Nangmah emaw, i hriat mi emaw hnute cancer vei nia hriat chuan hlauhna leh mangang nasa tak i neih chu thil pangngai a ni. Chutiang bawkin kan tar chhoh zel chuan ruh a chak lo deuh deuh a, tlu tê tê pawhin a tikehsawm thei a ni. Mahse, damdawi lama hmasawnna avang hian heng natnate hi enkawlna tha tak tak a awm ta a ni. Vawiin hian chutiang enkawlna bik pakhat chu kan sawi dawn a ni.
A awlsam zawngin, heng SERM te hi engte nge ni?
SERMs hi Selective Estrogen Receptor Modulators tih tawi a ni a . Hei hi hormone therapy chi khat a ni. Hei hian kan taksaa hormone estrogen hnathawh dan enkawl a huam a ni. Manager fing tak angin ngaihtuah rawh. Taksa hmun thenkhata estrogen-in nghawng a neih chu a block a, hmun thenkhatah chuan estrogen angin taksa tanpui nan a thawk bawk.
He class a damdawi lian ber pahnih chu Tamoxifen leh Raloxifene te an ni . Tunah hian hengte hi hnute cancer leh ruh natna chi hrang hrang enkawlna tha tak atan hman a ni.
Heng SERM damdawi te hian taksa chhungah engtin nge hna an thawh?
Hei hi hriatthiam a harsa deuh mai thei a, mahse a takah chuan a awlsam khawp mai. Hei hi entirnan han hrethiam ila.
Estrogen hi key angin ngaihtuah rawh. Kan taksa cell te hian he key nena inmil receptor an nei a. He chabi hi kawngkaah i dah chuan kawngkhar chu a inhawng a, cell-ah message a thawn a ni.
- Breast cancer-ah chuan: Breast cancer cell thenkhat ( Hormone Receptor positive emaw ER-positive cancer tia koh) te hian estrogen tih key atanga thuchah chu an lo thang lian a, an inthen darh theih nan an mamawh a ni. SERM damdawi hian heng cancer cell-te kawngkhar (receptor) chu a block a, hna a thawk a ni. Kawngkhar keyhole-a thil dang dah ang mai a ni. Tichuan estrogen tak tak chuan chabi a thleng thei lo va, kawngkhar chu a hawng thei lo. Chuvângin, cancer cell-te chuan ṭhanlenna tûr thuchah chu an hloh a, an ṭhanlenna chu a reh emaw, a hniam emaw a ni.
- Ruh chhungah: Chutih rual chuan he SERM damdawi hi kan ruh a kal chuan chutah chuan estrogen angin hna a thawk a ni. Chu chu ruh chhunga kawngkharteah a kal a, chu kawngkhar chu a hawng a, ruhte chu a tichak a, calcium a vawng reng thei tihna a ni. Hei hian ruh natna (osteoporosis) a veng thei a ni.
He damdawi thiltihtheihna mak tak hi i hmu tawh em? Damdawi pakhat hian hmun hnih ah kawng hrang hrang pahnihin hna a thawk a. Chuvangin "Selective" tih a ni.
SERM hmanna ber berte chu engte nge ni?
Doctor-te chuan he enkawlna hi thil awmdan pahnih-ah an rawt ber a ni.
1. Hnute cancer tan
SERMs hi enkawlna pawimawh tak a ni a, a bik takin hormone-sensitive (ER-positive) hnute cancer tan chuan a pawimawh hle.
- Cancer vei theihna sang tak nei tan: Chhungkaw zinga tu emaw chuan hnute cancer a nei tawh a nih chuan, emaw, genetic test-a an genetic mutations a awm tih finfiah a nih chuan cancer vei theihna tipungtu an nei a nih chuan, he damdawi hi cancer a lo awm loh nan an pe thin.
- Cancer surgery hnuah: Cancer chu surgery hmanga lakchhuah a nih hnuah SERMs hmangin cancer a lo let leh loh nan (`recurrence`) leh hnute dang cancer a lo awm loh nan SERMs hman a ni.
- DCIS-ah: Ductal Carcinoma in Situ (DCIS) lo lang leh tur venna atan, cancer hmasa ber, hnute kawng hrang hranga lo awm thin.
- Taksa zawng zawnga cancer darh tawh tan: Taksa chhunga taksa peng dang a cancer darh tawh control nan (Metastatic Breast Cancer).
- Mipa hnute cancer tan: Mipa tan hnute cancer vei hi a tlem hle nachungin, he damdawi hi a lo awm a nih chuan a tan pawh hman a ni.
2. Ruh natna (osteoporosis) tan
SERM Raloxifene tih hi ruh hloh control nan, ruh tichaktu atan leh ruh tliak hlauhawmna tihziaawmna atan hman a ni a, a bik takin postmenopausal hmeichhiaah te hman a ni.
He enkawlna hi engtiang chiahin nge a hlawhtlin?
Ni e, hei hi enkawlna tha tak a ni. Zirna hrang hrangah chuan a bik takin damdawi Tamoxifen hian hnute cancer vei theihna chu 40% velin a tihniam thei tih a tarlang .
- Mi pakhatin a hnute pakhat cancer avanga operation nei tawhin Tamoxifen a ei chuan a hnute dang cancer vei theihna chu 50% in a tlahniam a ni .
- Menopause hmaa cancer vei tawh tan chuan cancer lo awm leh theihna chu 30% leh 50% inkar a tlahniam thei a ni .
- Raloxifene hian menopause hnua osteoporosis vanga spinal fracture awm theihna pawh nasa takin a tihziaawm tih hmuhchhuah a ni bawk.
Enkawl lai hian eng nge thleng?
He enkawlna hi pill emaw liquid emaw angin pek a ni tlangpui a, nitin ei thin a ni. I dinhmun leh i doctor-in a rawtna a zirin enkawl hun chhung hi a inang lo thei.
- Tamoxifen: Hnute cancer venna emaw enkawlna atana ei thinte chuan he damdawi hi kum 5 chhung a zawnin an ei tlangpui. I doctor chuan he hun hi kum 10 thleng a ti sei thei a ni. Kum engemaw zat hnuah damdawi dang (aromatase inhibitor ang chi)-ah pawh i thlak thei bawk.
- Raloxifene: Hnute cancer hlauhawmna tihziaawmna tur emaw, ruh natna atana ei thinte chuan nitin pill atan an doctor-in a rawt chhung chu ei tur a ni.
A pawimawh ber chu he damdawi hi doctor-in a sawi angin a hun chhung zawng ei tur a ni. A chanve vel tihtawp chuan duhthusam a chhuah lo mai thei.
He enkawlna hian eng side effect nge a neih theih?
Cancer enkawlna dang ang bawkin SERM hian side effect engemaw zat a nei thei a ni. Mahse, mi zawng zawngin an tawng vek dawn lo. Chung zinga a tam zawk chu enkawl theih a ni.
| Tamoxifen hian side effect a neih tlangpui leh a awm lo | |
|---|---|
| Side effect a awm thei | Hrilhfiahna |
| Side effect awm tlangpui (hmeichhia) . | |
| Hot flash a rawn chhuak ta | Menopause symptom nen a inang. |
| Zan a thawk hah | Mut a buai thei. |
| Thlasik/vaginal bleeding mumal lo | Hmeichhe naupai hmaa an thlasik hun (menstrual cycle) hi a danglam thei a ni. |
| Vaginal a vawt, a hring, a chhuak | Mipat hmeichhiatna lama harsatna a awm thei. |
| Rare mahse side effect na tak tak a awm | |
| Thisen a chhuak thin | Ke ruh (Deep Venous Thrombosis) emaw, lung (Pulmonary Embolism)-ah emaw a awm thei. |
| Uterine cancer vei theihna a awm | Risk a tlem hle. Thisen chhuahna danglam tak i neih chuan doctor hnenah i hriattir tur a ni. |
| Mit (cataract) a awm | Hmuh danah danglamna a awm a nih chuan fimkhur rawh. |
| Thai | A natna hi a tlem hle a, mahse a na hle. |
Raloxifene hian side effect inang chiah (e.g. hot flashes, ke na) a nei thei a, mahse Tamoxifen aiin uterine cancer vei theihna a hniam zawk. I doctor chuan hei hi chipchiar zawkin a hrilhfiah ang che.
Side effects te enkawl nan eng nge ka tih theih ang?
Heng side effects te nena nun awlsam zawk nan nangmah ngeiin thil engemaw zat i tih theih a awm.
- Hot flashes tan: Caffeine awmna in tur, coffee leh tea te hi tihtlem la. Mi thenkhat chuan phytoestrogens awmna ei tur soybean, chickpeas, leh lentils te ei hian hahdamna an hmu thei.
- Mut theih lohna tan: Exercise neih fo hian mut thatna a tisang thei.
- Vaginal dryness: Hei atan hian vaginal moisturizer bik hman theih a awm. Hengte hi doctor zawt rawh.
Engtikah nge damdawi lam thurawn i lak nghal ang?
Side effect tlangpui a nasat chuan doctor hnenah hrilh rawh. Mahse, a hnuaia symptoms te hi i neih chuan damdawi in emergency department (ETU) ah kal nghal la emaw 1990 ah call la, hengte hi natna khirh tak, stroke emaw, lung chhunga thisen zam (pulmonary embolism) ang chi chhinchhiahna a ni thei.
- Taksa emaw hmai emaw sir khatah rilru hah emaw, chak lohna emaw.
- Thusawi harsa, tawngkam slurring.
- Lu na na tak a lo awm nghal.
- Thâwk harsa nghal.
- A chhan hriat theih loh rilru, kut, kekawrte emaw, hmuiah emaw natna nasa tak a awm.
Heng symptoms te hi ngaihthah suh. A rang taka hmalak chuan nunna a chhanhim thei a ni.
Take-Home Thuchah a ni
- SERMs hi damdawi chi khat bik a ni a, hormone estrogen hnathawh dan control tu a ni. Hnute cancer leh ruh natna enkawlna tha tak an ni.
- Heng damdawi te hian hnute cancer cell te thanna a titawp a, ruh tichak turin a pui bawk.
- Tamoxifen leh Raloxifene te hi SERM hman tlanglawn ber pahnih an ni.
- Damdawi zawng zawng ang bawkin side effect awm thei a awm a, mahse a tam zawk chu enkawl theih a ni. An chungchang hi i doctor nen zalen takin sawi rawh.
- Thisen zam leh stroke ang chi side effect na tak, mahse hmuh tur awm lo tak takte chu hre reng ang che. Chutiang chhinchhiahna a lo awm chuan damdawi lam thurawn la nghal rawh.
- SERM enkawlna hi i tan a tha em tih te, a thatna leh that lohna te chu i doctor chauhvin thurawn tha ber a pe thei che a ni. Chuvangin zawhna i neih apiang zawh hlau suh.
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