Depression hi a lan dan angin a awlsam lo. Chumi nena nun chu thil harsa tak a ni fo thin. Mi thenkhat chuan an tana enkawl dan tur dik tak an zawn theih nan hun rei tak a ngai thin. A châng chuan, damdawi pakhat chauh hian hahdamna famkim a pe lo thei bawk. A chhan a awm. Hei hi a tir atangin i hrethiam ang u.
Engvangin nge depression hi a lo awm? Engtin nge Rexulti ang damdawi hian a puih theih ang?
A awlsam zawngin, Major Depressive Disorder (MDD)-ah chuan kan thluaka chemical thenkhat level a tlahniam a. Hengte hi neurotransmitter kan ti a. Serotonin leh dopamine tih hi i hre tawh mai thei . Hengte hi chemical messenger lian ber berte an ni a, kan ngaihtuahna, ruahmanna, hlim taka kan awm dan, kan ngaihven dan leh kan mut dan ang chi thilte thununtu an ni. Chuvangin hengte hi a tlem chuan depression symptoms a lo lang thin.
Heng chemical level te hi siam that lehna tura pui turin antidepressant hi an pe tlangpui. Mahse a chang chuan heng damdawi te hian natna lanchhuahna a tihziaawm thei a, mahse nitin nunah hnathawh theih loh khawpa natna lanchhuahna a hnutchhiah thei a ni. Mi thenkhat chuan enkawlna an dawn chuan a then chauh an chhang thin. Hei hi treatment-resistant depression an ti a.
Hei hi doctor ten tuna an damdawi hman mek zingah damdawi dang an dah belh hian a ni. Hei hi adjunctive treatment an ti a . Chu chu, tuna enkawlna "puitling" tura pek, a thatna "boost" turin damdawi pek a ni.
Rexulti (brexpiprazole) hi chutiang damdawi dang pakhat a ni. Hengte hi damdawi chi khat, second-generation antipsychotics an tih zingah an tel a ni. Heng damdawi thar zawkte hian damdawi hlui aiin side effect an nei tlem zawk a, chu chu khur, taksa ruh khauh, leh taksa rihna tihpun te hi a ni. Rexulti hian thluaka chemicals te chu kawng danglam takin a control a, symptoms a tihziaawm rualin side effects awm theihna a ti tlem bawk.
Engtin nge Rexulti hian taksa chhungah hna a thawh?
Rexulti hian thluaka dopamine leh serotonin level tihsan hmangin hna a thawk ber a ni. A bik takin he damdawi hian thluaka receptor thenkhatah a binding a, dopamine trapped chu a chhuah tir thei a ni. Serotonin hnathawh a tichak bawk a, hei hian mood a ti tha thei a, depression symptoms a tihziaawm thei bawk.
He damdawi hi engtin nge ka hman ang?
Rexulti hi ni khatah vawi khat ei thin pill a ni. Chaw ei rual leh ei loh pawhin ei theih a ni. A tlangpuiin dose hniam tak, milligram chanve (0.5mg) vel atanga tan a ni. Chumi hnuah chuan i doctor chuan i taksain a chhan dan te, damdawi dang i ei dan te, leh i kal emaw, i thin emaw a thawh that dan a zirin a dose chu a tipung zauh zauh ang. Depression tan chuan ni khatah milligram 3 (3mg) a ni.
A pawimawh ber chu i doctor thupek dik taka zawm hi a ni. Nitin a hun takah damdawi ei hi i thluak chemistry balance theihna tur, i symptoms control theihna tur leh hnathawh that theihna awmchhun a ni.
He damdawi hian a tidam nghal lo che tih hre reng ang che. I natna lan chhuah dan a danglam tih hriat nan kar engemaw zat a ngai thei. Chuvangin damdawi hman reng hi hlawhtlinna kawngkhar a ni.
He damdawi hlawhtlinna chungchangah hian zirchianna eng nge a sawi?
Rexulti hi depression tan engtiang chiahin nge a tangkaiin a him tih hriat tumin zirchianna lian tak pahnih neih a ni tawh bawk. Heng zirchiannaah hian mi pawl khat chu Rexulti pek an ni a, pawl dang chu placebo pek an ni bawk. Hei hian zirchiangtute chu damdawiin a nghawng dik tak chu a teh thei ta a ni.
Heng zirchianna result atanga a lan dan chuan kar 6 hnuah Rexulti an ei thin antidepressant damdawi ei thin tam zawk chuan depression symptoms moderate to mild an nei a ni.
A hnuaia table hian result a tarlang mai a ni. Score a hniam poh leh symptoms a na zual thin.
| Pawl | A tir lamah depression level (average score) 1.1. | Kar 6 hnua depression level (average score) 1.1. | Score hrang hrang (hmasawnna) 1.1. |
|---|---|---|---|
| Zirna 1: Placebo (dummy pill) tih a ni. | 27.3 | 22.1 | -5.2 |
| Zirna 1: Rexulti 2 mg | 26.9 a ni | 18.5 a ni | -8.4 |
| Zirna 2: Placebo (dummy pill) tih a ni. | 26.5 a ni | 20.2 | -6.3 |
| Zirna 2: Rexulti 1 mg | 26.5 a ni | 18.9 a ni | -7.6 |
| Zirna 2: Rexulti 3 mg | 26.5 a ni | 18.2 | -8.3 |
Heng zirchianna atanga i hmuh angin Rexulti ei thinte hian an natna lan chhuah danah hmasawnna nasa tak an nei a ni. Heng zirchiannate hian nitin nunah, chhungkua nena, khawtlang nunah, leh hnathawhna/sikul lama an hnathawh theihna chu a lo tha chho tih a nemnghet bawk.
Engtin nge damdawi hian hna a thawk em tih ka hriat theih ang?
Kar tlemte emaw, thla engemaw zat emaw chhungin i natna lan chhuahnaah hmasawnna nasa tak i hmu tan ang. I chhungte leh i thiante pawhin nangmah a danglamna chu an hmu ang.
- Mood a tha zawk
- Energy emaw motivation emaw tam zawk
- Mut tha zawk
- Hmanlai thil tih nuam i tih thinte ngaihven.
- Lungkhamna emaw, lungkhamna emaw a tlahniam
- Ei duhna a tipung
- Concentration tha zawk
Heng inthlak danglamna te hi zan khat thil thuah a thleng lo. Zawi zawiin an thleng thin. Chuvangin, i symptoms inthlak danglamna te hi i chhinchhiah reng a pawimawh. Eng chen nge enkawl i mamawh tih hi mi hrang hrangah a inang lo. Thenkhatin hun rei lote chhung atan an mamawh a, thenkhat erawh chuan hun rei tak chhung an mamawh thung.
A pawimawh ber chu i natna lan chhuah dan a tha chho zel nia i hriat avangin i doctor nen inbia lovin i damdawi ei kha bansan loh tur a ni. Chutianga i tih chuan i symptoms chu a zual leh thei. Thla engemaw zat hnua i rilru a hahdam loh chuan chu pawh chu i doctor hnenah hrilh bawk ang che.
Side effects leh engtin nge kan enkawl ang?
Rexulti hian a side effect langsar ber chu taksa rihna sang, mutthilh, luak chhuak, flu ang chi natna, leh rilru hah (thut theih lohna) te hi a ni. Hengte hi mi zawng zawngah a thleng vek lo va, mahse hun kal zelah a tlahniam tlangpui.
| Side effect a awm thei | Eng nge i tih theih |
|---|---|
| Taksa rihna sang, cholesterol/sugar tihpun | Nunphung hrisel tak hmang rawh. Exercise la, i eitur ah thlai, thei leh sa thau lo te dah tel bawk ang che. Oil, chi leh sugar te tihtlem rawh. I doctor chuan i rihna, i thisen sang, cholesterol leh sugar level te a enfiah fo ang. |
| Mutthilh emaw, luak chhuak emaw | Mut hah i hriat chuan zan mut hmain damdawi hi ei hmasa phawt ang che. Thut emaw, mu emaw atang chuan zawi zawiin tho rawh. Damdawi hian engtin nge a nghawng che tih i hriat hma chuan lirthei khalh loh tur. |
| Hahdam lohna (Akathisia) . | Hei hian hmun khata awm thei lo leh vakvai mai maia inhriatna a kawk a ni. Exercise light tak tak, kea kal leh stretching te hian a pui thei a ni. Thâwk lak exercise leh meditation ang chi thil hmangin i rilru timuang rawh. Coffee, tea, leh cola ang chi thilte hi tihtlem la, he rilru put hmang hi a tipung thei a ni. |
| Heat intolerance a ni | He damdawi hian taksain a tihlum theihna a ti tlem thei a ni. Khua lum lutuk leh tui tlakchham loh tur. Thawmhnaw rit lo ha la, tui tam tak in rawh. |
| Pum natna, chaw ei kham, hmui vawt | Damdawi chu ei tur nen ei tur a ni. I hmui a vawt chuan tui tlemte in fo la, ice cube chu in la, a nih loh leh sugar-free gum chew rawh. Constipated i nih chuan tui tam tak in la, fiber tamna ei tur (wheat bran, beans, fruits) ei thin ang che. |
Hengte hi thil thleng thei tam ber a ni. Heng harsatnate hi a awm reng emaw, a zual emaw chuan doctor hnenah hrilh ngei ang che.
Damdawi dangah harsatna a awm thei em? (Drug nena inzawmna) .
Awle. Damdawi thenkhat chu Rexulti nena ei hian Rexulti thatna a tipung emaw a ti tlem thei a, a side effects a tipung thei bawk. Entirnan, antifungal thenkhat (e.g., ketoconazole), antibiotics thenkhat (e.g., clarithromycin), antidepressant thenkhat (e.g., fluoxetine, paroxetine), leh grapefruit tui thlengin Rexulti nghawng hi a thlak danglam thei a ni.
Chuvangin, i doctor hnenah damdawi, vitamin leh herbal product i ei zawng zawngte hrilh vek a pawimawh hle a, chutiang chuan Rexulti dose chu i duh angin a siamrem thei ang.
Enkawl lai hian eng test nge tih tur?
I doctor chuan damdawi i ei tan hma leh i ei lai hian i hriselna enfiah turin test thenkhat a ti ang.
- I rit zawng, i san zawng leh i kawrfual vel.
- Thisen chhiar kim (CBC) a ni.
- Chaw ngheia thisen cholesterol leh sugar test (Fasting lipid profile leh thisen thlum).
- Thisen sang a ni.
- AIMS test hmangin taksa chetna pangngai lo (e.g., duh loh zawnga ke leh ke inthlak danglamna) a awm leh awm loh enfiah thin.
Heng test te hi damdawiin i taksa a nghawng dan dik tak hriat theihna awmchhun a ni.
Take-Home Thuchah a ni
- Rexulti hi "add-on" damdawi a ni a, depression damdawi ei tawhte bakah hian pek thin a ni a, a thatna tihpun nan.
- Hei hian hlimna leh phurna nena inzawm thluaka chemical awmte chu a inthlauhna hmangin hna a thawk a ni.
- Damdawi hi doctor-in a tih ang chiah chiah, a pek zat angin ei fo ang che.
- I natna lan chhuah dan a tha zawk a nih pawhin doctor rawn hmasa lovin damdawi ei kha tihtawp loh tur a ni.
- Side effects te, taksa rihna sang, mutthilh leh hahdam lohna te hi hre reng ang che. An tibuai a nih chuan doctor nen inbia ang che.
- Damdawi dang zawng zawng, vitamin leh hmanlai damdawi i ei zawng zawngte chu i doctor hnenah hriattir a pawimawh hle.
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