Nangmah emaw i hriat mi emaw chuan i doctor-in hnute cancer atan Tamoxifen a pe tawh em? A nih loh leh cancer vei theihna sang tak i neih avangin an rawn pe che em? He damdawi hming i hriat hian hlauhna tlem, hriat duhna leh zawhna tam tak neih hi thil pangngai a ni. "Hei hian cancer a tidam tak tak ang em? A side effects te chu eng nge ni?" I ngaihtuah a ni mai thei. Chuvangin, vawiin hian Tamoxifen hi eng nge a nih, taksa a tihchhiat dan, leh kan hriat reng tur te kan sawi dawn a, awlsam takin, kan thianpa nen kan inbia ang maiin.
A awlsam zawngin, Tamoxifen chu eng nge ni?
Tamoxifen hi hnute cancer enkawlna atana hman tlanglawn tak a ni. Mahse, hnute cancer chi hrang hrang tan pek a ni lo. A bik takin hormone receptor-positive hnute cancer vei te tan pek thin a ni .
Chu chu eng nge a awmzia? Ngaihtuah teh, hnute cancer cell thenkhat chu naute riltam ang mai an ni. Kan taksain a pianphung anga a siam chhuah hormone pahnih an mamawh a, chu chu an lo thang lian a, a darh zel a ni. Anni chu estrogen leh progesterone te an ni . Tamoxifen damdawi hian a tih chu chu cancer cell te chu an mamawh "chaw" an hmuh theih loh nan a titawp a, chu chu hormone estrogen a ni.
Chu bakah, doctor-te chuan he damdawi hi hnute cancer vei theihna sang tak nei (entir nan, chhungkaw zinga mi pakhatin cancer a vei tawh a nih chuan, emaw, ``(BRCA)`` ang chi genetic mutations a neih chuan) cancer venna atan an rawt bawk.
Tamoxifen hmanga enkawlna hian eng hlawkna ber nge a neih?
He damdawi hian khawvel hmun hrang hranga hmeichhe maktaduai tam tak nunna a chhanhim thei a ni. A hlawkna ber thenkhat chu:
- Cancer lo awm leh tur venna: Operation, chemotherapy, radiation therapy hnua cancer lo kir leh theihna hi 30% atanga 50% in a tlahniam a ni.
- Hnute dang venhim: Hnute pakhata cancer nei tan chuan hnute hrisel dang cancer vei theihna chu 50% velin a tlahniam a ni.
- Invasive cancer ven dan: Cancer hmasa ber (Ductal Carcinoma in Situ emaw DCIS) nei tan chuan, chu chu hnute tui kawngkhar (milk ducts)-ah chauh a awm a, chu chuan invasive cancer a nih theihna chu 50% velin a ti tlem a ni.
- Ruh tichaktu: He damdawi hian ruh natna (osteoporosis) a veng thei bawk a, ruh a tichak bawk a, hei hi menopause hnua lo awm thei a ni.
- Cholesterol tihhniam: Thisen a cholesterol tha lo awm zat tihhniamna kawngah pawh eng emaw chen a pui bawk.
Damdawi ei dan leh a side effects te pawh i zir dawn bawk ang.
I doctor chuan tamoxifen hi nitin a rualin pill (`Nolvadex®`) emaw, liquid (`Soltamox®`) emaw angin ei turin a hrilh tlangpui ang che. Enkawl hun chhung hi kum 5 emaw kum 10 emaw vel a ni thei. Hei hi i dinhmun a zirin i doctor-in a ruat ang.
Damdawi dang ang bawkin tamoxifen hian side effect engemaw zat a nei thei a ni. Chung zinga a tam zawk chu a serious lo a, mi zawng zawngin kan hmu vek lo. Mahse, anmahni fimkhur a pawimawh.
| Side effect awm dan (nature) a ni | A sawifiahna leh a lan chhuah dan |
|---|---|
| Side effect awm fo thin | |
| Menopause ang chi natna lanchhuahna | Hot flashes, zan lama thawk hah, leh vaginal dryness te. |
| Taksa rihna sang/swelling | Mi thenkhat chu an thau chho thei a, ke ang chi hmunah chuan a hring (edema) an nei thei bawk. |
| Thlasik mumal lo | Menstrual cycle mumal lo emaw, chawlhsan vek emaw. |
| Natna tenau dangte | Ke a hring, luak chhuak, vaginal discharge, vun rawng, hah, lu na. Mipaah chuan erectile dysfunction a awm thei. |
| Risk na tak mahse a tlem hle a, damdawi lam pan vat ngai a ni | |
| Thisen a chhuak thin | Ke ruh chhunga thisen zam (Deep Vein Thrombosis - DVT) emaw stroke emaw ang chi dinhmun. |
| Mit (cataract) a awm | Mit lama harsatna awm thei, mit hmuh lohna (blurred vision). |
| Uterine cancer a ni | Endometrial cancer vei theihna chance a tlem hle. |
Heng hlauhawmna lian tak takte hi a tlem hle a, mahse hriat reng a pawimawh. I doctor hian he damdawi hi a pe a, a chhan chu damdawi hlawkna hian a hlauhawmna a tluk phah hle a ni.
Doctor hmuh vat a ngaih hunah!
Tamoxifen i ei a, a hnuaia symptoms te hi i neih chuan doctor hnenah hrilh nghal la, a nih loh leh damdawi in Emergency Department (ETU) ah pawh tlai lovin kal rawh.
- A rilru a na nghal emaw thawk harsa emaw .
- Khawsik .
- Stroke chhinchhiahna chu thusawi thiam lo , mit hmuh fiah lo , leh kut, ke, a nih loh leh hmai sir khata rilru hah nghal mai te hi a ni.
- Ke, ke ruh, a nih loh leh kea hring lutuk .
- Tih theih loh khawpa luak chhuak .
Damdawi ei dawnin heng thilte hi fimkhur hle ang che.
Naupai lai hian he damdawi hi ka ei thei ang em?
No. A ni lo tak zet. Tamoxifen i ei laiin nau i pai a nih chuan i naute hian piansualna nasa tak a nei thei a ni. Chuvangin he damdawi hi i ei lai leh damdawi i ei loh hnu thla hnih chhung chu naupai loh tur a ni. I doctor nen non-hormonal birth control method (condom ang chi) hman dan tur sawipui rawh.
Tamoxifen hi chemotherapy a ni em?
Ni lo, hengte hi thil chi hrang hrang pahnih a ni. Tamoxifen hi hormone hmanga enkawlna a ni a . A bik takin, damdawi chi khat ``Selective Estrogen Receptor Modulators - SERMs.`` tih hming pu a ni.`` Chemotherapy hi cell inthen chak tak tak (cancer cell bakah cell hrisel te) thattu enkawlna a ni. Mahse tamoxifen hian hormone activity chauh a target a ni.
He damdawi ka ei lai hian ei leh in tur ka ei loh tur a awm em?
Awle. Ei leh in thenkhat hian tamoxifen thatna a ti tlem thei a, chuvangin ei loh hi a finthlak hle.
- Grapefruit a ni
- Tangerines a ni
- Zu awmna in tur eng pawh
Take-Home Thuchah a ni
- Tamoxifen hi hormone-a innghat hnute cancer enkawlna tha tak, nunna chhanhim thei a ni.
- I damdawi ei tur chu i doctor-in a tih ang chiah chiah, a hun takah leh a hun takah ei a pawimawh hle.
- Side effects hlau suh, mahse fimkhur hle ang che. A bik takin thisen zam emaw, stroke emaw chhinchhiahna (ke na, rilru na, tawng thiam lo) te chu fimkhur hle ang che. Chung zinga pakhat tal i tawn chuan doctor thurawn la nghal rawh.
- He damdawi hi i ei lai leh i ei hnu thla 2 chhung chu naupai loh tur a ni. Naupai venna him tak hman dan tur chungchangah i doctor nen sawiho rawh.
- Zawhna, hlauhthawnna, rinhlelhna i neih apiang chu i doctor nen zalen takin sawipui rawh. I tanpui turin an inpeih reng a ni.
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