I taksa peng pakhat chauh, entîr nân, kut, ke, a nih loh leh vun hmun engemaw zât chu a dang zawng aiin a ṭhang chak zâwk tih han ngaihtuah teh. Hei hi mi thenkhat pianpui nasat em em a ni. Damdawi lam hawi chuan he group of conditions hi PIK3CA-Related Overgrowth Spectrum, a tawi zawngin PROS kan ti thin. Hei hi a hmutu tan pawh harsatna tam tak thlentu tak a ni a, chutiang bawkin a tawngtu tan pawh harsatna tam tak a thlen thin. Vawiin hian he thuziak ah hian he PROS hi eng nge a nih tih leh he natna atana hman bik damdawi pawm hmasak ber Vijoice chungchang kan sawi dawn a ni.
PROS hi eng nge ni tak tak?
A awlsam zawngin PROS hi genetic condition a ni. Kan taksaah hian cell te thanlenna, inthen darh leh thihna thunun thei gene kan nei vek a. `PIK3CA` hi chutiang gene pawimawh tak pakhat a ni. He gene hi kan cell te than dan control tu `switch` angin han ngaihtuah teh.
Mahse, PROS vei miah chuan `PIK3CA` gene-ah hian chhiatna, a nih loh leh mutation a awm a. Hei hian `switch` chu `on` position-ah a awm tir thin. Tichuan protein sawi tur hian hna a thawk rang lutuk a, a thawk nasa lutuk bawk. Chuvângin, taksa pêng ṭhenkhat, entîr nân, vun, thisen kalna , ruh , leh thluak chu thunun theih lohvin a ṭhang ṭan a ni.
A pawimawh ber chu PROS hian taksa peng tinreng a nghawng lo. Taksa peng hrang hrangah a inang lo thei a, mi tin a inang lo thei bawk. Chuvangin, a natna lan chhuah dan pawh a inang lo hle.
Tun thleng hian PROS hi damdawi kimchang a la awm lo. Treatment-ah chuan symptoms enkawl dan tur ngaihtuah a ni. Entirnan, natna, natna leh seizure damdawi te, leh a lo thang lian lo tak takte paih chhuah nan operation te . Mahse, operation hnuah chuan chutiang thannate chu a lo thang leh thei tih a hlauhawm hle.
Vijoice (alpelisib) damdawi hian engtin nge hna a thawh?
Hetah hian damdawi Vijoice hi a lo lut a, Vijoice hi PROS chhan bulpui ber, genetic mutation avanga hyperactivity awm chu target hmasa ber a ni.
Hemi atana active ingredient chu alpelisib a ni . He damdawi hi a takah chuan hnute cancer chi hrang hrang tan hman a ni . A chhan chu, itCancer cells te hi PIK3 pathway overactivity vangin an thang lian a, PROS-a ang bawkin.
Chuvangin Vijoice-in a tih chu PIK3 pathway a block a, chu chu ‘on’ position-a ‘switch’ tang ang maiin a thawk a ni. Hei hian cells te than dan pangngai lo chu a ti slow a, tissue lo thang tawh te chu a ti tlem a, symptoms te a control bawk.
He damdawi hian eng hlawkna nge a neih?
He damdawi (EPIK-P1 leh EPIK-P3) chungchanga zirchianna an neihah chuan damlote tan hlawkna nasa tak a awm tih hmuhchhuah a ni.
| Chhawr tangkai | Hrilhfiahna awlsam tak |
|---|---|
| A te zawk a lo thang lian (lesions) . | He damdawi ei tam tak hian an thau natna (lipomas) leh vascular malformations te chu 20% emaw a aia tam emawin an volume a tlahniam tih hmuhchhuah a ni. |
| Surgery mamawhna a tlahniam | Vijoice ei thin naupang 70% vel leh puitling 90% vel chuan operation an mamawh lo. |
| Symptom tihziaawmna | Damlote chuan natna, natna, leh hahna ang chi symptoms te chu nasa takin a tlahniam tih an sawi. |
| Nitin hnathawh awlsam zawka siam | He zirchiannaa tel damlo 81% vel chuan nitin hna an thawh theihna leh an nunphung quality chu damdawi hman hma aiin a ṭha zawk tih an sawi. |
Pawimawh: Heng result te hi mi zawng zawng tan a inang lo mai thei. He damdawi hi i tan a tha em tih leh a thatna leh a hlauhawmna te chu i doctor nen sawiho rawh .Anmahni biak a, thutlukna siam a tha ber.
Side effects awm tam ber chu engte nge ni a, engtin nge kan enkawl ang?
Damdawi dang ang bawkin Vijoice hian side effect a nei thei a ni . Mahse, heng zinga a tam zawk hi chu a na lo emaw, a na lo emaw a ni a, enkawl theih a ni.
| Side effect a awm thei | Engtin nge enkawl dan tur leh eng nge ngaihven tur tih |
|---|---|
| Kawthalo | Tui leh tui ang chi tui tam tak in thin ang che. I natna lan chhuah dan, riltam na tak, pum na, emaw, i bawlhhlawh thisen emaw, mucus emaw ang chi i neih chuan i doctor hnenah hrilh nghal rawh . |
| Tui tlakchhamna (dehydration). | Diarrhea hian tui tlakchhamna a thlen thei. Luak chhuak nasa lutuk, hahna, leh zun chhuah tlem ang chi symptoms te chu fimkhur rawh. Hengte hian i kal (kidney) a nghawng thei a, chuvangin doctor hnenah hrilh nghal rawh. |
| Kawng natna (Stomatitis) . | Kawng na leh na a awm thei. Zu awmna hmui silfai loh tur. I hmui chu tui lum tak hmangin silfai ang che. Chaw rimtui, acidic tak tak lakah chuan inthiarfihlim rawh. |
| Thisen thlum sang (Hyperglycemia) . | He damdawi i ei tan hma leh i enkawl chhung hian i doctor chuan i thisen sugar level a enfiah ang. Tuihal tam lutuk, zun tam lutuk, hah lutuk ang chi symptom i neih chuan doctor hnenah hrilh rawh. Diabetes mellitus vei te hian he thil hi an fimkhur hle tur a ni. |
| Sam tihthianghlim (Alopecia) . | Enkawl laiin sam a tla emaw, a hring emaw a awm thei. Shampoo mild tak tak hmang rawh. Hemi chungchang hi i doctor nen sawiho rawh. |
Damdawi dangah harsatna a awm thei em?
Awle. Vijoice hian damdawi dang thenkhat nen a inzawm thei bawk. A awlsam zawngin damdawi thenkhat hian Vijoice hmanna a ti tlem thei a ni. Vijoice hian damdawi dang thenkhatte thatna a tidanglam thei bawk.
Entirnan, epilepsy damdawi carbamazepine, TB tan rifampin, leh thlai chi hrang hrang St. John’s wort te hian hei hi a nghawng thei a ni.
Chuvangin, he damdawi hi i tan hmain i doctor hnenah tuna i damdawi ei zawng zawng (vitamin, herbal products, leh painkillers te pawh tel) i hrilh hmasak a pawimawh a, chutiang chuan a tul anga siamthatna a siam thei ang.
Take-Home Thuchah a ni
- PROS hi thil awm lo tak a ni a, taksa peng thenkhat chu `PIK3CA` an tih gene a mutation vangin a lo thang lian lo hle.
- Vijoice (alpelisib) hi he natna thlentu underlying process target tura damdawi pawm hmasak ber a ni.
- Hei hian a lo than dan pangngai lote chu a tihtlem thei a, operation mamawhna a ti tlem thei a, nunphung a tichangtlung thei bawk.
- Side effects, diarrhea, thisen sugar sang, leh hmui natna te a awm thei a, chu chu enkawl a, doctor hriattir a pawimawh hle.
- Damdawi dang i ei zawng zawng chu i doctor hriattir a pawimawh hle. Damdawi eng pawh hi damdawi lam thurawn tel lovin ei tan ngai suh, titawp ngai suh.
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