Myasthenia Gravis (MG) vei tan beiseina thar: Damdawi Zilbrysq (Zilucoplan) chungchang hi i zir dawn teh ang!

Myasthenia Gravis (MG) tih natna i nei em? Chuti a nih chuan he taksa chak lohna, mitmeng tlahniam, tawng harsa, leh ei leh in hian i nunah eng ang harsatna nge a thlen theih tih i hre chiang hle mai thei. Hetiang dinhmun hi control turin damdawi chi hrang hrang tam tak i hman a ngai a ni. Mahse i lawmna tur pakhat chu tun hnaiah he natna enkawl nan hian damdawi thar an rawn chhuak ta a ni. Vawiin hian Zilbrysq, injection thar, in lama hman theih tur chungchang kan sawi dawn a ni.

A hmasain Myasthenia Gravis (MG) hi eng nge a nih i en ang u.

A awlsam zawngin sawi ila, Myasthenia Gravis (MG) hi autoimmune condition a ni. Chumi awmzia chu kan taksa ngeia invenna system, a nih loh leh immune system hian kan taksa hrisel tak takte chu a rawn bei sual tan tihna a ni.

Kan thluak hian taksa peng pakhat hnenah ‘contract’ turin thuchah a thawn ang tih han ngaihtuah teh. He thuchah hi nerve pakhatah a kal a. Nerve leh muscle inzawmna hmun chu ‘junction’ ang mai a ni. Hei hi neuromuscular junction kan ti a. He junction-ah hian nerve message dawngtu ‘receptor’ bik an awm a. MG ah chuan kan immune system hian heng receptor te hi ‘acetylcholine receptors’ an tih te hi a bei thin. Tichuan thluak atanga thuchah lo lut chu taksa ruh (muscle) hian a dawng tha lo hle a ni. Chumi avang chuan taksa ruh chu a chau nghal vat a, a chak lo bawk.

MG vei zawng zawng hian symptom inang an nei vek lo. Mi thenkhat chuan symptoms an nei nghal vat a , thenkhat erawh chuan kum tam tak chhung chu symptoms an pung zauh zauh thung. A châng chuan remission hun (symptoms a reh hunah) a awm thei bawk.

Engtin nge damdawi Zilbrysq hian hna a thawh?

MG enkawlna tum ber chu acetylcholine receptor kaltlangin nerve message thawn chhuah leh a ni. Hetiang ti tur hian damdawi pyridostigmine (Mestinon), steroid prednisone, leh immunosuppressants te hi hman a ni tlangpui.

Zilbrysq hi damdawi class thara mi a ni a, kawng danglam takin hna a thawk a ni. Hengte hi ‘complement inhibitor’ kan ti a.

Kan immune system hian kan taksa ruh a bei tih ka sawi kha i hre reng em? He attack process-ah hian ``complement pathway`` tih hming pu thil pakhat a awm a, chu chuan hmun pawimawh tak a chang a ni. Zilbrysq hian a tih tur chu he complement system activity hi block a ni. Tichuan immune system chuan receptor-te chunga attack hlauhawm tak takte chu a ti tlem ta a ni. Chumi avang chuan nerve message te chu taksa peng hrang hrangah a kal tha leh tan a, taksa chakna chu a lo tha leh ta a ni.

Zilbrysq hi MG nei zawng zawngin an hmang thei ang em?

Ni lo, mi zawng zawngin an ti thei lo. He damdawi hi thisenah antibody bik ``anti-acetylcholine receptor antibody'' an tih nei tan chauh phal a ni. MG vei tam zawk (80%-90% vel) hian he antibody hi an nei a ni. Mahse hei hi i thisenah i neih loh chuan he damdawi hian a puih vak lo mai thei. Chuvangin, he damdawi hi i ei tan hmain i doctor chuan thisen test bik a nei ang a, he antibody hi i nei em tih a enfiah ang.

He damdawi hi engtin nge i hman?

Zilbrysq hi damdawi tui tak a ni a, nitin vun hnuaiah inject thin a ni. A kekawrte, pum chhungah emaw, kut chunglam hnung lamah emaw inject theih a ni.

• A dahkhawmna: He damdawi hi refrigerator-ah dah tur a ni.
• Hman hmain: Vaccine hi inject hma minute 30-45 vel refrigerator atangin la chhuakin room temperature-ah dah la. Hei hian injection laiin hrehawmna a ti tlem ang.
• Training: He damdawi hi i dawn hmasak ber hian i doctor emaw nurse emaw chuan a inject dan dik tak a entir ang che. Damdawi hi a dose dik tak hmuh theih nan a hrilh ang chiah chiah inject a pawimawh hle. I hriat chian loh thil a awm chuan doctor zawt nawn leh rawh.

Damdawi ei tan hmaa hriat tur bik

Hei hi a pawimawh hle a, chuvangin ngun takin ngaihven rawh.

He damdawi hian natna khirh tak tak thenkhat, a bik takin meningococcal infection te a tipung thei a ni . Hetiang hlauhawmna avang hian he damdawi hi himna program bik Zilbrysq REMS program tih hmang chauhvin a awm thei a ni. He program-ah hian nang leh i doctor te pahnih in inziak lut tur a ni.

He program kalpui mek zingah hian i doctor chuan meningococcal infection chungchang te, a ven dan tur te, a natna lan chhuah dan hriat dan tur te, leh a natna lan chhuah chuan damdawi lam thurawn lak nghal a pawimawhzia te a zirtir ang che.

• Vaccine: Infection hlauhawmna tihziaawm nan i doctor chuan Zilbrysq i tan hma kar hnih tal meningococcal vaccine i dawng tawh tih a enfiah ang. Damdawi hi hmanhmawh taka tan a ngai a, vaccine i la lo a nih chuan vaccine hman a nih hma chuan antibiotics i ei a ngai dawn a ni.
• Safety Card: ‘Patient Safety Card’ bik pek i ni ang. He card hi engtik lai pawhin i hnenah i vawng reng tur a ni. Damdawi i ei lai te, chutiang bawkin damdawi i chawlhsan hnu thla hnih chhung pawh i bula dah a pawimawh hle. He card hi doctor dang enkawltu hnenah i entir thei ang.

Side effects leh engtin nge kan enkawl ang?

Damdawi dang ang bawkin Zilbrysq hian side effect engemaw zat a nei thei a, mahse a tam zawk chu enkawl theih a ni.

Engtiang chiahin nge result ka beisei theih ang?

Zilbrysq hi i tan a tha a nih chuan damdawi i ei tan atanga kar hmasa chhungin i natna lan chhuahnaah hmasawnna engemaw zat i hmu mai thei. Mi tam zawk chuan thla khat chhungin result tha ber an hmu thin.

Thla khat emaw thla hnih emaw chhung damdawi i ei hnua i symptoms-ah hmasawnna i hmuh loh chuan i doctor nen inbia ang che. Enkawl dan dang a sawipui ang che.