Myasthenia gravis tan beiseina thar: Ultomiris (Ravulizumab) chungchang hi i zir dawn em ni?

A chang chuan chakna nei lo ang maiin i inhria em, i taksa ruhte pawh a chak lo hle em? A bîk takin mitmeng pakhat emaw, pahnih emaw a tlakbuak a, i hmêl lan dân a danglam emaw, thusawi emaw, ei emaw i harsat chuan? Hengte hi Myasthenia Gravis tih hming pu natna chhinchhiahna a ni thei . Hei hi hlauhawm tak ni mahse tunah chuan a enkawlna tha tak tak a awm ta. Vawiin hian chutiang enkawlna thar, hlawhtling tak pakhat kan sawi dawn a ni.

Myasthenia Gravis hi eng nge ni tak tak?

A awlsam zawngin, hei hi i taksa ngeia immune system-in i taksa ruh (muscle) a beih nana dinhmun a ni. Hei hi autoimmune condition kan ti a.

Muscle pakhat hian kan thluak atang hian nerve leh muscle cell inzawmna hmunah signal a dawng a. He point of contact hi neuromuscular junction an ti a. Hetah hian neurotransmitter acetylcholine an tih chuan signal chu muscle hnenah a thawn a, "Okay, tunah chuan ti rawh," a ti a.

Mahse, myasthenia gravis vei tam tak chuan he acetylcholine signal dawngtu receptor te beitu antibodies an nei thin. Heng antibodies te hi anti- acetylcholine receptor (AChR) antibodies an ti a . Heng antibody te avang hian muscle te hian thluak atanga signal an dawng tha lo hle. Chumi rah chhuah chu taksa ruh chak lohna a ni.

Ultomiris (Ravulizumab) hian engtin nge hna a thawh?

Myasthenia gravis hi damdawi a la awm lo. Mahse, natna lan chhuah dan control thei leh nun pangngai nei thei tur enkawlna tha tak tak a awm nual. Chutiang damdawi thar pakhat chu Ultomiris hi a ni.

Ultomiris hi antibody bik a ni a , kan immune system a protein pakhat C5 tih chu a block a ni. He C5 protein hi taksa ruh tichhe theitu a ni. Chuvangin Ultomiris hian a tihtawp chuan i immune system hian muscle cells a tichhia tawh lo. Chu chu he damdawi hian natna bul thlenga kal nghalin hna a thawk tihna a ni.

Engtin nge he enkawlna hi pek a nih?

He damdawi hi saline ang chi intravenous infusion (IV infusion) angin pek che a ni. Hei hi doctor emaw, damdawi in emaw, clinic emaw-a health worker trained-in a pek che a ni.

A tlangpuiin, initial dose pek i ni ang a, kar hnih hnuah dose dang pek leh a ni ang. Chumi hnuah chuan he damdawi hi kar riat danah i ei chhunzawm zel a ngai ang . Mahse, i doctor chuan eng chen nge i ei a ngaih dawn tih leh eng dose nge (a tlangpuiin i taksa rih zawng a zirin) i ei tur tih a rel ang .

Damdawi hi a hun taka ei a pawimawh hle. Dose i miss a nih chuan doctor ko hmasa phawt ang che .

Engtin nge damdawi hian hna a thawk em tih i hriat theih ang?

I taksa ruhte chu zawi zawiin a chak chho zel tih i hre tan ang. I nitin hna chu awlsam takin i ti thei ang. Clinical study-ah chuan kar khat chhung lek chhungin symptoms-ah hmasawnna engemaw zat hmuh a ni.

Mahse, danglamna i neih loh chuan, emaw, i natna lan chhuah dan chu a zual deuh niin a lang a nih chuan, i doctor nen inbiakna neihpui ngei ang che . A ti thei a niDose thlak la, damdawi dang pe la, a nih loh leh enkawlna dang hmang rawh.

Side effect awm thei te chu engte nge ni?

Damdawi dang ang bawkin side effect tenau te a nei thei bawk. Side effects awm tam ber chu:

• Bloating (ril\am) 1.1.
• Hnar emaw, kawr emaw natna
• Hrawk thip
• Khawsik natna lan chhuah dan tlangpui

I pum natna thunun nan ei tur light tak tak, buhfai, banana, leh chhang ei thin ang che. Tui tam tak in thin ang che. Coffee ang chi caffeinated drinks i ei tlem zawk rawh. Heng hmalaknate hian a puih loh chuan, emaw, ril na emaw, hnar luang emaw ang chi symptoms a awm reng chuan i doctor nen inbia ang che . I tana enkawlna tha ber tur chu amah hian a ruat ang.

Hriat tur bikte chu engte nge ni? (REMS Programme) tih a ni.

Hei hi a pawimawh hle mai!

Ultomiris hi damdawi a ni a, risk management program bik (Risk Evaluation and Mitigation Strategy - REMS) hnuaia pek a ni. Hei hi a chhan chu bacteria infection meningococcal an tih, a bik takin meningitis, thluak leh ruhro tichhe thei, vei theihna a tlem hle a, mahse na tak a ni .

Hemi avang hian i doctor chuan damlo himna card bik a pe ang che .

• Heng natna lan chhuah dan (e.g. khawsik thut, lu na, kawng khauh, luak chhuak, luak chhuak, leh êng laka hriatna) chiang takin a tarlang a ni.
• Chutiang symptoms a awm chuan Emergency Treatment Unit (ETU)-ah kal nghal tur a ni tih pawh sawi a ni bawk.
• He card hi engtik lai pawhin i hnenah dah reng a pawimawh hle — enkawl lai leh enkawlna a tawp hnu thla 8 thleng pawh.

Tin, enkawlna i tan hmain i doctor chuan meningococcal natna laka vaccine pek i nih leh nih loh a zawt ang che. A nih loh chuan enkawl tan hma kar hnih tal vaccine la turin an fuih ang che.

Damdawi dang chungchanga harsatna awm

Damdawi dang i ei a nih chuan doctor hrilh a pawimawh hle a, a bik takin:

• Thisen atanga plasma lakchhuahna enkawlna (plasma exchange emaw plasmapheresis) .
• Immunoglobulin (IVIg) hmanga thisen kal tlanga enkawlna
• Nausen piang thar Fc receptor (FcRn) blocking damdawi hmanga myasthenia gravis natna vei

Hetiang thil hian Ultomiris natna a tihziaawm thei a ni. Chuvangin i doctor hnenah damdawi i ei zawng zawng, vitamin pawh hrilh rawh.