atanga dam leh theih nan eng chen nge a ngaih?
Niacin supplement i ei tan chuan mi tam tak chuan ni engemaw zat chhungin hmasawnna an hmuchhuak thin. Gastrointestinal symptoms (diarrhea ang chi) hi a tlangpuiin a reh hmasa ber thin , a tlangpuiin kar hmasa chhungin a reh thin. Vun leh hmui natna hi a dam theih nan kar hnih vel a ngai thei. Nasat lutuk chuan hun rei zawk a daih thei. Khawngaihin hre reng ang che: thluak lama chhiatna nasa tak leh dementia hi a chang chuan tihdanglam theih loh a ni thei.
Doctor-te chuan nakin lawkah primary pellagra laka inven nan ei leh in inthlau tak neih an rawt a ni. Niacin tlakchhamna hi micronutrient tlakchhamna dang nen a inmil fo a, chung zawng zawng chu ei leh in hrisel hmanga chinfel theih a ni.
Secondary pellagra enkawl hi a buaithlak zawk. Supplement hian a puih laiin, i taksain niacin a metabolize dik theih loh chuan a tawk lo mai thei. Hetiang hunah hian dam lehna chu natna bulpui hriatchhuah leh enkawlnaah a innghat vek a, hei hi hun rei tak chhunga tih theih a ni.
Take-Home Thuchah hnuhnung ber
Ram changkang zawkah chuan primary pellagra hi a tam zawkin tihbo a nih laiin, ei tur tlemte nei population tan chuan hlauhawm tak a la ni reng thung. Kan khawtlang nunah hian zu hmansual leh hriselna dinhmun hnuaia awmte avang hian secondary niacin tlakchhamna hi ngaihtuahawm a la ni reng a—a bik takin nutrient absorption tichhe thei a ni. Heng symptoms te hi i neih i rinhlelh chuan i awmna hmuna damdawi inah medical professional hnen atangin kaihhruaina zawng nghal rawh.
Hriat tur pawimawh ber chu, ei leh in hi i ei leh in atanga tan a nih laiin, i taksa chhungril lam thil kalphung hi i hriselna tur dik tak tidanglamtu a ni. I taksa hian hrisel taka awm theih nan chhungril hnathawh (complex internal functions) a rinchhan a ni. I ngaihtuah tûr chhinchhiahna i hmuh chuan—a bîk takin i chaw ei khâwmna nêna inzawm thilte—khawngaihin mi thiam doctor thurâwn la rawh. Vitamin tlakchhamna tenau tak pawh hian i hriselna nasa takin a nghawng thei a ni. Chuvangin, ei leh in inthlau tak ei hi ngaihtuah la, nun hrisel nei la, hriselna lama harsatna i neih chuan doctor rawn vat rawh.
Pellagra, Niacin, Vitamin B3, Ei leh in lama harsatna, Vun natna, Luak chhuak, Dementia
