Kia ako tātou mō ētahi raruraru o te pūnaha repe o tō tinana? - Ngā Mate Pūkahukahu Endocrine Maha (MEN)

He rite tō tātou tinana ki tētahi mīhini whakamiharo, kāore? Kia tika ai te mahi a tēnei mīhini, me mahi tahi, me taurite hoki ia wāhanga. He pūnaha tino nui kei roto i tō tātou tinana, e kiia nei ko te pūnaha endocrine . Ko ngā repe o tēnei pūnaha ka whakaputa i ngā homoni e whakahaere ana i ngā mahi maha o roto i tō tātou tinana. Heoi, i ētahi wā ka hē te pūnaha nei. I tēnei rā ka kōrero tātou mō tētahi āhuatanga onge engari he tino nui hei mōhio. Koia te Multiple Endocrine Neoplasia , e mōhiotia ana ko te (MEN).

Nā, he aha tēnei pūnaha endocrine?

Ki te whakarapopoto, ko tā tātou pūnaha endocrine he whatunga o ngā repe me ngā okana i roto i tō tātou tinana. Koinei ngā mea e whakaputa ana i ngā matū e kiia nei ko ngā homoni , ā, e tukuna ana ki roto i te toto. Whakaarohia ēnei homoni hei karere iti e kawe ana i ngā karere i roto i ō tātou tinana. Mā ēnei karere e tohutohu ō tātou okana, kiri, me ngā uaua ki te aha me mahi, me te wā hoki me mahi ai.

He maha ngā repe me ngā whekau matua o te pūnaha endocrine:

• Hypothalamus: Kei te pūtake o tō tātou roro tēnei. He maha ngā mea e whakahaeretia ana e ia i roto i te pūnaha endocrine.
• Te repe pituitary: Ko tēnei repe iti, e hono ana ki te hypothalamus, e whakaputa ana i ngā homoni e whakahaere ana i te maha atu o ngā repe, tae atu ki te repe thyroid, ngā repe adrenal, ngā ovaries, me ngā testicles.
• Tairoiti: Ko tēnei repe āhua pūrerehua kei mua o te kaki e whakahaere ana i te pākia o te tinana, koinei te whakamahinga o te pūngao mai i te kai e kainga ana e tātou.
• Ngā repe parathyroid: Ko ēnei repe iti e whā, e tata ana ki te repe tairoi, e whakahaere ana i ngā taumata o te konupūmā me te whākōkī i roto i tō tātou tinana.
• Ngā repe adrenal: Ko ēnei repe e rua, kei runga ake i ngā whatukuhu, e whakahaere ana i te pākia o te tinana, te toto totoka, te whanaketanga ā-ira tangata, me te urupare ki te ahotea.
• Repe pineal: Ka whakaputahia e tēnei repe te homoni melatonin hei whakahaere i tā tātou huringa moe.
• Te repeure: Koinei te wāhi e hangaia ai te insulin. He mea tino nui mō te pākia o te tinana me te whakahaere i te huka toto. He wāhanga anō hoki ia o tā tātou pūnaha nakunaku.
• Ngā whekau ovary: Koinei te wāhi e hangaia ai ngā homoni ira wahine, arā, te estrogen, te progesterone, me te testosterone.
• Ngā whakamātautau: I te wā e whakaputa ana te parāoa i roto i ngā tāne, ka whakaputahia hoki te homoni testosterone ki konei.

Nā, he aha te Multiple Endocrine Neoplasia (MEN)?

Ko te Multiple Endocrine Neoplasia (MEN) he mate ira onge e puta ai ngā pukupuku i roto i ngā repe me ngā kiko o te pūnaha endocrine, i kōrerotia i mua ake nei. I ētahi wā ka huri ēnei pukupuku hei matepukupuku.

E rua ngā momo matua o tēnei mate (MEN):

1. Te maha o ngā pukupuku endocrine momo 1 (MEN momo 1): He āhuatanga tēnei e puta ai ngā pukupuku maha i roto i ngā repe rerekē o te pūnaha endocrine. Ka kiia hoki tēnei ko te MEN-1 me te mate a Wermer.

2. Te maha o ngā neoplasia endocrine momo 2 (MEN momo 2): He mate pukupuku ira tēnei e pā ana ki ētahi repe. Ka pāngia te hunga whai MEN2 e tētahi momo mate pukupuku tairoi e kiia nei ko te mate pukupuku tairoi medullary (MTC) . He nui ake hoki te tūponotanga o te whakawhanake i ngā pukupuku i roto i ētahi atu repe o te pūnaha endocrine. Ka kiia hoki tēnei ko te MEN-2 me te Sipple syndrome.

He aha i puta ai tēnei āhuatanga "(TĀNE)"?

Ko ēnei momo '(MEN)' e rua, e puta mai ana i ngā huringa o ō tātou ira , arā, ngā whakarerekētanga ira . Whakaarohia he rite ki tētahi pukapuka tohutohu kei roto i tō tātou tinana, arā, ngā ira. Mēnā he hē tētahi reta i roto i tēnei pukapuka tohutohu, arā, ki te whakarerekētia tētahi ira, ka taea te whakararuraru i ētahi o ngā mahi a te tinana.

• (momo MEN 1) ka puta mai i te whakarerekētanga ira i roto i te ira MEN1 . Ko tēnei ira MEN1 he ira pehi pukupuku . Arā, he ira e āwhina ana ki te whakahaere i te wehenga pūtau me te ārai i te hanganga o ngā pukupuku. Ki te kore tēnei ira e mahi tika, ka taea e ētahi pūtau te tipu haere i waho o te mana whakahaere, ka hanga pukupuku.
• (MEN momo 2) ka puta mai i te whakarerekētanga ira i roto i te ira RET . Ko tēnei ira RET he ira e pā ana ki te whanaketanga o te mate pukupuku. Ina whakarerekētia tēnei ira, ka tipu haere ngā pūtau i roto i ētahi okana me ngā repe, ā, ka puta he pukupuku.

Ka taea te tuku iho i ēnei whakarerekētanga ira mai i ngā mātua, ka taea rānei te puta noa i te wā e whanake ana te kukune i roto i te kōpū. Mena he MEN tō tētahi o ngā mātua, e 50% te tūponotanga ka pāngia te tamaiti e tēnei mate.

Kia ako tātou i ētahi atu kōrero mō te momo (MEN) (MEN momo 1)

Ka puta he pukupuku i roto i ētahi repe o te pūnaha endocrine i te hunga whai MEN momo 1. Ko ngā wāhi e tino pāngia ana ko:

• Ngā repe parathyroid: Koinei te mea tino noa.
• Te ara gastrointestinal pancreatic: Ko te tikanga ka taea e ngā pukupuku te puta i roto i te pancreas, te puku, me ētahi atu wāhanga o te pūnaha nakunaku, pērā i te duodenum.
• Te repe pituitary.

I te nuinga o te wā, ko ngā puku e puta mai ana me te MEN momo 1 ehara i te matepukupuku (pai) . Heoi, ko ētahi puku ka matepukupuku (kino).Ka taea hoki te horapa (metastasize) ki ētahi atu wāhanga o te tinana. Ko ngā repe he pukupuku kei roto, ka tukuna he nui rawa o te homoni ki roto i te toto. Koinei te take e puta ai ngā momo tohu me ngā raruraru hauora.

Neke atu i te 20 ngā momo pukupuku endocrine me ngā momo pukupuku kore-endocrine kua kitea e ngā tākuta i roto i te hunga whai MEN momo 1. Tērā atu anō ngā momo pukupuku kāore i te tino kitea, pērā i:

• Ngā pukupuku neuroendocrine e whanake ana i roto i te thymus (he kōpuku lymph i roto i te uma) me te bronchi (ngā ara manawa i roto i ngā pukahukahu).
• Ka puta ngā pukupuku adrenocortical i te paparanga o waho o ngā repe adrenal.
• Ngā puku momona (Lipomas) e puta ana i raro i te kiri.
• Te mate pukupuku o te ū.
• Ko ngā pukupuku pērā i te meningioma me te ependymoma ka puta i roto i te roro, i te taurakira rānei.

He aha ngā tohu o te (MEN momo 1)?

Ka rerekē ngā tohu o te momo MEN 1 i ia tangata, i ia tangata. Kei ngā repe e pāngia ana, me te nui o te homoni e whakaputaina ana e rātou. Tērā pea kāore he tohu o ētahi tāngata, ko ētahi he ngawari noa iho, ā, ko ētahi he kino rawa atu, he morearea hoki. Ka rerekē ngā tohu i ia tangata, i ia tangata, ahakoa i roto i te whānau kotahi, ahakoa i waenga i ngā māhanga.

Kia tirohia ētahi o ngā momo matua o ngā puku me ō rātou tohu e pā ana:

• Nā ngā raruraru o ngā repe parathyroid (hyperparathyroidism):

E 90% o te hunga whai (MEN momo 1) ka pāngia e tēnei mate i te 50 tau te pakeke. I roto i tēnei, ka kaha rawa te mahi a ngā repe parathyroid.

• Ngā tohu māmā: mamae hononga, ngoikore uaua, ngenge, pouri, uaua ki te arotahi, ngaro te hiahia kai.
• Ngā tohu kino: whakapairuaki, ruaki, pōhēhē, wareware, nui te matewai me te mimi pinepine, mate kōroke, mamae wheua.

• Nā ngā pukupuku i roto i te repeure me te wāhanga tuatahi o te whekau iti (Gastrinomas):

Tata ki te 40% o ngā pakeke whai MEN momo 1 ka pāngia e ngā pukupuku e kiia nei ko ngā gastrinoma. Ka puta he homoni e kiia nei ko te gastrin, ka nui rawa te waikawa e puta mai i te puku.

• Ngā Tohu: Mamae puku, korere, ngaungau (reflux waikawa), mate puku (mate peptic).
• Ko tētahi atu pukupuku e kitea ana i tēnei kāwai ko te insulinoma . Ka puta te insulin i tēnei, ka taea ai te whakaheke i te huka toto (hypoglycemia).
• Ngā Tohu: te pōhēhē, te wiri, te werawera, te hiakai nui, te manukanuka, te tere o te pā o te ngakau, ngā huringa tirohanga mō te wā poto.

• Nā ngā pukupuku pituitary (prolactinomas):

Tata ki te 25% o te hunga whai MEN momo 1 ka pāngia e ngā pukupuku pituitary. Ko ngā mea tino kitea ko ngā prolactinomas, e whakaputa ana i te homoni prolactin .

• Ngā tohu i roto i ngā wāhine: te koretake o te paheketanga, te mutu rānei o te paheketanga (amenorrhea), te uaua ki te hapu tamariki, te rere mai i ngā uma i te wā kāore i te hapu, i te whāngai u rānei (galactorrhea), te hekenga o te hiahia moepuku.
• Ngā tohu i roto i ngā tāne: Te hekenga o te hiahia moepuku nā te hekenga o ngā taumata testosterone, te ngoikore o te ure (ED), me te uaua ki te hapu tamariki.
• Mena he nui te puku: te ānini, te whakapairuaki/te ruaki, te panoni o te tirohanga (te tirohanga takirua, te heke o te tirohanga taha).

He mea nui: Ehara i te mea ka pāngia te katoa e ngā tohumate ōrite. Kāore tēnei rārangi i te katoa. He maha atu anō ngā momo puku ka puta i roto i te (MEN momo 1).

Me ako anō hoki tātou mō te momo (MEN) 2 (MEN momo 2)

Ko te hunga katoa e pāngia ana e te MEN momo 2 ka pāngia e te momo matepukupuku tairoi e kiia nei ko te matepukupuku tairoi medullary (MTC) . Ka pāngia tēnei momo matepukupuku e tētahi momo pūtau motuhake i roto i te repe tairoi e kiia nei ko ngā pūtau C. Ka whakaputahia e ēnei pūtau he homoni e kiia nei ko te calcitonin. Ka horapa te MTC ki ngā kōpū lymph me ētahi atu okana. Ko te maimoatanga matua ko te tango pokanga i te repe tairoi (thyroidectomy).

Waihoki, ko te hunga whai (MEN momo 2) ka pāngia pea e tētahi, e rua rānei o ngā āhuatanga e whai ake nei:

• Pheochromocytoma: He pukupuku onge tēnei e tupu ana i te wāhanga waenga o tētahi, o ngā repe adrenal rānei e rua (adrenal medulla). I te nuinga o te wā, ehara ēnei i te matepukupuku. Tata ki te 10%-15% o ngā take ka huri hei matepukupuku ka horapa.
• Hyperparathyroidism: Ka piki ake ngā taumata konupūmā toto nā te nui rawa o te homoni parathyroid (PTH) e hangaia ana e ngā repe parathyroid.

He aha ngā tohu o te (MEN momo 2)?

He rerekē anō hoki ngā tohu i konei. Ko te nuinga o ngā tohu ka puta mai i ngā taumata tiketike o ngā homoni e whakaputaina ana e te mate pukupuku (MTC) me ētahi pukupuku.

• Ngā tohu o te mate pukupuku tairoi waenga (MTC):
• He puku kei mua o te kaki, he mamae te kaki, he rerekē te reo (he pāorooro), he maremare, he uaua ki te horomi, he uaua ki te manawa.

• Ngā tohu i puta mai i te Pheochromocytoma: (e puta ana i te 50% o ngā take)
• Ka puta noa ngā tohu ina nui rawa ngā homoni e whakaputaina ana e ēnei pukupuku, pērā i te adrenaline. Kāore ētahi pukupuku e whakaputa homoni, ā, kāore pea e whakaatu i tētahi tohu.
• Ngā tohu noa (he maha ngā wā ka haere mai, ka haere atu): te toto toto tiketike (te toto toto tiketike), te ānini, te werawera nui, kāore he take, te tere o te ngakau, te koretake rānei o te ngakau, te wiri.

• Ngā tohu e pā ana ki te hyperparathyroidism:
• Pērā i te (MEN momo 1), ka puta pea ngā tohu pēnei i te mamae o ngā hononga, te ngoikore o te uaua, te ngenge, te pouri, te uaua ki te arotahi, te kore hiahia kai, te whakapairuaki, te ruaki, te matewai nui me te mimi pinepine, te mate kōroke, me te mamae o te wheua.

Ko wai ka pāngia e tēnei mate (MEN)? He aha te auau o tēnei mate?

Ka pāngia ngā tāne me ngā wāhine e te mate (MEN). He rerekē te tau e puta ai te mate (MEN momo 1). Kua kitea tēnei mate i roto i ngā tamariki e 8 tau te pakeke me ngā pakeke e 80 tau te pakeke.

He mate onge te '(MEN)'.

• E pāngia ana te tata ki te kotahi i roto i te 30,000 tāngata e te momo TĀNE.
• E pāngia ana te tata ki te kotahi i roto i te 35,000 tāngata e te momo TĀNE 2.

E whakapono ana ētahi kairangahau tera pea ka nui ake te tokomaha o te hunga e pāngia ana e ēnei āhuatanga nā te kore e tino kitea te mate, nā te hē rānei o te tautuhi i tōna mate.

Me pēhea te tātaritanga a ngā tākuta i te mate (MEN)? (Tauātanga)

He uaua te tautuhi i te mate (MEN), nā te mea ka pā ki ngā repe rerekē.

• Te tautuhi i te (MEN momo 1):

Ko te tikanga ka kitea te tangata he MEN momo 1 mēnā kei a ia kia rua, neke atu rānei, ngā pukupuku endocrine nui e toru kua whakahuatia i runga ake nei (ngā pukupuku parathyroid, ngā pukupuku pituitary, me/ranei ngā pukupuku o te ara kai), mēnā rānei kei a ia tētahi o aua pukupuku, ā, he momo MEN momo 1 kei tētahi o te whānau.

• Ngā Whakamātautau:
• Ngā whakamātautau toto: Tirohia mēnā he nui ngā taumata o ētahi homoni (hei tauira, te homoni parathyroid (PTH), te konupūmā).
• Ngā whakamātautau whakaahua: Ka āwhina ēnei ki te kimi i ngā wāhi kei reira ngā puku, pērā i te matawai CT (matawai tomography rorohiko) te MRI rānei (matawai whakaahua aukume).
• Whakamātautau ira: Ka tirohia mēnā he whakarerekētanga ira i roto i te ira MEN1.

• Te tautuhi i te (MEN momo 2):

Ka tāpaetia te tangata kei te mate pukupuku tairoi medullary (MTC) me te pheochromocytoma me/ranei te hyperplasia, te adenoma rānei o ngā repe parathyroid.

• Ngā Whakamātautau:
• Ngā whakamātautau toto: Tirohia ngā taumata o ngā homoni pēnei i te calcitonin (mō te MTC), te homoni parathyroid (PTH), me ngā catecholamines (mō te pheochromocytoma).
• Ngā whakamātautau whakaahua: Ka whakamahia te 'scan CT' me te 'scan MRI' rānei.
• Whakamātautau ira: Ka tirohia mēnā he whakarerekētanga ira i roto i te ira RET.

He aha ngā maimoatanga mō te (MEN)?

Ko te maimoatanga o te MEN e whakawhirinaki ana ki ngā repe endocrine me ngā whekau e pāngia ana. I te nuinga o te wā ka uru atu he rōpū tākuta maha-mātauranga, tae atu ki ngā endocrinologists , ngā taote pokanga , me ngā tohunga mate pukupuku .

Tērā pea he maha ngā kōwhiringa maimoatanga:

• Rongoā: Whakahaeretia ngā tohumate me te whakaiti i ngā pānga o te taikaha o ngā homoni.
• Pokanga: Tangohia te puku, te repe katoa rānei e pāngia ana (hei tauira, te repe tairoiti).
• Whakaora homoni: Mena ka tangohia he repe endocrine mā te pokanga, ka tukuna ki waho ngā homoni e hangaia ana e ia.
• Maimoatanga matepukupuku: Mena kua horapa te matepukupuku ki ētahi atu wāhi (kua horapa ki roto i te tinana), me whakamahi ngā maimoatanga pēnei i te chemotherapy me te radiation therapy .

Nā te mea he motuhake ia tūroro (MEN), he rerekē te mahere maimoatanga e pai ana mō te katoa. Kaua e wehi ki te kōrero ki tō tākuta mō ngā kōwhiringa maimoatanga e pai ana mōu.

Ka taea te whakaora katoa i te mate (MEN)? Ka taea te ārai?

Engari, kāore anō kia kitea he rongoā mō te mate (MEN) i tēnei wā. Heoi, ka taea te whakahaere . Ka rongoatia e ngā tākuta ngā huringa o ia repe mā te pokanga, mā te rongoā rānei e tika ana i taua wā.

Kāore e taea te aukati i te whanaketanga o te (MEN), nā te mea i puta mai i tētahi whakarerekētanga ira. Ka taea te tuku iho i ēnei whakarerekētanga ira mai i ngā mātua, ka puta noa rānei i te wā o te kukune.

Heoi, ki te mea kua kitea he mate MEN i roto i tētahi mema o te whānau tata (matua, teina, tuākana rānei), he mea nui kia kōrero koe ki tō tākuta mō ngā whakamātautau ira mō te MEN. Mā te mahi pera ka āwhina i te kimi wawe i ngā pukupuku mēnā kei a koe te mate.

He aha ngā mea ka puta ina noho tahi koe me (MEN)? (Matapae)

Ko te matapae mō te MEN e whakawhirinaki ana ki ētahi āhuatanga:

• Te tere o te tautuhi i te (MEN).
• Ko ēhea ngā repe endocrine e pāngia ana?
• Ahakoa he mate pukupuku te puku, kāore rānei.
• Te momo maimoatanga i whakamahia.
• Ko te tikanga tēnei mēnā kua horapa te pukupuku ki ētahi atu wāhanga o te tinana (kua horapa ki roto i te tinana).

Mena kua tākutatia koe kei te mate MEN, ka taea e tō tākuta te hoatu ki a koe te whakaaro pai mō tō maimoatanga me te huarahi whakamua.

Āhea te wā e tika ai kia kite i te tākuta me ngā pātai nui hei pātai

Mena kua tāpaetia koe kei te mate MEN, me toro atu koe ki tō tākuta i ia wā, i ia wā, kia aroturukitia ai tō āhua, kia mōhio ai hoki kei te tika te haere o tō maimoatanga.

Waihoki, ki te mea he '(MEN)' tō tētahi o tō whānau, kōrero ki tō tākuta mō ngā whakamātautau ira, e ai ki te kōrero i mua ake nei.

Mena kei a koe te '(MEN)', he pai pea te pātai atu ki tō tākuta i ēnei pātai:

• He aha te momo (TĀNE) kei a au?
• He aha te pānga o (MEN) ki tōku tinana?
• He aha ngā tohu me tirotiro e au?
• He aha ngā kōwhiringa maimoatanga kei a au?
• He aha ngā painga me ngā ngoikoretanga o ngā momo tikanga maimoatanga rerekē?
• Kia pēhea te roa ka angitu ai te maimoatanga?
• Me whakamātauria te toenga o tōku whānau mō (MEN)?

Hei whakamutunga, ngā mea hei maumahara (Karere hei tango ki te kāinga)

He mate onge te maha o ngā neoplasia endocrine (MEN). Waihoki, nā te mea he maha ngā tohu ka puta mai i te MEN, ā, ehara i te mea he rite tonu te āhua o te katoa, he uaua pea te mōhio mēnā kei a koe tēnei mate.

Ki te puta mai ētahi tohu hou e āwangawanga ai koe, ki te kite rānei koe i ētahi huringa o tō tinana, ko te mea pai ko te toro atu ki te tākuta.

Ahakoa ka puta noa mai ētahi o ngā mate (MEN), ka taea hoki te horapa i roto i ngā whānau. Mena kei tētahi o ō whanaunga tata te mate (MEN), he mea nui kia whakamātauria ō ira kia kitea ai mēnā kei te mōrearea koe. Kōrero ki tō tākuta mō ō pātai katoa mō tō mōrearea ki te whakawhanake i te (MEN). Kei reira rātou hei āwhina i a koe. Kaua e mataku, kaua e mataku, kaua hoki e wehi ki te pātai.