E mōhio ana koe ki tēnei karere iti i roto i tō tinana? (Adrenocorticotropic Hormone - ACTH)

Kua whakaaro koe ki te aha ka puta i roto i tō tinana ina pāngia koe e te ahotea, ina pāngia rānei koe e te nui o te pēhanga? He hoa iti tō tō tātou tinana kāore e kitea e tātou, ā, e āwhina ana i a tātou i ēnei wā. Ko ACTH tōna ingoa. I tēnei rā, ka kōrero tātou mō tēnei ACTH.

He aha te ACTH?

He kupu ngāwari noa iho, ko te ACTH he homoni e hangaia ana e tō repe pituitary. He mahi nui tāna ki te urupare a tō tinana ki te ahotea . Ina tukuna te ACTH, ka tohu i ō repe adrenal kia whakaputa i te cortisol, e mōhiotia ana e tātou katoa ko te "hormone ahotea," me tētahi rōpū homoni ira tangata e kiia nei ko ngā androgens.

Tērā pea kei te whakaaro koe he aha ēnei homoni, tika? He matū ngā homoni e whakarite ana i ngā mahi maha i roto i tō tinana. He rite ki ngā karere. Ka haere ēnei karere mā roto i ō toto ki ō whekau, kiri, uaua, me ētahi atu kiko. Mā ēnei tohu e tohutohu ki tō tinana he aha te mea hei mahi me te wā hei mahi.

He repe iti, he rite te rahi ki te pīni tō repe pituitary, kei te pūtake o tō roro, i raro noa i te hypothalamus. He wāhanga ia o tō pūnaha endocrine. E rua ngā wāhanga o te repe pituitary: ko ​​te lobe o mua me te lobe o muri. Ko tō repe pituitary o mua te mea e hanga ana, e tuku ana hoki i te ACTH.

He aha te mea ka tupu me te ACTH?

Ko te mahi matua a te ACTH he whakaoho i ō repe adrenal ki te tuku i te homoni cortisol. Whakaarohia he rite te ACTH ki te āpiha rangatira e kī ana ki ō repe adrenal kia hanga cortisol.

He tino nui te homoni cortisol e hiahiatia ana e ō tātou tinana. E pā ana ki te nuinga o ngā okana me ngā kiko o te tinana. E mōhiotia ana te cortisol ko te "hormone ahotea," engari he maha atu anō āna mahi nui i roto i ō tātou tinana.

Anei ētahi mea nui mō te cortisol:

• Ko koe te kaiwhakahaere i te urupare a tō tinana ki te ahotea .
• Ka āwhina i te whakahaere i te whakamahinga a tō tinana i ngā ngako, ngā pūmua, me ngā warowaihā, arā, ko tō pākia o te tinana .
• Ka whakaitihia te mumura , arā, te pupuhi me te whero i ngā wāhanga rerekē o te tinana.
• Whakahaere i te toto toto .
• Ka whakahaere i ngā taumata huka toto .
• Ka āwhina anō hoki ki te whakahaere i tō huringa moe-ara .

Ehara i te mea ko tēnei anake, he mahi anō tā te ACTH. Arā, ka whakaoho i ngā repe adrenal ki te tuku i ngā homoni ira tangata e kiia nei ko ngā androgens. Hei tāpiri, ka āwhina te ACTH ki te hanga matū e whakaoho ana i te hanga o ngā homoni, pērā i te adrenaline me te noradrenaline.

Me pēhea te whakahaere i ngā taumata ACTH?

Ko ngā taumata ACTH o tō tinana e whakahaerehia ana e tētahi pūnaha tino whakamere. Ka kiia ko te pūnaha urupare. Kei roto ko tō hypothalamus, te repe pituitary, ngā repe adrenal, me ētahi homoni. Ka kiia e mātou tēnei pūnaha katoa ko te tuaka Hypothalamic-Pituitary-Adrenal (HPA) . He ahua uaua, kāore? Engari he māmā noa iho.

Whakaarohia kei te hono tō repe pituitary ki tō hypothalamus mā te kakau iti o ngā uaua toto me ngā io. Ka kiia tēnei ko te kakau pituitary. Mā tēnei kakau ka kōrero te hypothalamus ki te repe pituitary me te kī atu ki a ia kia tukuna ētahi homoni. Ko tō hypothalamus tētahi wāhanga o tō roro e whakahaere ana i ngā mea pēnei i te toto toto, te tere o te manawa, te pāmahana o te tinana, me te nakunaku.

Ko ngā repe adrenal he repe iti, tapatoru e rua kei runga ake i ō whatukuhu.

Nā, kia tirohia te mahi a tēnei pūnaha urupare e whakahaere ana i ngā taumata ACTH:

• Ina heke te taumata cortisol o tō tinana, ka tukuna e tō hypothalamus tētahi homoni e kiia nei ko te Corticotrophin-Releasing Hormone (CRH) .
• Ka whakaohokia e tēnei CRH tō mua o te pituitary lobe ki te tuku i te ACTH.
• Kātahi ka whakaohokia e te ACTH ō repe adrenal, inā koa te adrenal cortex, kia tukuna te cortisol me ngā androgens.
• Ina piki ake ngā taumata cortisol pēnei, ka tukuna he tohu ki te hypothalamus kia whakahekehia ngā taumata CRH. Ā, koinei te otinga o te huringa. He rite ki te 'pana whakaweto' .

Ehara i te mea koinā anake, ina pāngia koe e te ahotea , arā, te ahotea hinengaro, ka whakaohokia te hanga ACTH, ā, ka piki ake ngā taumata cortisol.

Heoi, ki te mea he raruraru kei tō hypothalamus, kei tō repe pituitary, kei tō repe adrenal rānei, ka raru pea te taurite o ngā homoni e whai wāhi ana ki tēnei tukanga, arā, ko te ACTH.

Me pēhea te tirotiro i ngā taumata ACTH?

Ka mahia he whakamātautau toto hei tirotiro i ō taumata ACTH. Ko te tikanga o tēnei ko te tango i tētahi tauira toto iti mai i tētahi uaua i tō ringa.

He maha ngā wā ka tonoa e ngā tākuta he whakamātautau cortisol me te whakamātautau ACTH hei whakatau mēnā he raruraru kei te repe pituitary, kei te repe adrenal rānei.

Waihoki, i ētahi wā ka mahi pea ngā tākuta i tētahi mea e kīia nei he whakamātautau whakaohooho ACTH . Mā tēnei ka whakamātautau i te pai o te urupare a ō repe adrenal ki te ACTH. Ka āwhina hoki tēnei ki te tautuhi i ngā raruraru o te pituitary me/ranei ngā repe adrenal.

He aha te taumata ACTH noa?

Pērā i te cortisol, ko te taumata o te ACTH i roto i tō toto ka teitei rawa i te ata pō. Ka heke haere i te roanga o te rā, ka tae ki tōna taumata iti rawa i te waenganui pō. Heoi, ki te mahi koe i te huringa pō, ā, ka moe koe i ngā wā rerekē o te rā, ka rerekē pea tēnei tauira.

Nō reira, ko te tikanga me tango toto i te ata mō ngā whakamātautau ACTH. I te nuinga o te wā, ko te awhe noa mō ngā taumata ACTH i waenga i te 7:00 i te ata me te 10:00 i te ata he 7.2 ki te 63.3 pikokaramu ia miririta (7.2 ki te 63.3 pg/mL) .

Engari kia maumahara ki tētahi mea. Ka rerekē pea ēnei awhe noa i ia taiwhanga ki ia taiwhanga, i ia wā, i ia tangata ki ia tangata. Mena he whakamātautau ACTH tāu, mā tō tākuta e pānui ō hua, ā, ka kī atu ki a koe mēnā me whai whakamātautau anō.

Ka aha mēnā ka piki ake ngā taumata ACTH?

Mena he teitei ō taumata ACTH, he nui pea ō taumata cortisol. Nā te mea he maha ngā pānga o te cortisol ki te tinana, ka pāngia pea koe e ngā pānga taha o te cortisol teitei, kaua ko ngā tohu o te ACTH teitei. I ētahi wā, ina kore ō repe adrenal e whakaputa i te cortisol i te nui, ka piki ake ngā taumata ACTH. I aua wā, ka pāngia pea koe e ngā tohu o te cortisol iti, kaua ko te ACTH teitei.

He maha ngā take pea mō te pikinga o ngā taumata ACTH:

• Te mate a Cushing: Koinei te tino take o te pikinga o ngā taumata ACTH. Nā te puku kore-matepukupuku (adenoma) i roto i te repe pituitary tēnei i puta ai te nui rawa o te ACTH. Kātahi ka piki ake ngā taumata cortisol. He mea nui kia mārama ki te rerekētanga i waenga i te mate a Cushing me te mate a Cushing . Ko te mate a Cushing tētahi o ngā take maha o te mate a Cushing.
• Puku homoni adrenocorticotropic ectopic: He tino onge, ka taea e te puku e whanake ana i waho o tō repe pituitary te tuku i te nui rawa o te ACTH. Ko ngā puku ka taea te whakaputa ACTH i tēnei ara (ahakoa he tino onge) ko ngā pukupuku carcinoid kore-matepukupuku o ngā pukahukahu, ngā pukupuku pūtau moutere o te pancreas, te carcinoma medullary o te tairoi, ngā pukupuku pūtau iti o te pukahukahu, me ngā pukupuku o te repe thymus .
• Te ngoikore o te adrenal tuatahi: Ka puta tēnei āhuatanga ina pakaru ō repe adrenal i tētahi mea, ā, kāore e taea e rātou te whakaputa tika i te cortisol. Te mate a AddisonKoinei te tino take o te ngoikore o te adrenal tuatahi. Nā reira, ka tukuna e tō repe pituitary he nui ake te ACTH nā te mea e hiahia ana ia ki te whakaoho i ngā repe adrenal.

Ka aha mēnā ka heke ngā taumata ACTH?

Mena he iti ngā taumata ACTH nā te raruraru o te repe pituitary, ka iti anō hoki ngā taumata cortisol. Heoi, ki te teitei ngā taumata cortisol nā te raruraru o te repe adrenal, ka iti pea ngā taumata ACTH.

He maha ngā take e iti ai ngā taumata ACTH:

• Te mate a Cushing: Ka taea e te mate a Cushing te puta mai i te pukupuku o te repe adrenal, i te whakamahinga roa rānei o ngā rongoā corticosteroid mō ētahi atu āhuatanga, ka iti ai te taumata ACTH. Nā te mea kāore e taea e tō repe pituitary te tuku i te ACTH i te nuinga o te wā nā te nui rawa o te cortisol.
• Te ngoikore o te puku: He tino onge tēnei āhuatanga. Koinei te wā e iti rawa ai te whakaputanga o tētahi, o ētahi, o ngā homoni katoa rānei e tō repe pituitary. Ko te ACTH tētahi o ngā homoni ka pāngia. Ko te kino ki tō repe pituitary, pērā i te pukupuku, te pokanga, te rongoā irahiko rānei, ka pā te ngoikore o te puku.

Kua mārama pea koe i nāianei he mea nui te ACTH mō te whakahaere i ō taumata cortisol. Mena kei te pāngia koe e ngā tohu o te taumata cortisol teitei, iti rānei, pērā i te pikinga, te hekenga rānei o te taumaha, te toto toto tiketike, iti rānei, kia kite koe i tō tākuta. Ka taea e ia te whakahaere i ngā whakamātautau toto cortisol me te ACTH hei whakatau mena ko ō repe adrenal, ko tō repe pituitary rānei te take o ō tohu.

Nā, he aha ngā mea me maumahara tātou?

He homoni tino nui te ACTH e whakaputaina ana e te repe pituitary e āwhina ana ki te whakahaere i te ahotea i roto i te tinana.

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- Koinei te mea e whakaoho ana i ngā repe adrenal ki te whakaputa i te "hormone ahotea" cortisol .

- He maha ngā mea e whakahaeretia ana e te cortisol, pērā i te pākia o te tinana, te toto toto tiketike, me ngā taumata huka toto.

- Ka whakahaerehia ngā taumata ACTH e tētahi pūnaha matatini e uru ana ki te hypothalamus, te repe pituitary, me ngā repe adrenal .

- Ki te piki, ki te heke rānei ngā taumata ACTH, ka pā mai pea te mate a Cushing, te mate a Addison rānei.Ka puta pea ngā momo raruraru hauora.

- Ki te pā mai ētahi tohu ki a koe mō tēnei mea, he pai ake te toro atu ki te tākuta me te kore wehi, me te rapu tohutohu.

ACTH , Hormone Adrenocorticotropic, Cortisol, Repe Pituitary, Repe Adrenal, Ngā Hormone, Taumahatanga