ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡꯒꯤ ꯁꯔꯨꯛ ꯑꯃꯈꯛꯇꯅꯥ, ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯈꯨꯠꯁꯥ ꯑꯃꯥ, ꯈꯣꯡ ꯑꯃꯥ ꯅꯠꯠꯔꯒꯥ ꯈꯣꯡꯒꯤ ꯑꯀꯛꯅꯕꯥ ꯃꯐꯝ ꯑꯃꯥ, ꯑꯇꯣꯞꯄꯁꯤꯡꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯌꯥꯡꯅꯥ ꯆꯥꯎꯈꯠꯂꯀꯏ ꯍꯥꯌꯅꯥ ꯈꯅꯕꯤꯌꯨ꯫ ꯃꯁꯤ ꯃꯤꯑꯣꯏ ꯈꯔꯅꯥ ꯄꯣꯀꯄꯥ ꯌꯥꯝꯅꯥ ꯇꯣꯏꯅꯥ ꯊꯣꯀꯄꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ꯫ ꯃꯦꯗꯤꯀꯦꯂꯒꯤ ꯋꯥꯍꯟꯊꯣꯛꯀꯤ ꯃꯇꯨꯡ ꯏꯟꯅꯥ, ꯑꯩꯈꯣꯌꯅꯥ ꯀꯟꯗꯤꯁꯅꯁꯤꯡꯒꯤ ꯀꯥꯡꯂꯨꯞ ꯑꯁꯤꯕꯨ ꯄꯤ.ꯑꯥꯏ.ꯀꯦ.꯳ꯁꯤ.ꯑꯦ.ꯒꯥ ꯃꯔꯤ ꯂꯩꯅꯕꯥ ꯑꯣꯚꯔꯒ꯭ꯔꯣꯊ ꯁ꯭ꯄꯦꯛꯠꯔꯦꯝ, ꯅꯠꯔꯒꯥ ꯊꯣꯏꯗꯣꯛ ꯍꯦꯟꯗꯣꯛꯅꯥ ꯄꯤ.ꯑꯥꯔ.ꯑꯣ.ꯑꯦꯁ . ꯃꯁꯤ ꯇꯁꯦꯡꯅꯥ ꯎꯔꯤꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯗꯨꯗꯥ, ꯃꯁꯤꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯃꯁꯤ ꯊꯦꯡꯅꯔꯤꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯗꯨꯗꯁꯨ ꯈꯨꯗꯣꯡꯆꯥꯗꯕꯥ ꯀꯌꯥ ꯊꯣꯀꯍꯜꯂꯤꯕꯥ ꯋꯥꯐꯝ ꯑꯃꯅꯤ꯫ ꯉꯁꯤ, ꯑꯥꯔꯇꯤꯀꯜ ꯑꯁꯤꯗꯥ, ꯑꯩꯈꯣꯌꯅꯥ ꯃꯁꯤꯒꯤ ꯄ꯭ꯔꯣꯁ ꯑꯁꯤ ꯀꯔꯤꯅꯣ ꯑꯃꯁꯨꯡ ꯀꯟꯗꯤꯁꯟ ꯑꯁꯤꯒꯤꯗꯃꯛꯇꯥ ꯑꯈꯟꯅꯅꯥ ꯑꯌꯥꯕꯥ ꯄꯤꯈꯤꯕꯥ ꯑꯍꯥꯅꯕꯥ ꯗ꯭ꯔꯒ ꯑꯣꯏꯔꯤꯕꯥ ꯚꯤꯖꯣꯏꯁꯀꯤ ꯃꯇꯥꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯒꯅꯤ꯫
ꯄ꯭ꯔꯣꯁ ꯍꯥꯌꯕꯁꯤ ꯇꯁꯦꯡꯅꯥ ꯀꯔꯤꯅꯣ?
ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯄ꯭ꯔꯣꯁ ꯑꯁꯤ ꯖꯦꯅꯦꯇꯤꯛ ꯐꯦꯛꯇꯔꯁꯤꯡꯅꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ꯫ ꯑꯩꯈꯣꯌ ꯄꯨꯝꯅꯃꯛꯀꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯆꯥꯎꯈꯠꯄꯥ, ꯌꯦꯟꯊꯣꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯁꯤꯕꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯥ ꯖꯤꯅꯁꯤꯡ ꯂꯩ꯫ `PIK3CA` ꯑꯁꯤ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯖꯤꯟ ꯑꯃꯅꯤ꯫ ꯖꯤꯟ ꯑꯁꯤꯕꯨ ꯑꯩꯈꯣꯌꯒꯤ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯆꯥꯎꯈꯠꯄꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯥ `ꯁ꯭ꯕꯤꯠ` ꯑꯃꯥ ꯑꯣꯏꯅꯥ ꯈꯅꯕꯤꯌꯨ꯫
ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, PROS ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ, `PIK3CA` ꯖꯤꯅꯗꯥ ꯑꯁꯣꯏꯕꯥ ꯑꯃꯥ, ꯅꯠꯠꯔꯒꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯃꯥ ꯂꯩ꯫ ꯃꯁꯤꯅꯥ `ꯁ꯭ꯕꯤꯠ` ꯑꯁꯤ `ꯑꯣꯟ` ꯄꯣꯖꯤꯁꯟꯗꯥ ꯊꯃꯖꯤꯜꯂꯤ꯫ ꯑꯗꯨꯗꯒꯤ ꯋꯥꯍꯪ ꯍꯪꯂꯤꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯗꯨꯅꯥ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯑꯃꯁꯨꯡ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯊꯕꯛ ꯇꯧꯕꯥ ꯍꯧꯏ꯫ ꯃꯁꯤꯒꯤ ꯃꯍꯩ ꯑꯣꯏꯅꯥ ꯍꯀꯆꯥꯡꯒꯤ ꯁꯔꯨꯛ ꯈꯔꯗꯤ ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯈꯣꯡ, ꯕ꯭ꯂꯗ ꯚꯦꯁꯦꯂꯁꯤꯡ , ꯁꯔꯨ , ꯑꯃꯁꯨꯡ ꯕ꯭ꯔꯦꯟ ꯑꯁꯤ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯗꯅꯥ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ ꯍꯧꯏ꯫
ꯃꯔꯨꯑꯣꯏꯕꯥ ꯋꯥꯐꯃꯗꯤ ꯄ꯭ꯔꯣꯁ ꯑꯁꯤꯅꯥ ꯍꯀꯆꯥꯡꯒꯤ ꯁꯔꯨꯛ ꯈꯨꯗꯤꯡꯃꯛꯇꯥ ꯁꯣꯀꯍꯟꯗꯦ꯫ ꯃꯁꯤ ꯍꯀꯆꯥꯡꯒꯤ ꯁꯔꯨꯛ ꯑꯃꯗꯒꯤ ꯑꯇꯣꯞꯄꯥ ꯁꯔꯨꯛ ꯑꯃꯗꯥ, ꯑꯃꯁꯨꯡ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯈꯦꯠꯅꯕꯥ ꯌꯥꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤꯁꯨ ꯌꯥꯝꯅꯥ ꯇꯣꯞ ꯇꯣꯞꯄꯥ ꯑꯣꯏ꯫
ꯍꯧꯖꯤꯛ ꯐꯥꯑꯣꯕꯗꯥ ꯄꯤ.ꯑꯥꯔ.ꯑꯣ.ꯑꯦꯁ.ꯀꯤ ꯃꯄꯨꯡ ꯐꯥꯕꯥ ꯂꯥꯌꯦꯡ ꯑꯃꯠꯇꯥ ꯂꯩꯔꯃꯗꯦ꯫ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯃꯦꯅꯦꯖ ꯇꯧꯕꯗꯥ ꯃꯤꯠꯌꯦꯡ ꯊꯃꯈꯤ꯫ ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯑꯅꯥꯕꯥ, ꯁꯣꯛ-ꯄꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯊꯤꯡꯅꯕꯥ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ, ꯑꯃꯁꯨꯡ ꯑꯁꯣꯛ-ꯑꯄꯟ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯕꯥ ꯒ꯭ꯔꯣꯊꯁꯤꯡ ꯂꯧꯊꯣꯛꯅꯕꯥ ꯁꯔꯖꯔꯤ ꯇꯧꯕꯥ꯫ ꯑꯗꯨꯕꯨ ꯁꯔꯖꯔꯤꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯑꯗꯨꯒꯨꯝꯕꯥ ꯒ꯭ꯔꯣꯊꯁꯤꯡ ꯑꯗꯨ ꯑꯃꯨꯛ ꯍꯟꯅꯥ ꯍꯦꯅꯒꯠꯂꯀꯄꯒꯤ ꯔꯤꯁ꯭ꯛ ꯂꯩꯈꯤ꯫
ꯗ꯭ꯔꯒ ꯚꯤꯖꯣꯏꯁ (alpelisib) ꯑꯁꯤ ꯀꯔꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯕꯒꯦ?
ꯃꯁꯤꯗꯥ ꯗ꯭ꯔꯒ ꯚꯤꯖꯣꯏꯁ ꯑꯁꯤ ꯂꯥꯀꯏ, ꯚꯤꯖꯣꯏꯁ ꯑꯁꯤ ꯖꯦꯅꯦꯇꯤꯛ ꯃ꯭ꯌꯨꯇꯦꯁꯅꯅꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯍꯥꯏꯄꯔꯑꯦꯛꯇꯤꯚꯤꯇꯤ ꯑꯣꯏꯔꯤꯕꯥ ꯄꯤ.ꯑꯥꯔ.ꯑꯣ.ꯑꯦꯁ.ꯀꯤ ꯃꯈꯥ ꯄꯣꯜꯂꯤꯕꯥ ꯃꯔꯝ ꯑꯁꯤꯕꯨ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯑꯍꯥꯅꯕꯥ ꯗ꯭ꯔꯒꯅꯤ꯫
ꯃꯁꯤꯗꯥ ꯑꯦꯛꯇꯤꯕ ꯏꯅꯒ꯭ꯔꯦꯗꯤꯌꯦꯟꯇ ꯑꯁꯤ ꯑꯂꯄꯦꯂꯤꯁꯤꯕꯅꯤ . ꯗ꯭ꯔꯒ ꯑꯁꯤ ꯇꯁꯦꯡꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯈꯔꯗꯥ ꯁꯤꯖꯤꯟꯅꯩ . ꯃꯗꯨꯒꯤ ꯃꯔꯃꯗꯤ, ꯃꯁꯤꯅꯤ꯫ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯄꯤ.ꯑꯥꯏ.ꯀꯦ.꯳ ꯄꯥꯊꯀꯤ ꯑꯣꯚꯔꯑꯦꯛꯇꯤꯚꯤꯇꯤꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯍꯦꯅꯒꯠꯂꯀꯏ, ꯃꯁꯤ ꯄꯤ.ꯑꯣ.ꯑꯦꯁ.ꯇꯥ ꯑꯣꯏꯔꯀꯄꯒꯨꯝꯅꯥ ꯍꯦꯅꯒꯠꯂꯀꯏ꯫
ꯑꯗꯨꯅꯥ ꯚꯤꯖꯣꯏꯁꯅꯥ ꯇꯧꯔꯤꯕꯥ ꯑꯁꯤ ꯄꯤ.ꯑꯥꯏ.ꯀꯦ.꯳ꯒꯤ ꯂꯝꯕꯤ ꯑꯁꯤ ꯕ꯭ꯂꯣꯛ ꯇꯧꯕꯅꯤ, ꯃꯁꯤꯅꯥ ‘ꯑꯣꯟ’ ꯄꯣꯖꯤꯁꯟꯗꯥ ꯂꯦꯞꯂꯤꯕꯥ ‘ꯁ꯭ꯕꯤꯠ’ ꯑꯃꯒꯨꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯏ꯫ ꯃꯁꯤꯅꯥ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯑꯦꯕꯅꯣꯔꯃꯦꯜ ꯑꯣꯏꯕꯥ ꯒ꯭ꯔꯣꯊ ꯊꯤꯡꯏ, ꯍꯥꯟꯅꯅꯥ ꯍꯦꯅꯒꯠꯂꯛꯂꯤꯕꯥ ꯇꯤꯁꯨꯁꯤꯡꯒꯤ ꯁꯥꯏꯖ ꯍꯟꯊꯍꯜꯂꯤ ꯑꯃꯁꯨꯡ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯏ꯫
ꯍꯤꯗꯥꯛ ꯑꯁꯤꯒꯤ ꯀꯥꯟꯅꯕꯁꯤꯡ ꯀꯔꯤꯅꯣ?
ꯗ꯭ꯔꯒ ꯑꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯄꯥꯡꯊꯣꯀꯈꯤꯕꯥ ꯁ꯭ꯇꯗꯤꯁꯤꯡ (ꯏ.ꯄꯤ.ꯑꯥꯏ.ꯀꯦ.-ꯄꯤ.꯱ ꯑꯃꯁꯨꯡ ꯏ.ꯄꯤ.ꯑꯥꯏ.ꯀꯦ.-ꯄꯤ.꯳)ꯅꯥ ꯑꯅꯥꯕꯁꯤꯡꯗꯥ ꯃꯁꯛ ꯊꯣꯀꯄꯥ ꯀꯥꯟꯅꯕꯥ ꯎꯠꯂꯦ꯫
| ꯀꯥꯟꯅꯕ | ꯏꯆꯝ ꯆꯝꯕꯥ ꯃꯌꯦꯛ ꯁꯦꯡꯅꯥ ꯇꯥꯀꯄꯥ꯫ |
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| ꯑꯄꯤꯀꯄꯥ ꯒ꯭ꯔꯣꯊꯁꯤꯡ (ꯂꯦꯁꯟ) . | ꯗ꯭ꯔꯒ ꯑꯁꯤ ꯂꯧꯈꯤꯕꯥ ꯃꯤꯑꯣꯏ ꯀꯌꯥ ꯑꯃꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯑꯁꯣꯛ-ꯑꯄꯟ ꯊꯣꯀꯍꯅꯕꯥ ꯐꯦꯇꯤ ꯇꯤꯎꯃꯔ (ꯂꯥꯏꯄꯣꯃꯥꯁ) ꯑꯃꯁꯨꯡ ꯚꯦꯁꯀꯨꯂꯥꯔ ꯃꯦꯂꯐꯣꯔꯃꯦꯁꯅꯁꯤꯡꯒꯤ ꯚꯣꯜꯌꯨꯝ ꯑꯁꯤ ꯲꯰% ꯅꯠꯠꯔꯒꯥ ꯃꯁꯤꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯍꯟꯊꯔꯀꯄꯥ ꯎꯕꯥ ꯐꯪꯂꯦ꯫ |
| ꯁꯔꯖꯔꯤꯒꯤ ꯃꯊꯧ ꯇꯥꯕꯥ ꯍꯟꯊꯔꯀꯄꯥ꯫ | ꯚꯤꯖꯣꯏꯁ ꯂꯧꯔꯤꯕꯥ ꯑꯉꯥꯡꯁꯤꯡꯒꯤ ꯆꯥꯎꯔꯥꯛꯅꯥ 70% ꯑꯃꯁꯨꯡ ꯑꯍꯂꯁꯤꯡꯒꯤ 90%ꯗꯤ ꯁꯔꯖꯔꯤꯒꯤ ꯃꯊꯧ ꯇꯥꯗꯦ꯫ |
| ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯥꯀꯁꯤꯅꯕꯥ꯫ | ꯄꯦꯁꯦꯟꯇꯁꯤꯡꯅꯥ ꯑꯅꯥꯕꯥ, ꯁꯣꯛ-ꯄꯅꯕꯥ, ꯑꯃꯁꯨꯡ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯍꯟꯊꯔꯀꯄꯒꯤ ꯔꯤꯄꯣꯔꯠ ꯇꯧꯔꯀꯈꯤ꯫ |
| ꯅꯨꯡꯇꯤꯒꯤ ꯊꯕꯀꯁꯤꯡ ꯍꯦꯟꯅꯥ ꯂꯥꯌꯊꯣꯀꯍꯅꯕꯥ꯫ | ꯁ꯭ꯇꯗꯤꯁꯤꯡ ꯑꯁꯤꯗꯥ ꯁꯔꯨꯛ ꯌꯥꯈꯤꯕꯥ ꯄꯦꯁꯦꯟꯇꯁꯤꯡꯒꯤ ꯆꯥꯎꯔꯥꯛꯅꯥ ꯸꯱%ꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯅꯨꯡꯇꯤꯒꯤ ꯊꯕꯛ ꯊꯧꯔꯃꯁꯤꯡ ꯄꯥꯡꯊꯣꯀꯄꯥ ꯉꯝꯕꯥ ꯑꯃꯁꯨꯡ ꯄꯨꯟꯁꯤꯒꯤ ꯃꯒꯨꯟ ꯑꯁꯤ ꯗ꯭ꯔꯒ ꯑꯁꯤꯒꯤ ꯃꯃꯥꯡꯗꯥ ꯂꯩꯔꯝꯕꯥ ꯑꯗꯨꯒꯥ ꯆꯥꯡꯗꯝꯅꯕꯗꯥ ꯐꯒꯠꯂꯀꯈꯤ ꯍꯥꯌꯅꯥ ꯔꯤꯄꯣꯔꯠ ꯇꯧꯈꯤ꯫ |
ꯃꯔꯨꯑꯣꯏꯕꯥ: ꯃꯁꯤꯒꯤ ꯐꯂꯁꯤꯡ ꯑꯁꯤ ꯃꯤꯄꯨꯝ ꯈꯨꯗꯤꯡꯃꯛꯀꯤ ꯑꯣꯏꯅꯥ ꯃꯥꯟꯅꯗꯕꯥ ꯌꯥꯏ꯫ ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯆꯨꯝꯃꯤ ꯑꯃꯁꯨꯡ ꯃꯁꯤꯒꯤ ꯀꯥꯟꯅꯕꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯈꯨꯗꯣꯡꯊꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯀꯔꯤꯅꯣ ꯍꯥꯌꯕꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯕꯤꯌꯨ꯫ꯃꯈꯣꯌꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯗꯨꯅꯥ ꯋꯥꯔꯦꯞ ꯂꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯐꯩ꯫
ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌꯗꯨ ꯀꯔꯝꯅꯥ ꯃꯦꯅꯦꯖ ꯇꯧꯒꯗꯒꯦ?
ꯍꯤꯗꯥꯛ ꯑꯃꯍꯦꯛꯇꯒꯨꯝꯅꯥ ꯚꯤꯖꯣꯏꯁꯅꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ . ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯃꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯌꯥꯝꯕꯗꯤ ꯃꯌꯥꯏ ꯑꯣꯏꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯃꯌꯥꯏ ꯑꯣꯏꯕꯥ ꯑꯣꯏ ꯑꯃꯁꯨꯡ ꯃꯦꯅꯦꯖ ꯇꯧꯕꯥ ꯌꯥꯏ꯫
| ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ꯫ | ꯃꯇꯧ ꯀꯔꯝꯅꯥ ꯃꯦꯅꯦꯖ ꯇꯧꯒꯗꯒꯦ ꯑꯃꯁꯨꯡ ꯀꯔꯤꯗꯥ ꯄꯨꯛꯅꯤꯡ ꯆꯪꯒꯗꯒꯦ꯫ |
|---|---|
| ꯈꯣꯡ ꯍꯥꯝꯗꯕ | ꯏꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯖꯨꯁꯒꯨꯝꯕꯥ ꯐ꯭ꯂꯨꯏꯗ ꯃꯔꯥꯡ ꯀꯥꯌꯅꯥ ꯊꯀꯎ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯁꯥꯊꯤꯕꯥ ꯗꯥꯏꯔꯤꯌꯥ, ꯁ꯭ꯇꯣꯃꯥꯛ ꯀ꯭ꯔꯌꯥꯝꯄ, ꯅꯠꯠꯔꯒꯥ ꯅꯍꯥꯛꯀꯤ ꯁ꯭ꯇꯣꯂꯗꯥ ꯏ ꯅꯠꯠꯔꯒꯥ ꯃ꯭ꯌꯨꯀꯁꯒꯨꯝꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯩꯔꯕꯗꯤ, ꯈꯨꯗꯛꯇꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯍꯥꯌꯌꯨ . |
| ꯗꯤꯍꯥꯌꯗ꯭ꯔꯦꯁꯟ ꯂꯩꯕꯥ꯫ | ꯗꯥꯏꯔꯤꯌꯥꯅꯥ ꯗꯤꯍꯥꯌꯗ꯭ꯔꯦꯁꯟ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯌꯥꯝꯅꯥ ꯁꯥꯊꯤꯅꯥ ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ, ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ, ꯑꯃꯁꯨꯡ ꯌꯨꯔꯤꯅꯔꯤ ꯍꯟꯊꯕꯥ ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯌꯦꯡꯁꯤꯜꯂꯨ꯫ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡꯗꯥ ꯁꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ, ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯈꯨꯗꯛꯇꯥ ꯈꯪꯍꯜꯂꯨ꯫ |
| ꯃꯆꯤꯟꯖꯥꯛ ꯁꯣꯀꯄꯥ (Stomatitis) . | ꯃꯤꯠ ꯁꯣꯟꯊꯕꯥ ꯑꯃꯁꯨꯡ ꯑꯅꯥꯕꯥ ꯊꯣꯀꯄꯥ ꯌꯥꯏ꯫ ꯌꯨ ꯌꯥꯎꯕꯥ ꯃꯥꯎꯊꯋꯥꯁꯁꯤꯡ ꯁꯤꯖꯤꯟꯅꯔꯣꯏꯗꯕꯅꯤ꯫ ꯅꯍꯥꯛꯀꯤ ꯃꯤꯠ ꯑꯗꯨ ꯇꯔꯨ-ꯇꯅꯥꯅꯕꯥ ꯏꯁꯤꯡꯅꯥ ꯁꯦꯡꯗꯣꯀꯎ꯫ ꯃꯆꯤ ꯑꯣꯏꯕꯥ, ꯑꯦꯁꯤꯗꯤꯛ ꯑꯣꯏꯕꯥ ꯆꯤꯟꯖꯥꯀꯁꯤꯡꯗꯒꯤ ꯂꯥꯞꯅꯥ ꯂꯩꯌꯨ꯫ |
| ꯕ꯭ꯂꯗ ꯁꯨꯒꯔ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ (Hyperglycemia) . | ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯂꯧꯕꯥ ꯍꯧꯗ꯭ꯔꯤꯉꯩꯗꯥ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯂꯥꯏꯌꯦꯡꯒꯤ ꯃꯇꯃꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯕ꯭ꯂꯗ ꯁꯨꯒꯔꯒꯤ ꯆꯥꯡ ꯑꯗꯨ ꯌꯦꯡꯁꯤꯅꯒꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯌꯥꯝꯅꯥ ꯋꯥꯅꯥ ꯇꯀꯈꯥꯌꯔꯕꯥ, ꯌꯥꯝꯅꯥ ꯇꯣꯏꯅꯥ ꯏꯁꯤꯡ ꯇꯨꯡꯁꯤꯅꯕꯥ, ꯅꯠꯠꯔꯒꯥ ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯩꯔꯕꯗꯤ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯈꯪꯍꯜꯂꯨ꯫ ꯗꯥꯏꯑꯦꯕꯦꯇꯤꯖ ꯃꯦꯂꯤꯇꯁꯅꯥ ꯅꯥꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯅꯥ ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯃꯔꯨꯑꯣꯏꯅꯥ ꯆꯦꯀꯁꯤꯅꯒꯗꯕꯅꯤ꯫ |
| ꯆꯨꯝꯅꯥ ꯆꯨꯃꯊꯣꯀꯄꯥ (Alopecia) . | ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯇꯃꯗꯥ ꯆꯨꯃꯊꯣꯀꯄꯥ ꯅꯠꯠꯔꯒꯥ ꯆꯨꯃꯊꯣꯀꯄꯥ ꯌꯥꯏ꯫ ꯃꯌꯥꯏ ꯑꯣꯏꯕꯥ ꯁꯦꯝꯄꯨ ꯁꯤꯖꯤꯟꯅꯧ꯫ ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯇꯥꯟꯅꯧ꯫ |
ꯑꯇꯣꯞꯄꯥ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡꯗꯥ ꯈꯨꯗꯣꯡꯆꯥꯗꯕꯥ ꯊꯣꯀꯄꯥ ꯌꯥꯕ꯭ꯔꯥ?
ꯍꯣꯏ. ꯚꯤꯖꯣꯏꯁꯅꯥ ꯑꯇꯩ ꯍꯤꯗꯥꯛ ꯈꯔꯒꯥ ꯏꯟꯇꯔꯦꯛꯇ ꯇꯧꯕꯥ ꯌꯥꯏ꯫ ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯍꯤꯗꯥꯛ ꯈꯔꯅꯥ ꯚꯤꯖꯣꯏꯁꯀꯤ ꯏꯐꯦꯛꯇ ꯍꯟꯊꯍꯅꯕꯥ ꯉꯝꯃꯤ꯫ ꯚꯤꯖꯣꯏꯁꯅꯥ ꯑꯇꯣꯞꯄꯥ ꯍꯤꯗꯥꯛ ꯈꯔꯒꯤ ꯏꯐꯦꯛꯇꯤꯕꯅꯦꯁꯁꯨ ꯍꯣꯡꯗꯣꯀꯄꯥ ꯌꯥꯏ꯫
ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯏꯄꯤꯂꯦꯄꯁꯤꯒꯤꯗꯃꯛꯇꯥ ꯀꯥꯔꯕꯥꯃꯥꯖꯦꯄꯤꯟ, ꯇ꯭ꯌꯨꯕꯔꯀꯨꯂꯣꯁꯤꯁꯀꯤꯗꯃꯛꯇꯥ ꯔꯤꯐꯥꯝꯄꯤꯟ, ꯑꯃꯁꯨꯡ ꯁꯦꯟꯇ ꯖꯣꯅꯁ ꯋꯔꯇꯒꯨꯝꯕꯥ ꯍꯔꯕꯦꯜ ꯄꯣꯠꯊꯣꯀꯁꯤꯡꯒꯨꯝꯕꯥ ꯍꯤꯗꯥꯀꯁꯤꯡꯅꯥ ꯃꯁꯤꯗꯥ ꯁꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫
ꯃꯔꯝ ꯑꯗꯨꯅꯥ, ꯅꯍꯥꯛꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯍꯧꯗ꯭ꯔꯤꯉꯩꯗꯥ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯍꯧꯖꯤꯛ ꯂꯧꯔꯤꯕꯥ ꯍꯤꯗꯥꯛ ꯄꯨꯝꯅꯃꯛ (ꯚꯤꯇꯥꯃꯤꯟ, ꯍꯔꯕꯦꯜ ꯄ꯭ꯔꯗꯛꯇꯁꯤꯡ, ꯑꯃꯁꯨꯡ ꯄꯦꯟ ꯀꯤꯂꯔꯁꯤꯡ ꯌꯥꯎꯅꯥ) ꯈꯪꯍꯅꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ, ꯃꯗꯨꯅꯥ ꯃꯍꯥꯛꯅꯥ ꯃꯊꯧ ꯇꯥꯕꯥ ꯑꯦꯗꯖꯁ꯭ꯇꯃꯦꯟꯇ ꯑꯃꯍꯦꯛꯇꯕꯨ ꯇꯧꯕꯥ ꯉꯃꯒꯅꯤ꯫
ꯇꯦꯛ-ꯍꯣꯝ ꯃꯦꯁꯦꯖ ꯇꯧꯕꯥ꯫
- PROS ꯑꯁꯤ `PIK3CA` ꯀꯧꯕꯥ ꯖꯤꯅꯒꯤ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯃꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯍꯀꯆꯥꯡꯒꯤ ꯁꯔꯨꯀꯁꯤꯡ ꯑꯁꯤ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯊꯣꯀꯄꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ꯫
- ꯚꯤꯖꯣꯏꯁ (ꯑꯦꯂꯄꯦꯂꯤꯁꯤꯕ) ꯑꯁꯤ ꯂꯥꯌꯅꯥ ꯑꯁꯤ ꯊꯣꯀꯍꯜꯂꯤꯕꯥ ꯃꯈꯥ ꯄꯣꯜꯂꯤꯕꯥ ꯊꯧꯑꯣꯡ ꯑꯁꯤꯕꯨ ꯄꯥꯟꯗꯝ ꯊꯝꯅꯕꯥ ꯑꯌꯥꯕꯥ ꯄꯤꯔꯕꯥ ꯑꯍꯥꯅꯕꯥ ꯗ꯭ꯔꯒꯅꯤ꯫
- ꯃꯁꯤꯅꯥ ꯑꯦꯕꯅꯣꯔꯃꯦꯜ ꯑꯣꯏꯕꯥ ꯒ꯭ꯔꯣꯊꯁꯤꯡ ꯍꯟꯊꯍꯅꯕꯗꯥ, ꯁꯔꯖꯔꯤꯒꯤ ꯃꯊꯧ ꯇꯥꯕꯥ ꯍꯟꯊꯍꯅꯕꯗꯥ ꯑꯃꯁꯨꯡ ꯄꯨꯟꯁꯤꯒꯤ ꯃꯒꯨꯟ ꯐꯒꯠꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫
- ꯗꯥꯏꯔꯤꯌꯥ, ꯕ꯭ꯂꯗ ꯁꯨꯒꯔ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ, ꯑꯃꯁꯨꯡ ꯃꯤꯠ ꯁꯣꯟꯊꯕꯥ ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯊꯣꯀꯄꯥ ꯌꯥꯏ, ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌꯕꯨ ꯃꯦꯅꯦꯖ ꯇꯧꯕꯥ ꯑꯃꯁꯨꯡ ꯗꯣꯛꯇꯔꯗꯥ ꯈꯪꯍꯅꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫
- ꯅꯍꯥꯛꯅꯥ ꯂꯧꯔꯤꯕꯥ ꯑꯇꯩ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛ ꯄꯨꯝꯅꯃꯛꯀꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯈꯪꯍꯅꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯃꯦꯗꯤꯀꯦꯂꯒꯤ ꯄꯥꯎꯇꯥꯛ ꯌꯥꯎꯗꯅꯥ ꯀꯩꯗꯧꯉꯩꯗꯥ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛ ꯑꯃꯠꯇꯥ ꯂꯧꯕꯥ ꯍꯧꯒꯅꯨ ꯅꯠꯠꯔꯒꯥ ꯊꯤꯡꯖꯤꯜꯂꯣꯏꯗꯕꯅꯤ꯫
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