He aha te Somatostatin? Kia ako tātou mō tēnei homoni whakamiharo i roto i ō tātou tinana!

I tēnei rā ka kōrero tātou mō tētahi kaikawe matū tino rerekē, tino hira hoki i roto i ō tātou tinana. Ko tōna ingoa ko te somatostatin. Kāore pea koe i rongo i tēnei ingoa i mua. Engari i mōhio koe, he maha ngā mea e āwhina ana ki te whakahaere i roto i ō tātou tinana, pērā i tētahi kaiwhakahaere ngaro. Me titiro tātou ki te aha te somatostatin, me pēhea tana mahi, me tōna hiranga ki tō tātou hauora.

He aha rawa te Somatostatin?

He kupu ngāwari, he homoni te somatostatin e hangaia ana i roto i tō tātou tinana. Tērā pea kei te whakaaro koe he aha ngā 'homoni'. He tino māmā noa iho. He matū ngā homoni e kawe ana i ngā karere i waenga i ngā wāhanga rerekē o tō tātou tinana. He rite rātou ki ngā 'kaituku mēra' i roto i tō tātou tinana. E kī ana ēnei karere ki ō tātou whekau, kiri, me ngā uaua kia mahi i tētahi mea, kia mutu rānei te mahi i tētahi mea.

Nō reira, ko tēnei homoni motuhake e kiia nei ko te somatostatin te mea nui hei aukati i te hanga o ētahi atu homoni, hei whakahaere i ētahi mahi i roto i tā tātou pūnaha nakunaku (ara gastrointestinal (GI), ā, hei whakahaere hoki i te tere o te wehenga o ngā pūtau (ina koa ko ngā pūtau matepukupuku). He rite ki te pirihimana waka, ina nui rawa tetahi mea, ka tukuna e ia te tohu, "Āe, āe, kati inaianei."

Kei hea tēnei somatostatin e hangaia ai?

Nā, kia tirohia tātou kei hea tēnei homoni somatostatin whakamiharo e hangaia ana i roto i tō tātou tinana. He maha ngā wāhi e hangaia ai:

• Te ara puku (GI): Koinei te pūnaha okana roa, rite ki te ngongo, e rere ana mai i te waha ki te nono, e āwhina ana i a tātou ki te nakunaku i te kai e kainga ana e tātou. Koinei te wāhi e noho ai ō whekau.
• Te repe taiaki: He repe tēnei kei roto i tō tātou puku. He okana te repe taiaki e whakaputa ana i ētahi matū. Ka whakaputa te repe taiaki i ngā whākōkī hei āwhina i te nakunaku kai, me ngā homoni nui pērā i te insulin me te glucagon .
• Hypothalamus: Kei roto i tō tātou roro tēnei. He rite ki te 'pokapū whakahaere' o tō tātou tinana. Ka āwhina ki te pupuri i te homeostasis (arā, te pupuri i tētahi taiao ā-roto pumau). Ka tukuna hoki e ia he whakahau ki te repe pituitary, kei raro i te hypothalamus, kia tukuna ētahi homoni.
• Pūnaha Io Matua (CNS): Kei roto i tēnei ko tō tātou roro me te taurakira. Mā roto i tēnei pūnaha io ka tukuna ngā karere mai i te roro ki te toenga o te tinana.

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Ngā ingoa kē atu mō te somatostatin

E mōhiotia ana hoki a Somatostatin e ētahi atu ingoa. Mēnā ka whakahuatia tētahi o ēnei ingoa e tō tākuta, ko te mea pea e kōrero ana rātou mō taua mea anō:

• SS, SST, SOM rānei
• Hormone aukati tipu (GHIH)
• Te tauwehe aukati tukunga somatotropin (SRIF)
• Te homoni aukati tukunga somatotropin (SRIH)

Ka whakamahia anō hoki te somatostatin hei rongoā?

Ae, i ētahi wā, ka whakamahia e ngā tākuta te somatostatin waihanga hei rongoā hei rongoā i ētahi mate. Hei tauira:

• Ētahi mate puku
• He āhuatanga onge te acromegaly e nui rawa ai te homoni tipu e whakaputaina ana e te tinana.
• Ko ētahi momo mate pukupuku e kiia nei ko ngā pukupuku neuroendocrine (NET) .
• Ētahi atu mate o te pūnaha endocrine (arā, te pūnaha repe e whakaputa ana i ngā homoni).

He aha ngā mahi matua a te homoni somatostatin?

Āe, kia titiro tātou he aha te mahi matua a tēnei homoni somatostatin.

Ki te kī ngāwari, ko tāna mahi matua he aukati i te hanga o ētahi atu homoni e hangaia ana e tō tātou pūnaha endocrine me te whakahaere i te tukunga o ētahi mea huna mai i te pūnaha exocrine.

Ko te 'pūnaha endocrine' e pā ana ki te pūnaha e whakaputa ana i ngā homoni mai i ngā repe i roto i te tinana ki roto i te toto. Hei tauira, ko te repe thyroid, te repe pituitary, me ngā repe adrenal . Ko te 'pūnaha exocrine' e pā ana ki te pūnaha e tuku ana i ngā hua i hangaia e ngā repe mā roto i tētahi awaawa. Hei tauira, ko ngā repe huware me ngā repe werawera .

Nō reira, pērā i te whakaweto i te puna wai, ka aukati te somatostatin i te rere o ētahi homoni me ngā mea huna kāore e hiahiatia ana e tō tātou tinana mō te wā poto. Whakaarohia, ki te waiho noa i te puna wai kia tuwhera, ka maumauria te wai, tika? Waihoki, ki te nui ake ngā homoni e hangaia ana e te tinana i tā te tinana e hiahia ana, ka puta pea ngā raruraru. Mā te somatostatin tēnā e whakahaere.

Ko tētahi atu mea, ka āwhina te somatostatin i te aukati i te tere wehewehe o ngā pūtau, pērā i ngā pūtau matepukupuku.

He matū kawe ira anō hoki tōna mahi i roto i te pūnaha io matua (CNS). Ko te kawe ira he karere matū e tukuna ana e tētahi pūtau io (neuron) hei awe i tētahi atu pūtau.

Te pānga o te somatostatin ki ngā wāhanga rerekē o tō tātou tinana

Nā, kia tirohia te pānga o te somatostatin ki ia wāhanga o tō tātou tinana:

• I roto i te hypothalamus: Ka aukati te Somatostatin i te tukunga o ngā homoni e hangaia ana e te repe pituitary, pērā i te homoni tipu , te homoni whakaoho tairoi (TSH) , me te prolactin .
• I roto i te repeure: I konei, te insulin ,Ka aukati i te tukunga o ngā homoni repeure pērā i te glucagon me te gastrin , ā, ka whakahaere anō hoki i te tukunga o ngā whākōkī repeure e āwhina ana i te nakunaku kai.
• I roto i te pūnaha nakunaku (ara GI): Ka whakaiti i ngā hinu whakaputanga o te puku, e whakaohokia ana i te wā e kai ana tātou. Ka whakawhāiti hoki i te tukunga o ngā homoni nakunaku pērā i te secretin me te gastrin .
• I roto i te pūnaha io matua (CNS): I konei, ka whai wāhi ki te whakarerekē i te huarahi e tukuna ai ngā karere mā roto i ngā io (neurotransmission) me te huarahi e hangaia ai ngā maharatanga.

He aha ngā take e tukuna ai te somatostatin?

Āe, kei te whakaaro pea koe, 'Me pēhea te tukunga o tēnei somatostatin? He aha te take?' Ki te pono, kāore anō kia tino mārama ngā kaipūtaiao ki te whakahaere a ō tātou tinana i te tukunga o tēnei somatostatin, me ēhea kiko e whakaoho ana i tōna tukunga. Tae noa ki tēnei wā, kua kitea he maha ngā momo pūtau me ngā pūmua rerekē e whai wāhi ana.

Kua whakaatuhia e tētahi rangahau ko te hukahuka , te pūtake pūngao matua o tō tātou tinana, ehara i te mea ko ia anake te kaiwhakahaere o te tukunga o te somatostatin, engari ka whai wāhi atu hoki ki tōna whakaputanga. I roto i taua rangahau, i kitea e ngā kaipūtaiao ina iti te taumata hukahuka i roto i te toto, ka whakaoho te insulin i te tukunga o te somatostatin (arā, ka mutu te whakaputanga o te insulin), ā, ina teitei te taumata hukahuka i roto i te toto , ka whakaoho te glucagon i te tukunga o te somatostatin (arā, ka mutu te whakaputanga o te glucagon).

Arā, nā te mea ka whakaitihia e te insulin te taumata huka toto, ina iti te huka toto, ka tukuna te somatostatin hei ārai i tōna hekenga, hei aukati i te tukunga o te insulin. He mea whakamiharo te whakahaeretanga o ngā mea i roto i ō tātou tinana, kāore?

Ngā raruraru me ngā āhuatanga e pā ana ki te Somatostatin

I te nuinga o te wā, he onge ngā raruraru nui o te somatostatin. Engari ko te mate matua e puta mai ana ko te momo mate pukupuku tino onge e kiia nei ko te somatostatinoma . He pukupuku tēnei e tupu ana i roto i te pūnaha endocrine. Ka tupu tēnei pukupuku i roto i te repe taiaki, i te pūnaha nakunaku rānei (ara GI). Mā tēnei ka nui rawa te hanga o te somatostatin.

Ka puta noa mai tēnei āhuatanga, e kiia nei ko te somatostatinoma, i ētahi wā, ka hono atu rānei ki ētahi mate ira . Ko ētahi o ēnei āhuatanga ko:

• Ngā Pūngāwerewere Endocrine Maha (momo MEN 1):He tino onge anō hoki tēnei āhuatanga ira, e puta ai he maha ngā pukupuku i ngā wāhanga rerekē o te pūnaha endocrine.
• Neurofibromatosis momo 1 (NF1): He mate tuku iho anō hoki tēnei. Ka puta ngā ira café-au-lait me ngā pukupuku pai i runga i te kiri.
• Te mate a Von Hippel-Lindau: He mate tuku iho onge anō hoki tēnei. Ka taea e ia te whakaputa i ngā pukupuku pai, kino rānei i roto i te roro, te taurakira, ngā kanohi, ngā whatukuhu, te repe taiaki, me ngā repe adrenal.

Ina nui rawa te whakaputanga o te somatostatin, ka tino heke te whakaputanga o ētahi atu homoni endocrine. Ka rite pea ngā tohu o tēnei ki ngā tohu o ētahi atu mate. Nō reira, he uaua pea i ētahi wā te tautuhi tika i tētahi āhuatanga e kiia nei ko te somatostatinoma.

Ko te mea nui, he tino onge ēnei raruraru e pā ana ki te somatostatin, arā, kāore he mea e manukanuka ai te nuinga o te tangata.

Waihoki, he iti noa iho ngā pūrongo mō ngā taumata somatostatin i raro iho i te tikanga i roto i te tinana o te tangata.

He aha ngā whakamātautau e tirotiro ana i ngā taumata o te somatostatin?

Nā te mea he onge rawa ngā raruraru e pā ana ki te somatostatin, kāore ngā tākuta e whakamātautau i ngā taumata somatostatin o te katoa. Heoi, ki te whakapaehia he pukupuku onge e whakaputa nui rawa ana i te somatostatin e kiia nei ko te somatostatinoma, e ai ki te kōrero i mua ake nei, ka whakamahia he whakamātautau toto e kiia nei ko te somatostatin-like-immunoreactivity (SLI) hei tautuhi.

Āhea ahau me toro atu ki te tākuta mō aku taumata somatostatin?

Kāore koe e manukanuka ki ō taumata somatostatin, nā te mea he iti noa ngā raruraru e pā ana ki tēnei.

Heoi, mēnā kua tāpaetia tētahi mema o te whānau tata (matua, teina rānei) ki tētahi mate pēnei i te multiple endocrine neoplasia momo 1 (MEN momo 1), te neurofibromatosis momo 1 (NF1), te mate Von Hippel-Lindau rānei, he mea nui kia kōrero koe ki tō tākuta. Nā te mea he mate tuku iho ēnei, tera pea ka tūpono koe ki te whakawhanake i te somatostatinoma. Kātahi ka taea e tō tākuta te whakahaere whakamātautau hei tirotiro mēnā kei a koe te mate.

Ngā mea tino nui hei maumahara (Karere hei kawe ki te kāinga)

Āe, koinei ngā mea tino nui hei maumahara māu mai i ngā mea i kōrerohia e tātou i tēnei rā:

• He homoni 'matua' te Somatostatin e whai wāhi nui ana ki roto i te tinana, e whakahaere ana i ētahi atu homoni.
• Ko te nuinga o te wā, ka whakahaere i ngā mea pēnei i te whakaputanga o ētahi atu homoni, te mahi a te pūnaha nakunaku, me te tere o te wehenga o ngā pūtau.
• He tino onge te nuinga o ngā raruraru e pā ana ki te somatostatin.Ko te raruraru matua he pukupuku onge e kiia nei ko te somatostatinoma.
• Mena kei roto i tō whānau ngā āhuatanga ira pēnei i te MEN momo 1, te NF1, te mate Von Hippel-Lindau rānei , kōrero ki tō tākuta.
• Kaua e wehi noa iho i tēnei. He mea nui kia mōhio tātou ki ēnei pūnaha whakamiharo o roto i ō tātou tinana.

Nō reira, he mea huna te somatostatin, engari he mea tino nui, i roto i ō tātou tinana. Mēnā kei te mahi tika ia i tana mahi, kāore he mea e wehi ai tātou!