He aha te Aldosterone? Kia kite tātou me pēhea tōna pānga ki tō toto toto!

Kua rongo koe i te Aldosterone? Kua whakahuatia pea e tō tākuta, kua rongo rānei koe i te ingoa i a koe e kōrero ana mō tō toto toto . He homoni iti engari he mea nui rawa atu i roto i ō tātou tinana. Ka āwhina i te whakahaere i ngā taumata o te konutai me te pāhare pāporo i roto i ō tātou tinana, ā, ka pupuri i te toto toto kia mau tonu. Nō reira, me kōrero tātou mō te Aldosterone i tēnei rā i roto i tētahi huarahi māmā e mārama ai koe, āe?

He aha te aldosterone? Nō hea mai?

He whakarāpopototanga noa iho, ko te Aldosterone he homoni e hangaia ana e ō repe adrenal . E mōhio ana koe he aha ēnei repe adrenal? He repe iti e rua, he tapatoru te āhua, he rite ki ngā pōtae iti kei runga i ō whatukuhu. He wāhanga rātou o tā tātou pūnaha endocrine . He maha ngā homoni e hangaia ana e ēnei repe he mea nui ki ō tātou tinana.

He rite ngā homoni ki ngā karere matū e whakarite ana i te mahi a ō tātou tinana. Ka haere rātou i roto i te toto, ka tohutohu i ngā okana, i ngā uaua, me ētahi atu kiko ki te aha me mahi, me te wā hoki hei mahi.

Nā, ko tēnei homoni , ko te Aldosterone, e whakahaere ana i ngā taumata o te konutai me te pāhare pākawa i roto i ō toto. Ko ēnei konutai me te pāhare pākawa e kiia ana ko ngā electrolytes . Koinei ngā mea e āwhina ana ki te pupuri i te taurite o ngā wai o te tinana, ā, e āwhina ana hoki i ngā io me ngā uaua kia mahi tika. Waihoki, ko te Aldosterone te kaiwhakahaere i te nui o te wai e mimitihia ana e ngā whatukuhu. Ka whakanui ake tēnei i te nui o te toto, ā, ka pā ki te toto toto.

Nō reira, ahakoa he iti, he teitei rānei ō taumata aldosterone, ka pā ki tō hauora.

He aha te ratonga e tukuna ana e te aldosterone ki tō tātou tinana?

Ko te mahi matua a te Aldosterone he āwhina i te whakahaere i tō toto toto. He maha ngā huarahi e whai wāhi atu ai ki tēnei mahi nui:

• Ka tukuna e te Aldosterone he tohu ki ngā whekau pēnei i ō whatukuhu me te koroni kia whakanuia te nui o te konutai e tāpirihia ana ki ō toto, kia whakanuia rānei te nui o te pāhare pāporo e tukuna ana i roto i tō mimi.
• Ina piki ake ngā taumata konutai i tēnei ara, ka tīmata te tinana ki te pupuri wai, ka piki ake te rahinga o te toto.

He mea nui tēnei katoa ina iti te toto toto, kia hoki ai ki tōna taumata hauora.

Hei tāpiritanga, ka āwhina anō te aldosterone ki te pupuri i te pH (arā, te toenga waikawa-pūtake) me ngā taumata electrolyte o tō toto.

Me pēhea te whakahaere i ngā taumata aldosterone? Kia tirohia tata atu tātou!

Ko te Aldosterone tētahi wāhanga o tētahi whatunga matatini o ngā homoni, ngā whākōkī, ngā pūmua, me ngā tauhohenga e kiia nei ko te Pūnaha Renin-Angiotensin-Aldosterone (RAAS) . Koia te kawenga matua mō te whakahaere i te toto toto.

Whakaarohia tēnei hei tukanga taahiraa-i-te-taahiraa:

1. Tuatahi, ina heke tō toto toto , ka tukuna he whākōkī e kīia nei ko te renin ki roto i ō toto mai i ō whatukuhu.

2. Ka haere tēnei renin ka wawahi i tētahi pūmua e kiia nei ko te angiotensinogen , e hangaia ana i roto i tō ate. Ko tētahi o ngā wāhanga ko te angiotensin I. Kāore tēnei e kaha ana i taua wā, arā, kāore he pānga nui.

3. Kātahi ka puta mai te Angiotensin-Converting Enzyme (ACE) mai i ō pukahukahu ka wāwāhi i tēnei Angiotensin I kia maha atu ngā wahi. Ko tētahi o aua wahi ko te homoni hohe e kiia nei ko te Angiotensin II .

4. Koinei te wāhi e mahi ai te Angiotensin II i te mahi nui:

• Ko tētahi ko te whakanui ake i te toto toto mā te whakawhāiti i ngā pakitara uaua o ngā oko toto iti (arterioles).
• Ko tētahi atu, ka "tohu" i ō repe adrenal kia tukuna te aldosterone.
• Ka kī atu hoki ki tō repe pituitary kia tukuna te Hormone Antidiuretic (ADH) , e mōhiotia ana ko te Vasopressin .

5. Nō reira, ka mahi tahi te Aldosterone me te ADH ki te kī atu ki ngā whatukuhu kia pupuri i te konutai i roto i te tinana. Ka meinga e te Aldosterone ngā whatukuhu kia whakaputa i te pāhare pāporo ki roto i te mimi. Ina piki ake ngā taumata konutai i roto i te toto, ka puritia te wai i roto i te tinana. Ka piki ake te rahinga toto me te toto toto.

Koinei te otinga o te Pūnaha Renin-Angiotensin-Aldosterone. E mārama ana koe ki taua tukanga?

Ka taea hoki te whakahohe i tēnei pūnaha e ētahi atu homoni pērā i te corticosteroids , te estrogen, me ngā homoni tairoi .

Mena he raruraru kei tētahi wāhanga o tēnei pūnaha, ka pā ki tō toto toto me ngā taumata konutai me te pāhare pāporo. Heoi, he mea nui kia mahara he maha atu anō ngā mea ka pā ki tō toto toto, pērā i te cholesterol teitei, te ira tangata, me ētahi rongoā.

Me pēhea te tirotiro i ngā taumata o te aldosterone?

Ko te whakamātautau matua e whakamahia ana e ngā tākuta hei tirotiro i ngā raruraru e pā ana ki te aldosterone ko te Whakamātautau Ōwehenga Aldosterone: Renin . Nā te mea he tata te whanaungatanga o te renin me te aldosterone, ka taea e tēnei whakamātautau te whakatau mēnā he raruraru noa iho te raruraru ki te hanga me te mahi aldosterone, mēnā rānei he raruraru kei te pūnaha renin-angiotensin tonu.

Mō tēnei Whakamātautau Ārotiroterene: Renin, ka tangohia he tauira toto mai i tētahi uaua i tō ringa.

Ka taea hoki e ngā tākuta te ine i te nui o te aldosterone i roto i tō toto me/ranei i tō mimi.

I ētahi wā, ka whakahau pea tō tākuta i tētahi whakamātautau whakaurunga catheter hei tango i tētahi tauira toto mai i tētahi uaua i roto i tō whatukuhu (mō te renin) i tētahi uaua rānei i roto i tō repe adrenal (mō te aldosterone). He whakamātautau tēnei e mahia ana i roto i te hōhipera e tētahi tohunga hihi-X kua whakangungua motuhaketia.

He aha ngā taumata noa o te aldosterone?

Ka rerekē pea ngā uara noa mō ngā taumata aldosterone i ia taiwhanga ki ia taiwhanga. Nō reira, kia tirohia te awhe noa i runga i tō pūrongo taiwhanga, pātai atu rānei ki tō tākuta mēnā he pātai āu mō ō hua.

Ka rerekē te awhe noa mō ngā taumata aldosterone i roto i te toto i runga i te pakeketanga. I te nuinga o te wā, ko ngā taumata noa e whai ake nei:

• Mō ngā pēpi 1 ki te 12 marama: 5.8 – 110.0 nanograms ia teririta (ng/dL)
• Mō ngā tamariki 1 ki te 5 tau te pakeke: < 36.0 ng/dL
• Mō ngā tamariki 6 ki te 9 tau te pakeke: < 24.0 ng/dL
• Mō ngā tamariki 10 ki te 11 tau te pakeke: < 15.0 ng/dL
• Mō ngā tamariki 12 ki te 14 tau te pakeke: < 22.0 ng/dL
• Mō ngā taiohi 15 ki te 17 tau te pakeke: 3.0 – 32.0 ng/dL
• Ngā pakeke 18 ki te 99 tau te pakeke: 3.1 – 35.4 ng/dL

Ina tirohia ngā taumata aldosterone i roto i te whakamātautau mimi 24-hāora, ko te awhe noa kei waenga i te 3 – 25 maikirokaramu ia 24 hāora (3 – 25 maikirokaramu/24 hāora).

He aha te mea ka tupu mēnā ka piki ake ngā taumata o te aldosterone?

Ina teitei ake ngā taumata aldosterone i te tikanga, ka kiia tēnei he hyperaldosteronism .

Ko te tino take o tēnei ko te Aldosteronism Tuatahi , e mōhiotia ana ko te mate a Conn . Ka puta tēnei āhuatanga i tētahi pukupuku kore-matepukupuku (pai) e tupu ana i roto i tētahi o ō repe adrenal.Mā tēnei ka nui ake te aldosterone e whakaputaina e te repe i tōna rahinga e tika ana. Ina piki ake ngā taumata aldosterone, ka piki ake ngā taumata konutai ( hypernatremia ) ā, ka heke ngā taumata pāhare pāporo ( hypokalemia ). Ka puta he kore taurite o ngā electrolytes i roto i tēnei.

Ngā tohu o te aldosterone teitei

Mēnā he aldosteronism tuatahi, arā, ina teitei ake ngā taumata aldosterone, ka puta ngā tohu pēnei i:

• Te toto toto tiketike (hypertension)
• Ānini
• Te ngoikore o te uaua , ina koa he iti rawa ngā taumata pāhare pāporo
• Te matewai nui me te mimi pinepine

Mena kei a koe ēnei tohu, he mea tino nui kia rapu tohutohu hauora tonu atu.

He aha te mea ka tupu mēnā ka heke te taumata o te aldosterone?

Ina iti iho ngā taumata aldosterone i te mea noa, ka kiia tēnei he hypoaldosteronism . He ngoikore tēnei o te aldosterone, he koretake rānei tōna mahi. Ina iti ngā taumata aldosterone, ka heke ngā taumata konutai ( hyponatremia ), ka piki ake ngā taumata pāhare pāporo ( hyperkalemia ), ā, ka nui rawa te waikawa ka puta i te tinana ( metabolism acidosis ).

He maha ngā take pea o te hypoaldosteronism:

• Te mate a Addison: He mate onge tēnei. E kiia ana hoki ko te ngoikore o te adrenal tuatahi . He mate pūnaha ārai mate tēnei. Ko te tikanga ka whakaekea e tō ake pūnaha ārai mate te wāhanga o waho (cortex) o ngā repe adrenal. Ka hangaia ngā homoni aldosterone me te cortisol ki reira. Ka heke te taumata o ngā homoni e rua.
• Te Whēterotanga o te Repe Adrenal (CAH): He rōpū mate ira tēnei e pā ana ki ngā repe adrenal. Ka whānau mai te hunga whai CAH me te korenga o ētahi whākōkī e hiahiatia ana hei hanga homoni e whakaputaina ana e ngā repe adrenal.
• Ngā āhuatanga hauora: Ka taea e te hunga mate huka, te mate tākihi, te paihana mata, te mate hauora kino rānei te whakawhanake i te hypoaldosteronism.
• Ētahi rongoā: Ngā rongoā anti-inflammatory kore-steroidal (NSAID) , HeparinKa taea hoki tēnei āhuatanga te puta mai i ngā rongoā e hoatu ana hei rongoā i te mate manawa.

Ngā tohu o te iti o te aldosterone

I te nuinga o te wā, ka puta pea ngā tohu pēnei i te iti o te taumata aldosterone (Hypoaldosteronism):

• Te toto toto iti (hypotension)
• ngoikore o te uaua
• Whakapairuaki
• Ngā tere o te ngakau
• Ngā rerekētanga o te pā o te ngakau (Arrhythmia)

I runga i te pūtake o tō hypoaldosteronism, tera pea ka pā mai ētahi atu tohu. Hei tauira, i roto i te mate a Addison, ka taea e ngā taumata cortisol iti te whakaputa i ngā huringa kiri (pērā i ngā ira pango me ngā kopa kiri) me ngā taumata huka toto iti ( hypoglycemia ).

Ki te pā mai tētahi o ēnei tohu ki a koe, me toro atu ki tō tākuta tonu.

Hei whakamutunga, ngā mea hei maumahara (Karere hei tango ki te kāinga)

He homoni nui te Aldosterone hei whakahaere i te toto toto. Mena kei te uaua koe ki te pupuri i te toto toto hauora, ā, kei te kitea hoki he huringa o ngā taumata pāhare pāporo i roto i tō toto, he mea pai kia kōrero koe ki tō tākuta mō ētahi atu tikanga whakahaere toto toto me ngā whakamātautau tāpiri. Kātahi ka taea e ia te tono whakamātautau hei tirotiro mēnā he taumata aldosterone rerekē ō tohu.

Ko tāku tumanako ka whai hua ēnei kōrero ki a koe! Kia ora tonu!

` Aldosterone, Aldosterone, Homoni, Pēhanga Toto, Repe Adrenal, Konutai, Pāhare pākawa