Myasthenia Gravis (gMG) vei te tan Vyvgart leh Vyvgart Hytrulo chungchang hi i zir dawn nia.

Myasthenia Gravis (gMG) tih natna i nei em? Nitin hna thawh harsa i ti em, i ke ruhte chu a hring vek ang maiin i hria em, i mitmeng pawh a rit em? Hei hi thil hahthlak tak a ni tih ka hria. Mahse lungngai suh, he natna enkawlna atana pui turin enkawlna thar, hmasawn tak tak a awm a ni. Vawiin hian chutiang damdawi thar pahnih kan sawi dawn a ni. Anni chu Vyvgart leh Vyvgart Hytrulo te an ni. Eng nge an nih, engtin nge an hnathawh tih leh i tan an tha em tih te han thlir ila.

A awlsam zawngin, Myasthenia Gravis chu eng nge ni?

Hei hi hrethiam tur chuan kan taksa chanchin tlem han thlir ila. I thluak hi ‘boss’ a ni tih han ngaihtuah teh. "I kut phar rawh" tih thupek a pe a ni. He thupek hi ‘wire’ zawhin electrical message ang maiin nerve hrang hrangah a kal kual a ni. He thuchah hian taksa ruh a thlen chuan ruh hian a hna a thawk a, kut chu a chawi sang tihna a ni.

Mahse he nerve leh muscle inzawmna hi a dik theih nan chuan protein bik acetylcholine receptor (AChR) an tih a ngai a ni. Hei hi plug ang a ni.

Myasthenia Gravis (gMG) hi autoimmune natna a ni a . A awlsam zawngin kan taksa ‘sipai’ ( immune system ) te hian hriat lohvin ‘plug’ tha tak tak, AChR te chu an rawn bei tan ta a ni. Anmahni beih nan hian ralthuam antibodies an tih te an hmang thin. Chuvang chuan nerve message te hian taksa ruh (muscles) te chu a thleng tha lo hle a ni. A rah chhuah chu? Muscle te chu a chak lo va, a chau awlsam hle. Hei hian mitmeng tla, tawng leh ei harsa, leh ke ruhte a ti na lo tih ang chi symptoms a thlen thin.

Chuti a nih chuan engtin nge heng Vyvgart leh Vyvgart Hytrulo damdawi te hian a puih?

Vyvgart (efgartigimod alfa-fcab) hi protein a ni a, a bik takin laboratory-ah a siam a ni. Hei hi monoclonal antibody an ti a .

He damdawi hian hna a thawk tha hle. Kan AChR tha tak takte beitu antibodies tha lo tak tak a awm a, he damdawi hian chu antibody te chu a kal a, a inzawm khawm thin. A dik tak chuan, chutiang antibodies thenkhat , neonatal Fc receptors (FcRn) -ah chuan a inzawm tlat a ni. Chutiang a nih chuan taksain awlsam takin chutiang antibody tha lo chu a paih chhuak thei a ni.

Vyvgart Hytrulo hi Vyvgart nen damdawi inang, efgartigimod alfa a ni. Chuvangin chutiang bawk chuan hna a thawk a ni. Mahse chu bakah chuan, .Tin, hyaluronidase an tih pawh a awm bawk. Hei hian damdawi chu vun hnuaia inject a nih chuan taksain a hip lut tha zawk thin.

Damdawi pek danah hian danglamna tlem a awm a:

• Vyvgart: Intravenous saline solution ( IV infusion ) angin minute 60 vel pek thin a ni.
• Vyvgart Hytrulo: Vun hnuaia injection te tak te (subcutaneous injection) angin pek thin a ni. Hei hi second 20-90 chhungin tihfel a ni.

Heng enkawlna pahnih hi kar khatah vawi khat kar li chhunga pek thin a ni tlangpui.

Engtin nge he damdawi hi i tan a tha em tih i hriat theih ang?

Vyvgart emaw Vyvgart Hytrulo emaw hi i tan a tha mai thei.

• GMG nei puitling i nih chuan.
• Test-naah kan sawi tawh AChR antibodies kha i thisenah i nei tih finfiah a nih chuan.

I doctor , a bik takin neurologist , chuan he damdawi hi i tan a tha em tih chu i thisen test result leh medical history a zirin a rel ang.

He damdawi chungchanga zirchiannate hian eng nge a sawi?

Vyvgart hman tangkai dan zirchian nan hian special clinical trial ADAPT trial an tih chu an nei a. He trial-a a ngaih pawimawh ber chu AChR antibodies nei gMG vei te symptoms tihziaawmna kawngah damdawi hian engtiang chiahin nge a thawh hlawk tih en a ni.

Hei hi tehna atan hian zirchiangtute chuan hmanraw bik Myasthenia Gravis-Specific Activities of Daily Living scale (MG-ADL) tih chu an hmang a. Hei hian damlote tan nitin thil tih (thusawi, ei leh in, leh chair atanga tho ang chi) tih harsat zia a teh a ni.

Research-ah hian damlote chu group hnih-ah an ṭhen a.

1. Pawl pakhat chu damdawi Vyvgart pek an ni.

2. Group dang chu placebo pek an ni . Chu chu damdawi ang deuh, mahse damdawi active tak tak nei lo thil tihna a ni.

Hemi chungchanga thil danglam tak chu, damdawi eitu damlote emaw, damdawi petu doctor-te emaw pawhin damdawi dik tak dawngtu leh placebo dawngtu an hre lo.

Research atanga chhuak chu eng nge ni?

A rah chhuah chu a fuh tak zet a ni.

Hei hian Vyvgart hian gMG symptoms tihziaawmna kawngah a thawh hlawkzia a tilang chiang hle. Vyvgart Hytrulo hian damdawi inang a pai avangin chutiang atan pawh chuan result chu a dik a ni.

Side effects pawh kan hre tur em ni?

Damdawi dang ang bawkin heng damdawi te hian side effect engemaw zat a nei thei a ni. Hengte hi fimkhur a pawimawh hle.

Thil pawimawh ber: Hetiang symptom danglam tak tak i neih chuan thil tenawm tak nia ngaiin ngaihthah suh la, i doctor nen inbia ngei ang che.

Damdawi dang leh vaccine dang ka ngaihtuah a ngai em?

Ni e, a dik tak zet. Vyvgart leh Vyvgart Hytrulo te hi i taksa hriselna tichhe thei damdawi an ni. Chuvangin,

• He enkawlna i tan hmain i doctor hnenah i ei tur damdawi dang zawng zawng (vitamin leh traditional medicines te pawh tel) te hrilh hmasa phawt ang che .
• Vaccine: He treatment cycle chhung hian vaccine i lak a ngai a nih chuan doctor hnenah hriattir hmasak phawt tur a ni.
• Non-live vaccine: Entirnan, mumps, pneumonia, leh influenza laka invenna. Hengte hi a hlawk lo thei em tih erawh hriat chian a la ni lo.
• Vaccine nung: 1.1.He enkawl chhung hian vaccine, measles, mumps, leh rubella te pek hi a tha lo.

A tawpah chuan Myasthenia Gravis nena khawsak hi a harsa thei hle. Mahse Vyvgart ang chi tunlai enkawlna hmang hian i nunphung chu nasa taka a lo ṭhan theihna chance a sang hle. A pawimawh ber chu doctor nen inbiak reng a, a thupek zawm hi a ni.