Kei te pāngia tō hoa aroha, tō whaea, tō pāpā, tō kuia, tō koroua rānei, e te mate a Alzheimer? E mōhio ana tātou katoa ki te pouri me te kore āwhina e puta mai ana i te ngaromanga haere o te mahara me te wareware i ngā kanohi kua mōhiotia. Ko te mate a Alzheimer he āhuatanga ka arahi ki te ngaronga o te mahara, te kino o te roro, tae noa ki te mate. Ahakoa kāore he rongoā mō tēnei mate, kei reira ngā rongoā ka taea te whakaroa i tōna tere me te whakarato i te whakamarie ki te tūroro. I tēnei rā ka kōrero tātou mō tētahi momo rongoā motuhake. Koia ko ngā NMDA Receptor Antagonists . Ahakoa he ahua uaua te ingoa, kia mārama noa tātou.
He kōrero matū iti e puta ana i roto i te roro
He wāhi whakamiharo tō tātou roro. Kei roto ngā piriona pūtau io, arā, ngā 'neurons'. Ka tukatukahia e ēnei pūtau ngā kōrero, ka maumahara ki ngā kōrero, ā, ka kōrero ki ētahi atu wāhanga o te tinana me aha mā te tuku tohu hiko me ngā tohu matū ki a rātou anō.
Ka karangatia e tātou ngā karere e kawe ana i ēnei tohu matū he 'neurotransmitters'. Ko tētahi o aua karere ko te 'glutamate' .
Whakaarohia noa te glutamate hei poti e kawe ana i te karere mai i tētahi pūtau io ki tētahi atu. Me whai tauranga motuhake tēnei poti hei haere ki tētahi atu pūtau, hei tauranga. Ko taua tauranga te mea e kiia nei e tātou ko te kaiwhakawhiwhi NMDA ('N-methyl-D-aspartate' receptor). Ina piri te poti e kīia nei ko te glutamate ki tēnei tauranga NMDA, ka tukuna e ia tētahi atu matū nui e kīia nei ko te 'calcium' ki roto i te pūtau. Ko tēnei konupūmā te mea e whakaoti ana i taua karere, ā, e āwhina ana i a tātou ki te ako me te maumahara i tētahi mea. He tukanga noa tēnei i roto i te roro hauora.
Na, he aha te mea ka tupu i roto i te mate a Alzheimer?
I roto i ngā pūtau roro o te tangata e pangia ana e te mate a Alzheimer , ka tīmata te whakaputa i te nui rawa o te glutamate . Ko te mea ka tupu, ka nui rawa te konupūmā e rere ana ki roto i aua pūtau io. Whakaarohia te mea ka tupu mēnā ka whakakīia he tāke wai ki te nui rawa o te wai? Ka puea ake. Waihoki, ina nui rawa te konupūmā e kohia ana ki roto i ngā pūtau, ka tīmata te pakaru o aua pūtau. Ko tēnei kino te mea e whakanui haere ana i ngā tohu o te mate a Alzheimer.
Anei te āwhina a ngā NMDA Receptor Antagonists
Ko te akomanga rongoā e kiia nei ko ngā kaiwhakahē i ngā kaiwhakawhiwhi NMDA ka mahi mā te whakaiti i te maha o ngā wāhi ka taea e aua poti glutamate tāpiri te taunga ki te kaiwhakawhiwhi NMDA. Arā, ka ārai te rongoā i ētahi o ngā tauranga. Engari ko te mea nui ko te tuku a ēnei rongoā i ngā karere nui kia rere . Arā, ka whakahaere noa i te rerenga kino o te konupūmā me te kore e whakararuraru nui i te mahi noa o te roro. Ka whakaitihia e tēnei te kino ki ngā pūtau io, ā, ka whakahaere i te tere o te mate.
I te rongoā i te mate a Alzheimer, he maha ngā wā ka whakamahia e ngā tākuta ngā rongoā e aro ana ki tētahi atu neurotransmitter e kiia nei ko te acetylcholine. Engari he momo rongoā nui ngā kaiwhakahē i ngā kaiwhiwhi NMDA e mahi ana i tētahi atu huarahi.
Ko te rongoā matua mō te kaiwhakawhiwhi NMDA e whakaaetia ana mō te rongoā i te mate a Alzheimer ko te memantine (ingoa waitohu `Namenda XR`). He maha ngā wā ka tohua e ngā tākuta mō ngā wāhanga ngawari ki te kino o te mate. I ētahi wā, ka hoatu te memantine me ngā `aukati cholinesterase` kua whakahuatia i mua ake nei, e whakanui ana i ngā taumata acetylcholine. Ka taea e tēnei te arahi ki ngā hua pai ake mō ētahi tūroro.
Engari kia maumahara, kāore ēnei rongoā e mahi ōrite mō te katoa.
Kia tūpato hoki tātou ki ngā pānga taha.
Pērā i ngā rongoā katoa, he iti noa ngā pānga taha o tēnei.
- Ko te whanoke te tohu tino kitea.
- Hei tāpiritanga, ka pā mai pea ngā āhuatanga pēnei i te mamae o te upoko me te mate pāwera .
- He tino onge te tūponotanga o te pōhēhētanga i roto i te roro .
Ki te pāngia koe, tō tūroro rānei e tētahi o ēnei āhuatanga, me whakamōhio tonu koe ki tō tākuta . Ehara i te mea pai kia mutu te tango rongoā, kia whakarerekē rānei i te horopeta māu ake.
Ētahi atu rongoā o tēnei whānau me ō rātou whakamahinga
Kei roto i tēnei whānau ētahi atu rongoā e kiia nei ko ngā NMDA receptor antagonists. Ko ētahi o ēnei e kitea ana i roto i te oranga o ia rā. Ko ētahi he ahua morearea ake, ā, ka whakamahia kinotia hei rongoā. Kei te rangahau hoki ngā kaipūtaiao i ngā painga o tēnei momo rongoā mō ētahi atu mate pūnaha io, pērā i te mate a Parkinson me te ALS (amyotrophic lateral sclerosis).
Kia ako tātou i ētahi atu kōrero mōna i te ripanga i raro nei.
| Ingoa Rongoā | Te whakamahinga matua | Ngā mea nui me ngā mōrearea |
|---|---|---|
| Teketorometoropana | Kei roto i ngā tirikara maremare. | He haumaru te nuinga, engari ka morearea pea mēnā ka tangohia i ngā horopeta nui. |
| Ketamine | He rongoā whakamoe (mō te tangata me te kararehe). | Whakamahia hei whakamamae i te mamae i te wā e pokanga ana. Engari ka whakamahia kinotia hei "rongoā karapu". Ka puta pea he moemoeā me ngā kare ā-roto o te wehenga mai i te tinana. Kei te haere tonu ngā rangahau mō tōna whakamahinga mō ngā āhuatanga pēnei i te pouri. |
| Phencyclidine (PCP) | I whakamahia kinotia hei tarukino. | I whakawhanakehia i te tuatahi hei rongoā whakangote, engari i whakamutua te whakamahinga nā te mea he nui ngā pānga taha (whakaaro pohehe, pōhēhē). He raau taero kino e mōhiotia ana ko "Angel Dust". E hono ana ki ngā whanonga tutu. |
Karere Tangohia ki te Kāinga
- Ahakoa kāore e taea te whakaora katoa i te mate a Alzheimer, ka taea e ngā rongoā aukati i te kaiwhakawhiwhi NMDA pērā i te memantine te āwhina i te whakahaere i ngā wāhanga ngawari ki te kino o te mate mā te whakaiti i te kino ki ngā pūtau roro.
- Ko te mahi a ēnei rongoā mā te tiaki i ngā pūtau io mai i te nui rawa o te glutamate i roto i te roro.
- Pērā i ngā rongoā katoa, ka puta pea ngā pānga taha pēnei i te whanoke. Kōrerohia tēnei ki tō tākuta i ngā wā katoa. Kaua rawa e whakarerekē i te horopeta, kaua hoki e mutu te tango i te rongoā māu ake.
- Ko tēnei momo tarukino, pērā i te Ketamine me te PCP, ka whakamahia kinotia hei narcotics, ā, he tino morearea. He rerekētanga nui i waenga i ēnei me ngā rongoā kua tohua mō te mate a Alzheimer.
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